WO2012040444A3 - Treatment of patients with incipient alzheimer's disease - Google Patents

Treatment of patients with incipient alzheimer's disease Download PDF

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Publication number
WO2012040444A3
WO2012040444A3 PCT/US2011/052731 US2011052731W WO2012040444A3 WO 2012040444 A3 WO2012040444 A3 WO 2012040444A3 US 2011052731 W US2011052731 W US 2011052731W WO 2012040444 A3 WO2012040444 A3 WO 2012040444A3
Authority
WO
WIPO (PCT)
Prior art keywords
patients
disease
treatment
incipient alzheimer
incipient
Prior art date
Application number
PCT/US2011/052731
Other languages
French (fr)
Other versions
WO2012040444A2 (en
Inventor
Charles F. Albright
Robert Mark Berman
Vladimir Coric
Howard Feldman
Ronald N. Marcus
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of WO2012040444A2 publication Critical patent/WO2012040444A2/en
Publication of WO2012040444A3 publication Critical patent/WO2012040444A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Abstract

Disclosed are methods for the treatment of patients with incipient Alzheimer's disease and the use of compounds that may be inhibitors of the enzymes that form β -amyloid (A β), e.g., A β 42, in particular γ-secretase.
PCT/US2011/052731 2010-09-24 2011-09-22 Treatment of patients with incipient alzheimer's disease WO2012040444A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38601410P 2010-09-24 2010-09-24
US61/386,014 2010-09-24

Publications (2)

Publication Number Publication Date
WO2012040444A2 WO2012040444A2 (en) 2012-03-29
WO2012040444A3 true WO2012040444A3 (en) 2012-06-28

Family

ID=45874374

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/052731 WO2012040444A2 (en) 2010-09-24 2011-09-22 Treatment of patients with incipient alzheimer's disease

Country Status (1)

Country Link
WO (1) WO2012040444A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2961746B1 (en) 2013-02-28 2018-01-03 Bristol-Myers Squibb Company Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors
TW201444798A (en) 2013-02-28 2014-12-01 必治妥美雅史谷比公司 Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002047671A2 (en) * 2000-11-17 2002-06-20 Eli Lilly And Company Lactam compound to inhibit beta-amyloid peptide release or synthesis
US20020111343A1 (en) * 1996-12-23 2002-08-15 Jing Wu Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-Amyloid peptide release and/or its synthesis by use of such compounds
WO2003053912A1 (en) * 2001-12-20 2003-07-03 Bristol-Myers Squibb Company α-(N-SULPHONAMIDO)ACETAMIDE DERIVATIVES AS β-AMYLOID INHIBITORS
WO2005023772A1 (en) * 2003-09-09 2005-03-17 F. Hoffmann-La Roche Ag Malonamide derivatives blocking the activity of gama-secretase
WO2009008980A2 (en) * 2007-07-05 2009-01-15 Schering Corporation Tetrahydropyranochromene gamma secretase inhibitors
WO2009058552A1 (en) * 2007-10-31 2009-05-07 Bristol-Myers Squibb Company A novel alpha-(n-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020111343A1 (en) * 1996-12-23 2002-08-15 Jing Wu Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-Amyloid peptide release and/or its synthesis by use of such compounds
WO2002047671A2 (en) * 2000-11-17 2002-06-20 Eli Lilly And Company Lactam compound to inhibit beta-amyloid peptide release or synthesis
WO2003053912A1 (en) * 2001-12-20 2003-07-03 Bristol-Myers Squibb Company α-(N-SULPHONAMIDO)ACETAMIDE DERIVATIVES AS β-AMYLOID INHIBITORS
WO2005023772A1 (en) * 2003-09-09 2005-03-17 F. Hoffmann-La Roche Ag Malonamide derivatives blocking the activity of gama-secretase
WO2009008980A2 (en) * 2007-07-05 2009-01-15 Schering Corporation Tetrahydropyranochromene gamma secretase inhibitors
WO2009058552A1 (en) * 2007-10-31 2009-05-07 Bristol-Myers Squibb Company A novel alpha-(n-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BLENNOW ET AL.: "CSF markers for incipient Alzheimer's disease.", LANCET NEUROL, vol. 2, 2003, pages 605 - 613, XP004811238, DOI: doi:10.1016/S1474-4422(03)00530-1 *
HAMPEL ET AL.: "Biological markers for early detection and pharmacological treatment of Alzheimer's disease.", DIALOGUES CLIN NEUROSCI., vol. 11, 2009, pages 141 - 157 *
LILLY.: "Lilly Halts Development of Semagacestat for Alzheimer's Disease Based on Preliminary Results of Phase III Clinical Trials.", PR NEWSWIRE, 17 August 2010 (2010-08-17), pages 1 - 2 *
MANGIALASCHE ET AL.: "Alzheimer's disease: clinical trials and drug development.", LANCET NEUROL, vol. 9, July 2010 (2010-07-01), pages 702 - 716, XP027598946, DOI: doi:10.1016/S1474-4422(10)70119-8 *
SHAW ET AL.: "Cerebrospinal Fluid Biomarker Signature in Alzheimer's Disease Neuroimaging Initiative Subjects.", ANN NEUROL, vol. 65, 2009, pages 403 - 413 *

Also Published As

Publication number Publication date
WO2012040444A2 (en) 2012-03-29

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