WO2012019678A1 - Appareil et procédé d'enrobage de fibres creuses - Google Patents

Appareil et procédé d'enrobage de fibres creuses Download PDF

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Publication number
WO2012019678A1
WO2012019678A1 PCT/EP2011/003337 EP2011003337W WO2012019678A1 WO 2012019678 A1 WO2012019678 A1 WO 2012019678A1 EP 2011003337 W EP2011003337 W EP 2011003337W WO 2012019678 A1 WO2012019678 A1 WO 2012019678A1
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WO
WIPO (PCT)
Prior art keywords
potting compound
annular part
filter
mold
fiber membranes
Prior art date
Application number
PCT/EP2011/003337
Other languages
German (de)
English (en)
Inventor
Christian Carow
Original Assignee
Hemacon Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hemacon Gmbh filed Critical Hemacon Gmbh
Publication of WO2012019678A1 publication Critical patent/WO2012019678A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B01D63/022—Encapsulating hollow fibres
    • B01D63/0222—Encapsulating hollow fibres using centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B01D63/022—Encapsulating hollow fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
    • B29C39/02—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B29C39/04—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles using movable moulds not applied
    • B29C39/08—Introducing the material into the mould by centrifugal force
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
    • B29C39/02—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B29C39/10—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles incorporating preformed parts or layers, e.g. casting around inserts or for coating articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
    • B29C39/02—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B29C39/028—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles having an axis of symmetry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/14—Filters

Definitions

  • the invention relates to an apparatus and a method for casting hollow fibers, for example in the production of a filter assembly.
  • the apparatus and method of the invention have particular application in the manufacture of filter assemblies and other devices employing hollow fibers as filter elements or membranes, e.g. Filter assemblies for separating blood into plasma and cellular components (e.g., for plasmapheresis or plasma separation), or filter assemblies for dialyzing, or gas transfer devices in which one or more gases transfer from one medium to another, such as, for example. in the accumulation of blood with oxygen and / or the removal of carbon dioxide from the blood.
  • Filter assemblies for separating blood into plasma and cellular components e.g., for plasmapheresis or plasma separation
  • filter assemblies for dialyzing or gas transfer devices in which one or more gases transfer from one medium to another, such as, for example. in the accumulation of blood with oxygen and / or the removal of carbon dioxide from the blood.
  • the filter assemblies for separating blood into plasma and cellular components provide e.g. a method in which the blood in a sterilized closed system in both its individual components, in particular red blood cells and plasma, decomposed and can be preserved directly component by component.
  • a good example of such a filter arrangement is described in detail in published international patent document WO 02/1 3888 A1.
  • a membrane capillary bundle can be made by means of a centrifugal casting process. can be embedded in a hardening potting compound and thus secured and sealed.
  • the conventional methods, in which the potting compound is typically held in one or more reservoirs in the spinning device or centrifuge used for spinning often be extremely expensive in the filling and the provision of the reservoir, as well as in the implementation of the dosage Optimization and control of the process with respect to the curing of the potting compound.
  • the potting compound is preferably introduced into the line systems immediately after mixing the components, which are connected directly to the filter arrangements.
  • the apparatus according to the invention for casting hollow-fiber membranes is therefore designed in particularly preferred embodiments such that the potting compound can be used directly from the supply line (eg from a mixing tap) for any number of modules and thus no storage containers, in particular none with the Rotary device rotating reservoir, for (possibly premixed) potting compound within the rotating device are needed.
  • the spin casting process for embedding and sealing the hollow fiber membranes is very time critical.
  • the potting compound must be pressed between the hollow fibers in such a way that it penetrates into all interstices and thus excludes cavities or air bubbles as far as possible.
  • the duration of the casting or the time for hardening the casting compound and its pressure and the embedding height are therefore very critical process parameters.
  • modules eg filter arrangements
  • an apparatus for casting hollow-fiber membranes is provided in the production of a membrane device, in particular a filter arrangement.
  • the apparatus comprises a rotating device or centrifuge which has at least one rotatable first section for supplying a potting compound and at least one rotatable second section for fastening a plurality of filter arrangements.
  • Each filter assembly mounted in the second section has a bundle of hollow fiber membranes held in a mold and, as is typical in a centrifugal casting process, the potting compound is moved from the first section about its axis by centrifugal force towards each upon rotation of the rotary device Grouting mold pressed in the second section.
  • the apparatus according to the invention is characterized, inter alia, by the fact that the first section comprises a metering device which, by rotating the rotary device, distributes the potting compound substantially evenly to the plurality of filter arrangements.
  • filter assemblies is for the purpose of a simplified description of the invention, in other words, those skilled in the art will recognize that other devices employing hollow fibers as permeable or porous membranes, such as gas transfer devices or dialyzers not necessarily as filter arrangements, nevertheless for the purposes of this description also in the term “filter arrangements” are included.
  • Hollow fiber membranes in the context of the present invention are hollow fiber membranes in the conventional sense, eg hollow fiber membranes suitable for gas transfer devices, dialysis machines or plasmapheresis, and consist of conventional hollow fiber membrane materials such as polyethersulfone or polysulfone.
  • the hollow fiber membranes are not ceramic.
  • Preferred hollow fiber membranes in the context of the present invention are highly porous hollow fiber membranes, wherein the Hohimaschinemembranmaterial preferably has a porosity of 50-80%, more preferably from 60-80%, for example about 70%, ie 70% pore volume to 30% structure volume.
  • Hollow-fiber membranes in the context of the present invention preferably have a pore diameter of at least 100 nm, more preferably of at least 200 nm, and preferably of not more than 2000 nm, more preferably of not more than 1500 nm.
  • Particularly preferred hollow fiber membranes in the context of the present invention have a preferably substantially uniform pore diameter in the range from 100 to 2000 nm, preferably in the range from 200 to 1500 nm, particularly preferably in the range from 200 to 700 nm, for example a pore diameter of about 200 , 300, 400, 500, 600 or 700 nm, preferably with previously defined porosity.
  • Hohi textileen in the context of the present invention preferably have an inner diameter of more than 200 m, for example in a range of 200 - 3000 ⁇ , preferably from 200 to 1500 m, more preferably from 200 to 500 ⁇ , for example about 300 ⁇ , and / or preferably a wall thickness of more than 30 ⁇ ⁇ , more preferably of more than 50 ⁇ , for example in a range of 30-200 ⁇ - ⁇ , preferably in a range of 50-1 50 ⁇ , for example about 100 ⁇ on.
  • Hollow fiber membranes in the context of the present invention preferably have a transmembrane flux (TMF) of more than 0.1 ml / min cm 2 bar, preferably more than 1 ml / min cm 2 bar, preferably more than 10 ml / min cm 2 bar, more preferably between 10 and 100 ml / min cm 2 bar, eg between 1 5 and 50 ml / min cm 2 bar, and / or preferably a sieving coefficient for albumin of more than 0.01, preferably of more than 0.1, especially preferably from between 0.5 to 1, for example about 1 on.
  • TMF transmembrane flux
  • the metering device comprises an annular part which rotates about the axis with the rotary device, and a feed line which feeds or injects the potting compound into the annular part in such a way that the supplied potting compound turns by rotating the rotary device - tion on the annular part substantially evenly distributed.
  • the supply line does not rotate with the rotating device, so that the annular part moves relative to the supply line during the feeding or injection of the potting compound. mass turns.
  • the rotational speed of the rotary device or of the annular part during the supply or injection of the potting compound should be so high that the annular part undergoes several revolutions during the feeding or injection of the potting compound.
  • the number of revolutions during the feeding or injection of the potting compound is preferably in the range of 100 to 1000, and more preferably in the range of 300 to 600.
  • the supply line extends into the annular part and remains substantially static or stationary at Feeding or injecting the potting compound.
  • the feeding or injection of the potting compound is preferably carried out with a substantially constant throughput or with a substantially constant injection rate.
  • the supply line is formed as possible, so that the potting compound is fed or injected directly into the annular part, wherein the supplied potting compound by the rotation of the rotating device then distributed substantially evenly on the annular part.
  • the feed line should also preferably supply the potting compound on a radially inner side of the annular part, so that the potting compound is distributed substantially uniformly when rotating the rotary device on this inner side of the ring or annular part.
  • the radially inner side of the annular part is provided with a circumferential cavity for receiving the potting compound.
  • the supply line for the potting compound is not through a connection such as a pipe or a hose with the rotating device, e.g. connected to the metering device.
  • there is no continuous mechanical connection such as a pipe or a hose between the feed line (the feeding of the potting compound in the apparatus) and the filter assemblies or Vergussformen (with filter assemblies).
  • the potting compound is normally a curable or curing material, which is pressed in a not yet cured, that is still liquid state by means of the metering by the centrifugal force in the casting molds or thrown becomes.
  • the potting compound of a synthetic resin, for example based on a polyurethane, polysulfide, polyester, polyamide, vinyl ester, epoxy, alkyd or the like.
  • the potting compound can be, for example, a polyurethane resin, polysulfide resin, polyester resin, polyamide resin, vinyl ester resin, epoxy resin or alkyd resin. Therefore, the potting compound normally consists of at least two components which must be mixed together, namely a polymer or resin component and a hardener or catalyst component.
  • the feed line has a mixing device which mixes the component of the potting compound during its feeding or injection into the annular part.
  • the mixing device has at least one element that mixes the components together by means of the flow of the injection-molding potting compound through the feed line.
  • the element could be a rotatable element, a screw and / or a twist.
  • the feed line comprises an outlet tube which directs the potting compound directly into the annular part, and the element (ie the rotatable element, the screw and / or the swirl) is located in the cavity of the outlet tube so that the outlet tube forms a mixing chamber for the potting compound , Since the supply of Vergussmassenkomponenten possibly under a pressure (for example, air pressure), the flowing through the supply line components of the potting compound can be mixed together. As a result, the potting compound essentially applies only on arrival in the annular part of the metering device as a curable or curing material. This reservoir for the (already mixed) potting compound or possibly pre-filled and / or segmented potting are redundant and their disadvantages eliminated. This has great advantages for the determination and for the control of the process, because only when injecting the potting compound does the reaction time to cure the resin.
  • the element ie the rotatable element, the screw and / or the swirl
  • the apparatus according to the invention is designed such that during operation, a supply of the potting compound in the metering device and thus in the directly connected to the filter assemblies line systems immediately after mixing the components of the potting compound in the Supply line is possible and thus no reservoir for (possibly premixed) potting compound within the rotating device are needed.
  • the apparatus according to the invention for casting hollow-fiber membranes does not comprise reservoirs for the potting compound or optionally pre-filled and / or segmented potting chambers, in particular no reservoirs for the potting compound or optionally pre-filled and / or segmented potting chambers within the rotary device (or the centrifuge ) of the apparatus according to the invention.
  • the apparatus according to the invention does not comprise reservoirs for potting compound, in particular no reservoir for potting compound whose components such as polymer or resin component and curing agent or catalyst component are already mixed, ie for already premixed potting compound .
  • the apparatus according to the invention preferably does not comprise reservoirs for potting compound which have to be filled with potting compound, in particular with premixed potting compound, before the apparatus is put into operation.
  • the apparatus according to the invention does not comprise reservoirs for potting compound, which rotate with the rotating device during operation of the apparatus according to the invention.
  • the apparatus according to the invention preferably does not comprise a segmented distribution container, in particular a segmented distribution container rotating with the rotating device during operation of the apparatus according to the invention.
  • the apparatus according to the invention preferably does not include any (possibly segmented) distribution container for potting compound which is optionally positioned in the rotational axis of the rotary device.
  • the apparatus of the invention is preferably designed so that the mixed potting compound directly after mixing of the components, for example by the mixing device within the supply line (eg within an outlet tube), and feeding or injecting the potting compound into the metering device by centrifugal force directly into the piping is conveyed, which are preferably directly connected to the modules (eg the filter assemblies).
  • the apparatus of the invention preferably comprises only one, preferably a single supply line with preferably integrated mixing device (eg a mixing valve) within the rotating device, which is preferably designed and positioned in the apparatus according to the invention, that the potting compound directly from the supply line (eg a mixing valve) for Any number of modules (eg to be filled filter assemblies) is used.
  • the supply line eg the outlet pipe
  • the supply line is preferably designed such that it does not rotate with the rotating device during operation of the apparatus and is not connected to the rotating device by a mechanical connection (such as pipe or hose).
  • each of the filter assemblies has a housing in which the bundle of hollow fiber membranes is disposed, and at least one end portion of the bundle is held in the mold.
  • the housing in particular a wall of the housing, at least partially forms the casting mold.
  • the housing has an end cap in which the end portion of the bundle of hollow fiber membranes is held so that the end cap of the housing at least partially forms the mold.
  • opposite ends or end portions of the bundled hollow fiber membranes are held in two groups at the same end of the housing in the mold.
  • the second portion of the rotating device has a plurality of mounts for receiving the plurality of filter assemblies.
  • the brackets are distributed around a circumference of the second section, as far as possible equidistant, and when the filter assemblies are mounted in the second section of the apparatus, the casting mold of each filter assembly is located at a radially outward end of the housing.
  • the plurality of filter assemblies are distributed substantially evenly around the circumference of the second portion.
  • the axis of rotation of the rotating device is located outside of a filter assembly mounted in the holder, that is not between the two ends of a mon notorious filter arrangement.
  • the annular part is formed with a plurality of eg radial passages and these are preferably distributed substantially evenly around the circumference of the annular part.
  • Each passage is in communication with the casting mold of one of the filter assemblies, ie in communicating connection in the sense of communicating tubes, such as via a flexible hose.
  • each passage has a fitting on a radially outer side of the annular part, via which this passage is connected to the casting mold of the respective filter arrangement, preferably by means of the flexible hose.
  • This arrangement in particular the application of the principle of communicating tubes, allows an exact determination of the embedding height and allows, in particular in connection with the metering device, for example in the form of an open metering ring, a particularly homogeneous distribution of the casting compound.
  • the casting molds of the filter assemblies are only connected on one side to the piping system for the potting compound (eg with a flexible hose), so that potting compound can preferably only enter the filter arrangement on one side of the casting mold. It is therefore preferred that each of the casting molds of the filter assemblies has no more than one access for potting compound.
  • the access to the casting mold is mounted on the radially outer side, preferably on the end face of the casting mold with filter arrangement.
  • the apparatus according to the invention is designed such that the path of the potting compound, eg from metering device (eg metering ring) until access of the potting compound in the mold, having identical distances and thus the residence time (preferably a few seconds, eg 1 - 20 seconds) of the potting compound in the supply systems is identical for all filter modules. It is further preferred that the total injection time (preferably 30-60 seconds) of the potting compound can be selected to be short in relation to the curing time (eg 5 to 20 min), and thus the most homogeneous potting compound is supplied to the filter.
  • the path of the potting compound eg from metering device (eg metering ring) until access of the potting compound in the mold, having identical distances and thus the residence time (preferably a few seconds, eg 1 - 20 seconds) of the potting compound in the supply systems is identical for all filter modules.
  • the total injection time (preferably 30-60 seconds) of the potting compound can be selected to be short in relation to the curing time (
  • the annular member has a plurality of storage chambers for accumulating the potting compound, each storage chamber being in communicating communication with one of the passages.
  • These chambers are as far as possible on the inner side of the annular part and are preferably, like the passages, distributed substantially uniformly around the circumference of the annular part.
  • Each chamber has a diameter that is significantly larger than a diameter of the passageway connected to that chamber.
  • Each stowage chamber functions as a kind of hopper for the mold in communication with it.
  • the annular part also called “metering ring” or simply “ring”, is preferably designed as an open, continuous or circular ring with a circumferential on the radially inner side cavity.
  • the lower side of the ring is preferably provided with a radially inwardly extending protective layer which can absorb dripping of the injected or injected potting compound. This protective layer may, for example, be formed as a plate below the annular part.
  • the second portion of the rotary device for fixing the filter assemblies in the axial direction is offset from the first portion for supplying the potting compound.
  • the second portion is disposed below the first portion.
  • the casting mold of each filter assembly mounted in the second section is located at a radial distance R 4 from the axis of rotation, which is ideally greater than a radial distance R, the radially outer side of the annular member, but greater than a radial distance R 3 of the radial inner side of the annular part of the rotation axis.
  • the apparatus has a plurality of second sections for fastening the filter arrangements, wherein the second sections are offset from each other in the axial direction (ie, along the axis of rotation) or stacked one above the other.
  • the number of filter assemblies made in a single operation of the apparatus can be significantly increased, e.g. doubled or tripled.
  • a relatively high number of filter arrangements can be fastened and made by the casting method according to the invention.
  • the number of filter orders in each second section is in the range of about 20 to 200, preferably in the range of about 50 to 100.
  • the invention further provides a method for casting hollow-fiber membranes in the production of a membrane device, in particular a filter arrangement, preferably a filter arrangement with highly porous hollow-fiber membranes, as described above, using the apparatus according to the invention.
  • the use of the apparatus according to the invention for producing a membrane device in particular a filter arrangement, preferably a filter arrangement with highly porous hollow-fiber membranes, as described above, is provided.
  • the invention also provides a method for casting hollow-fiber membranes in the production of a membrane device, in particular a filter arrangement, which method comprises the following steps: Providing a rotating device or centrifuge having a first portion for supplying a potting compound and a second portion for fixing a plurality of filter assemblies,
  • each filter assembly comprising a bundle of hollow fiber membranes held in a mold, and each mold being in communication with the first potting compound supply section,
  • the first section functions as a metering device which distributes the potting compound to the plurality of filter assemblies substantially uniformly by rotating the rotating device and pressed by centrifugal force through the respective compounds in the molds or flings.
  • the first portion comprises an annular part which rotates about the axis with the rotating device. The potting compound is supplied or injected during rotation of the rotating device in the annular part, so that the supplied potting compound by the rotation of the rotating device on the annular part substantially evenly distributed.
  • the feeding or injection of the potting compound via a supply line, which preferably does not rotate with the rotating device about the axis, so that the annular part rotates relative to the supply line.
  • a supply line which preferably does not rotate with the rotating device about the axis, so that the annular part rotates relative to the supply line.
  • the number of revolutions of the annular part during the feeding or the injection of the potting compound is preferably in the range of 100 to 1000, and more preferably in the range of 300 to 600.
  • the supply or injection of the potting compound is preferably carried out with a substantially constant throughput or with a substantially constant injection rate.
  • the potting compound is supplied or injected directly on a radially inner side of the annular part, so that the potting compound during rotation of the rotating device on the inner side of the annular part in Substantially evenly distributed, eg along a circumferential cavity on the radially inner side of the annular part.
  • the annular member is formed with a plurality of passages which are preferably substantially uniformly distributed about the circumference of the annular member, each passage being in communicating communication with the mold of one of the filter assemblies, preferably via a flexible hose the potting compound is pressed or hurled into the potting molds by means of the centrifugal force through the passages and via the respective connections.
  • the mixed potting compound is mixed immediately after mixing the components, e.g. after mixing the components in the mixing device within the feed line (e.g., within the outlet tube), metered into the metering device, and conveyed by centrifugal force directly into the conduit systems directly connected to the modules (e.g., the filter assemblies).
  • the implementation of the method according to the invention requires no storage container for (possibly premixed) potting compound, in particular no supply or distribution container for (possibly premixed) potting compound which rotates with the rotary device.
  • the second section of the rotary device for fastening the filter arrangements in the axial direction is offset from the first section for supplying the casting compound. Therefore, the potting compound is pushed or thrown from the first section in the axial direction or along the axis of rotation into the potting forms.
  • each passage in the dosing ring is in communicating connection with a filter arrangement offset in a peripheral or a direction extending along the axis. Therefore, the potting compound is preferably additionally pressed or thrown from the first section into the potting forms of the second section in a peripheral or in a direction running around the axis.
  • the method comprises the further step of: mixing components of the potting compound during the feeding or injection of the potting compound into the annular part.
  • the mixing of the components is effected by a mixing device and / or by the flow of the supplied or injected potting compound.
  • the components of the potting compound are pressed under pressure through a supply line, wherein the supply line includes the mixing device (such as a rotatable element, a swirl and / or a screw), which mixes the components flowing through each other.
  • the mixing device such as a rotatable element, a swirl and / or a screw
  • the shaping of the casting in the filter arrangements can be determined and controlled very precisely.
  • the potting compound is supplied or injected into the annular part only after the rotary device or the centrifuge has reached an optimum rotational speed.
  • the rotation time or spin time can be optimized for the course of the process.
  • the method comprises the further step of closing the ends of the individual hollow-fiber membranes in the end region of the bundle of hollow-fiber membranes in each filter arrangement before the filter arrangements are fastened in the second section of the rotary device.
  • This can ensure that the potting compound does not penetrate through open ends of the hollow fibers in the inner cavities of the fiber.
  • the closing of the ends of the individual hollow-fiber membranes takes place in the end region of the bundle by sclerosing the hollow-fiber membranes, preferably with heat, for example with a hot wire.
  • already closed hollow-fiber membranes are embedded over a single feed line of the casting compound to the casting mold.
  • Guidance form each casting mold (with filter assembly) only a single lead for potting compound.
  • the method according to the invention comprises a multiplicity of embedding processes, that is to say the embedding or embedding of a multiplicity of modules, e.g. Filter assemblies with hollow fiber membranes, e.g. greater than 5, preferably greater than 10, preferably greater than 20, e.g. from about 20 to 200, preferably in the range of about 50 to 100 modules (e.g., filter assemblies), where the plurality of embedding operations are parallel and preferably result in substantially identically embedded filter assemblies.
  • modules e.g. Filter assemblies with hollow fiber membranes, e.g. greater than 5, preferably greater than 10, preferably greater than 20, e.g. from about 20 to 200, preferably in the range of about 50 to 100 modules (e.g., filter assemblies), where the plurality of embedding operations are parallel and preferably result in substantially identically embedded filter assemblies.
  • Figure 1 is a schematic partial side view or a cross section of an apparatus according to an embodiment of the invention.
  • FIG. 2 shows a schematic plan view of the first section of the apparatus according to the exemplary embodiment in FIG. 1.
  • FIG. 1 shows a vertical cross-section through an apparatus 1 according to the invention for casting hollow-fiber membranes, which cross-section was taken along a central half-plane II shown in FIG.
  • the apparatus 1 comprises a rotating device or centrifuge 2 comprising a frame with a central shaft 3 for rotation about a central axis A and spokes 4 extending radially outwardly therefrom.
  • the rotary device or centrifuge 2 has a rotatable first section 10 for supplying a potting compound and a rotatable second portion 20 disposed below the first portion 10 for securing a plurality of filter assemblies 30.
  • each filter assembly 30 has a housing 31 in which a bundle 32 is disposed of hollow fiber membranes, and at least one end or an end portion of the bundle 32 is held in a mold V, wherein the mold V in this embodiment of the housing 31 itself, in particular of a side wall 33 and / or of an end cap 34 of the housing 31, at least partially formed.
  • Each filter assembly 30 is received in a respective bracket 21 in the second section 20 and fastened there.
  • the holders 21 are distributed essentially equidistantly on a rotary plate 22 around a circumference of the second section 20, and the filter arrangements 30 are mounted in the second section 20 of the apparatus 1 in such a way that the casting mold V of each filter arrangement 30 extends radially outwardly directed end of the housing 31 is located.
  • the rotary plate 22 of the second section 20 is rigidly connected to the shaft 3 via the lower spokes 4, so that the second section 20 rotates about the axis A with the rotary device 2.
  • the first section 10 of the apparatus 1 according to the invention comprises a metering device which evenly distributes the potting compound to the plurality of filter arrangements 30 by rotating the rotary device 2.
  • the metering device has an annular portion 1 1, which is rigidly connected to the shaft 3 via the upper spokes 4 and thereby rotates with the rotating device 2 about the axis A. Furthermore, the metering device in the first section 10 has a feed line 12 which supplies or injects the potting compound into the annular part 11.
  • the supply line 12 terminates in an outlet tube 13 which extends into the annular part 11 and does not rotate with the rotary device 2, so that the annular part 11 rotates relative to the supply line 12 during the feeding or injection of the casting compound , In other words, the outlet tube 1 3 remains substantially static during the feeding or injection of the potting compound.
  • the annular part 1 1, also called “metering” or simply “ring” is formed as an open, circular ring with a circumferential on the radially inner side cavity or concave curvature 14.
  • the lower side of the ring 1 1 is on a bottom ring plate 15, which connects it to the spokes 4 and forms a protective layer for catching a dripping of the injected potting compound. Since the outlet pipe 13 in the immediate vicinity of the cavity 14 has its outlet opening, the potting compound is supplied from the supply line 12 at a radially inner side of the annular part 1 1 or injected.
  • the metering ring 1 1 is further formed with a plurality of radial bores 16, which passages between see the radially inner and outer sides of the ring 1 1 form.
  • each passage 1 6 has a connecting piece 1 7 for connecting a tube or a flexible hose 18 which is in communicating connection with the casting mold V of one of the filter assemblies 30 secured in the second section 20.
  • the potting compound which consists in this embodiment of a polyurethane resin, is supplied or injected in the direction R about its axis A in the first section 10 when rotating the rotating device 2. More specifically, as the rotating device 2 is rotated, the casting compound 2 is supplied through the inlet 12 and out the outlet tube 13 directly on the inner side of the annular part 11. Since the ring 1 1 rotates together with the shaft 3 about the axis A, the ring 1 1 rotates at a relatively high speed with respect to the substantially static outlet pipe 1 3.
  • the rotary device or centrifuge 2 for example, at a speed in the range from 200 to 800 revolutions per minute, preferably in the range of 300 to 500 revolve per minute.
  • the high speed of the ring 1 1 when injecting the resin causes the supplied amount of resin over the entire circumference of the ring 1 1 is injected and distributed over several revolutions.
  • the potting compound is distributed by the rotation of the rotating device 2 to the metering ring 1 1 substantially uniformly.
  • the potting compound by the centrifugal force on the passages 1 6 and the hoses 18 to the plurality of filter assemblies 30 also substantially evenly distributed and squeezed into each of the casting molds V.
  • the potting compound or the polyurethane resin is mixed in this embodiment in the supply line 12 during feeding or injection into the metering ring 1 1. That is, the polymer or resin component of the polyurethane resin is combined with the hardener or catalyst component and mixed by means of a mixing device in the feed line 12.
  • the mixing device has, for example, an element which mixes these components with one another by the flow of the injection-molding potting compound through the feed line 12.
  • the element may e.g. in the form of a screw and / or a swirl in the outlet pipe 13, so that the outlet pipe 1 3 forms a mixing chamber for the potting compound.
  • the components of the casting compound flowing through the supply line 12 in the outlet pipe 13 are mixed with one another.
  • the polyurethane resin is substantially only on arrival in the annular part 1 1 a curable or curing material.
  • the second section 20 for fastening the filter arrangements 30 lies below the first section 10 for the supply of the potting compound.
  • the second section 20 is offset from the first section 10 in the axial direction (ie along the axis A).
  • the casting mold V of each filter assembly 30 mounted in the second section lies at a radial distance R 4 from the axis of rotation A, which is slightly larger than a radial distance R, the radially outer side of the annular part 1 1.
  • the rotary device 2 is operated at the optimum rotational speed until the potting compound or the resin in the molds V blocks and hardens. At this time, the potting around the hollow fibers and between the hollow fibers at the end of the housing 31 is finished and the centrifuge 2 can be switched off. However, the hoses 18 are then filled with hardened resin and are no longer usable. However, these can be replaced very easily for the next charge of filter assemblies 30 in the apparatus 1.
  • the filter arrangements 30 should be positioned and secured in the second section 20, a radial distance R s of the desired fill level from the axis of rotation A is slightly greater than the radial distance R, the radially outer side of the annular part 11.
  • the radius R in this embodiment, is preferably in the range of 200 mm to 800 mm, more preferably in the range of 400 mm to 600 mm.
  • the metering ring 11 has a plurality of chamber or storage chamber 19 for collecting the potting compound on the inner side of the metering ring 11, each storage chamber 19 being in communicating connection with a respective one. ligen passage 16 is.
  • each storage chamber 19 Since each chamber 19 has a diameter which is considerably larger than a diameter of the passage 1 6 connected to it, each storage chamber 19 functions as a kind of filling funnel for the casting mold V which is thus in communicating connection.
  • the resin injected into the ring 11 is guided via the chambers 19 by means of the respective hoses 18 in the corresponding Vergussformen V.
  • each passageway 16 in the metering ring 11 is in communication with the filter assembly 30 via the hose 18, with a filter arrangement 30 displaced in a peripheral or a direction running along the axis.
  • the radial distance R 4 of each mold V from the axis of rotation A should be greater than a radial distance R 2 of each stagnation chamber 19 from the axis. Otherwise, the remnants of the potting compound would have to be removed from the bores 16 and from the storage chambers 19 after each operation of the apparatus 1.

Landscapes

  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

L'invention concerne un appareil (1) pour enrober des membranes à fibres creuses d'un ensemble filtre. L'appareil (1) comprend un dispositif rotatif (2) qui présente une première partie (10) pour amener une matière à couler et au moins une deuxième partie (20) pour fixer plusieurs ensembles filtre (30). Chaque ensemble filtre (30) présente un paquet (32) de membranes à fibres creuses qui sont maintenues dans un moule de coulée (V) et une rotation du dispositif rotatif (2) autour de son axe (A) presse ou projette par force centrifuge la matière à couler de la première partie (10) vers chaque moule (V) dans la deuxième partie (20). La première partie (10) comprend un dispositif de dosage qui répartit de manière pratiquement uniforme la matière à couler vers les différents ensembles filtre (30) grâce à la rotation du dispositif rotatif (2). L'invention concerne également un procédé correspondant pour enrober des membranes à fibres creuses d'un ensemble filtre.
PCT/EP2011/003337 2010-08-09 2011-07-05 Appareil et procédé d'enrobage de fibres creuses WO2012019678A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010033826A DE102010033826A1 (de) 2010-08-09 2010-08-09 Apparat und Verfahren zum Vergießen von Hohlfasern
DE102010033826.5 2010-08-09

Publications (1)

Publication Number Publication Date
WO2012019678A1 true WO2012019678A1 (fr) 2012-02-16

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PCT/EP2011/003337 WO2012019678A1 (fr) 2010-08-09 2011-07-05 Appareil et procédé d'enrobage de fibres creuses

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DE (1) DE102010033826A1 (fr)
WO (1) WO2012019678A1 (fr)

Citations (9)

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DD112904A1 (fr) 1974-02-14 1975-05-12
JPS51103083A (ja) * 1975-03-10 1976-09-11 Teijin Ltd Mokangataryutaibunrikino seikeisochi
DE3813576A1 (de) 1988-04-22 1990-03-15 Igor Groza Hilfsgeraet fuer die herstellung von kapillardialysatoren
WO2002013888A1 (fr) 2000-08-15 2002-02-21 Heim Medizintechnik Gmbh Ensemble filtre pour fractionner du sang en plasma et en composants cellulaires et dispositif pour son application sur un donneur
US20040183228A1 (en) * 2003-03-20 2004-09-23 Martin Stillig Method and apparatus for manufacturing filters
JP2005000760A (ja) * 2003-06-10 2005-01-06 Nok Corp 遠心ポッティング装置
EP1385605B1 (fr) 2001-04-04 2007-01-24 U.S. Filter Wastewater Group, Inc. Procede de formation d'un pot pour des fibres creuses
DE102006021066A1 (de) * 2006-05-05 2007-11-08 Fresenius Medical Care Deutschland Gmbh Verfahren und Vorrichtung zum Einbringen einer Vergußmasse in eine Filtervorrichtung
JP2009131746A (ja) * 2007-11-29 2009-06-18 Toray Ind Inc ポッティング材注入用容器およびそれを用いた中空糸膜モジュールの製造方法

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Publication number Priority date Publication date Assignee Title
US4219426A (en) * 1976-03-19 1980-08-26 Organon Teknika B.V. Dialysis device
US4497104A (en) * 1982-12-20 1985-02-05 Baxter Travenol Laboratories, Inc. Separation device manufacture
CS253465B1 (en) * 1985-06-26 1987-11-12 Ilja Krejci Centrifuge for haemodialsisators' mass single-ended face seal
HU209743B (en) * 1988-12-22 1994-10-28 Tatabanyai Banyak Vallalat Method and device for setting a bundle of filter - membranes consisting of capillary - membranes in a case
ATE347439T1 (de) * 2001-12-18 2006-12-15 Mann & Hummel Gmbh Verfahren zur herstellung eines hohlfasermembranmoduls und hohlfasermembranmodul

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD112904A1 (fr) 1974-02-14 1975-05-12
JPS51103083A (ja) * 1975-03-10 1976-09-11 Teijin Ltd Mokangataryutaibunrikino seikeisochi
DE3813576A1 (de) 1988-04-22 1990-03-15 Igor Groza Hilfsgeraet fuer die herstellung von kapillardialysatoren
WO2002013888A1 (fr) 2000-08-15 2002-02-21 Heim Medizintechnik Gmbh Ensemble filtre pour fractionner du sang en plasma et en composants cellulaires et dispositif pour son application sur un donneur
EP1385605B1 (fr) 2001-04-04 2007-01-24 U.S. Filter Wastewater Group, Inc. Procede de formation d'un pot pour des fibres creuses
US20040183228A1 (en) * 2003-03-20 2004-09-23 Martin Stillig Method and apparatus for manufacturing filters
JP2005000760A (ja) * 2003-06-10 2005-01-06 Nok Corp 遠心ポッティング装置
DE102006021066A1 (de) * 2006-05-05 2007-11-08 Fresenius Medical Care Deutschland Gmbh Verfahren und Vorrichtung zum Einbringen einer Vergußmasse in eine Filtervorrichtung
JP2009131746A (ja) * 2007-11-29 2009-06-18 Toray Ind Inc ポッティング材注入用容器およびそれを用いた中空糸膜モジュールの製造方法

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DE102010033826A1 (de) 2012-02-09

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