WO2012083408A8 - Composições farmacêuticas antimaláricas contendo derivados de diterpenos caurânicos - Google Patents

Composições farmacêuticas antimaláricas contendo derivados de diterpenos caurânicos Download PDF

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Publication number
WO2012083408A8
WO2012083408A8 PCT/BR2011/000513 BR2011000513W WO2012083408A8 WO 2012083408 A8 WO2012083408 A8 WO 2012083408A8 BR 2011000513 W BR2011000513 W BR 2011000513W WO 2012083408 A8 WO2012083408 A8 WO 2012083408A8
Authority
WO
WIPO (PCT)
Prior art keywords
kaurenic
malaria
pharmaceutical compositions
compositions containing
derivatives
Prior art date
Application number
PCT/BR2011/000513
Other languages
English (en)
French (fr)
Other versions
WO2012083408A1 (pt
Inventor
Alaíde Braga de OLIVEIRA
Fernando de Pilla VAROTTI
Ronan BATISTA
Original Assignee
Universidade Federal De Minas Gerais - Ufmg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade Federal De Minas Gerais - Ufmg filed Critical Universidade Federal De Minas Gerais - Ufmg
Publication of WO2012083408A1 publication Critical patent/WO2012083408A1/pt
Publication of WO2012083408A8 publication Critical patent/WO2012083408A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
    • C07D303/10—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals in which the oxirane rings are condensed with a carbocyclic ring system having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A presente invenção descreve composições farmacêuticas contendo derivados caurânicos produzidos a partir do ácido caurenoico e de outros diterpenos, bem como a sua atividade antimalárica. Os mesmos podem ser utilizados isoladamente ou em combinação para o tratamento de malária.
PCT/BR2011/000513 2010-12-23 2011-12-23 Composições farmacêuticas antimaláricas contendo derivados de diterpenos caurânicos WO2012083408A1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
BRPI1015495-7A BRPI1015495B1 (pt) 2010-12-23 2010-12-23 Composições farmacêuticas antimaláricas contendo derivados de diterpenos caurânicos
BR014100004504 2010-12-23
BRPI1015495-7 2010-12-23

Publications (2)

Publication Number Publication Date
WO2012083408A1 WO2012083408A1 (pt) 2012-06-28
WO2012083408A8 true WO2012083408A8 (pt) 2012-12-06

Family

ID=46312933

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR2011/000513 WO2012083408A1 (pt) 2010-12-23 2011-12-23 Composições farmacêuticas antimaláricas contendo derivados de diterpenos caurânicos

Country Status (2)

Country Link
BR (1) BRPI1015495B1 (pt)
WO (1) WO2012083408A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016077581A1 (en) * 2014-11-12 2016-05-19 University Of Florida Research Foundation, Inc. Isosteviol triazoles and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1202069C (zh) * 2003-01-17 2005-05-18 南京中医药大学 一种二萜单体化合物在制备抗癌药物中的应用
CN1900046B (zh) * 2005-07-20 2011-03-30 北京华医神农医药科技有限公司 贝壳杉烷型二萜化合物及其制备方法与应用

Also Published As

Publication number Publication date
BRPI1015495A2 (pt) 2016-03-01
WO2012083408A1 (pt) 2012-06-28
BRPI1015495B1 (pt) 2023-02-14

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