WO2012105796A3 - 회전하는 나노선 및 이를 이용한 세포 괴사 유도 방법 - Google Patents

회전하는 나노선 및 이를 이용한 세포 괴사 유도 방법 Download PDF

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Publication number
WO2012105796A3
WO2012105796A3 PCT/KR2012/000742 KR2012000742W WO2012105796A3 WO 2012105796 A3 WO2012105796 A3 WO 2012105796A3 KR 2012000742 W KR2012000742 W KR 2012000742W WO 2012105796 A3 WO2012105796 A3 WO 2012105796A3
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WO
WIPO (PCT)
Prior art keywords
cell
nanowire
cell necrosis
necrosis
rotating
Prior art date
Application number
PCT/KR2012/000742
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English (en)
French (fr)
Other versions
WO2012105796A2 (ko
Inventor
최성회
박정래
김영근
Original Assignee
고려대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 고려대학교 산학협력단 filed Critical 고려대학교 산학협력단
Priority to EP12742595.7A priority Critical patent/EP2671613A4/en
Priority to US13/982,943 priority patent/US20130309280A1/en
Publication of WO2012105796A2 publication Critical patent/WO2012105796A2/ko
Publication of WO2012105796A3 publication Critical patent/WO2012105796A3/ko
Priority to US14/811,039 priority patent/US20160022300A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/70—Manipulators specially adapted for use in surgery
    • A61B34/73—Manipulators for magnetic surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/06—Magnetotherapy using magnetic fields produced by permanent magnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00345—Micromachines, nanomachines, microsystems

Abstract

본 발명은 이중극자(dipole)를 갖고 있는 자성 나노선(magnetic nanowire)을 제조하여 세포 내에 도입한 후, 교류 자기장 인가에 따른 물리적 회전력을 이용하여 세포를 교반하여 세포를 괴사시키는 세포괴사 방법과 원리를 제시하고 있다. 따라서 본 발명의 세포 괴사 유도용 조성물을 암 세포와 같이 제거가 요구되는 세포에 적용하면, 세포 내로 도입된 나노선이 회전함으로써 세포에 물리적 충격을 가하여 괴사시킬 수 있다. 부가적으로 자기장 인가에 따른 유도전류에 의한 발열로 온열치료 효과를 가미할 수 있으며 나노선 표면에 약물을 부착하여 치료효과를 높일 수도 있다.
PCT/KR2012/000742 2011-02-01 2012-01-31 회전하는 나노선 및 이를 이용한 세포 괴사 유도 방법 WO2012105796A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP12742595.7A EP2671613A4 (en) 2011-02-01 2012-01-31 ROTARY NANOFIL AND METHOD FOR INDUCING CELL NECROSIS BY USING THE SAME
US13/982,943 US20130309280A1 (en) 2011-02-01 2012-01-31 Spinning nanowires and method for inducing cell eradication using same
US14/811,039 US20160022300A1 (en) 2011-02-01 2015-07-28 Spinning nanowires and method for inducing cell eradication using the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2011-0010114 2011-02-01
KR20110010114 2011-02-01

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/982,943 A-371-Of-International US20130309280A1 (en) 2011-02-01 2012-01-31 Spinning nanowires and method for inducing cell eradication using same
US14/811,039 Continuation-In-Part US20160022300A1 (en) 2011-02-01 2015-07-28 Spinning nanowires and method for inducing cell eradication using the same

Publications (2)

Publication Number Publication Date
WO2012105796A2 WO2012105796A2 (ko) 2012-08-09
WO2012105796A3 true WO2012105796A3 (ko) 2012-11-29

Family

ID=46603205

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/000742 WO2012105796A2 (ko) 2011-02-01 2012-01-31 회전하는 나노선 및 이를 이용한 세포 괴사 유도 방법

Country Status (4)

Country Link
US (1) US20130309280A1 (ko)
EP (1) EP2671613A4 (ko)
KR (2) KR20120089211A (ko)
WO (1) WO2012105796A2 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160022300A1 (en) * 2011-02-01 2016-01-28 Korea University Research And Business Foundation Spinning nanowires and method for inducing cell eradication using the same
JP6635791B2 (ja) 2013-02-20 2020-01-29 スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ 広視野ラマン撮像装置および関連方法
US10912947B2 (en) 2014-03-04 2021-02-09 Memorial Sloan Kettering Cancer Center Systems and methods for treatment of disease via application of mechanical force by controlled rotation of nanoparticles inside cells
EP3113760A4 (en) * 2014-03-04 2017-08-23 Memorial Sloan Kettering Cancer Center Applying mechanical force by remote-controlled rotation
US20170172438A1 (en) * 2014-04-04 2017-06-22 President And Fellows Of Harvard College Systems and methods for injectable devices
CA2956210A1 (en) 2014-07-28 2016-02-04 Memorial Sloan Kettering Cancer Center Metal(loid) chalcogen nanoparticles as universal binders for medical isotopes
CA2990223A1 (en) 2015-07-01 2017-01-05 Memorial Sloan Kettering Cancer Center Anisotropic particles, methods and uses thereof
US11078453B2 (en) 2016-01-04 2021-08-03 King Abdullah University Of Science And Technology Nanoneedles for intracellular applications
KR101772686B1 (ko) 2016-02-02 2017-08-29 연세대학교 원주산학협력단 나노입자 약물 전달 장치 및 그의 제어 방법
KR101916413B1 (ko) 2016-11-03 2018-11-07 연세대학교 원주산학협력단 나노입자 집중 장치 및 그의 구동 방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020187504A1 (en) * 2001-05-14 2002-12-12 Daniel Reich Multifunctional magnetic nanowires
US20080014442A1 (en) * 2004-11-25 2008-01-17 Arnar Rida Tailored Magnetic Particles and Method to Produce Same
KR20080074423A (ko) * 2007-02-09 2008-08-13 영남대학교 산학협력단 생체 내의 유체 내에서 자성체의 위치 조절 방법

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5067522B2 (ja) 2005-04-08 2012-11-07 ソニー株式会社 二次電池用電解液および二次電池
KR100848689B1 (ko) 2006-11-01 2008-07-28 고려대학교 산학협력단 다층 나노선 및 이의 형성방법
KR20080053146A (ko) 2006-12-09 2008-06-12 (주) 난네트 온라인 정보 처리의 효율적 방법

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020187504A1 (en) * 2001-05-14 2002-12-12 Daniel Reich Multifunctional magnetic nanowires
US20080014442A1 (en) * 2004-11-25 2008-01-17 Arnar Rida Tailored Magnetic Particles and Method to Produce Same
KR20080074423A (ko) * 2007-02-09 2008-08-13 영남대학교 산학협력단 생체 내의 유체 내에서 자성체의 위치 조절 방법

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FAN, DONGLEI ET AL.: "Subcellular-resolution delivery of a cytokine through precisely manipulated nanowires.", NATURE NANOTECHNOLOGY, vol. 5, no. 7, July 2010 (2010-07-01), pages 545 - 551, XP055127909 *
See also references of EP2671613A4 *

Also Published As

Publication number Publication date
KR101406632B1 (ko) 2014-06-11
KR20120089211A (ko) 2012-08-09
EP2671613A2 (en) 2013-12-11
KR20140040788A (ko) 2014-04-03
EP2671613A4 (en) 2015-06-03
WO2012105796A2 (ko) 2012-08-09
US20130309280A1 (en) 2013-11-21

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