WO2012067536A1 - Microsource à haute dose de rayonnement radioactif - Google Patents

Microsource à haute dose de rayonnement radioactif Download PDF

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Publication number
WO2012067536A1
WO2012067536A1 PCT/RU2011/000088 RU2011000088W WO2012067536A1 WO 2012067536 A1 WO2012067536 A1 WO 2012067536A1 RU 2011000088 W RU2011000088 W RU 2011000088W WO 2012067536 A1 WO2012067536 A1 WO 2012067536A1
Authority
WO
WIPO (PCT)
Prior art keywords
capsule
titanium
source
radioactive
vanadium
Prior art date
Application number
PCT/RU2011/000088
Other languages
English (en)
Russian (ru)
Inventor
Андрей Александрович КУДРИН
Александр Альбертович КУЗНЕЦОВ
Original Assignee
Kudrin Andrei Alexandrovich
Kuznetsov Alexandr Albertovich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kudrin Andrei Alexandrovich, Kuznetsov Alexandr Albertovich filed Critical Kudrin Andrei Alexandrovich
Publication of WO2012067536A1 publication Critical patent/WO2012067536A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/04—Radioactive sources other than neutron sources
    • G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
    • G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019—Sources therefor

Definitions

  • the invention relates to medicine, in particular to radiation sources used in brachytherapy, made in the form of containers or capsules of small size, firmly connected to the guide cable.
  • a known source of radiation for brachytherapy comprising a capsule-shaped body for placement of radioactive material in it and a guide cable provided with a cylindrical end, on the surface of which circular grooves are made.
  • the capsule is equipped with a smooth-walled cylindrical cavity into which the cylindrical end of the cable with grooves is inserted. After introducing the end of the cable into the cavity, the capsule walls surrounding the cylindrical cavity are crimped, forming an integral connection (patent RU 2357774, IPC A61N5 / 10, published on October 27, 2008).
  • a disadvantage of the known device is the complexity of its manufacture, since titanium is a very fragile material, and the size of the capsules and the portion of the cable with grooves are very small.
  • the outer diameter of the capsule is about 1.06 mm
  • the outer diameter of the cavity into which the end of the cable is inserted is about 1.09 mm.
  • the walls often break down due to the brittleness of titanium, which entails a decrease in the yield.
  • a disadvantage of the known device is that the cable is attached either with epoxy glue, which is a relatively weak material rial, or by welding. In this case, dissimilar metals have to be welded, which is difficult from the point of view of technology.
  • the source contains a case in the form of a tube made of titanium, in which natural thulium-169 is placed in the form of a wire of small diameter (approximately 0.45-0.65 mm), which is partially covered with gold, which is an X-ray marker, or a dusting, or foil wrap.
  • thulium is placed in a tube of titanium, the latter is sealed by means of plugs connected to the tube by laser welding.
  • the capsule obtained in this way is placed in a nuclear reactor and thulium-169 is activated as a result of exposure to neutron radiation by converting thulium-169 into thulium-170.
  • a disadvantage of the known device is that the source casing is made of titanium, which makes it difficult to attach flexible cables to it, allowing the radioactive radiation source to be freely introduced into the patient’s body and removed.
  • the high-dose micro-source of radioactive radiation claimed as an invention is aimed at providing a flexible connection of the housing with the cable and achieving high doses of radioactive radiation.
  • a high-dose micro-source of radioactive radiation contains a capsule of titanium or vanadium placed in a stainless steel case in the form of a hollow tube sealed at both ends with radioactive material placed in it and a flexible cable attached to the case.
  • the means of sealing the cavity of the capsule is made in the form of balls of titanium or vanadium, which are connected to the ends of the tube by laser welding.
  • the specified result is also achieved by the fact that the means of sealing the cavity of the capsule is made in the form of bushings in the form of truncated cones of titanium or vanadium, attached to the ends of the tube by laser welding.
  • the specified result is also achieved by the fact that the means of sealing the cavity of the capsule is made in the form of T-shaped bushings of titanium or vanadium, attached to the ends of the tube by laser welding.
  • the indicated result is also achieved by the fact that ytterbium oxide powder (Yb 2 0 3 ) is used as the radioactive material, enriched in the Yb isotope to a content of 35.8 ⁇ 0.3 atomic percent and subjected to neutron radiation to obtain activity from 0 5 Ki to 15 Ki.
  • Yb 2 0 3 ytterbium oxide powder
  • the l68 Yb isotope is transformed into the 169 Yb isotope.
  • the construction of the stainless steel housing makes it relatively easy to attach a flexible cable made of the same material to it.
  • the execution of the capsule with the radioactive material placed in it from titanium is due to the fact that, to activate the source, it is placed in a neutron radiation flux which is so intense that it causes the capsule to be heated to temperatures above the melting temperature of the steel. Therefore, the capsule made of such a refractory material as titanium allows it to be irradiated with a neutron flux with the power required for activation, and its placement inside the stainless steel housing allows solving the problem of attaching a flexible cable to it.
  • stainless steel is an inert material, which makes it possible to use the proposed radiation source for introduction into the patient's body.
  • Sealing can be carried out by any of the known methods (for example, flattening the ends of the tube, pressing it into the ends of the bushings, etc.). It is most expedient to carry out sealing using balls or bushings in the form of truncated cones, or T-shaped bushings made of titanium or vanadium, connected to the ends of the tube by laser welding.
  • ytterbium oxide powder (Yb 2 (>?), Enriched in the l 68 Yb isotope to a content of 35.8 ⁇ 0.3 atomic percent, as a radioactive material makes it possible to achieve high radiation doses of my source. Furthermore, for the same capsule with the powder of ytterbium oxide (Yb 2 0z) is subjected to neutron radiation to obtain l69 Yb with an activity of 0.5 to 15 Ki Ki. The flux and fluence of the radiation necessary for this are selected experimentally or by calculation.
  • the high-dose micro radiation source contains a housing 1 made of stainless steel to which a flexible cable 2 is attached by any of the known methods (laser welding, argon atmosphere welding, swivel joint).
  • a capsule made of titanium or vanadium is placed inside the housing 1 in the form hollow tube 3, sealed using balls 4 or bushings in the form of truncated cones 5 or T-shaped bushings 6 made of titanium or vanadium, attached to the ends of the tube 3 by laser welding.
  • Powder 7 of ytterbium oxide (Yb 2 0 3 ) enriched in the l68 Yb isotope to a content of 35.8 ⁇ 0.3 atomic percent is placed inside the capsule.
  • a high-dose micro-source of radioactive radiation is manufactured as follows. Powder is placed in a tube 3 of titanium or vanadium
  • High-dose micro-source of radiation is used as follows. To irradiate the tumor tissue in the patient’s body, the source is introduced into the body by the known methods used in brachytherapy and held in it until the tissue receives the required dose, after which it is removed using a flexible cable 2.
  • Rats with sarcoma M-1 were placed in a special plastic container of four animals.
  • a 169 Yb microsource needle was inserted into the center of the tumor to a depth of ⁇ 4 mm.
  • the duration of irradiation of each tumor was 100 min, which made it possible to irradiate the periphery of the tumor with a dose of at least 30 Gy at a dose rate of ⁇ 0.3 Gy / min.
  • the radiation efficiency l69 Yb was compared with standard gamma radiation of 60 Co (Luch-1 installation).
  • the experimental data were processed using standard statistical analysis methods.
  • the sample mean value (X) and the standard deviation of the mean value (S ⁇ ) were calculated.
  • a high-dose micro-source of radioactive radiation provides a flexible connection between the body and the cable and allows to achieve high doses of radioactive radiation with a high degree of efficiency of treatment of tumor diseases.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

L'invention concerne une source à haute dose de rayonnement radioactif comprenant une capsule de titane ou de vanadium, se présentant sous la forme d'un tube creux (3) hermétiquement fermé à ses deux extrémités, et qui est placée dans un logement (1) en acier inoxydable, une matière radioactive étant placée dans ladite capsule; et un câble flexible (2) est fixé au logement. La matière radioactive utilisée est une poudre (7) d'oxyde d'Ytterbium (Yb2Oз) enrichie en isotope168 Yb jusqu'à une teneur de pourcentages atomiques de 35,8±0,3 et soumise à un rayonnement neutronique pour produire l'isotopel69 Yb dont l'activité est comprise entre 0,5 Ci et 15 Ci.
PCT/RU2011/000088 2010-11-15 2011-02-17 Microsource à haute dose de rayonnement radioactif WO2012067536A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2010146373 2010-11-15
RU2010146373 2010-11-15

Publications (1)

Publication Number Publication Date
WO2012067536A1 true WO2012067536A1 (fr) 2012-05-24

Family

ID=46084266

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2011/000088 WO2012067536A1 (fr) 2010-11-15 2011-02-17 Microsource à haute dose de rayonnement radioactif

Country Status (1)

Country Link
WO (1) WO2012067536A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU1967U1 (ru) * 1995-01-05 1996-04-16 Научно-исследовательский и конструкторский институт монтажной технологии Малогабаритный радиоизотопный источник для внутриполостной лучевой терапии
US20040254418A1 (en) * 2003-06-10 2004-12-16 Munro John J. X-ray and gamma ray emitting temporary high dose rate brachytherapy source
RU2357774C2 (ru) * 2004-09-15 2009-06-10 ЮТи-БЭТИЛ, ЭлЭлСи Соединение троса с радиоактивной капсулой-источником, используемой в брахитерапии

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU1967U1 (ru) * 1995-01-05 1996-04-16 Научно-исследовательский и конструкторский институт монтажной технологии Малогабаритный радиоизотопный источник для внутриполостной лучевой терапии
US20040254418A1 (en) * 2003-06-10 2004-12-16 Munro John J. X-ray and gamma ray emitting temporary high dose rate brachytherapy source
RU2357774C2 (ru) * 2004-09-15 2009-06-10 ЮТи-БЭТИЛ, ЭлЭлСи Соединение троса с радиоактивной капсулой-источником, используемой в брахитерапии

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