WO2012042213A1 - Nouvelle interaction entre les protéines sbi et c3d de staphylococcus aureus - Google Patents

Nouvelle interaction entre les protéines sbi et c3d de staphylococcus aureus Download PDF

Info

Publication number
WO2012042213A1
WO2012042213A1 PCT/GB2011/001414 GB2011001414W WO2012042213A1 WO 2012042213 A1 WO2012042213 A1 WO 2012042213A1 GB 2011001414 W GB2011001414 W GB 2011001414W WO 2012042213 A1 WO2012042213 A1 WO 2012042213A1
Authority
WO
WIPO (PCT)
Prior art keywords
sbi
lys
complement inhibitor
ser
ala
Prior art date
Application number
PCT/GB2011/001414
Other languages
English (en)
Inventor
Jean Van Den Elsen
Stefan Bagby
Original Assignee
Bath Ventures
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bath Ventures filed Critical Bath Ventures
Publication of WO2012042213A1 publication Critical patent/WO2012042213A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Abstract

L'invention concerne la protéine Sbi de Staphylococcus aureus et, en particulier, l'interaction entre Sbi et la protéine C3d du complément. La structure cristalline du complexe Sbi-C3d révèle une interaction inattendue entre Sbi et la surface convexe de C3d, ce qui suggère que des fragments et variants particuliers de Sbi peuvent avoir une utilité en tant qu'inhibiteurs de la voie alterne du complément. L'invention concerne de nouveaux peptides et leurs utilisations dans l'inhibition d'états inflammatoires caractérisés par une activation indésirable de la voie du complément.
PCT/GB2011/001414 2010-09-29 2011-09-29 Nouvelle interaction entre les protéines sbi et c3d de staphylococcus aureus WO2012042213A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201016403A GB201016403D0 (en) 2010-09-29 2010-09-29 Novel interaction between staphylococcus aureus Sbi and C3d protiens
GB1016403.6 2010-09-29

Publications (1)

Publication Number Publication Date
WO2012042213A1 true WO2012042213A1 (fr) 2012-04-05

Family

ID=43128179

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2011/001414 WO2012042213A1 (fr) 2010-09-29 2011-09-29 Nouvelle interaction entre les protéines sbi et c3d de staphylococcus aureus

Country Status (2)

Country Link
GB (1) GB201016403D0 (fr)
WO (1) WO2012042213A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11771758B2 (en) 2021-03-04 2023-10-03 Helix Nanotechnologies, Inc. Compositions including SBI adjuvants and methods of use thereof

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984001031A1 (fr) 1982-08-27 1984-03-15 Roger Philip Ekins Mesure de la concentration d'un produit
WO1988001058A1 (fr) 1986-08-06 1988-02-11 Roger Philip Ekins Determination de la concentration d'analyte a l'aide de deux substances de marquage
WO1989001157A1 (fr) 1987-08-06 1989-02-09 Multilyte Limited Determination des concentrations ambiantes de differents analytes
EP0373203A1 (fr) 1988-05-03 1990-06-20 Isis Innovation Méthode et dispositif pour l'analyse de séquences de polynucléotides.
WO1993008472A1 (fr) 1991-10-15 1993-04-29 Multilyte Limited Methode de dosage par liaison a l'aide d'un reactif marque
WO1995018377A1 (fr) 1993-12-24 1995-07-06 Multilyte Limited Dosage a l'aide de proteines liantes
WO1995018376A1 (fr) 1993-12-24 1995-07-06 Multilyte Limited Titrage par retour a l'aide de deux marqueurs differents
WO1995024649A1 (fr) 1994-03-11 1995-09-14 Multilyte Limited Test de fixation a l'aide d'agents de fixation possedant des groupes d'extremite
WO2007138238A1 (fr) 2006-05-30 2007-12-06 Iknowledge Ltd Procédé et appareil de retransmission télévisuelle d'une partie de cartes
WO2007138328A2 (fr) * 2006-05-31 2007-12-06 The University Of Bath NOUVELLES APPLICATIONS DE LA PROTÉINE Sbi DE STAPHYLOCOCCUS AUREUS

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984001031A1 (fr) 1982-08-27 1984-03-15 Roger Philip Ekins Mesure de la concentration d'un produit
WO1988001058A1 (fr) 1986-08-06 1988-02-11 Roger Philip Ekins Determination de la concentration d'analyte a l'aide de deux substances de marquage
WO1989001157A1 (fr) 1987-08-06 1989-02-09 Multilyte Limited Determination des concentrations ambiantes de differents analytes
EP0373203A1 (fr) 1988-05-03 1990-06-20 Isis Innovation Méthode et dispositif pour l'analyse de séquences de polynucléotides.
WO1993008472A1 (fr) 1991-10-15 1993-04-29 Multilyte Limited Methode de dosage par liaison a l'aide d'un reactif marque
WO1995018377A1 (fr) 1993-12-24 1995-07-06 Multilyte Limited Dosage a l'aide de proteines liantes
WO1995018376A1 (fr) 1993-12-24 1995-07-06 Multilyte Limited Titrage par retour a l'aide de deux marqueurs differents
WO1995024649A1 (fr) 1994-03-11 1995-09-14 Multilyte Limited Test de fixation a l'aide d'agents de fixation possedant des groupes d'extremite
WO2007138238A1 (fr) 2006-05-30 2007-12-06 Iknowledge Ltd Procédé et appareil de retransmission télévisuelle d'une partie de cartes
WO2007138328A2 (fr) * 2006-05-31 2007-12-06 The University Of Bath NOUVELLES APPLICATIONS DE LA PROTÉINE Sbi DE STAPHYLOCOCCUS AUREUS

Non-Patent Citations (55)

* Cited by examiner, † Cited by third party
Title
"Remington's Pharmaceutical Sciences, 20th Edition,", 2000, LIPPINCOTT, WILLIAMS & WILKINS
AINLEY WADE: "Handbook of Pharmaceutical Excipients, 2nd edition,", 1994, AMER PHARMACEUTICAL ASSN
ALTSCHUL ET AL., METHODS IN ENZYMOLOGY, vol. 266, 1996, pages 460 - 480
ATKINS ET AL: "S. aureus IgG-binding proteins SpA and Sbi: Host specificity and mechanisms of immune complex formation", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 45, no. 6, 3 December 2007 (2007-12-03), pages 1600 - 1611, XP022476940, ISSN: 0161-5890, DOI: 10.1016/J.MOLIMM.2007.10.021 *
ATKINS, K. L., BURMAN, J. D., CHAMBERLAIN, E. S., COOPER, J. E., POUTREL, B., BAGBY, S., JENKINS, A. T., FEIL, E. J., VAN DEN ELSE, MOL IMMUNOL, vol. 45, 2008, pages 1600 - 1611
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
BURMAN J D ET AL: "Interaction of human complement with Sbi, a staphylococcal immunoglobulin-binding protein: Indications of a novel mechanism of complement evasion by Staphylococcus aureus", JOURNAL OF BIOLOGICAL CHEMISTRY 20080620 AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY INC. US, vol. 283, no. 25, 20 June 2008 (2008-06-20), pages 17579 - 17593, XP002665349, DOI: DOI:10.1074/JBC.M800265200 *
BURMAN, J. D., LEUNG, E., ATKINS, K. L., O'SEAGHDHA, M. N., LANGO, L., BERNADO, P., BAGBY, S., SVERGUN, D. I., FOSTER, T. J., ISEN, J BIOL CHEM, vol. 283, 2008, pages 17579 - 17593
CCP4, ACTA CRYSTALLOGR D BIOL CRYSTALLOGR, vol. 50, 1994, pages 760 - 763
CLACKSON, T., WELLS, J. A., SCIENCE, vol. 267, 1995, pages 383 - 386
CLARK E A ET AL: "A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 48, no. 4, 1 January 2011 (2011-01-01), pages 452 - 462, XP027578513, ISSN: 0161-5890, [retrieved on 20101104] *
DE HAAS, C. J., VELDKAMP, K. E., PESCHEL, A., WEERKAMP, F., VAN WAMEL, W. J., HEEZIUS, E. C., POPPELIER, M. J., VAN KESSEL, K. P,, J EXP MED, vol. 199, 2004, pages 687 - 695
DELAGLIO, F., GRZESIEK, S., VUISTER, G. W., ZHU, G., PFEIFER, J., BAX, A., J BIOMOL NMR, vol. 6, 1995, pages 277 - 293
DOPPER ET AL., EUR. J. IMMUNOL., vol. 33, 2003, pages 2098 - 2107
EMSLEY, P., COWTAN, K., ACTA CRYSTALLOGR D BIOL CRYSTALLOGR, vol. 60, 2004, pages 2126 - 2132
FRANKE, D. S., D.I., J. APPL. CRYST., vol. 42, 2009, pages 342 - 346
HAIR, P. S., WARD, M. D., SEMMES, O. J., FOSTER, T. J., CUNNION, K. M., J INFECT DIS, vol. 198, 2008, pages 125 - 133
HAMMEL, M, SFYROERA, G., RICKLIN, D., MAGOTTI, P., LAMBRIS, J. D., GEISBRECHT, B. V., NAT IMMUNOL, vol. 8, 2007, pages 430 - 437
HAMMEL, M., SFYROERA, G., PYRPASSOPOULOS, S., RICKLIN, D., RAMYAR, K. X., POP, M., JIN, Z., LAMBRIS, J. D., GEISBRECHT, B. V., J BIOL CHEM, vol. 282, 2007, pages 30051 - 30061
HASPEL, N., RICKLIN, D., GEISBRECHT, B. V., KAVRAKI, L. E., LAMBRIS, J. D., PROTEIN SCI, vol. 17, 2008, pages 1894 - 1906
HAUPT, K., REUTER, M., VAN DEN ELSEN, J., BURMAN, J., HALBICH, S., RICHTER, J., SKERKA, C., ZIPFEL, P. F., PLOS PATHOG, vol. 4, 2008, pages E1000250
HUSTON ET AL., PNAS USA, vol. 85, 1988, pages 5879 - 5883
ISENMAN DAVID ET AL: "Mutational analyses reveal that the staphylococcal immune evasion molecule Sbi and complement receptor 2 share overlapping contact residues on C3d: Implications for the controversy regarding the CR2/C3d co-crystal structure", MOLECULAR IMMUNOLOGY, vol. 45, no. 16, Sp. Iss. SI, October 2008 (2008-10-01), & 22ND INTERNATIONAL COMPLEMENT WORKSHOP; BASEL, SWITZERLAND; SEPTEMBER 28 -OCTOBER 02, 2008, pages 4095 - 4096, XP002665351, ISSN: 0161-5890 *
ISENMAN, D. E., LEUNG, E., MACKAY, J. D., BAGBY, S., VAN DEN ELSEN, J. M., J IMMUNOL, vol. 184, 2010, pages 1946 - 1955
JANSSEN, B. J., CHRISTODOULIDOU, A., MCCARTHY, A., LAMBRIS, J. D., GROS, P., NATURE, vol. 444, 2006, pages 213 - 216
JANSSEN, B. J., HUIZINGA, E. G., RAAIJMAKERS, H. C., ROOS, A., DAHA, M. R., NILSSON-EKDAHL, K., NILSSON, B., GROS, P., NATURE, vol. 437, 2005, pages 505 - 511
KONAREV, P. V., VOLKOV, V. V., SOKOLOVA, A. V., KOCH, M. H. J., SVERGUN, D. I., J. APPL. CRYSTALLOGR., vol. 36, 2003, pages 1277 - 1282
KRISSINEL, E., HENRICK, K., J MOL BIOL, vol. 372, 2007, pages 774 - 797
LANGLEY, R., WINES, B., WILLOUGHBY, N., BASU, I., PROFT, T., FRASER, J. D., J IMMUNOL, vol. 174, 2005, pages 2926 - 2933
LEE, L. Y., LIANG, X., HOOK, M., BROWN, E. L., J BIOL CHEM, vol. 279, 2004, pages 50710 - 50716
LONG, F., VAGIN, A. A., YOUNG, P., MURSHUDOV, G. N., ACTA CRYSTALLOGR D BIOL CRYSTALLOGR, vol. 64, 2008, pages 125 - 132
LOWY, F. D., N ENGL J MED, vol. 339, 1998, pages 520 - 532
NAGAR, B., JONES, R. G., DIEFENBACH, R. J., ISENMAN, D. E., RINI, J. M., SCIENCE, vol. 280, 1998, pages 1277 - 1281
OTWINOWSKI, Z., MINOR, W.: "Processing of X-ray Diffraction Data Collected in Oscillation Mode", 1997, ACADEMIC PRESS
PERRAKIS, A, MORRIS, R., LAMZIN, V. S., NAT STRUCT BIOL, vol. 6, 1999, pages 458 - 463
PETOUKHOV, M. V, SVERGUN, D. I., BIOPHYS J, vol. 89, 2005, pages 1237 - 1250
RICKLIN, D., RICKLIN-LICHTSTEINER, S. K., MARKIEWSKI, M. M., GEISBRECHT, B. V., LAMBRIS, J. D., J IMMUNOL, vol. 181, 2008, pages 7463 - 7467
ROOIJAKKERS, S. H, WU, J., RUYKEN, M., VAN DOMSELAAR, R., PLANKEN, K. L., TZEKOU, A., RICKLIN, D., LAMBRIS, J. D., JANSSEN, B. J.,, NAT IMMUNOL, vol. 10, 2009, pages 721 - 727
ROOIJAKKERS, S. H., RUYKEN, M., ROOS, A., DAHA, M. R., PRESANIS, J. S., SIM, R. B., VAN WAMEL, W. J., VAN KESSEL, K. P., VAN STRIJ, NAT IMMUNOL, vol. 6, 2005, pages 920 - 927
SEELEN ET AL., JOURNAL OF NEPHROPATHY, vol. 18, no. 6, 2005, pages 642 - 653
SEELEN, M. A. ET AL.: "Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of a simple ELISA", J IMMUNOL METHODS, vol. 296, 2005, pages 187 - 98, XP004738473, DOI: doi:10.1016/j.jim.2004.11.016
SVERGUN, D. 1., J. APPL. CRYSTALLOGR., vol. 25, 1992, pages 495 - 503
SVERGUN, D. I., BIOPHYS J, vol. 76, 1999, pages 2879 - 2886
SZAKONYI, G., GUTHRIDGE, J. M., LI, D., YOUNG, K., HOLERS, V. M., CHEN, X. S., SCIENCE, vol. 292, 2001, pages 1725 - 1728
THURMAN, HOLERS, J. IMMUNOL., vol. 176, 2006, pages 1305 - 1310
UPADHYAY A ET AL: "Structure-function analysis of the C3 binding region of Staphylococcus aureus immune subversion protein Sbi", JOURNAL OF BIOLOGICAL CHEMISTRY 20080808 AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY INC. US, vol. 283, no. 32, 8 August 2008 (2008-08-08), pages 22113 - 22120, XP002665350, DOI: DOI:10.1074/JBC.M802636200 *
UPADHYAY, A., BURMAN, J. D., CLARK, E. A., LEUNG, E., ISENMAN, D. E., VAN DEN ELSEN, J. M., BAGBY, S., J BIOL CHEM, 2008
UPADHYAY, A., WU, H. L., WILLIAMS, C., FIELD, T., GALYOV, E. E., VAN DEN ELSEN, J. M., BAGBY, S., BIOCHEM J, vol. 411, 2008, pages 485 - 493
VOLKOV, V. V., SVERGUN, D. I., JOURNAL OF APPLIED CRYSTALLOGRAPHY, vol. 36, 2003, pages 860 - 864
VRANKEN, W. F., BOUCHER, W., STEVENS, T. J, FOGH, R. H., PAJON, A., LLINAS, M., ULRICH, E. L., MARKLEY, J. L., IONIDES, J., LAUE,, PROTEINS, vol. 59, 2005, pages 687 - 696
WARD, E.S. ET AL., NATURE, vol. 341, 1989, pages 544 - 546
WIDMER, H., JAHNKE, W., CELL MOL LIFE SCI, vol. 61, 2004, pages 580 - 599
WIESMANN, C., KATSCHKE, K. J., YIN, J., HELMY, K. Y., STEFFEK, M., FAIRBROTHER, W. J., MCCALLUM, S. A., EMBUSCADO, L., DEFORGE, L., NATURE, vol. 444, 2006, pages 217 - 220
WILLIAMS, C., GALYOV, E. E., BAGBY, S., BIOCHEMISTRY, vol. 43, 2004, pages 11998 - 12008
ZHANG, L., JACOBSSON, K., STROM, K., LINDBERG, M., FRYKBERG, L., MICROBIOLOGY, vol. 145, 1999, pages 177 - 183

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11771758B2 (en) 2021-03-04 2023-10-03 Helix Nanotechnologies, Inc. Compositions including SBI adjuvants and methods of use thereof

Also Published As

Publication number Publication date
GB201016403D0 (en) 2010-11-10

Similar Documents

Publication Publication Date Title
Mrosek et al. Molecular determinants for the recruitment of the ubiquitin‐ligase MuRF‐1 onto M‐line titin
Pazgier et al. Human defensins: synthesis and structural properties
Brouwer et al. Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers
Derivery et al. The Wave complex is intrinsically inactive
Eckert et al. The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity
Bajic et al. Human C3a and C3a desArg anaphylatoxins have conserved structures, in contrast to C5a and C5a desArg
Janssen et al. Structural insights into the central complement component C3
Senkovich et al. Structure of a complex of human lactoferrin N-lobe with pneumococcal surface protein a provides insight into microbial defense mechanism
Isenman et al. Mutational analyses reveal that the staphylococcal immune evasion molecule Sbi and complement receptor 2 (CR2) share overlapping contact residues on C3d: implications for the controversy regarding the CR2/C3d cocrystal structure
US11512124B2 (en) Fibronectin type III domain proteins with enhanced solubility
Schatz-Jakobsen et al. Structural and functional characterization of human and murine C5a anaphylatoxins
Garcia et al. Diversity in the C3b convertase contact residues and tertiary structures of the staphylococcal complement inhibitor (SCIN) protein family
WO2007138328A2 (fr) NOUVELLES APPLICATIONS DE LA PROTÉINE Sbi DE STAPHYLOCOCCUS AUREUS
Makthal et al. Structural and functional analysis of RopB: a major virulence regulator in S treptococcus pyogenes
AU2017300021A1 (en) Agents and methods for the prevention or treatment of H. pylori infections
Clark et al. A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d
EP2951198A1 (fr) Inhibition du système du complément
Luthra et al. Evidence that immunization with TP0751, a bipartite Treponema pallidum lipoprotein with an intrinsically disordered region and lipocalin fold, fails to protect in the rabbit model of experimental syphilis
US20190359653A1 (en) Selective peptide inhibitors of frizzled
WO2012042213A1 (fr) Nouvelle interaction entre les protéines sbi et c3d de staphylococcus aureus
Li et al. Total chemical synthesis of human psoriasin by native chemical ligation
US20110046075A1 (en) Secreted Staphylococcus Aureus Proteins And Peptides For Use In Inhibiting Activation Of The Complement System
JP2023549878A (ja) 自己抗体に対する回避率又は活性が向上したａｄａｍｔｓ１３バリアント
Li et al. Crystal structure of human coactosin‐like protein at 1.9 Å resolution
Ahn Structural and functional characterisation of properdin and properdin-binding complement inhibitors from ticks

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11767281

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 11767281

Country of ref document: EP

Kind code of ref document: A1