WO2012117402A1 - Dispositif d'anastomose - Google Patents

Dispositif d'anastomose Download PDF

Info

Publication number
WO2012117402A1
WO2012117402A1 PCT/IL2012/050064 IL2012050064W WO2012117402A1 WO 2012117402 A1 WO2012117402 A1 WO 2012117402A1 IL 2012050064 W IL2012050064 W IL 2012050064W WO 2012117402 A1 WO2012117402 A1 WO 2012117402A1
Authority
WO
WIPO (PCT)
Prior art keywords
tubular element
state
vessel
proximal end
anchoring
Prior art date
Application number
PCT/IL2012/050064
Other languages
English (en)
Inventor
Ronen Paz
Shahar Peled
Original Assignee
Seamvad Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seamvad Ltd. filed Critical Seamvad Ltd.
Publication of WO2012117402A1 publication Critical patent/WO2012117402A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064—Surgical staples, i.e. penetrating the tissue
    • A61B2017/0641—Surgical staples, i.e. penetrating the tissue having at least three legs as part of one single body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A61B2017/1107—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis for blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A61B2017/1135—End-to-side connections, e.g. T- or Y-connections

Definitions

  • This invention relates to anastomosis devices, in particular devices for forming end-to-side anastomosis.
  • a device for insertion within a vessel comprising an opening within its wall, particularly useful for forming end-to-side anastomosis.
  • the device comprises a tubular element configured for taking at least a first state and a second state, configured for being deformed from said first state to said second state without changing its perimeter, at least one of said first and second states allowing the insertion of said device within said opening, and a plurality of anchoring members projecting from the tubular element and having such orientation and length as to allow the anchoring of the tubular element at least to said vessel to seal said opening.
  • the device according to the presently disclosed subject matter can be used for anchoring two tube-like vessels, a first vessel comprising a first vessel proximal end and a second vessel comprising an incision within its wall to which the proximal end of the first vessel is to be anchored.
  • the tubular element of the device can be configured for:
  • the anchoring members projecting from the tubular element can have such orientation and length as to penetrate the proximal end of the first vessel upon its eversion when the tubular element is in its first state and to subsequently penetrate the second vessel adjacent said incision when the tubular element is in the third state.
  • the device according to the presently disclosed subject matter can further comprise at least one end member or at least one couple of opposite end members, for fulfilling an auxiliary function different from that of the surface to which they are attached or on which they are formed.
  • the end members can, for example, be configured for strengthening areas of the tubular element, which have the risk to be weakened due to a corresponding deformation of the tubular element.
  • Such areas can have a curvature essentially greater than that of the remaining areas of the tubular element, which can happen, for example, when the tubular element changes its state from a wide state (for example of substantially circular shape, to a narrow state (for example of an elliptic shape), both as seen in its cross-section taken perpendicular to its axis of symmetry.
  • the end members can contribute to the sealing of the opening or an incision of the blood vessel in which the tubular member is inserted or can be used to manipulate the tubular element.
  • the tubular element can be configured to be deformed between at least two of its three states by the application thereto of an external force by a user.
  • the tubular element can be a unitary body, or can comprise two or more components assembled together.
  • the tubular element can comprise proximal and distal end surfaces, an outer side surface and a proximal boundary defined by the intersection of the proximal end surface with the outer side surface, and can have a normal axis of symmetry perpendicular to said proximal and distal surfaces, at least in said first state of the tubular element.
  • the tubular element can be configured for bending such that its axis of symmetry in its bended state is tilted with respect to direction of said normal axis of symmetry.
  • the third state of the tubular element can be different from the first state.
  • the third state of the tubular element can be different from the second state.
  • the anchoring members can have mechanical properties different from those of the tubular element.
  • the anchoring members can be made of a material different from that of the tubular element.
  • the anchoring members can take two or more orientations with respect to the tubular member.
  • the anchoring members can have a first, normal orientation, a second orientation different from the first orientation and a third orientation different at least from the second orientation
  • the anchoring members can be configured, in their second orientation, for facilitating the everting of the proximal end over the tubular member, and, at least in their third state, for anchoring the everted end of the first vessel to the second vessel.
  • a method for joining two hollow tube-like vessels, a first vessel comprising a proximal end and a second vessel comprising an incision within its wall to which the proximal end of the first vessel is to be inserted comprising:
  • a device comprising a tubular element configured for taking at least a first state, a second state obtained by the deformation of the element relative to the first state, and a third state different from at least said second state, and having a plurality of anchoring members projecting from the tubular element; mounting the tubular element over the first vessel adjacent to, and spaced from, the proximal end thereof;
  • Fig. 1A is a schematic perspective view of a device according to one example of the presently disclosed subject matter
  • Fig. IB is a schematic top view of the device shown in Fig. 1A;
  • Fig. 1C is a schematic perspective view of a device according to another example of the presently disclosed subject matter.
  • Fig. ID is a schematic perspective view of a device according to a further example the presently disclosed subject matter
  • Fig. IE is a schematic front view of the device shown in Fig. ID, wherein its anchoring members are in a state different of that shown in Fig. ID;
  • Fig. 2 schematically illustrates one example of how a device according to the presently disclosed subject matter can be bent
  • Figs. 3A to 3C schematically illustrate a proximal end boundary of the device shown in Fig. IB, in three different states thereof;
  • FIG. 4A to 4E schematically illustrate one example of a method, in which a device shown in Figs. 1A and IB can be used;
  • FIG. 5 schematically illustrates one possible use of a device according to the presently disclosed subject matter, in its bended state as shown in Fig. 3C;
  • Fig. 6A is a schematic front view of a device according to a further example of the presently disclosed subject matter
  • Fig. 6B schematically illustrates a possible use of the device shown in Fig. 6A
  • Fig. 7 schematically illustrates a proximal end boundary of a device according to a still further example of the presently disclosed subject matter.
  • Figs. 1A and IB illustrate one example of a device generally designated as 10 for anastomosis of two blood vessels, according to the presently disclosed subject matter.
  • the device 10 comprises a tubular element 20 having a proximal end 16 and a distal end 18 with an axis of symmetry A, and a plurality of anchoring members 30 disposed at its proximal end 16 and projecting therefrom outwardly and distally.
  • the tubular element 20 has an inner side surface 21, an outer side surface 23, both parallel to the axis of symmetry A, a proximal annular end surface 22 (not fully seen), a distal annular end surface 24, each having an imaginary center (not designated) via which the axis of symmetry A passes, and a width W defined by the distance between the proximal and the distal end surfaces along the axis of symmetry A.
  • the tubular element 20 further has a proximal end boundary 25 and a distal end boundary 27, each formed by the intersection of the outer side surface 23 with the respective proximal or distal end surface 22, 24 of the element 20.
  • the tubular member 20 can further comprise one or more end members constituting an integral part of the tubular member 20 or attached to the outer side surface 23 or one of the end surfaces 22 and 24.
  • the end members can be configured for strengthening areas adjacent thereto, as illustrated in Figs. 3A to 3C, can be used for applying an external force to the tubular member, by, for example, an applicator (not shown), and/or can be used for sealing purposes, as detailed below with reference to Figs. 4 A to 5.
  • the tubular element 20 is configured for being deformable, and in the context of the present description, this means that at least a portion of the element 20 can change its shape without changing its perimeter, as described below with reference to Figs. 3A to 3C. It should be indicated that though these figures show both an example of end members and the manner in which the tubular element 20 can be deformed, these features do not have to be necessarily used in combination, and the tubular member can be deformable as shown also without the end members illustrated in the above figures, or with end members different from those shown.
  • the tubular element 20 can be a unitary body, as shown in Figs. 1A and IB, configured for being deformed due to the deformability of its material, which can elastic, plastic or shape memory material, in particular, superelasitc material.
  • the tubular element 20 can be in the form of an assembly whose deformability of achieved due to the deformability of the material(s) from which its components are made, or due to a the construction of the assembly allowing movement of its components relative to each other, thereby changing the shape and dimensions of the assembly.
  • the material(s) can be of the same kind as mentioned above with respect to Figs. 1A and IB, and in the latter case, the assembly can comprise a plurality of components connected to each other so as to allow the tubular element's deformation between at least a compressed state in which the components are disposed close to each other, and an expanded state in which the components are spaced from each other.
  • the tubular member 20 when the tubular member 20 is assembled of two or more components, it can comprise two or more end members 41 used, in this case, also for the attachment of the components one to the other.
  • Figs. 3A and 3C illustrate a normal, non-deformed state (Fig. 3A), and two deformed states (Fig. 3B and 3C) of the tubular element 20.
  • the element 20 can be designed to take any desired number of deformed states, including only one such state.
  • the non-deformed and deformed states of the tubular element 20 differ from each other at least in the shape and dimensions of its proximal end boundary 25 in these states.
  • the boundary 25 can be defined by two dimensions along two mutually perpendicular axes lying in an imaginary plane of the proximal end of the element 20 and passing through its center defined by the intersection with said plane of the axis of symmetry A, one of the two axes passing through the most distanced points of the boundary 25.
  • these dimensions are Di and D 2 and, in the described example, they are essentially equal as shown in Fig.
  • the non-deformed boundary 25 in this example is generally in the form of a circle having a diameter D.
  • these dimensions are respectively Bi and B 2 , and Ci and C 2, and they are unequal as a result of the deformed shape of the boundary 25 in these states, which in both states has the form of an ellipse, but the ellipse in the first deformed state shown in Fig. 3B is more elongated than the ellipse in the second deformed state shown in Fig. 3C.
  • the dimensions of the boundary 25 in its above states can be defined as follows: Di»D 2 , B 2 >Bi, C 2 >Ci.
  • the end members 41 define the major dimensions C 2 and B 2 measured therebetween.
  • the deformation of the tubular element 20 from the first, non-deformed state shown in Fig. 3A to its first deformed state shown in Fig. 3B is normally to be achieved by the application thereto of an external force (in this example, a compressing force), and its deformation from the first deformed state to the second deformed state, or from any of the deformed states back into the first, non-deformed state, can be achieved either by the application thereto of an external force (in this example, an expanding force) or spontaneously, e.g. due to the elastic behavior of the tubular element 20.
  • an external force in this example, an expanding force
  • spontaneously e.g. due to the elastic behavior of the tubular element 20.
  • the tubular member 20 when made of a shape-memory material, the tubular member 20 can be normally open and thus can return to its non-deformed open state without an application thereto of an external force.
  • end areas ai and a 2 of the tubular element 20 are subjected to stress which is decreased due to the end members 41.
  • the tubular member 20 (shown in this figure without the anchoring members) can be further deformed to a bent state, in which at least a portion thereof is bent such that its axis of symmetry in the bent state Ai (which in fact is a curved line passing through the centers of the proximal and end surfaces, and through the center of any cross-section of the tubular element taken perpendicular to that line), is tilted with respect to the axis of symmetry A of the tubular element 20 in its normal state.
  • the tubular element has to be wide enough to allow such a bending.
  • the anchoring members 30, which can constitute an integral part of the tubular element 20 (being formed therewith as a unitary body) or be fixedly attached thereto, are spaced along the outer face 23 of the tubular element 20.
  • the anchoring members 30 have free ends 32 and fixed ends 34 fixedly attached to the proximal end surface 22 of the tubular element 20.
  • the anchoring members 30 are shaped so as to allow them to penetrate the tissue of a blood vessel, i.e. have a sufficient sharpness at least at their free ends 32, and are long enough to anchor the tissues of two blood vessels, as will be specified and shown below.
  • the anchoring members 30 can have more than one orientation with respect to the tubular element 20.
  • the anchoring members 30 can have a first, normal state, in which they are configured for anchoring an everted end of the blood vessel to the tubular member 20 and for anchoring one blood vessel to the other, as described in detail below, and a second state, in which the orientation of the anchoring members facilitates the everting process, as detailed below.
  • the anchoring members 30 can have more than two orientations.
  • the anchoring members 30 can have three different orientations: a first normal orientation, a second orientation during the everting process, and a final anchoring orientation, different from the second orientation.
  • Figs. 1A to IE show several examples of the anchoring members in accordance with the presently disclosed subject matter.
  • Figs. 1A, IB and 1C show the anchoring members 30 having a shape curved to different extents and oriented differently relative to a plane perpendicular to the side surface 23.
  • the anchoring members shown in Figs. 1A and IB are curled and lie fully in such plane, with their free ends 32 extending away from their fixed ends 34 fixed to the side surface 23 of the tubular member 20, intermediate portions 33 extending at least partially along the side surface 23, and distal portions with said free ends 34 pointing in a direction towards the side surface 23, as shown in Fig, IB.
  • the anchoring members 30' can extend totally or partially transversely with respect to the surface perpendicular to the surface 23, as shown for example in Fig. 1C.
  • Fig. ID shows anchoring members 30" that are completely straight and extend either along or transversely to the above plane.
  • the free ends of the anchoring members can be spaced from their fixed ends along the side surface and away from the end surface of the tubular member.
  • the above orientation can be normal orientations of the anchoring members, intermediate and/or their final orientations.
  • Fig. IE shows an example of a second orientation of the anchoring members 30", in which they extend away from the end surface of the tubular member in alignment with the side surface 23.
  • the anchoring members 30 can be oriented in the opposite direction, i.e. can extend along and parallel to the side surface 23 of the tubular member 20.
  • the deformation of the anchoring members 30 between their different states can be achieved either by the application thereto of an external force or spontaneously, e.g. due to the elastic behavior of the anchoring members 30.
  • the anchoring members 30 can be made of any material, similar or different of that of the tubular member 20, allowing penetration of a blood vessel and, if required, deformation between at least two states.
  • the anchoring members can be made of a shape memory material, in particular, superelasitc material.
  • Figs. 4A to 4E illustrating the end-to-side anastomosis procedure using the device 10 according to the presently disclosed example, to connect a first blood vessel Vi to a second blood vessel V 2 .
  • the first blood vessel Vi has a wall Wi of a thickness wj, with an external surface EXTi of an initial diameter DIN, an internal surface INTi and a proximal portion P terminating at a proximal end E
  • the second blood vessel V2 has a wall W2 of a thickness w3 ⁇ 4 with an external surface EXT 2 , an internal surface INT 2 , in which an incision INS has been made within the wall W 2 , of dimensions D' and D".
  • the device 10 is mounted over the external surface EXTi of the first vessel Vi so that the inner surface 21 of the tubular element 20 is in contact with the external surface EXTi of the first vessel Vi.
  • the tubular element 20 is in its first state and its diameter D corresponds to the initial diameter DIN of the first vessel and the anchoring members 30 are preferably kept, by means of an external force, in their second state, for the facilitation of the everting process.
  • the device 10 is mounted adjacent the proximal end E and spaced thereform by the proximal portion P of a length L at least equal to the width W of the tubular element 20.
  • proximal portion P of the first vessel Vi is then everted over the tubular element 20, while the anchoring members 30 are kept in their second orientation, and the everted end is kept, possibly by an external force, anchored to the tubular member.
  • Fig. 4C illustrates the next step during which an external force is applied to the tubular member 20, directly or indirectly by a user, deforming it, together with the everted proximal portion P, from its non-deformed state (illustrated by Fig. 4A) to its first deformed state (illustrated by Fig. 4B).
  • the extent of the deformation of the tubular member 20 is dependent on the dimensions D' and D" of the incision INS of the second vessel V 2 , as the device 10 with the proximal portion P of the first vessel Vi everted thereon is intended to be inserted therein.
  • the deformation of the tubular element 20 can be such that the dimensions Bi and B 2 of its proximal boundary 22 in its first deformed state be smaller than the corresponding dimensions D' and D", and more particularly smaller than (D'-
  • the device 10 being kept anchored to the proximal portion P of the first vessel Vi, is inserted in the incision INS as shown by an arrow 50 such that the tubular member 20, while being in its first deformed state, entirely enters the lumen of the second vessel V 2 .
  • the device 10 While the device 10 is within the lumen of the vessel V 2 , it can be deformed.
  • the deformation can bring the device into its initial state, which it had before having been deformed.
  • the device can be brought into its second deformed state such as illustrated in Fig. 3C, in which dimensions CI and C2 of the boundary 25 of the tubular element 20 and its shape are such as to prevent it from being retracted from the incision INS.
  • the deformation can be achieved spontaneously (due to the elasticity of the material of the tubular element 20 or its being made of a memory shape material or by an external force.
  • the deformation in the second deformed state should be such that the minor dimension C2 of the boundary 25 of the tubular element 20 be at least slightly greater than the D" of the incision INS.
  • Fig. 4E illustrates the final step during which the device 10 is pulled outwardly from the lumen of the vessel V 2 , as shown by an arrow 40.
  • the anchoring members 30 are deformed spontaneously or by means of an external force back to their normal orientation or to their final orientation (for example orientations shown in Figs. 1A to ID), anchoring thereby the proximal portion P of the first vessel Vi to the tissue adjacent the incision.
  • a passage (not seen) created between the lumens of the vessels Vi and V 2 after the anchoring has been completed, have to be wide enough to provide proper fluid communication therebetween. This has to be taken into consideration when deforming the tubular element 20 to its second deformed state, or its dimensions have to be further adjusted after the pulling is completed.
  • the tubular element 20 can be bent, as described above with reference to Fig. 3, so as to create an acute angle a between the vessels, as shown in Fig. 5.
  • tits width W is not uniform.
  • Fig. 6A shows a tubular member 60, in which a proximal surface 62 is not parallel to the distal surface 64. This configuration allows achieving an acute angle between the vessels Vi and V 2 without bending the tubular element, as shown in Fig, 6B.
  • Fig. 7 shows one example of a tubular member 70 with one such end member 71, which may be particularly useful for the configuration shown in Fig. 6B.
  • a sealing unit can be provided, such as, for example, a sleeve covering at least the device 10 and the tissue of the vessels Vi and V 2 adjacent the device 10.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)

Abstract

L'invention concerne un dispositif pour insertion au sein d'un vaisseau comprenant une ouverture au sein de sa paroi, le dispositif comprenant un élément tubulaire conçu pour adopter au moins un premier état et un deuxième état, conçu pour être déformé de son premier état audit deuxième état sans changer son périmètre, au moins l'un parmi lesdits premier et deuxième états permettant l'insertion dudit dispositif au sein de ladite ouverture; et une pluralité d'éléments d'ancrage faisant saillie à partir de l'élément tubulaire et ayant une orientation et une longueur adaptées à permettre l'ancrage de l'élément tubulaire au moins audit vaisseau pour obturer ladite ouverture.
PCT/IL2012/050064 2011-03-01 2012-03-01 Dispositif d'anastomose WO2012117402A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161447864P 2011-03-01 2011-03-01
US61/447,864 2011-03-01

Publications (1)

Publication Number Publication Date
WO2012117402A1 true WO2012117402A1 (fr) 2012-09-07

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PCT/IL2012/050064 WO2012117402A1 (fr) 2011-03-01 2012-03-01 Dispositif d'anastomose

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WO (1) WO2012117402A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9055946B2 (en) 2008-11-26 2015-06-16 Phraxis Inc. Anastomotic connector
WO2016023907A3 (fr) * 2014-08-12 2016-04-07 Anastomosis As Anastomose minimalement traumatique
US9308311B2 (en) 2011-06-15 2016-04-12 Phraxis, Inc. Arterial venous spool anchor
US10456239B2 (en) 2011-06-15 2019-10-29 Phraxis Inc. Anastomotic connector and system for delivery
US10786346B2 (en) 2012-06-15 2020-09-29 Phraxis Inc. Arterial anchor devices forming an anastomotic connector

Citations (8)

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WO2001000108A1 (fr) * 1999-06-25 2001-01-04 Contini, Emilio Dispositif destine a relier un implant a un canal corporel
WO2001041623A2 (fr) * 1999-05-30 2001-06-14 By-Pass, Inc. Dispositifs et procedes d'anastomose
US20030212418A1 (en) * 2000-10-12 2003-11-13 Cardica, Inc. Implantable superelastic anastomosis device
US20050234483A1 (en) * 2000-11-06 2005-10-20 Cardica, Inc. Unitary anastomosis device
EP1593347A1 (fr) * 2000-01-05 2005-11-09 Integrated Vascular Systems, Inc. Dispositif de fermeture d'une overture dans un tissu
US20060069401A1 (en) * 2004-09-27 2006-03-30 Wright David W Fastener apparatus for tissue and methods of deployment and manufacture
US20070167964A1 (en) * 1996-09-16 2007-07-19 Willis Geoffrey H Tubular anastomosis ring having alternating flexible and rigid sections
US20100160847A1 (en) * 2008-12-19 2010-06-24 St. Jude Medical, Inc. Systems, apparatuses, and methods for cardiovascular conduits and connectors

Patent Citations (8)

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Publication number Priority date Publication date Assignee Title
US20070167964A1 (en) * 1996-09-16 2007-07-19 Willis Geoffrey H Tubular anastomosis ring having alternating flexible and rigid sections
WO2001041623A2 (fr) * 1999-05-30 2001-06-14 By-Pass, Inc. Dispositifs et procedes d'anastomose
WO2001000108A1 (fr) * 1999-06-25 2001-01-04 Contini, Emilio Dispositif destine a relier un implant a un canal corporel
EP1593347A1 (fr) * 2000-01-05 2005-11-09 Integrated Vascular Systems, Inc. Dispositif de fermeture d'une overture dans un tissu
US20030212418A1 (en) * 2000-10-12 2003-11-13 Cardica, Inc. Implantable superelastic anastomosis device
US20050234483A1 (en) * 2000-11-06 2005-10-20 Cardica, Inc. Unitary anastomosis device
US20060069401A1 (en) * 2004-09-27 2006-03-30 Wright David W Fastener apparatus for tissue and methods of deployment and manufacture
US20100160847A1 (en) * 2008-12-19 2010-06-24 St. Jude Medical, Inc. Systems, apparatuses, and methods for cardiovascular conduits and connectors

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9055946B2 (en) 2008-11-26 2015-06-16 Phraxis Inc. Anastomotic connector
US9308311B2 (en) 2011-06-15 2016-04-12 Phraxis, Inc. Arterial venous spool anchor
US9597443B2 (en) 2011-06-15 2017-03-21 Phraxis, Inc. Anastomotic connector
US10456239B2 (en) 2011-06-15 2019-10-29 Phraxis Inc. Anastomotic connector and system for delivery
US10786346B2 (en) 2012-06-15 2020-09-29 Phraxis Inc. Arterial anchor devices forming an anastomotic connector
US11020215B2 (en) 2012-06-15 2021-06-01 Phraxis, Inc. Venous anchor devices forming an anastomotic connector
US10835366B2 (en) 2012-08-16 2020-11-17 Phraxis Inc. Arterial and venous anchor devices forming an anastomotic connector and system for delivery
WO2016023907A3 (fr) * 2014-08-12 2016-04-07 Anastomosis As Anastomose minimalement traumatique
JP2017524479A (ja) * 2014-08-12 2017-08-31 アナストモーシス エイエスＡｎａｓｔｏｍｏｓｉｓ Ａｓ 最小外傷性吻合
US10631864B2 (en) 2014-08-12 2020-04-28 Anastomosis As Minimally traumatic anastomosis

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