WO2012050315A3 - Sel d'azétidinium en tant que précurseur de fp-cit, procédé pour préparer sélectivement celui-ci, et synthèse de fp-cit - Google Patents

Sel d'azétidinium en tant que précurseur de fp-cit, procédé pour préparer sélectivement celui-ci, et synthèse de fp-cit Download PDF

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Publication number
WO2012050315A3
WO2012050315A3 PCT/KR2011/007210 KR2011007210W WO2012050315A3 WO 2012050315 A3 WO2012050315 A3 WO 2012050315A3 KR 2011007210 W KR2011007210 W KR 2011007210W WO 2012050315 A3 WO2012050315 A3 WO 2012050315A3
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WO
WIPO (PCT)
Prior art keywords
cit
precursor
synthesis
preparing same
selectively preparing
Prior art date
Application number
PCT/KR2011/007210
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English (en)
Korean (ko)
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WO2012050315A2 (fr
Inventor
지대윤
이병세
박상돈
지형민
성현주
Original Assignee
(주)퓨쳐켐
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by (주)퓨쳐켐 filed Critical (주)퓨쳐켐
Publication of WO2012050315A2 publication Critical patent/WO2012050315A2/fr
Publication of WO2012050315A3 publication Critical patent/WO2012050315A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un sel d'azétidinium d'un composé de N-(3-sulfonyloxypropyl)-2-β-carbométhoxy-3-β-(4-iodophényl)trophane, un procédé sélectif pour préparer celui-ci et l'application de celui-ci, et plus particulièrement, concerne un procédé pour préparer sélectivement le sel d'azétidinium du composé de N-(3-sulfonyloxypropyl)-2-β-carbométhoxy-3-β-(4-iodophényl)trophane par dissolution du composé de N-(3-sulfonyloxypropyl)-2-β-carbométhoxy-3-β-(4-iodophényl)trophane dans un solvant polaire et ensuite chauffage de celui-ci.
PCT/KR2011/007210 2010-10-13 2011-09-30 Sel d'azétidinium en tant que précurseur de fp-cit, procédé pour préparer sélectivement celui-ci, et synthèse de fp-cit WO2012050315A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0099759 2010-10-13
KR1020100099759A KR101269588B1 (ko) 2010-10-13 2010-10-13 Ｆｐ―ｃｉｔ 전구체로서의 아제티디늄 염, 이의 선택적 제조방법 및 ｆｐ―ｃｉｔ의 합성

Publications (2)

Publication Number Publication Date
WO2012050315A2 WO2012050315A2 (fr) 2012-04-19
WO2012050315A3 true WO2012050315A3 (fr) 2012-06-14

Family

ID=45938770

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/007210 WO2012050315A2 (fr) 2010-10-13 2011-09-30 Sel d'azétidinium en tant que précurseur de fp-cit, procédé pour préparer sélectivement celui-ci, et synthèse de fp-cit

Country Status (2)

Country Link
KR (1) KR101269588B1 (fr)
WO (1) WO2012050315A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111909159A (zh) * 2019-05-08 2020-11-10 成都弘达药业有限公司 一种依匹哌唑有关物质及其制备方法
CN113024542B (zh) * 2021-03-11 2022-01-14 江苏省原子医学研究所 一种氘代托品烷衍生物及其应用
CN114487184B (zh) * 2022-01-21 2023-09-22 江苏省原子医学研究所 一种测定2β-甲酯基-3β-(4-氯苯基)托品烷及其有关物质的方法
KR20230159083A (ko) * 2022-05-13 2023-11-21 (주)듀켐바이오 Fp-cit 전구체의 제조방법 및 이에 의해 제조된 fp-cit 전구체를 이용한 [18f]fp-cit의 제조방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090257949A1 (en) * 2008-04-04 2009-10-15 Avid Radiopharmaceuticals, Inc. Radiopharmaceutical Imaging of Neurodegenerative Diseases
US20100113763A1 (en) * 2004-12-15 2010-05-06 Futurechem Co., Ltd. Method for preparation of organofluoro compounds in alcohol solvents
US20100256389A1 (en) * 2007-12-07 2010-10-07 Franziska Wagner Method for producing precursors for l-2- [18f] fluorophenylalanine and 6- [18f] fluoro-l--meta-tyrosine and the alpha-methylated derivatives thereof, precursor, and method for producing l-2- [18f] fluorophenylalanine and 6- [18f] fluoro-l-meta-tyrosine and the alpha-methylated derivatives from the precursor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100113763A1 (en) * 2004-12-15 2010-05-06 Futurechem Co., Ltd. Method for preparation of organofluoro compounds in alcohol solvents
US20100256389A1 (en) * 2007-12-07 2010-10-07 Franziska Wagner Method for producing precursors for l-2- [18f] fluorophenylalanine and 6- [18f] fluoro-l--meta-tyrosine and the alpha-methylated derivatives thereof, precursor, and method for producing l-2- [18f] fluorophenylalanine and 6- [18f] fluoro-l-meta-tyrosine and the alpha-methylated derivatives from the precursor
US20090257949A1 (en) * 2008-04-04 2009-10-15 Avid Radiopharmaceuticals, Inc. Radiopharmaceutical Imaging of Neurodegenerative Diseases

Also Published As

Publication number Publication date
WO2012050315A2 (fr) 2012-04-19
KR101269588B1 (ko) 2013-06-05
KR20120038156A (ko) 2012-04-23

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