WO2012020272A3 - Nouveaux sels, polymorphes et solvates d'un ingrédient pharmaceutiquement actif - Google Patents

Nouveaux sels, polymorphes et solvates d'un ingrédient pharmaceutiquement actif Download PDF

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Publication number
WO2012020272A3
WO2012020272A3 PCT/HU2011/000086 HU2011000086W WO2012020272A3 WO 2012020272 A3 WO2012020272 A3 WO 2012020272A3 HU 2011000086 W HU2011000086 W HU 2011000086W WO 2012020272 A3 WO2012020272 A3 WO 2012020272A3
Authority
WO
WIPO (PCT)
Prior art keywords
febuxostat
polymorphs
solvates
new salts
new
Prior art date
Application number
PCT/HU2011/000086
Other languages
English (en)
Other versions
WO2012020272A2 (fr
Inventor
László Pongó
Balázs VOLK
József Barkóczy
András DANCSÓ
Gyula LUKÁCS
Gyula István SIMIG
László SZÁZDI
Péter TÖMPE
György RUZSICS
Zsuzsanna SZENT-KIRÁLLYI
Original Assignee
EGIS GYÓGYSZERGYÁR Nyilvánosan Müködö Részvénytársaság
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU1000429A external-priority patent/HU230879B1/hu
Priority claimed from HU1000431A external-priority patent/HUP1000431A2/hu
Priority claimed from HU1000430A external-priority patent/HUP1000430A2/hu
Application filed by EGIS GYÓGYSZERGYÁR Nyilvánosan Müködö Részvénytársaság filed Critical EGIS GYÓGYSZERGYÁR Nyilvánosan Müködö Részvénytársaság
Publication of WO2012020272A2 publication Critical patent/WO2012020272A2/fr
Publication of WO2012020272A3 publication Critical patent/WO2012020272A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne de nouveaux sels de febuxostat formés par des acides inorganiques ou organiques ou des bases, en un nouveau polymorphe et solvate de febuxostat, leur production et leur utilisation pour prévenir et traiter essentiellement la goutte ou l'hyperuricémie.
PCT/HU2011/000086 2010-08-13 2011-08-15 Nouveaux sels, polymorphes et solvates d'un ingrédient pharmaceutiquement actif WO2012020272A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
HU1000429A HU230879B1 (hu) 2010-08-13 2010-08-13 Febuxostat dietanolammónium só
HUP1000431 2010-08-13
HUP1000430 2010-08-13
HU1000431A HUP1000431A2 (en) 2010-08-13 2010-08-13 Acid addition salts of a pharmaceutical active ingredient
HU1000430A HUP1000430A2 (en) 2010-08-13 2010-08-13 New polymorphous and solvate forms of a pharmaceutical active ingredient
HUP1000429 2010-08-13

Publications (2)

Publication Number Publication Date
WO2012020272A2 WO2012020272A2 (fr) 2012-02-16
WO2012020272A3 true WO2012020272A3 (fr) 2012-04-05

Family

ID=89989888

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU2011/000086 WO2012020272A2 (fr) 2010-08-13 2011-08-15 Nouveaux sels, polymorphes et solvates d'un ingrédient pharmaceutiquement actif

Country Status (1)

Country Link
WO (1) WO2012020272A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101501253B1 (ko) * 2014-12-22 2015-03-12 제이투에이치바이오텍 (주) 결정성 페북소스타트 피돌레이트 염 및 이의 제조 방법
CN111320589A (zh) * 2020-01-08 2020-06-23 武汉伯睿科医药科技有限公司 一种非布司他钠盐a晶型及其制备方法和用途

Citations (3)

* Cited by examiner, † Cited by third party
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EP0513379A1 (fr) * 1990-11-30 1992-11-19 Teijin Limited Derive de 2-arylthiazole et composition pharmaceutique contenant ce derive
EP1020454A1 (fr) * 1998-06-19 2000-07-19 Teijin Limited Modifications polymorphes de 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazole-acide carboxylique et procedes de preparation associes
CN101386604A (zh) * 2008-10-23 2009-03-18 漆又毛 抑制黄嘌呤氧化酶活性的芳腈基噻唑衍生物及制备方法和用途

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1970547B (zh) 2006-12-07 2011-04-06 重庆医药工业研究院有限责任公司 非布司他的晶型及其制备方法
CN101412700B (zh) 2007-10-19 2011-06-08 上海医药工业研究院 非布司他的晶型及其制备方法
CN101684107A (zh) 2008-09-26 2010-03-31 上海优拓医药科技有限公司 非布索坦的新晶型及其制备方法
CN101386605B (zh) 2008-10-23 2010-09-08 中国科学院上海药物研究所 非布司他新型晶体及其制备方法
CN101684108B (zh) 2009-04-15 2012-01-11 天津市汉康医药生物技术有限公司 2-(3-氰基-4-异丁氧基苯基)-4-甲基-5-噻唑甲酸及其组合物
CN101648926B (zh) 2009-07-09 2011-11-16 石药集团欧意药业有限公司 一种非布司他晶型及其制备方法
CN101671315B (zh) 2009-08-19 2011-06-22 何广卫 非布索坦的新晶型及其制备方法
CN101671314B (zh) 2009-09-17 2011-11-23 中国药科大学 一种非布索坦的晶型体及制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0513379A1 (fr) * 1990-11-30 1992-11-19 Teijin Limited Derive de 2-arylthiazole et composition pharmaceutique contenant ce derive
EP1020454A1 (fr) * 1998-06-19 2000-07-19 Teijin Limited Modifications polymorphes de 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazole-acide carboxylique et procedes de preparation associes
CN101386604A (zh) * 2008-10-23 2009-03-18 漆又毛 抑制黄嘌呤氧化酶活性的芳腈基噻唑衍生物及制备方法和用途

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BASTIN ET AL.: "Salt Selection and Optimisation for Pharmaceutical New Chemical Entities", ORGANIC PROCESS RESEARCH AND DEVELOPMENT, vol. 4, no. 5, 1 January 2000 (2000-01-01), pages 427 - 435, XP002228592, DOI: 10.1021/OP000018U *
BERGE ET AL.: "PHARMACEUTICALS SALTS", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 66, no. 1, 1 January 1977 (1977-01-01), pages 1 - 19, XP000562636, ISSN: 0022-3549, DOI: 10.1002/JPS.2600660104 *
CANIVET ET AL.: "Supporting Information to: Nickel-Catalyzed Biaryl Coupling of Heteroarenes and Aryl Halides/Triflates", ORGANIC LETTERS, vol. 11, no. 8, 18 March 2009 (2009-03-18) - 2009, pages S1 - S48, XP055012634, Retrieved from the Internet <URL:http://pubs.acs.org/doi/suppl/10.1021/ol9001587/suppl_file/ol9001587_si_001.pdf> [retrieved on 20111121] *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; QI, YOUMAO ET AL: "Preparation of 2-(3-cyanophenyl)thiazole derivatives as xanthine oxidase inhibitors for treatment of hyperuricemia, hyperuricemia-induced gout, arthritis, or heart failure", XP002664043, retrieved from STN Database accession no. 2009:345547 *
HASEGAWA: "A FACILE ONE-POT SYNTHESIS OF 4-ALKOXY-1,3-BENZENEDICARBONITRILE", HETEROCYCLES, vol. 47, no. 2, 1 January 1998 (1998-01-01), pages 857 - 864, XP001056564, ISSN: 0385-5414 *

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Publication number Publication date
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