WO2012031562A1 - Modèle de biopsie assistée par navigation virtuelle pour un tissu tumoral incapable d'être visualisé par échographie - Google Patents

Modèle de biopsie assistée par navigation virtuelle pour un tissu tumoral incapable d'être visualisé par échographie Download PDF

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Publication number
WO2012031562A1
WO2012031562A1 PCT/CN2011/079491 CN2011079491W WO2012031562A1 WO 2012031562 A1 WO2012031562 A1 WO 2012031562A1 CN 2011079491 W CN2011079491 W CN 2011079491W WO 2012031562 A1 WO2012031562 A1 WO 2012031562A1
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Prior art keywords
tumor
model
carrageenan
gel
virtual navigation
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PCT/CN2011/079491
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English (en)
Chinese (zh)
Inventor
李凯
郑荣琴
张奥华
贺需旗
袁树芳
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中山大学
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Publication of WO2012031562A1 publication Critical patent/WO2012031562A1/fr

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    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
    • G09B23/30—Anatomical models
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine

Definitions

  • the invention belongs to the field of medical and health, and relates to Ultrasound-guided interventional therapy in the field of ultrasound, specifically related to a model of tumor tissue biopsy process that cannot be displayed by virtual navigation-assisted ultrasound.
  • Ultrasound-guided biopsy of liver tumor tissue is a common clinical technique.
  • ultrasound mainly plays a role in localizing tumors.
  • the premise of using ultrasound guidance is that ultrasound can show tumors, but it is affected by factors such as disorder of liver tissue, echoes of lesions, etc.
  • CT and ultrasound have different imaging principles. When ultrasound cannot show tumors, CT can often be displayed.
  • the current CT is a static imaging and is not suitable for guiding biopsy in real time.
  • Virtual navigation technology can use magnetic localization methods to fuse image information of different types or different times, such as three-dimensional ultrasound volume images and CT of the same patient.
  • the three-dimensional volume images were fused or fused with a three-dimensional ultrasound volume image of the same patient at different times. After the fusion, the three-dimensional data displayed by the two images can completely coincide in space, and the two images that are overlapped can be simultaneously displayed on the same screen, and the clinically useful information can be found by comparing the two images.
  • Virtual navigation technology successfully combines real-time imaging of ultrasound with high-resolution imaging of CT, and extracts the advantages of both through image fusion technology.
  • the object of the present invention is to provide a tumor biopsy process for virtual navigation-assisted ultrasound that cannot be displayed in view of the deficiencies of the prior art.
  • the model is used to promote the learning and training of virtual navigation technology.
  • Another object of the present invention is to provide a method of preparing the model.
  • the invention provides A model for a biopsy process of a tumor tissue that cannot be displayed by virtual navigation-assisted ultrasound, characterized in that the model consists of one or more tumor gels wrapped by a parenchymal gel
  • the parenchymal gel is made of carrageenan
  • the tumor gel is made of carrageenan, lipiodol, surfactant and milk.
  • the parenchy gum is a carrageenan obtained by mixing carrageenan dry product with hot physiological saline at a mass ratio of 1:45-55.
  • the physiological saline solution is stirred and cooled to prepare.
  • Tumor gel is made up of carrageenan - physiological saline solution with lipiodol, surfactant and milk according to the mass ratio (150-400) :1 : ( Mix 3-5): (15-40) in proportion (become carrageenan - saline - lipiodol - surfactant - milk solution), made by cooling.
  • the tumor gel is cut into small pieces of volume 0.5-2 cm3, and the cut tumor mass is wrapped with parenchymal glue.
  • the marking material is also attached to the substantial glue, and is a toothpick-shaped article made of bamboo, wood or plastic.
  • the preferred marking material is a toothpick.
  • the invention also provides a preparation method of the model, comprising the following steps:
  • Carrageenan - normal saline - lipiodol - surfactant - milk solution is cooled and solidified and cut into volume 0.5-2 Cubic centimeter of tumor gel block; the tumor gel block was placed in a carrageenan-physiological saline solution and cooled to prepare a model.
  • the invention selects carrageenan as the main raw material of the model.
  • Carrageenan is a polysaccharide extracted from seaweed. Its food grade dry colloid is cheap and is a commonly used material in the food and pharmaceutical industries.
  • Carrageenan produced in Hainan, China belongs to ⁇ - family, this family of carrageenan has good thermal reversibility, the melting point of solid carrageenan and the freezing point of liquid carrageenan at 40-60 ° C
  • the carrageenan can be reshaped between, ie, simple heating or cooling.
  • the colloid has the advantages of being easy to obtain, low in cost, low in production conditions, good in sound permeability, and difficult to deform the solid rubber.
  • the physiological saline solution has a suitable hardness, elasticity and brittleness after being turned into a solid, and is not easily deformed after being molded into a mold, and can be made into a substantive gel.
  • the present invention uses lipiodol as an additive to tumor gel.
  • Iodine oil can significantly increase the density of tissue, and it can improve CT after adding colloid. Value.
  • the surfactant is combined with lipiodol to distribute the lipiodol evenly in the liquid carrageenan.
  • CT The value has increased significantly.
  • the tumor gel was embedded in the parenchyma. Because the ultrasonic echoes of the two gels were the same, the ultrasound could not show the tumor gel. However, the CT value of the tumor gel was significantly higher than that of the parenchyma, so CT A scan reveals the tumor mass in the parenchymal gel.
  • Carrageenan The physiological saline solution is added with lipiodol, surfactant and milk to make tumor gel. After the tumor gel is embedded in the ordinary parenchyma, the gel can not be displayed by ultrasonic scanning, and CT It can be clearly displayed during the scan. The naked eye is generally colorless and translucent, while the tumor gel is white and opaque, which can be clearly distinguished by the naked eye.
  • the model of the present invention can accurately simulate the inability of the ultrasound to be displayed in the virtual navigation technique.
  • Tumor tissue, effective and objective real-time guided tissue biopsy tumor gel, ultrasound can not be displayed, CT scan can be used to simulate tumor lesions; tumor gel wrapped around the periphery of the gel, ultrasound and CT Can be displayed and can be identified with the naked eye and tumor glue, can simulate the normal tissue surrounding the tumor; the tumor gel in the model (simulated tumor lesion) can be used for tissue biopsy
  • the detected rubber strip can be observed with the naked eye, and the difference from the actual glue is obvious to verify the effect of the virtual navigation assisted biopsy.
  • the invention further explores the material used as a virtual navigation alignment mark in the solid rubber block model.
  • the ultrasonic image can be clearly displayed, and the present invention selects an ordinary toothpick.
  • a toothpick is inserted into the parison.
  • the toothpick can be clearly displayed on the ultrasound image and can be used for the alignment mark.
  • the present invention has the following beneficial effects:
  • the model provided by the present invention can accurately simulate that ultrasound cannot be displayed but CT
  • the model provided by the invention has low production cost, and the raw materials used are low-cost raw materials and have wide sources.
  • the top of the strip is the actual strip (shown by the left arrow), the left side of the middle strip is the tumor strip, and the right half is the strip (the right arrow), most Below is the tumor strip (shown by the up arrow), and the different strips can be distinguished by the naked eye.
  • Figure 2 shows the ultrasound image of the model after the fusion of the ultrasound image and the CT image.
  • the tumor gel is not seen in the model.
  • the right side of the model is the CT of the model.
  • the dried carrageenan produced in Hainan was dissolved in hot physiological saline at a ratio of 1:50, and all dissolved into carrageenan-physiological saline solution for use.
  • Iodine oil, detergent, milk and carrageenan - physiological saline solution by 1 : 5 : 20 : 200 The ratio is mixed and cooled to solidify into a tumor gel.
  • the solidified tumor gel is cut into a volume of 1 cubic centimeter of rubber and placed in carrageenan - In the physiological saline solution, after the solution is solidified, the bamboo toothpick is dispersed vertically into the parison gel to form a model.
  • One side of the toothpick marking block is a CT scan of the head end. Import Dicom format CT images into Mylab 90
  • the bamboo toothpick is high-density in the CT image and high-echo in the ultrasound image.
  • the ultrasound is combined with the CT image, and the tumor is used for biopsy (Fig. 2). Shown).
  • results of the virtual navigation assisted biopsy are verified by observing the biopsy strips.
  • Different results can be distinguished by the naked eye: a completely transparent parison strip representing normal tissue; and a semi-substantial half-substantial half-substantial half parenchyma representing a semi-lesion Semi-tumor strip; a fully milky white tumor strip representing a complete lesion (as shown 1 shown).

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Mathematical Analysis (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Pure & Applied Mathematics (AREA)
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Abstract

L'invention concerne un modèle de biopsie assistée par navigation virtuelle pour un tissu tumoral incapable d'être visualisé par échographie. Le modèle est constitué d'un gel correspondant à une tumeur et d'un gel substantiel. Le gel substantiel se compose de carraghénine. Le gel correspondant à une tumeur est fabriqué par addition d'huile iodée, de tensioactif et de lait dans de la carraghénine. Pour former le modèle, on laisse le gel substantiel envelopper un ou plusieurs blocs découpés de gel correspondant à une tumeur ayant un volume de 0,5-2 cm3. Dans la technologie de navigation virtuelle, le modèle est capable de simuler de manière réaliste un tissu tumoral incapable d'être visualisé par échographie, et le tissu normal situé autour, et de guider efficacement la technologie de navigation virtuelle pour faciliter en temps réel le positionnement et la biopsie du tissu tumoral incapable d'être visualisé par échographie. Le modèle simplifie l'opération et produit des résultats précis, et se prête donc à un apprentissage et à une formation en technologie de navigation virtuelle.
PCT/CN2011/079491 2010-09-10 2011-09-08 Modèle de biopsie assistée par navigation virtuelle pour un tissu tumoral incapable d'être visualisé par échographie WO2012031562A1 (fr)

Applications Claiming Priority (2)

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CN201010281470.1 2010-09-10
CN2010102814701A CN101950501B (zh) 2010-09-10 2010-09-10 一种用于虚拟导航辅助超声无法显示的肿瘤组织活检过程的模型

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10810907B2 (en) 2016-12-19 2020-10-20 National Board Of Medical Examiners Medical training and performance assessment instruments, methods, and systems

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* Cited by examiner, † Cited by third party
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CN101950501B (zh) * 2010-09-10 2012-03-14 中山大学 一种用于虚拟导航辅助超声无法显示的肿瘤组织活检过程的模型
CN104174122A (zh) * 2014-08-01 2014-12-03 深圳市普罗惠仁医学科技有限公司 一种用于热消融疗效评估的仿生水凝胶组合体及制备方法
CN105448169B (zh) * 2014-08-19 2018-09-28 中山大学附属第三医院 一种用于介入超声的活检模型
CN105206154A (zh) * 2015-09-24 2015-12-30 中国人民解放军第三军医大学第二附属医院 分叉血管模型、模具及制作方法
CN105590531B (zh) * 2015-12-16 2019-01-25 中山大学附属第三医院 一种模拟肿瘤超声造影表现用于肿瘤诊治研究的仿体模型
CN105427725B (zh) * 2015-12-16 2019-06-04 中山大学附属第三医院 一种用于超声单模态图像融合评估肿瘤消融范围的仿体模型
CN105374266B (zh) * 2015-12-16 2018-11-13 中山大学附属第三医院 一种用于模拟肿瘤超声造影的仿体模型

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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