WO2012044048A3 - 전도성 바이오-나노 융합 사슬 및 이의 제조방법 - Google Patents

전도성 바이오-나노 융합 사슬 및 이의 제조방법 Download PDF

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Publication number
WO2012044048A3
WO2012044048A3 PCT/KR2011/007119 KR2011007119W WO2012044048A3 WO 2012044048 A3 WO2012044048 A3 WO 2012044048A3 KR 2011007119 W KR2011007119 W KR 2011007119W WO 2012044048 A3 WO2012044048 A3 WO 2012044048A3
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WO
WIPO (PCT)
Prior art keywords
conductive
chain
synuclein
preparing same
nanoparticles
Prior art date
Application number
PCT/KR2011/007119
Other languages
English (en)
French (fr)
Other versions
WO2012044048A9 (ko
WO2012044048A2 (ko
Inventor
백승렬
이대견
Original Assignee
서울대학교산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 서울대학교산학협력단 filed Critical 서울대학교산학협력단
Publication of WO2012044048A2 publication Critical patent/WO2012044048A2/ko
Publication of WO2012044048A3 publication Critical patent/WO2012044048A3/ko
Publication of WO2012044048A9 publication Critical patent/WO2012044048A9/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B1/00—Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors
    • H01B1/20—Conductive material dispersed in non-conductive organic material
    • H01B1/22—Conductive material dispersed in non-conductive organic material the conductive material comprising metals or alloys

Abstract

전도성 바이오-나노 융합 사슬 및 이의 제조 방법이 개시되어 있다. 상기 사슬은 비전도성 알파-시뉴클린 아밀로이드 섬유( α -synuclein amyloid fibrils) 내에 전도성 나노입자 사슬이 선형으로 배열된 것이다. 이러한 사슬을 제조하기 위하여 먼저 알파-시뉴클린과 전도성 나노입자를 혼합하여 상기 전도성 나노입자를 상기 알파-시뉴클린으로 제1 코팅하도록 한다. 이후 상기 제1 코팅된 알파-시뉴클린을 야생형 알파-시뉴클린과 혼합하여 제2 코팅을 수행하도록 한다. 제2 코팅된 알파-시뉴클린 다수를 조립하여 아밀로이드 섬유를 제조하도록 한다. 다기능성 광도전성 나노 사슬이 구현된다.
PCT/KR2011/007119 2010-09-28 2011-09-28 전도성 바이오-나노 융합 사슬 및 이의 제조방법 WO2012044048A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0093600 2010-09-28
KR1020100093600A KR101723635B1 (ko) 2010-09-28 2010-09-28 전도성 바이오-나노 융합 사슬 및 이의 제조방법

Publications (3)

Publication Number Publication Date
WO2012044048A2 WO2012044048A2 (ko) 2012-04-05
WO2012044048A3 true WO2012044048A3 (ko) 2012-05-31
WO2012044048A9 WO2012044048A9 (ko) 2012-07-26

Family

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Family Applications (1)

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PCT/KR2011/007119 WO2012044048A2 (ko) 2010-09-28 2011-09-28 전도성 바이오-나노 융합 사슬 및 이의 제조방법

Country Status (2)

Country Link
KR (1) KR101723635B1 (ko)
WO (1) WO2012044048A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101576204B1 (ko) * 2014-03-04 2015-12-09 서울대학교산학협력단 PoP 나노구조체 및 이를 이용한 약물 전달 방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020152480A1 (en) * 1998-09-25 2002-10-17 Amgen Inc. Alpha-synuclein super-mutants accelerate alpha-synuclein aggregation
JP2009001589A (ja) * 1999-12-30 2009-01-08 Proteotech Inc アミロイド症およびα−シヌクレイン線維疾患の処置用ポリヒドロキシル化芳香族化合物
US20090280480A1 (en) * 2005-06-09 2009-11-12 Susan Lindquist Devices from Prion-Like Proteins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH044010A (ja) * 1990-04-21 1992-01-08 Toyo Tokushi Kogyo Kk 内燃機関用オイルフィルター用濾材
JP2882910B2 (ja) * 1991-06-27 1999-04-19 富士通株式会社 画像立体認識方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020152480A1 (en) * 1998-09-25 2002-10-17 Amgen Inc. Alpha-synuclein super-mutants accelerate alpha-synuclein aggregation
JP2009001589A (ja) * 1999-12-30 2009-01-08 Proteotech Inc アミロイド症およびα−シヌクレイン線維疾患の処置用ポリヒドロキシル化芳香族化合物
US20090280480A1 (en) * 2005-06-09 2009-11-12 Susan Lindquist Devices from Prion-Like Proteins

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
COLBY ET AL.: "Biotemplated synthesis of metallic nanoparticle chains on an a-synuclein fiber scaffold", JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, vol. 8, no. 2, 2008, pages 973 - 978 *
KANG ET AL.: "Characterization of surface-confined a-synuclein by surface plasmon resonance measurements", LANGMUIR, vol. 22, 2006, pages 13 - 17 *
LEE ET AL.: "Photoconductivity of pea-pod-type chains of gold nanoparticles encapsulated within dielectric amyloid protein nanofibrils of a-synuclein", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 50, 29 December 2010 (2010-12-29), pages 1332 - 1337, XP055012130, DOI: doi:10.1002/anie.201004301 *

Also Published As

Publication number Publication date
KR101723635B1 (ko) 2017-04-05
WO2012044048A9 (ko) 2012-07-26
WO2012044048A2 (ko) 2012-04-05
KR20120032139A (ko) 2012-04-05

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