WO2012021035A3 - 까마쪽나무 추출물 또는 이의 분획물을 유효성분으로 함유하는 당뇨합병증 예방 및 치료용 조성물 - Google Patents

까마쪽나무 추출물 또는 이의 분획물을 유효성분으로 함유하는 당뇨합병증 예방 및 치료용 조성물 Download PDF

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WO2012021035A3
WO2012021035A3 PCT/KR2011/005963 KR2011005963W WO2012021035A3 WO 2012021035 A3 WO2012021035 A3 WO 2012021035A3 KR 2011005963 W KR2011005963 W KR 2011005963W WO 2012021035 A3 WO2012021035 A3 WO 2012021035A3
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preventing
diabetes complications
composition
active ingredient
treating diabetes
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PCT/KR2011/005963
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English (en)
French (fr)
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WO2012021035A2 (ko
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김진숙
김정현
김영숙
김찬식
김기모
김온순
이윤미
이영섭
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한국한의학연구원
손은진
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Publication of WO2012021035A2 publication Critical patent/WO2012021035A2/ko
Publication of WO2012021035A3 publication Critical patent/WO2012021035A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

본 발명은 까마쪽나무(Litsea japonica) 추출물 또는 이의 분획물을 유효성분으로 함유하는 당뇨합병증 예방 및 치료용 조성물에 관한 것으로서, 더욱 구체적으로는, 까마쪽나무 추출물 또는 이의 분획물은 당뇨합병증의 지표인 최종당화산물의 생성 및 알도즈 환원효소의 활성을 억제하며, 당뇨 합병증 초기 증세인 당뇨성 안구질환(백내장 및 망막증) 및 발세포(podocyet) 소실을 예방하며, 특히 발세포 기능에 중요한 역할을 하는 슬릿 디아그램(slit diagram) 단백질인 네프린(Nephrin)의 발현 감소를 억제하므로, 당뇨성 신증 등 당뇨합병증 예방 및 치료용 조성물의 유효성분으로서 유용하게 이용될 수 있다.
PCT/KR2011/005963 2010-08-13 2011-08-12 까마쪽나무 추출물 또는 이의 분획물을 유효성분으로 함유하는 당뇨합병증 예방 및 치료용 조성물 WO2012021035A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0078391 2010-08-13
KR1020100078391A KR101243243B1 (ko) 2010-08-13 2010-08-13 까마귀쪽나무 추출물 또는 이의 분획물을 유효성분으로 함유하는 당뇨합병증 예방 및 치료용 조성물

Publications (2)

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WO2012021035A2 WO2012021035A2 (ko) 2012-02-16
WO2012021035A3 true WO2012021035A3 (ko) 2012-05-10

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PCT/KR2011/005963 WO2012021035A2 (ko) 2010-08-13 2011-08-12 까마쪽나무 추출물 또는 이의 분획물을 유효성분으로 함유하는 당뇨합병증 예방 및 치료용 조성물

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KR (1) KR101243243B1 (ko)
WO (1) WO2012021035A2 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014077424A1 (ko) * 2012-11-14 2014-05-22 한국 한의학 연구원 까치박달 추출물을 포함하는 당뇨합병증의 예방 또는 치료용 약학적 조성물 및 건강기능식품
KR101550002B1 (ko) * 2013-05-06 2015-09-07 (주)휴럼 까마귀쪽나무의 오일을 유효성분으로 함유하는 염증성 질환 예방 및 치료용 조성물과 이의 제조방법
KR101566924B1 (ko) * 2013-06-24 2015-11-06 (주)휴럼 까마귀쪽나무 열매로부터 추출되는 정유성분을 포함하는 위장질환 예방 및 치료용 조성물
KR101786463B1 (ko) 2014-08-04 2017-10-19 (주)휴럼 까마귀쪽나무 열매의 정유성분을 유효성분으로 하는 대사증후군 치료용 조성물 및 이의 제조방법
CN106265740B (zh) * 2016-08-29 2018-01-02 吉林省中科生物工程股份有限公司 脐带间充质干细胞联合黄芪多糖在制备治疗高血糖和糖尿病肾病药物中的应用
CN109106931B (zh) * 2018-08-23 2021-08-24 贵阳中医学院 一种治疗顽固性肾性水肿的药物及其制作方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080020738A (ko) * 2006-09-01 2008-03-06 재단법인 제주하이테크산업진흥원 항염활성 및 골대사 관련인자 억제활성을 나타내는까마귀쪽나무 추출물

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090091477A (ko) * 2008-02-25 2009-08-28 제주대학교 산학협력단 까마귀쪽나무 추출물을 유효성분으로 함유하는 암 질환의예방 및 치료용 조성물

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080020738A (ko) * 2006-09-01 2008-03-06 재단법인 제주하이테크산업진흥원 항염활성 및 골대사 관련인자 억제활성을 나타내는까마귀쪽나무 추출물

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
D. S. JANG ET AL.: "Flavonols from Houttuynia cordata with protein glycation and aldose reductase inhibitory activity", NATURAL PRODUCT SCIENCES, vol. 12, no. 4, 2006, pages 210 - 213, XP053005902 *
H. MATSUDA ET AL.: "Structural requirements of flavonoids and related compounds for aldose reductase inhibitory activity", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 50, no. 6, 2002, pages 788 - 795, XP002996843, DOI: doi:10.1248/cpb.50.788 *
S. H. JUNG ET AL.: "Inhibitory effects of naturally occurring flavonoids on rat lens aldose reductase", NATURAL PRODUCT SCIENCES, vol. 10, no. 1, 2004, pages 35 - 39 *
S.-Y. LEE ET AL.: "Flavonoids from the leaves of Litseajaponica and their anti-complement activity", PHYTOTHERAPY RESEARCH, vol. 19, 2005, pages 273 - 276 *

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Publication number Publication date
WO2012021035A2 (ko) 2012-02-16
KR20120015886A (ko) 2012-02-22
KR101243243B1 (ko) 2013-03-13

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