WO2012075700A1 - Système de coloscopie à fonction de balayage thermique infrarouge - Google Patents

Système de coloscopie à fonction de balayage thermique infrarouge Download PDF

Info

Publication number
WO2012075700A1
WO2012075700A1 PCT/CN2011/070518 CN2011070518W WO2012075700A1 WO 2012075700 A1 WO2012075700 A1 WO 2012075700A1 CN 2011070518 W CN2011070518 W CN 2011070518W WO 2012075700 A1 WO2012075700 A1 WO 2012075700A1
Authority
WO
WIPO (PCT)
Prior art keywords
infrared
infrared thermal
thermal scanning
colonoscope
probe
Prior art date
Application number
PCT/CN2011/070518
Other languages
English (en)
Chinese (zh)
Inventor
乔铁
Original Assignee
广州宝胆医疗器械科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 广州宝胆医疗器械科技有限公司 filed Critical 广州宝胆医疗器械科技有限公司
Publication of WO2012075700A1 publication Critical patent/WO2012075700A1/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0638Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements providing two or more wavelengths
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/31Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes, colonoscopes

Definitions

  • the invention belongs to the field of medical instruments, and particularly relates to a colonoscopy system with infrared thermal scanning function with infrared thermal scanning function. current technology
  • infrared imaging has been derived from military technology. It has been used for more than 40 years. With the development of various technologies such as medical imaging, infrared imaging, and multimedia, the temperature resolution of infrared imaging has reached 0. 05 degrees, and the spatial resolution has reached 0. 8mrad, the image sharpness has been greatly improved, the result analysis is intuitive and convenient, and its clinical application range is expanding. At present, infrared imaging diagnosis shows certain advantages in the following aspects: 1. Judging the location, extent and extent of acute and chronic inflammation; 2. Monitoring the blood supply function status of vascular lesions; 3. Tumor warning indication, full-course monitoring and efficacy evaluation. It can be seen that infrared imaging is an important complement to other morphological diagnostic methods such as B-ultrasound, CT, and MR.
  • Colonoscopy is the core instrument for colon surgery.
  • the colonoscope is connected with a camera host, an endoscope monitor and a cold light source host.
  • doctors can go deep into the colon to treat colitis, tumors and other diseases.
  • the object of the present invention is to overcome the deficiencies of the prior art and provide an electronic colonoscopy system with infrared thermal scanning function, which is obtained by introducing an infrared thermal scanning system into a colonoscopy system and multi-plane continuous cross-cutting scanning.
  • the data is transmitted to the host of the infrared thermal scanning system for image processing, and the static image of the stereoscopic blood vessel of the colon wall is clearly displayed.
  • the probe of the infrared thermal scanning system is used for stereoscopic scanning of the blood vessel of the colon wall and the surrounding tissue, and the doctor is provided with a infrared ray of the colon. Hot scan image.
  • the colonoscopy system with infrared thermal scanning function includes a colonoscope and a cold light source host connected to the colonoscope, a camera host, an endoscope monitor, and an infrared thermal scanning system on the colonoscope.
  • the infrared thermal scanning system includes an infrared thermal scanning probe, an infrared thermal scanning processing system host, and an infrared thermal scanning system monitor.
  • the colonoscope can be divided into two forms according to the optical system used: The first form is a colonoscope using an electronic ccd optical system, and the colonoscope of the electron optical system includes a soft inner cavity.
  • Mirror end, data connector, instrument channel, operating handle, the electronic ccd optical system of this type is mounted at the tip end of the end of the soft endoscope, using a CCD optical system of 3.0 or more optical lens, and
  • the CCD chip used is a 1/4" CCD with at least 480,000 effective pixels, and the lens has a field of view of 100 ° or more.
  • the second form is a colonoscope using an optical fiber optic system that includes a soft endoscope end, a data connector, an instrument channel, an eyepiece input, an operating handle, and an optical lens diameter of 3 or greater. . 0mm.
  • the diameter of the end of the soft endoscope is less than or equal to 15 mm, and the length is less than or equal to 2000 mm.
  • the end of the soft endoscope is made of a Microsoft material, and the tip end is curved. 0 ⁇
  • the function of the device channel diameter is greater than or equal to 3. 0mm.
  • the infrared thermal scanning probe includes a working end of the probe, an operating handle and a data line, and the working end of the probe passes through the instrument channel of the colonoscope and protrudes from the front end of the end of the soft endoscope.
  • the data line is connected to the infrared thermal scanning processing system host through a connector, and the infrared thermal scanning system monitor is connected to the infrared thermal scanning processing system host.
  • the outer end of the working end of the probe is less than 50mm, the outer diameter of the working end of the probe is less than or equal to 3.
  • the infrared portion of the probe is designed with an infrared region, the infrared device is equipped with an infrared device, the infrared device includes an infrared light source emitter, and the infrared receiving lens; the infrared light source emitter and the infrared receiving lens form a group of infrared devices, and the infrared region of the probe tip end portion is inside.
  • Three sets of identical infrared devices are integrated, and three sets of infrared devices are designed to each other at 60 degrees.
  • the infrared region can be rotated by the motor and linearly and cyclically moved to perform linear and circular scanning on the scanned object.
  • the operation handle of the infrared thermal scanning probe comprises a control switch, a mode selection switch, a fine adjustment switch and the like.
  • the data line is connected to the infrared heat treatment system host through a joint.
  • the infrared heat treatment system host of the present invention provides rich control buttons, switches, mode selection, infrared intensity fine adjustment, monitor menu and the like on the operation panel and the operation keyboard or the handheld operation device.
  • the mode selection can switch between different display modes, including the normal display mode and the night vision display mode.
  • the normal display mode refers to the display mode of infrared scanning under the illumination of the endoscope cold light source and the infrared light source, and the night vision display mode means no inside. Under the illumination of the mirror cold light source and the infrared light source, depending on the radiation intensity of the tissue itself, the doctor can compare the images in the two modes to obtain a better diagnostic effect from another angle.
  • the infrared heat treatment system host of the present invention has an output port externally connected to an operation keyboard or a handheld operation device, an infrared thermal scan monitor, etc., and the infrared thermal scan monitor scans and the infrared thermal scan probe scans one. To achieve synchronous scanning.
  • the infrared thermal scanning system of the present invention works on the principle that the colon wall and surrounding tissues are covered with abundant blood vessels, the arterial blood temperature is high, the venous blood temperature is low, and there is a certain heat exchange mechanism between the two, both of which Radiation of different wavelengths of infrared radiation, the temperature of the colon wall and surrounding tissues not only receives the blood flow in the blood vessels, but also the metabolism of the blood vessels. Therefore, the temperature of the colon wall and surrounding tissues will be rich or not due to blood vessels and metabolism.
  • the degree of activity varies, and the wavelength of infrared radiation radiated from the outside is also different. For colonic inflammation or tumors, the temperature is significantly higher than normal due to its active metabolism.
  • the infrared thermal scanning system has an accuracy of less than or equal to 0.05 degrees and a spatial resolution of at least 0.8 mrad.
  • the infrared thermal scanning probe scans at a close distance in the colonic tract to obtain a fine and precise infrared image.
  • the infrared thermal scanning system of the present invention has a working process: blood flow in the blood vessel of the colon wall and surrounding tissues and infrared radiation of tissue radiation are received by a precision infrared detector-infrared receiving lens of an infrared scanning probe entering the colonic channel.
  • the chip converts the optical signal into an electrical signal, and after pre-processing (such as amplification, filtering, etc.), the preamplifier and the main amplifier are amplified to a certain level and then enter the infrared heat treatment system host.
  • the signal input to the host also has a synchronization signal, a reference black body signal, and the like.
  • the data obtained by the multi-plane continuous cross-cut scan is transmitted to the host of the infrared thermal scanning system for image processing, and output to the infrared system monitor to clearly display the static image of the colonic stereoscopic blood vessel.
  • the doctor can analyze the image to find the colon wall and surrounding tissues. Abnormal vascular abnormalities, sparse vascular abnormalities, or abnormalities such as vascular missing areas provide doctors with immediate diagnosis.
  • the clinical application method of the colonoscopy system with infrared heat treatment probe according to the present invention is as follows: The doctor asks the patient to make a proper position, and after disinfection anesthesia, the colonoscope is passed into the rectum through the anus of the patient, and passes through the soft cavity of the colonoscope. The bending function of the end of the mirror smoothly enters the colonic tract. The doctor can make a clear observation through the colonoscope, and can pass the device to treat diseases such as colon polyps. The working end of the infrared heat treatment probe can pass through the instrument channel of the colonoscope. Enter the colonic tract, turn on the infrared thermal scanning function, and perform infrared thermal scanning on the wall of the colon wall and surrounding tissues to help the doctor discover potential lesions.
  • a colonoscope with an infrared thermal scanning probe with a colonoscope as a platform, an infrared thermal scanning probe is introduced into the colonic tract, and an infrared thermal scanning probe is used for linear and circular movement, and infrared rays are formed by temperature differences between blood vessels of the colon wall and blood vessels.
  • the infrared thermal scanning processing system of the present invention provides various working modes, including a normal display mode and a night vision display mode, and the doctor can make a correct diagnosis by analyzing and comparing the diagnostic images of different display modes.
  • the invention greatly enriches the diagnostic method of colon diseases and effectively improves the accuracy of diagnosis.
  • Figure 1 is a schematic illustration of a colonoscopy system with infrared thermal scanning functionality of the present invention.
  • FIGS. 2a and 2b are schematic views showing the appearance of two different forms of colonoscopes in the present invention.
  • Figures 3a and 3b are schematic views of the ends of the two different forms of colonoscope corresponding to Figures 2a and 2b above.
  • FIG. 4 is a schematic view showing the appearance of an infrared thermal scanning probe of the present invention.
  • Fig. 5 is a schematic view showing the working end portion of the infrared thermal scanning probe of the present invention.
  • Figure 6 is a schematic view showing the distribution of three sets of infrared devices in the present invention.
  • FIG. 7 is a schematic view showing a surgical method of a colonoscope system having an infrared thermal scanning probe function according to the present invention. detailed description
  • the colonoscopy system with infrared thermal scanning function comprises a colonoscope 1, a cold light source host 3, a camera host 4 and an endoscope monitor 8, an infrared thermal scanning probe 2, and an infrared heat treatment system host. 5. Operate the keyboard or handheld operating device 6, infrared thermal scanning system monitor 7.
  • FIG. 2a and 2b are schematic views showing the appearance of the colonoscope 1 of the present invention.
  • the colonoscope 1 according to the present invention can be divided into two forms according to the difference of the optical system: the first form is a colonoscope using an electronic ccd optical system, as shown in Fig. 2a, the colonoscope 1 includes a soft interior.
  • the electronic ccd optical system of the colonoscope 1 of this type is a tip end portion 111 mounted on the end portion 11 of the soft endoscope, which uses a CCD optical system having a diameter of 3.0 or more, and a CCD chip used. A 1/4", at least 480,000 effective pixel CCD with a lens field of view of 100 ° or more.
  • the second form is a colonoscope using an optical fiber optic system, as shown in Fig. 2b, which includes, in addition to the soft endoscope end 11, the data connector 14, the instrument channel 12, the operating handle 13, and the like. 0 ⁇
  • the eyepiece input end 15, the optical lens diameter is greater than or equal to 3. 0mm.
  • the diameter of the end of the soft endoscope is less than or equal to 15 mm, and the length is less than or equal to
  • the end of the soft endoscope is made of Microsoft material, and its tip end has a bending function.
  • the instrument channel diameter is greater than or equal to 3. 0mm.
  • the tip end portion 111 of the colonoscope 1 of the first form of the present invention is integrally designed with the following portions: an optical lens 14, a light guiding fiber 142, Instrument channel outlet 121;
  • the tip end portion 111 of the second form of colonoscope 1 is integrated with the following components: optical lenses 141 and 151, light guiding fiber 142, instrument channel outlet 121.
  • Fig. 4 is a view showing the appearance of the infrared thermal scanning probe 2 of the present invention.
  • the infrared thermal scanning probe 2 structure includes a probe working end portion 21, an operating handle 22 and a data line 23.
  • the probe working end portion 21 is 500 to 2000 mm long, and the outer diameter of the probe working end portion 21 is less than or equal to 3.0.
  • the operation handle 22 is designed with a control button 221, including a control switch, a mode selection switch, a fine adjustment switch, and the like.
  • the data line 23 is connected to the infrared heat treatment system main unit 5 through a joint.
  • Fig. 5 is a structural schematic view showing the front end of the probe working end portion 21, i.e., the probe tip end portion 211, of the present invention.
  • An infrared region 212 is disposed in the probe tip portion 211, an infrared device 212 is mounted on the infrared region 212, and an infrared light source emitter is included in the infrared device 212.
  • the infrared light source emitter and the infrared receiving lens form a group of infrared devices 213, and the probe works.
  • the infrared region 212 of the end portion 211 is integrated with three sets of the same infrared device 213, and the three infrared devices 213 are designed to be 60 degrees of each other; the infrared region 212 can be driven by the motor to rotate and linearly and cyclically move, so that the pair is scanned.
  • the body performs a linear and circular scan (as shown in Figure 6).
  • Fig. 7 is a schematic view showing the clinical operation of the colonoscopy system with infrared thermal scanning function according to the present invention.
  • the clinical use method is as follows: The doctor asks the patient to make a proper position. After disinfection and anesthesia, the colonoscope 1 is passed into the rectum 91 through the anus of the patient, and the curvature of the end of the colonoscope 1 is smoothly entered into the colonic tract 9, the doctor can The colonoscope 1 can be clearly observed, and the device can be used to treat diseases such as colon polyps; the working probe working end portion 21 of the infrared heat treatment probe 2 can smoothly enter the colonic channel 9 through the instrument channel 12 of the colonoscope 1, and the infrared light is turned on.
  • the thermal scanning function performs infrared thermal scanning on the wall of the colon wall and surrounding tissues to help doctors discover potential lesions.
  • Mode selection can switch between different display modes, including normal display mode and night vision display mode.
  • the normal display mode refers to the display mode of infrared scanning under the illumination of the endoscope cold light source 3 and the infrared light source, and the night vision display mode means no. Under the illumination of the endoscope cold light source and the infrared light source, depending on the radiation intensity of the tissue itself, the doctor can compare the images in the two modes to obtain a better diagnostic effect from another angle.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Optics & Photonics (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Endoscopes (AREA)

Abstract

L'invention concerne un système de coloscopie à fonction de balayage thermique infrarouge, qui comprend un coloscope (1) auquel sont reliés une source de lumière froide hôte (3), une caméra hôte (4) et un moniteur endoscopique (8). Le coloscope est équipé d'un système de balayage thermique infrarouge comprenant une sonde de balayage thermique infrarouge (2), un système hôte de traitement par balayage thermique infrarouge (5) et un moniteur de système de balayage thermique infrarouge (7). Le système de traitement par balayage thermique infrarouge offre plusieurs modes de fonctionnement, dont un mode d'affichage normal et un mode d'affichage en vision nocturne. Le système de coloscopie utilise la sonde de balayage thermique infrarouge (2) pour se déplacer de façon linéaire ou circulaire, et crée de ce fait un fond d'image tridimensionnel clair des vaisseaux sanguins de la paroi du côlon.
PCT/CN2011/070518 2010-12-10 2011-01-24 Système de coloscopie à fonction de balayage thermique infrarouge WO2012075700A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2010105817716A CN102100538B (zh) 2010-12-10 2010-12-10 具有红外线热扫描功能的结肠镜系统
CN201010581771.6 2010-12-10

Publications (1)

Publication Number Publication Date
WO2012075700A1 true WO2012075700A1 (fr) 2012-06-14

Family

ID=44153766

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2011/070518 WO2012075700A1 (fr) 2010-12-10 2011-01-24 Système de coloscopie à fonction de balayage thermique infrarouge

Country Status (2)

Country Link
CN (1) CN102100538B (fr)
WO (1) WO2012075700A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103932666A (zh) * 2011-12-30 2014-07-23 广州宝胆医疗器械科技有限公司 多普勒激光电子结肠镜系统
CN102697468A (zh) * 2012-01-18 2012-10-03 广州宝胆医疗器械科技有限公司 Oct电子结肠镜系统
CN110537893A (zh) * 2019-10-09 2019-12-06 南京速瑞医疗科技有限公司 软式3d电子内窥镜系统

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003245286A (ja) * 2002-02-22 2003-09-02 Olympus Optical Co Ltd 内視鏡手術システム
US20070167683A1 (en) * 2006-01-19 2007-07-19 Boston Scientific Scimed, Inc. Endoscopic system with integrated patient respiratory status indicator
CN101252878A (zh) * 2005-01-04 2008-08-27 沙丘医疗设备有限公司 体内操作的内窥镜系统
CN101322640A (zh) * 2007-06-14 2008-12-17 奥林巴斯医疗株式会社 内窥镜系统
CN102100540A (zh) * 2010-12-10 2011-06-22 广州宝胆医疗器械科技有限公司 一体化红外线热扫描结肠镜系统

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05228098A (ja) * 1992-02-20 1993-09-07 Asahi Optical Co Ltd 測温内視鏡
CN2551172Y (zh) * 2002-06-14 2003-05-21 台群科技股份有限公司 具有红外线的内视镜
US8774902B2 (en) * 2006-06-01 2014-07-08 Passive Imaging Medical Systems Engineering Ltd. (Pims) Method of infrared thermography for earlier diagnosis of gastric colorectal and cervical cancer
CN201977768U (zh) * 2010-12-10 2011-09-21 广州宝胆医疗器械科技有限公司 具有红外线热扫描功能的结肠镜系统

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003245286A (ja) * 2002-02-22 2003-09-02 Olympus Optical Co Ltd 内視鏡手術システム
CN101252878A (zh) * 2005-01-04 2008-08-27 沙丘医疗设备有限公司 体内操作的内窥镜系统
US20070167683A1 (en) * 2006-01-19 2007-07-19 Boston Scientific Scimed, Inc. Endoscopic system with integrated patient respiratory status indicator
CN101322640A (zh) * 2007-06-14 2008-12-17 奥林巴斯医疗株式会社 内窥镜系统
CN102100540A (zh) * 2010-12-10 2011-06-22 广州宝胆医疗器械科技有限公司 一体化红外线热扫描结肠镜系统

Also Published As

Publication number Publication date
CN102100538B (zh) 2012-11-21
CN102100538A (zh) 2011-06-22

Similar Documents

Publication Publication Date Title
WO2012075713A1 (fr) Système d'oesophagoscopie électronique à fonction de balayage thermique infrarouge
WO2012075704A1 (fr) Système d'oesophagoscopie intégrant un dispositif de balayage thermique infrarouge
WO2012075710A1 (fr) Système intégré de cystoscopie par balayage thermique infrarouge
CN102100540B (zh) 一体化红外线热扫描结肠镜系统
WO2012075700A1 (fr) Système de coloscopie à fonction de balayage thermique infrarouge
CN102100530B (zh) 一体化红外线热扫描十二指肠镜系统
WO2012075702A1 (fr) Système de gastroscopie électronique à fonction de balayage thermique infrarouge
WO2012075705A1 (fr) Système de gastroscopie intégrant un dispositif de balayage thermique infrarouge
WO2012075706A1 (fr) Système de cholécystoscopie intégrant un dispositif de balayage thermique infrarouge
WO2012075712A1 (fr) Système d'hystéroscopie intégrant une fonction de dispositif de balayage thermique infrarouge
WO2012075703A1 (fr) Système de bronchoscopie électronique à fonction de balayage thermique infrarouge
CN201996527U (zh) 具有红外线热扫描功能的电子腹腔镜系统
WO2012075696A1 (fr) Système endoscope de cholécystoscopie à fonction de balayage thermique infrarouge
WO2012075711A1 (fr) Système de colposcopie intégrant un dispositif de balayage thermique infrarouge
WO2012075709A1 (fr) Système d'endoscopie anale et intestinale intégrant un dispositif de balayage thermique infrarouge
CN201894634U (zh) 具有红外线热扫描功能的膀胱镜系统
WO2012075715A1 (fr) Système de sonde de balayage thermique infrarouge déformable
CN201939320U (zh) 一体化红外线热扫描喉镜系统
CN201920697U (zh) 一体化红外线热扫描膀胱镜系统
CN201899484U (zh) 一体化红外线热扫描结肠镜系统
CN201912042U (zh) 具有红外线热扫描功能的电子输卵管镜系统
CN201920693U (zh) 一体化红外线热扫描阴道镜系统
CN201977768U (zh) 具有红外线热扫描功能的结肠镜系统
CN201894631U (zh) 具有红外线热扫描功能的电子喉镜系统
WO2012075695A1 (fr) Système de cystoscopie à fonction de balayage thermique infrarouge

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11846592

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 11846592

Country of ref document: EP

Kind code of ref document: A1