WO2012034871A3 - Verfahren zum herstellen von wirkstoff-beads - Google Patents

Verfahren zum herstellen von wirkstoff-beads Download PDF

Info

Publication number
WO2012034871A3
WO2012034871A3 PCT/EP2011/065186 EP2011065186W WO2012034871A3 WO 2012034871 A3 WO2012034871 A3 WO 2012034871A3 EP 2011065186 W EP2011065186 W EP 2011065186W WO 2012034871 A3 WO2012034871 A3 WO 2012034871A3
Authority
WO
WIPO (PCT)
Prior art keywords
bead
active ingredient
producing
gravity
vacuum
Prior art date
Application number
PCT/EP2011/065186
Other languages
English (en)
French (fr)
Other versions
WO2012034871A2 (de
Inventor
Craig Vincze
Lori Jensen
Mareen Schmökel
Frieder NEUHÄUSSER-WESPY
Carsten Etzold
Original Assignee
Hamilton Bonaduz Ag
Hamilton Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hamilton Bonaduz Ag, Hamilton Company filed Critical Hamilton Bonaduz Ag
Priority to US13/822,697 priority Critical patent/US20130277872A1/en
Priority to CN2011800441102A priority patent/CN103209689A/zh
Priority to EP11757229.7A priority patent/EP2616049A2/de
Priority to JP2013528594A priority patent/JP2013537207A/ja
Publication of WO2012034871A2 publication Critical patent/WO2012034871A2/de
Publication of WO2012034871A3 publication Critical patent/WO2012034871A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/02—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

Die vorliegende Erfindung betrifft ein Verfahren zur automatisierten Herstellung von Wirkstoff-Beads (10; 12) mit einem gelartigen Trägermaterial, bevorzugt einem Bio-Polymer, wie etwa Agarose, und mit einem in das Trägermaterial eingebetteten biologisch aktiven Material, wie etwa einem Wirkstoff oder/und einem Wirkstoff erzeugenden Material, umfassend die folgenden Schritte: a) Bereitstellen einer fließfähigen, verfestigbaren Mischung (18), umfassend das Trägermaterial und das biologisch aktive Material, b) Verfestigen eines Kern-Beads (10) durch Einbringen einer vorbestimmten Menge (22) der fließfähigen Mischung (18) in ein Fluidbad (24), vorzugsweise Flüssigkeitsbad, besonders bevorzugt Ölbad, c) Entnehmen des Kern-Beads (10) aus dem Fluidbad (24), wobei zur Durchführung des Schritts c) eine Bead-Kontaktfläche (36; 42) eines Bead-Aufnahmewerkzeugs (34; 38) verwendet wird und Schritt c) hierzu entweder den folgenden Unterschritt ca1) oder den folgenden Unterschritt cb1) umfasst: ca1 ) Herstellen eines Anlageeingriffs zwischen dem Kern-Bead (10) und einer, vorzugsweise konkaven, Bead-Unterdruck-Kontaktfläche (42) eines Bead-Unterdruck-Aufnahmewerkzeugs (38) mittels Unterdruck, oder cb1) Herstellen eines Anlageeingriffs zwischen dem Kern-Bead (10) und einer, vorzugsweise konkaven, Bead-Schwerkraft-Kontaktfläche (36) eines Bead-Schwerkraft-Aufnahmewerkzeugs (34) in dem Fluidbad mittels Schwerkraft.
PCT/EP2011/065186 2010-09-14 2011-09-02 Verfahren zum herstellen von wirkstoff-beads WO2012034871A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US13/822,697 US20130277872A1 (en) 2010-09-14 2011-09-02 Process for the production of active substance beads
CN2011800441102A CN103209689A (zh) 2010-09-14 2011-09-02 用于制造活性成分珠粒料的方法
EP11757229.7A EP2616049A2 (de) 2010-09-14 2011-09-02 Verfahren zum herstellen von wirkstoff-beads
JP2013528594A JP2013537207A (ja) 2010-09-14 2011-09-02 活性物質ビーズの製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010040687.2 2010-09-14
DE102010040687A DE102010040687A1 (de) 2010-09-14 2010-09-14 Verfahren zum Herstellen von Wirkstoff-Beads

Publications (2)

Publication Number Publication Date
WO2012034871A2 WO2012034871A2 (de) 2012-03-22
WO2012034871A3 true WO2012034871A3 (de) 2012-09-07

Family

ID=44651711

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/065186 WO2012034871A2 (de) 2010-09-14 2011-09-02 Verfahren zum herstellen von wirkstoff-beads

Country Status (6)

Country Link
US (1) US20130277872A1 (de)
EP (1) EP2616049A2 (de)
JP (1) JP2013537207A (de)
CN (1) CN103209689A (de)
DE (1) DE102010040687A1 (de)
WO (1) WO2012034871A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE034618T2 (en) * 2012-01-31 2018-02-28 The Rogosin Inst Inc An improved process for producing macros
EP3403098B1 (de) 2016-01-12 2021-09-22 BioAtla, Inc. Diagnostika mit bedingt aktiven antikörpern
US10697972B2 (en) 2016-01-12 2020-06-30 Bioatla, Llc Diagnostics using conditionally active antibodies
DE102017106867B4 (de) 2017-03-30 2021-12-02 Hamilton Bonaduz Ag Verfahren zur Herstellung einer Portionseinheit

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185269A (en) * 1990-02-13 1993-02-09 Source Scientific Systems, Inc. Immunobead aspirator and method of use
USRE38027E1 (en) * 1994-01-13 2003-03-11 The Rogosin Institute Preparation of agarose coated, solid agarose-collagen beads containing secretory cells
US7297331B2 (en) * 1996-04-03 2007-11-20 The Rogosin Institute Beads containing restricted cancer cells producing material suppressing cancer cell proliferation
WO2010099893A2 (de) * 2009-03-06 2010-09-10 Wolfgang Folger Vorrichtungen und verfahren zur herstellung von eisperlen aus einem wässrigen gemisch

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200613A (en) * 1977-06-03 1980-04-29 Ramco Laboratories Inc. Radioimmunoassay apparatus
FI86777C (fi) * 1990-12-31 1992-10-12 Medix Biochemica Ab Oy Foerfarande foer diagnosticering av bristningen av fosterhinnorna samt reagensfoerpackning foer anvaendning daervid
US5837747A (en) * 1991-10-29 1998-11-17 Vivorx, Inc. Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
US5286495A (en) * 1992-05-11 1994-02-15 University Of Florida Process for microencapsulating cells
USRE39542E1 (en) * 1994-01-13 2007-04-03 The Rogosin Institute Preparation of agarose coated, solid agarose-collagen beads containing secretory cells
US5662840A (en) * 1994-06-10 1997-09-02 Fmc Corporation Process for making gel microbeads
US6558665B1 (en) * 1999-05-18 2003-05-06 Arch Development Corporation Encapsulating particles with coatings that conform to size and shape of the particles
DE19941661B4 (de) * 1999-09-01 2004-06-17 Graffinity Pharmaceuticals Ag Vorrichtung und Verfahren zum Aufnehmen und Plazieren
DE10237125A1 (de) * 2002-08-13 2004-03-11 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Kryokonservierung mit einem gas- oder dampfförmigen Kühlmedium
US20050147595A1 (en) * 2003-09-29 2005-07-07 Dagmar Meissner Bead embedded cells
JP4427411B2 (ja) * 2004-07-28 2010-03-10 日立ソフトウエアエンジニアリング株式会社 ビーズ配列装置及びビーズ配列方法
DE102005018949A1 (de) * 2005-04-18 2006-10-19 Ami-Agrolinz Melamine International Gmbh Harnstoffpartikel, Verfahren zu dessen Herstellung und dessen Verwendung
JP4520359B2 (ja) * 2005-05-13 2010-08-04 日立ソフトウエアエンジニアリング株式会社 粒子捕捉装置、並びに粒子配列方法及び粒子配列装置
SG131015A1 (en) * 2005-09-15 2007-04-26 Millipore Corp Method and apparatus for making porous agarose beads
US8932634B2 (en) * 2006-06-15 2015-01-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Hydrocolloid carrier beads with inert filler material

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185269A (en) * 1990-02-13 1993-02-09 Source Scientific Systems, Inc. Immunobead aspirator and method of use
USRE38027E1 (en) * 1994-01-13 2003-03-11 The Rogosin Institute Preparation of agarose coated, solid agarose-collagen beads containing secretory cells
US7297331B2 (en) * 1996-04-03 2007-11-20 The Rogosin Institute Beads containing restricted cancer cells producing material suppressing cancer cell proliferation
WO2010099893A2 (de) * 2009-03-06 2010-09-10 Wolfgang Folger Vorrichtungen und verfahren zur herstellung von eisperlen aus einem wässrigen gemisch

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "www.SPÄTZLE.de - Grundrezept", 1 January 2007 (2007-01-01), pages 1 - 3, XP002676399, Retrieved from the Internet <URL:http://www.spaetzle.de/prt/prt_schaben.html> [retrieved on 20120523] *

Also Published As

Publication number Publication date
EP2616049A2 (de) 2013-07-24
US20130277872A1 (en) 2013-10-24
JP2013537207A (ja) 2013-09-30
WO2012034871A2 (de) 2012-03-22
DE102010040687A1 (de) 2012-03-15
CN103209689A (zh) 2013-07-17

Similar Documents

Publication Publication Date Title
WO2012164078A3 (de) Verfahren zum herstellen eines formkörpers sowie vorrichtung
WO2012034871A3 (de) Verfahren zum herstellen von wirkstoff-beads
WO2012120043A3 (fr) Procédé de formation de gouttes d&#39;une première phase dispersées dans une deuxième phase sensiblement immiscible avec la première phase
WO2010044577A3 (ko) 동물조직 분말을 이용한 다공성 3차원 지지체의 제조방법 및 이를 이용하여 제조된 다공성 3차원 지지체
IL171145A (en) Method for the production of telmisartan
EP1762545A4 (de) Hydrotalcit-artige substanz, herstellungsverfahren dafür und verfahren zur immobilisierung eines gefahrstoffs
MX357583B (es) Capsulas de nucleo-corteza.
WO2012151192A3 (en) Molecular diagnostics platform
MX2014009252A (es) Producto acuoso acidico que comprende microcapsulas que contienen aceite y metodo para la fabricacion del mismo.
PT1748990E (pt) Processo para a preparação de telmisartan
WO2012069037A8 (de) Verfahren zum schichtweisen herstellen eines bauteils sowie vorrichtung
WO2012031872A3 (de) Wärmeisolierender formkörper und verfahren zu dessen fertigung
PL371777A1 (en) Wax coated cheese, packaging system for packing cheese portions as well as method for packaging cheese portions
PL1644257T3 (pl) Sposób wytwarzania kapsla do korkowania
IL177290A0 (en) Method for the production of liquid nitrate esters
WO2011121560A3 (en) Stabilized antibody preparations and uses thereof
PL2040915T3 (pl) Materiał kompozytowy, sposób jego wytwarzania oraz jego zastosowanie jako materiału opakowaniowego
GB2454902B (en) A method for the manufacture of III-V particles
WO2011056927A3 (en) Method for making polyamide particles
WO2011051718A3 (en) Micro-channel structure method and apparatus
WO2005105278A3 (en) Antisolvent emulsion solidification process
WO2006023856A3 (en) Microcapsules
AU2007246277A8 (en) Method for preparing nano-scale particle of active material
WO2004065443A3 (de) Speziell gefällte kieselsäuren für gummianwendungen
MY161112A (en) Polyamides having nanoparticles on the surface

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11757229

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 2013528594

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2011757229

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 13822697

Country of ref document: US