WO2012038273A1 - Système de polyuréthanes pour fabrication de moyens élastiques dotés de caractéristiques sanitaires et hygiéniques améliorées - Google Patents

Système de polyuréthanes pour fabrication de moyens élastiques dotés de caractéristiques sanitaires et hygiéniques améliorées Download PDF

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Publication number
WO2012038273A1
WO2012038273A1 PCT/EP2011/065637 EP2011065637W WO2012038273A1 WO 2012038273 A1 WO2012038273 A1 WO 2012038273A1 EP 2011065637 W EP2011065637 W EP 2011065637W WO 2012038273 A1 WO2012038273 A1 WO 2012038273A1
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WIPO (PCT)
Prior art keywords
component
polyurethane
polyurethane system
bentonite
ions
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PCT/EP2011/065637
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English (en)
Inventor
Ara Arshavirovich Abramyan
Mikhail Mefodievich Afanasyev
Viacheslav Ivanovich Beklemyshev
Anatoly Ivanovich Grigoriev
Igor Ivanovich Makhonin
Petr Ivanovich Makhonin
Umberto Orazio Giuseppe Maugeri
Lana Nizamovna Mukhamedieva
Oleg Igorevich Orlov
Vladimir Aleksandrovich Solodovnikov
Original Assignee
Closed Stock Company "Institute Of Applied Nanotechnology"
Fondazione Salvatore Maugeri Clinica Del Lavoro E Della Riabilitazione
Sib Laboratories Limited
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Application filed by Closed Stock Company "Institute Of Applied Nanotechnology", Fondazione Salvatore Maugeri Clinica Del Lavoro E Della Riabilitazione, Sib Laboratories Limited filed Critical Closed Stock Company "Institute Of Applied Nanotechnology"
Publication of WO2012038273A1 publication Critical patent/WO2012038273A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/72—Polyisocyanates or polyisothiocyanates
    • C08G18/74—Polyisocyanates or polyisothiocyanates cyclic
    • C08G18/76—Polyisocyanates or polyisothiocyanates cyclic aromatic
    • C08G18/7657—Polyisocyanates or polyisothiocyanates cyclic aromatic containing two or more aromatic rings
    • C08G18/7664—Polyisocyanates or polyisothiocyanates cyclic aromatic containing two or more aromatic rings containing alkylene polyphenyl groups
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/12—Powders or granules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/4833—Polyethers containing oxyethylene units
    • C08G18/4837—Polyethers containing oxyethylene units and other oxyalkylene units
    • C08G18/4845—Polyethers containing oxyethylene units and other oxyalkylene units containing oxypropylene or higher oxyalkylene end groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2110/00—Foam properties
    • C08G2110/0008—Foam properties flexible
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2110/00—Foam properties
    • C08G2110/0041—Foam properties having specified density
    • C08G2110/0058—≥50 and <150kg/m3

Definitions

  • the invention concerns chemistry of polyurethanes, in particular a polyurethane system intended for manufacturing of elastic products, preferably for medical purpose, for example orthopedic antibedsore mattresses, seats-pillows, anatomic pillows for back and for head, insoles-instep supports, orthopedic corsets, kneecaps, bandage products, footwear for various kinds of flat-footedness and defects of foots etc.
  • Their technical parameters have the improved sanitary and hygienic properties corresponding to the requirements for their operation.
  • the present invention can be also used for obtaining polyurethane wound dressings.
  • a process for obtaining polyurethane products is traditionally based on the use of a liquid polyurethane jet system whose components are mixed and filled in the form at low pressure; in alternative the formation of products is carried out with a reaction-injection method (REVI-technology).
  • the components of polyurethane jet system are selected depending on requirements for the end-product (density, durability, elasticity, temperature constancy etc.).
  • compositions containing the following components:
  • component A intended for structuring and determining molecular weight of polyurethanes, density of the vulcanization grid, structure of the cross- section chemical bonds, i.e. a complex of properties of polyurethanes and their purposes;
  • component B - isocyanate compounds determining speed of urethane-formation, strength properties, light and radiating resistance and also rigidity of polyurethanes.
  • Prepolymers both on the basis of methylenediphenyldiisocyanates (prepolymer - MDI) and toluenediisocyanates (prepolymer - TDI) are used as isocyanate compounds.
  • Esters and ethers are used as polyol compounds.
  • polyurethanes are based on interaction of polyisocyanate with one or more simple polyesterpolyols and waters. They do not provide effective pores formation. As a result the density of obtained polyurethanes is increased and such parameters as sufficient resistance to stress, worsens.
  • PLD-polyols with a dispersion of polyurea
  • Particles of graphite foam are used as a component (C) in the given patent. They are dispersed in a part of polyesterpolyol and the last part of polyesterpolyol is mixed with other agents including the activator, the accelerator, etc.
  • the use of particles of graphite foam in a polyurethane system and also an additional agent such as casein in the powdery form, provides an elastic polyurethane with improved properties of non inflammability derived from the given materials.
  • the polyol component (A) contains the agent (C), on the basis of an aluminosilicate mineral, dispersed in it.
  • agents (D) are dispersed in the polyol component (A) including the metal catalyst and a thixotropic agent such as silicon dioxide with a specific surface of 150m /g or more.
  • the agent (C) on the basis of the aluminosilicate mineral dispersed in the polyol component (A) has the average size of particles of 100 microns with a size of pores from 2 up to 5 A.
  • the polyurethane composition contains 1.2-2 % b.w. (by weight) of the agent (C).
  • Application of the named aluminosilicate mineral (the agent (C)) in the polyurethane composition provides adsorption of water during formation of urethane links. This promotes regulation of speed of interaction of isocyanate groups both with hydroxyl- containing oligomers and water, in the presence of the catalyst in the polyurethane system.
  • Polyester polyols are used as a component (A) in the given patent. Polyester polyols or a mix of polyester polyols consisting of high-molecular elastic polyols with molecular weight in the range from 1500 up to 10000, are preferably used. Prepolymers MDI, or a mix of polymers MDI with an amount of the isocyanate group (NCO) from 15 up to 40%, on the total weight of prepolymer, are preferably used as the component (B).
  • NCO isocyanate group
  • the invention is intended for use in surgery and traumatology for healing wounds of various etiologies.
  • Simple high-molecular polyesterpolyol containing dispersed in it activating additives namely: the catalyst of urethane-formation, on the basis of a mix of tertiary amines and organotin compounds; a chain extender of polyurethane; the foaming agent, a foam-opener and a foam-hardener, are used as the polyol compounds in polyurethane systems according to the given invention.
  • a mix of prepolymers MDI is used as isocyanate compound (component B).
  • a wound dressing obtained according to the given invention is poorly effective for antimicrobic influence on wounds of various etiologies.
  • the given polyurethane system is intended for manufacturing products used in motor industry, in particular for manufacturing seats, instrument panels, boards, boxes and details of internal or external car facing.
  • polyurethane system does not correspond to requirements for manufacturing products with improved sanitary- and-hygienic properties.
  • requirements are necessary for products of medical use including: antibedsore mattresses, sitting-pillows, anatomic pillows for the back or for the head, insoles-instep supports, orthopedic corsets, kneecaps, footwear for various kinds of flat-footedness and defects of foot and also for obtaining polyurethane wound dressings.
  • the problem of the present invention consisted in the creation of a polyurethane system for manufacturing products with improved sanitary and hygienic properties under use, both due to suppression of growth of microorganism in the products and due to improvement of their chemical stability deriving from decreasing in gas evolution of the volatile toxic organic compounds, displaying at operation of products under influence of agents such as temperatures, light, mechanical loadings and other factors which lead to destruction of polymeric materials.
  • a polyurethane system for manufacturing products with improved sanitary and hygienic properties containing structures on the basis of polyol compounds (component A), isocyanate compounds (component B) and the mineral agent (C) which is dispersed in polyol compound (component A).
  • component A polyol compounds
  • component B isocyanate compounds
  • C mineral agent
  • a mix of nano structured powders of bentonite intercalated by ions of silver (Ag + ) and ions of cerium (Ce 3+ ), in a ratio in the mix of 1 : (5- 10) (weight parts) is used as the agent (C) dispersed in the polyol component (A).
  • polyurethane system for manufacturing products according to the invention is used at the following contents of components, in % b.w.:
  • a nanostructured powder of bentonite intercalated by ions of cerium (Ce 3+ ) is obtained by modifying a semifinished product of bentonite with 0.3-2.0% water solution of nitrate salt of cerium Ce(N0 3 )3-6H 2 0.
  • Semifinished product of bentonite is obtained, after its enrichment with cations of sodium (Na + ), by processing with a 3-10% water solution of sodium chloride and subsequent cleaning from anions of chlorine. After intercalation bentonite is cleaned from salts of sodium by means of grinding.
  • polyol compound (component A) preferably is used as polyol compound (component A) with a hydroxyl number of mg(KON)/g of 66.0-77.0, and a content of water of 2-4% b.w..
  • isocyanate compound (component B) a compound on the basis of prepolymer MDI with an amount of isocyanate group (NCO) from 23 up to 40.0% on the total weight of the prepolymer, and preferably with an amount of group (NCO) of 30%.
  • the polyol compound (component A) and the isocyanate compound (component B), at formation of polyurethane system for manufacturing a product have the following ratio: (2-3) : (1-3) (parts b.w.).
  • simple high-molecular polyesterpolyol with the molecular weight 3000-10000, obtained on the basis of propylene oxide or ethylene oxide, with a content of water of 2.0-4.0 % b.w., is preferably used as the polyol compound (component A).
  • high-molecular polyesterpolyol on the basis of propylene oxide or ethylene oxide contains, in addition, dispersed in it, activating additives, namely: the catalyst of urethane-formation on the basis of a mix of tertiary amines and organotin compounds in a ratio 1: 1; a chain extender of polyurethane; a foaming agent; a foam-opener and a foam-hardener in the following contents with reference to the component (A), expressed as % b.w.:
  • a mix of prepolymers is used as isocyanate compound (component B).
  • One of prepolymers is obtained from a mix of 4.4, 2.4 and 2.2-isomers of diphenylmethanediisocyanate and low-molecular polyol from propylene oxide with molecular weight 240-250.
  • the second prepolymer is synthesized by heat treatment of the specified mix of isomers of diphenylmethanediisocyanate.
  • polyol compound (component A) on the basis of propylene oxide or ethylene oxide and isocyanate compound (component B) on the basis of the specified mix of prepolymers have the ratio (2-4) : 1 (parts b.w.) in the formation of polyurethane systems.
  • the present patent application can be industrially realized by using known technological processes, available equipments and materials intended for manufacturing structures and means for medical purposes.
  • the choice of the components A and B is determined by the technological process for manufacturing the elastomeric products and by their intended use.
  • a polyol component (A) - trade mark Voralux HK 490, with a hydroxyl number mg(KON)/g 66.0-77.0, and a content of water of 2.16-2.54 %.
  • An isocyanate component (B) trade mark Specflex NE 371. It identifies prepolymers MDI, whose number of the isocyanate group (NCO) is from 28.8 up to 30.8 %, on the total weight of prepolymer.
  • the mentioned isocyanate component (B) preferably has isocyanate groups (NCO) in amount of 30%.
  • the products named in item 1.1 and 1.2 are optimal for obtaining elastomeric articles with a method of formation which uses the RIM-technology; they are preferably used for obtaining orthopedic means.
  • the quantitative contents of a polyol component (A) and an isocyanate component (B), in polyurethane system specified in the invention is the optimum, taking into account also the specified ratios; the process of urethane-formation qualitatively worsens, or the characteristics of the obtained products considerably change as to their density, at decrease in the quantitative content of the given components in the system and at change of their weight ratio.
  • the given parameter is a determining parameter for manufacturing means of orthopedic use, of the above specified type, and it is preferably in limits from 80 up to 100 kg/m 3 .
  • the following method is used for obtaining a polyurethane system which is used for obtaining elastomeric products, as wound dressings, according to techniques described in the Russian patent No. 2379060, when formation of dressings is carried out directly on the wound surface, after mixing the components A and B.
  • the polyol compound (component A) is a simple high-molecular polyesterpolyol with the molecular weight 3000-10000. It is obtained on the basis of propylene oxide or ethylene oxide, with a content of water of 2.0-4.0 % b.w..
  • the given product has a trade mark LAPROL 3003, 3603, 5003, 6003. Analogues of these products have trade marks "Raradol" and "Demosthenes”.
  • Activation additives namely the catalyst of urethane-formation, the chain extender of polyurethane, a foam-opener, a foam-hardener and the foaming agent are as follows: low-boiling organic liquids, for example, H-pentene, isopentene, methylcyclopentene, etc., are used as the foaming agent; a mix of tertiary amines and organotin compounds in the ratio of 1 : 1 (parts b.w.), for example, triethylenediamine and dibutyltindioleate is used as the catalyst for urethane-formation (mixes of tertiary amines and organotin compounds possess a synergistic effect); alkanolamines are used as the chain extender.
  • low-boiling organic liquids for example, H-pentene, isopentene, methylcyclopentene, etc.
  • Polymethylenedisiloxanes for example, Dabko 2525 of the company Ajr Prodaks or Tegostab 8715 of the company Goldshmidt are used as a foam-hardener.
  • High- molecular polyols are used for adjustable foam-openers.
  • activation additives are dispersed into a polyol component (A) specified in the item 2.1.
  • the quantitative contents of activation additives specified in the present invention are optimum for obtaining effective polyurethane system intended for obtaining means as bandages for closing of wounds of various etiologies. This is also proved in the known specification of the Russian patent N. 2379060.
  • An isocyanate component (B) is a mix of prepolymers. One of them is obtained from a mix of 4.4-, 2.4-and 2.2-isomers of diphenylmethanediisocyanate and low- molecular polyol from propylene oxide, with molecular weight 240-250.
  • the second prepolymer is synthesized by heat treatment of the specified mix of isomers of diphenylmethanediisocyanate.
  • the named isocyanate component (B) has a trade mark Suprasek 2456 (company Hantsman).
  • the isocyanate component B chosen for realization of the present invention its quantitative content in polyurethane system, the weight ratio between used polyol and isocyanate components specified in the present invention are the optimum.
  • Said conditions correspond also to conditions for manufacturing wound dressings with the specified characteristics, using a polyurethane; manufactured dressings have a wide range of density from 44 kg/m 3 up to 100 kg/m 3. This is proved by the known specification of the Russian Patent No. 2379060.
  • Said antimicrobic agent is obtained according to the technology described in the Russian patent RU No. 2330673.
  • a natural mineral montmorillonite (bentonite in Na-form) is used for obtaining the antimicrobic agent.
  • Bentonite is processed with 3-10% water solution of sodium chloride with subsequent washing and filtering of the obtained semifinished product for removal of chlorine.
  • the semifinished product of bentonite is modified by 10-20% solution of silver nitrate, with retention interval of modified bentonite in the specified salt solution.
  • the obtained product is cleaned from salts of sodium; then it is grinded thus obtaining a powder of bentonite.
  • the size of the particles of the powder of bentonite is preferably no more than 150 nm.
  • Processing of the mineral with the named solution of salts is carried out at the ratio in parts by weight of bentonite : solution as 1 : (10-40).
  • the powder of bentonite intercalated by ions of silver contains from 2 up to 8% b.w. of silver, depending on the amount of activating and modifying agents.
  • the specified amount of the named metal in the bentonite powder is optimum. Increase in amount of metals leads to increase in costs for obtaining the antimicrobic agent and the decrease leads to worsening of antimicrobic activity.
  • the quantitative contents of a nanostructured powder of bentonite intercalated by ions of silver, specified in the present invention, is the optimum.
  • Said product is obtained by modifying a semifinished product of bentonite with 0,3- 2,0% water solution of nitrate salt of cerium Ce(N0 3 ) 3 -6H 2 C).
  • Bentonite is obtained after its enrichment with cations of Na + , by processing with 3-10% water solution of sodium chloride and subsequent cleaning from anions of chlorine.
  • bentonite is cleaned from salts of sodium with grinding up to the size of the particles preferably of no more than 150 nm.
  • cerium metal of variable valency
  • Ce0 2 cerium dioxide
  • the given metal pertains to biologically compatible materials and is used in medicine, for example in prosthetics and stomatology.
  • a 0,5% water solution of cerium nitrate Ce(N0 3 ) 3 -6H 2 0 was used in the process of intercalation of the semifinished product of bentonite, obtained after its enrichment with cations of Na + , for realization of the present invention.
  • the bentonite powder obtained after intercalation, cleaning and grinding contains cerium in the amount of no more than 0,5% b.w..
  • the quantitative contents of nano structured powder of bentonite intercalated by ions of cerium Ce 3+ specified in the present invention are the optimum to create the conditions of blocking peroxides which are formed in the oxidizing processes in operating products.
  • a 5% water solution of chloride sodium was used at the stage of obtaining the semifinished products of bentonite enriched with cations of sodium; the ultrasonic dispersant Sonopuls HD-2070 (company Bandelin) with power 35-75 W/cm and frequency 20-50 kHz was used at the stage of nano structuring bentonite intercalated by ions of Ag + or ions of Ce 3+ .
  • a method of microscopy was used for estimation of the size of particles of bentonite.
  • the given method was used for manufacturing polyurethane orthopedic pillows for the head. In total 163 pillows were produced. Special molds with the specified profile was used for manufacturing pillows.
  • a mix of nanostructured powders of bentonite intercalated by ions of silver (Ag + ) and ions of cerium (Ce 3+ ) in a ratio in the mix of 1 : 8 was introduced (by mixing over 2 hours under pressure) in a liquid polyol component (A) (trade mark Voralux HK490). 200 litres of polyol and 0.192 kg of the named mix of nanostructured powders of bentonite were used in total.
  • An isocyanate component (B) (trade mark Specflex NE 371), in amount of 72.0 kg, was used for 200 litres of the polyol component (A).
  • the ratio of the polyol component (A) to the isocyanate component (B) was of 2,6 : 1,01 parts b.w..
  • the polyol component (A) and the isocyanate component (B) were input in the profiled form from two nozzles under pressure. After the beginning of foaming (starts in 30sec) the form was closed with a cover. Reaction of urethane-formation lasts 10 minutes as a whole.
  • the produced pillow was taken out from the mould and was dried at room temperature.
  • Elastic means orthopedic pillows for the head, with density from 87 kg/m up to 90 kg/m were manufactured as a result of the given technological process and the specified amount of components used in the polyurethane system. That corresponds to technology requirements for the given kind of products. Weight of pillows was 1.4 - 1.5 kg- Example 2 - control
  • the present example was carried out according to the Example 1, but at absence of the mineral component (C) on the basis of a mix of nanostructured powders of bentonite and dispersed into the polyol component (A).
  • Elastic means orthopedic pillows for the head with density from 80 kg/m up to 83 kg/m were manufactured at realization of the given example.
  • a polyol component (A) (trade mark LAPROL 3003) was prepared by careful mixing 100 parts b.w. of polyol and the following additives, parts b.w.:
  • a mineral component (C) on the basis of a mix of a nanostructured powder of bentonite intercalated by ions of silver (Ag + ) or ions of cerium (Ce 3+ ) at a ratio in the mix, of 1:8, and 0.1 parts b.w. of the polyol component (A) are further input in the polyol component (A), containing the named activation additives.
  • the present example was carried out according to the Example 3, but at absence of the mineral component (C) on the basis of a mix of nano structured powder of bentonite dispersed into the component (A).
  • Polyurethane material with a density of 60 kg/m was obtained at realization of the given example.
  • Example 3 The given example was carried out according to the Example 3, but at presence of a dispersed mineral component (C) on the basis of nanostructured powder of bentonite intercalated by ions of cerium (Ce 3+ ) in amount of 0,1 parts b.w. in the polyol component (A).
  • C dispersed mineral component
  • Polyurethane material with the density of 63 kg/m was obtained at realization of the given example.
  • Efficiency of used polyurethane systems for manufacturing products with improved sanitary and hygienic properties was estimated basing on the presence of antiseptic properties in the products.
  • Estimation of antiseptic properties was carried out by cultivation of colonies of microorganisms (S. aureus) in Petri dishes. Then samples of polyurethane products manufactured according to Examples 3, 4 and 5 were placed in dishes with retention intervals within 5-7 days, at room temperature. Measurement of growth inhibition of test- organisms was carried out after expiration of retention interval. Correlation was carried out according to 4-5 tests.
  • the result of the researches confirms in the whole that the use of a polyurethane system according to the present invention, for manufacturing elastic products, considerably improves their sanitary and hygienic properties, both regarding suppression of growth of microorganisms and decrease in gas evolution of volatile toxic organic compounds, at operation of the products.

Abstract

Cette invention concerne de nouvelles compositions à base de polyuréthanes, en particulier des systèmes de polyuréthanes destinés à la fabrication d'articles élastiques, de préférence à vocation médicale, tels que matelas orthopédiques anti-escarres, coussins de siège, oreillers anatomiques, supports de semelles intérieures, corsets orthopédiques, protège-genou, bandages, chaussures pour divers défauts du pied et analogues. Ces nouveaux polyuréthanes modifiés possèdent des propriétés sanitaires et hygiéniques accrues qui les destinent spécifiquement aux applications susmentionnées. Le système de polyuréthanes de l'invention aux propriétés précitées contient un composé polyol (composant A), un composé isocyanate (composant B) et un agent minéral (C) dispersé dans le composé polyol (composé A). L'agent minéral est constitué d'un mélange de poudres nano-structurées de bentonite dans lequel sont intercalés de ions d'argent (Ag+) et des ions de cérium (Ce3+) selon un rapport de 1 :(5-10) en masse. Les articles produits à partir du nouveau système de polyuréthanes possèdent clairement des caractéristiques améliorées en ce qui concerne la suppression de croissances de microorganismes et la prévention de l'évolution de composés toxiques organiques volatiles.
PCT/EP2011/065637 2010-09-22 2011-09-09 Système de polyuréthanes pour fabrication de moyens élastiques dotés de caractéristiques sanitaires et hygiéniques améliorées WO2012038273A1 (fr)

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RU2010138861/05A RU2447098C1 (ru) 2010-09-22 2010-09-22 Полиуретановая система для изготовления эластичных изделий с улучшенными санитарно-гигиеническими свойствами
RU2010138861 2010-09-22

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Citations (10)

* Cited by examiner, † Cited by third party
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