WO2012092539A3 - Antibodies to dll4 and uses thereof - Google Patents

Antibodies to dll4 and uses thereof Download PDF

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Publication number
WO2012092539A3
WO2012092539A3 PCT/US2011/068044 US2011068044W WO2012092539A3 WO 2012092539 A3 WO2012092539 A3 WO 2012092539A3 US 2011068044 W US2011068044 W US 2011068044W WO 2012092539 A3 WO2012092539 A3 WO 2012092539A3
Authority
WO
WIPO (PCT)
Prior art keywords
dll4
antibodies
ligand
delta
bind
Prior art date
Application number
PCT/US2011/068044
Other languages
French (fr)
Other versions
WO2012092539A2 (en
Inventor
Jinhong Fan
Yuuichirou KAJIWARA
Gregory Landes
Spencer LIANG
Linda Masat
Jennifer STRATTON
Original Assignee
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Publication of WO2012092539A2 publication Critical patent/WO2012092539A2/en
Publication of WO2012092539A3 publication Critical patent/WO2012092539A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present disclosure relates to antibodies to delta-like ligand 4 (DLL4), including antibodies which bind to human DLL4, and their uses.
PCT/US2011/068044 2010-12-31 2011-12-30 Antibodies to dll4 and uses thereof WO2012092539A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201061429035P 2010-12-31 2010-12-31
US201061429037P 2010-12-31 2010-12-31
US201061429040P 2010-12-31 2010-12-31
US201061429042P 2010-12-31 2010-12-31
US61/429,040 2010-12-31
US61/429,035 2010-12-31
US61/429,042 2010-12-31
US61/429,037 2010-12-31

Publications (2)

Publication Number Publication Date
WO2012092539A2 WO2012092539A2 (en) 2012-07-05
WO2012092539A3 true WO2012092539A3 (en) 2012-10-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/068044 WO2012092539A2 (en) 2010-12-31 2011-12-30 Antibodies to dll4 and uses thereof

Country Status (1)

Country Link
WO (1) WO2012092539A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2707580T3 (en) 2011-09-23 2019-04-04 Oncomed Pharm Inc VEGF / DLL4 binding agents and uses thereof
DK3083683T3 (en) * 2013-12-17 2021-01-25 Mhs Care Innovation Llc COMPOSITIONS AND PROCEDURES FOR THE TREATMENT OF FATTY COLLECTIONS
GB201419094D0 (en) 2014-10-27 2014-12-10 Agency Science Tech & Res Anti-TIM-3-antibodies
AU2015340056A1 (en) 2014-10-27 2017-05-25 Agency For Science, Technology And Research Anti-TIM-3 antibodies
CN104479029A (en) * 2014-12-22 2015-04-01 中国人民解放军第四军医大学 Purification and renaturation method of Notch ligand Delta-like1 fusion protein
EP3579879A4 (en) 2017-02-09 2020-12-16 Memorial Sloan Kettering Cancer Center Anti-kir3dl1 antibodies
EP3477305A1 (en) 2017-10-25 2019-05-01 Universität Heidelberg Delta-like ligand 1 for diagnosing severe infections

Citations (5)

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WO2008042236A2 (en) * 2006-09-29 2008-04-10 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
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WO2008076379A2 (en) * 2006-12-14 2008-06-26 Regeneron Pharmaceuticals, Inc. Human antibodies to human delta like ligand 4
WO2010032060A1 (en) * 2008-09-19 2010-03-25 Medimmune Llc Antibodies directed to dll4 and uses thereof
WO2010151770A1 (en) * 2009-06-25 2010-12-29 Regeneron Pharmaceuticals, Inc. Method of treating cancer with dll4 antagonist and chemotherapeutic agent

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