WO2012087063A3 - 호흡기 바이러스의 다중 동시 진단 장치 및 이를 이용한 진단 방법 - Google Patents

호흡기 바이러스의 다중 동시 진단 장치 및 이를 이용한 진단 방법 Download PDF

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Publication number
WO2012087063A3
WO2012087063A3 PCT/KR2011/010033 KR2011010033W WO2012087063A3 WO 2012087063 A3 WO2012087063 A3 WO 2012087063A3 KR 2011010033 W KR2011010033 W KR 2011010033W WO 2012087063 A3 WO2012087063 A3 WO 2012087063A3
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Prior art keywords
chain reaction
polymerase chain
reactants
microfluidic chip
sensing
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PCT/KR2011/010033
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English (en)
French (fr)
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WO2012087063A2 (ko
Inventor
정재안
최재경
김원정
구태희
대현미
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주식회사 메디센서김해
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Publication of WO2012087063A2 publication Critical patent/WO2012087063A2/ko
Publication of WO2012087063A3 publication Critical patent/WO2012087063A3/ko

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

진단 장치가 제공된다. 이 진단 장치는 인플루엔자 A형 바이러스의 H1N1, H3N2, H5N1, H7N3 및 H9N2 아형들을 각각 검출하기 위한 각각의 항체가 제공된 5개의 감지 영역들로 구성된 감지부를 갖는 미세유체 칩, 미세유체 칩의 감지부로 생체시료에 포함된 5가지 아형들에 대한 중합효소 연쇄 반응물을 제공하기 위한 중합효소 연쇄 반응부, 미세유체 칩의 감지부의 항체에 특이 결합한 중합효소 연쇄 반응물에 광을 제공하여 형광 에너지를 발생시키기 위한 광원부, 및 항체에 특이 결합한 중합효소 연쇄 반응물로부터 발산되는 형광 에너지를 감지하는 센서부를 포함한다.
PCT/KR2011/010033 2010-12-24 2011-12-23 호흡기 바이러스의 다중 동시 진단 장치 및 이를 이용한 진단 방법 WO2012087063A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020100134574A KR20120072702A (ko) 2010-12-24 2010-12-24 호흡기 바이러스의 다중 동시 진단 장치 및 이를 이용한 진단 방법
KR10-2010-0134574 2010-12-24

Publications (2)

Publication Number Publication Date
WO2012087063A2 WO2012087063A2 (ko) 2012-06-28
WO2012087063A3 true WO2012087063A3 (ko) 2012-10-18

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Application Number Title Priority Date Filing Date
PCT/KR2011/010033 WO2012087063A2 (ko) 2010-12-24 2011-12-23 호흡기 바이러스의 다중 동시 진단 장치 및 이를 이용한 진단 방법

Country Status (2)

Country Link
KR (1) KR20120072702A (ko)
WO (1) WO2012087063A2 (ko)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007056723A2 (en) * 2005-11-07 2007-05-18 Digene Corporation Detection of nucleic acids by target-specific hybrid capture method
US20080280285A1 (en) * 2005-05-11 2008-11-13 Chen Zongyuan G Systems and Methods For Testing using Microfluidic Chips

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080280285A1 (en) * 2005-05-11 2008-11-13 Chen Zongyuan G Systems and Methods For Testing using Microfluidic Chips
WO2007056723A2 (en) * 2005-11-07 2007-05-18 Digene Corporation Detection of nucleic acids by target-specific hybrid capture method

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LIN, J-. H. ET AL.: "Rapid differentiation of influenza A virus subtypes and genetic screening for virus variants by high resolution melting analysis", JOURNAL OF CLINICAL MICROBIOLOGY, vol. 46, no. 3, March 2008 (2008-03-01), pages 1090 - 1097 *
MAHONY, J. B.: "Detection of respiratory viruses by molecular methods", CLINICAL MICROBIOLOGY REVIEWS, vol. 21, no. 4, October 2008 (2008-10-01), pages 716 - 747, XP055069076, DOI: doi:10.1128/CMR.00037-07 *
WANG, W. ET AL.: "Design of multiplexed assays for identification of avian influenza A virus subtypes pathogenic to humans by SmartCycler real-time reverse transcription-PCR", JOURNAL OF CLINICAL MICROBIOLOGY, vol. 747, no. 1, 29 October 2008 (2008-10-29), pages 86 - 92 *

Also Published As

Publication number Publication date
KR20120072702A (ko) 2012-07-04
WO2012087063A2 (ko) 2012-06-28

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