WO2012007113A1 - Polysaccharide polymer from the seeds of the tamarind tree for use in treating dry cough - Google Patents
Polysaccharide polymer from the seeds of the tamarind tree for use in treating dry cough Download PDFInfo
- Publication number
- WO2012007113A1 WO2012007113A1 PCT/EP2011/003284 EP2011003284W WO2012007113A1 WO 2012007113 A1 WO2012007113 A1 WO 2012007113A1 EP 2011003284 W EP2011003284 W EP 2011003284W WO 2012007113 A1 WO2012007113 A1 WO 2012007113A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dry cough
- tamarind
- seeds
- preparation
- polysaccharide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
Definitions
- the present invention relates to the use of polysaccharide polymer obtained from the seeds of the tamarind tree for treating dry cough.
- the present invention relates to treatment of the dry cough in children.
- Dry cough often occurs at the end of viral infections affecting the upper respiratory airways such as a cold and flu, or after the exposure to a variety of irritating factors including allergens, dust, smoke, cleaning agents, chemical air pollutants and contaminants, prolonged stay in dry environments and physical traumas.
- Dry cough typically does not last longer than 2-3 weeks.
- a person suffering from dry cough experiences an unpleasant feeling of burning and dryness of the high respiratory airways and an uncomfortable tickling in the throat, which usually begins the attacks of cough.
- dry cough is mild throughout the day and often gets more intense at night, preventing a person from sleeping or resting. Sometimes dry cough occurs only at night, after the person goes to sleep.
- Dry cough is very common in children. Children who cough during the night may have problems to sleep, and such problems may involve also their parents
- Traditional homemade remedies include, for example, fresh ginger, saline solution and honey.
- Tamarind tree is widespread in India, Africa and in the South East Asia.
- tamarind juice from the tamarind fruit can be a drink prepared by infusing dried tamarind pulp.
- Tamarind can also be useful for the preservation of food products and as a sauce in recipes.
- the tamarind seed finds various applications, once ground to the powder form (known as "tamarind gum” or “tamarind kernel powder”).
- tamarind kernel powder can be employed as thickener and a sizing agent in textile and paper industries; and as thickening, gelling, stabilizing and binding agent in food and pharmaceutical industries.
- a polysaccharide polymer obtained from the seeds of the tamarind tree provides dry cough relief and maintains the relief for an extended period of time that is long enough to allow, for example, the adults and children to fall asleep and enjoy a satisfactory sleep time.
- Tamarind seed polysaccharide is a nonionic, neutral, branched polysaccharide comprising a cellulose-like backbone substituted by xylose (a 1 ⁇ 6) and galacto ( ⁇ l ⁇ 2)xylose (a 1 ⁇ 6) substituents (Lang P. et al., Macromolecules, 1993, 26, 3992- 3998).
- Tamarind seed polysaccharide suitable for the preparations according to the present invention may be obtained according to any method known in the art, preferably following the methods described in WO 97/28787.
- Tamarind seed polysaccharide according to the invention is particularly effective for treating dry cough in children, especially at night, when cough is particularly bothersome because it disrupts sleep.
- a polysaccharide polymer obtained from the seeds of the tamarind tree according to the invention is locally administered to the mucous membranes of the high respiratory airways of a subject suffering from dry cough as an aerosolized liquid preparation, by suitable commercially available inhalation devices.
- the preparation according the invention contains from 0.25 to 0.5 w/v% (hereunder the unit “w/v%” is referred to as "%" for simplicity) of the polysaccharide polymer obtained from the seeds of the tamarind tree.
- the preparation according the invention contains 0.3% of the polysaccharide polymer obtained from the seeds of the tamarind tree.
- the preparation according to the invention can further comprise pH adjusting agents well known to a person skilled in the art, including pharmaceutically acceptable acids or bases and buffering agents.
- the acids may include one or more inorganic mineral acids such as hydrochloric, hydrobromic, sulfuric, phosphoric and nitric acid, or one or more organic acids such as acetic, succinic, tartaric, ascorbic, citric, glutamic, benzoic, methanesulphonic, ethanesulfonic and trifluoroacetic acid.
- the bases may include inorganic bases and organic bases, such as alkaline carbonate, alkaline bicarbonate, alkaline earth metal carbonate, alkaline hydroxide and alkaline - 4 - earth metal hydroxide.
- the inorganic base may be an alkaline hydroxide such as lithium hydroxide, potassium hydroxide, cesium hydroxide or sodium hydroxide; an alkaline carbonate may be calcium carbonate or sodium carbonate; an alkaline bicarbonate may be sodium bicarbonate.
- buffering agents include a phosphate buffer such as sodium dihydrogen phosphate commonly termed monosodium phosphate (NaH ⁇ PC ⁇ ) and disodium hydrogen phosphate commonly termed disodium phosphate (Na 2 HP0 4 ), an acetate buffer (sodium acetate-acetic acid system) a citrate buffer (sodium citrate-citric acid system) and mixtures thereof.
- the buffering agent is preferably selected from monosodium phosphate (NaH 2 P0 ), disodium phosphate (Na 2 HP0 ) or mixture thereof, and sodium citrate-citric acid system.
- the type and concentration of the pH adjusting agents suitable for use in the disclosed preparation would be dependent on the desired pH value which ranges within 6.0 to 8.0, preferably within 6.8 and 7.5.
- the isotonicity of the preparation vehicle is preferably adjusted by sodium chloride.
- the local administration to the mucous membranes of the high respiratory airways of a subject suffering from dry cough of the preparation according to the invention is carried out by an aerosol delivery system; the aerosolized liquid preparation is therefore sufficiently mobile to coat a wide area of the mucosal surface of the upper respiratory tract, thus providing effective relief of dry cough.
- the aerosol delivery system is a commercially available nebulizer, such as a jet nebulizer, which accepts the liquid preparation and transforms said liquid preparation into fine droplets, so that it can be easily inhaled through a mouthpiece or a face mask.
- a jet nebulizer such as a jet nebulizer
- a jet of air is forced through the preparation according to the invention, turning it into fine droplets which are moved along a tube.
- the subject inhales the preparation, through a mouthpiece or a face mask.
- a face mask is preferably used for pediatric subjects.
- the preparation according to the invention can be administered to a subject suffering from dry cough on as-needed or as-desired basis, for example, at least once daily and P2011/003284
- - 5 - preferably multiple, for example 2 or 3 times daily.
- the amount of the preparation administered to a subject may be dependent on a variety of factors, including the general quality of health of the subject, age, gender, weight, or severity of dry cough. For example, from 6 to 18 mg/day of tamarind seed polysaccharide can be administered to a subject in need thereof.
- a process for preparing a preparation as described above can be carried out according to methods well known to a person skilled in the art; for example, said process comprises dissolving the tamarind seed polysaccharide in purified water such as water for injections and adding a pH adjusting agent until the desired pH is reached.
- a polysaccharide polymer obtained from the seeds of the tamarind tree includes mixtures of polysaccharide polymers obtained from the seeds of the tamarind tree.
- high respiratory tract includes nasal, sinus, pharyngeal, laryngeal, tracheal, and bronchial compartments.
- inhalation or “administration by inhalation” refers to the introduction into the respiratory organs, especially into and/or via the airways, preferably into and/or via the nasal cavity and oral cavity.
- nebulizer includes jet nebulizers.
- polysaccharide polymer obtained from the seeds of the tamarind tree interchangeable with the term “tamarind seed polysaccharide” and abbreviated as "TSP" means any polysaccharide-enriched fraction obtainable from tamarind kernel powder currently available on the market.
- a partially purified polysaccharide fraction of tamarind gum is sold, for instance, by Dainippon Pharmaceutical Co. LTD of Osaka, Japan, under the trade name Glyloid ® .
- the concerned polysaccharide is preferably obtained following any method known in the art to give a practically pure tamarind seed polysaccharide from commercial tamarind gum sources.
- preparation is intended in a broader sense to include not only all conventional pharmaceutical preparations but also preparations useful as diet supplements, medical devices and food additives.
- the term "subject” refers to a human adult or a child afflicted with a dry cough.
- treating means relieving, suppressing, reducing, decreasing, delaying, ameliorating, calming or preventing onset, progression, severity, duration, frequency of dry cough and not necessarily indicates a total elimination the same.
- Example 1 illustrates some preparations according to the invention.
- TSP tamarind seed polysaccharide
- Example 2 illustrates the use in one adult subject of the first preparation of Example 1.
- Example 1 One subject with cough following inflammation of the upper airways was selected to test the preparation of Example 1.
- the preparation was locally administered by aerosol inhalation carried out by the nebulizer Fluirespira Professional (Zambon).
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES11745921.4T ES2560954T3 (en) | 2010-07-12 | 2011-07-01 | Polysaccharide polymer of tamarind tree seeds for use in the treatment of dry cough |
CN201180004954.4A CN102686232B (en) | 2010-07-12 | 2011-07-01 | Polysaccharide polymer from the seeds of the tamarind tree for use in treating dry cough |
SI201130726T SI2593119T1 (en) | 2010-07-12 | 2011-07-01 | Polysaccharide polymer from the seeds of the tamarind tree for use in treating dry cough |
EP11745921.4A EP2593119B1 (en) | 2010-07-12 | 2011-07-01 | Polysaccharide polymer from the seeds of the tamarind tree for use in treating dry cough |
MX2012005818A MX2012005818A (en) | 2010-07-12 | 2011-07-01 | Polysaccharide polymer from the seeds of the tamarind tree for use in treating dry cough. |
BR112012011818-8A BR112012011818B1 (en) | 2010-07-12 | 2011-07-01 | PREPARATION IN THE FORM OF A LIQUID DOSAGE FOR AEROSOLIZED TOPICAL APPLICATION |
EA201270563A EA023654B1 (en) | 2010-07-12 | 2011-07-01 | Polysaccharide polymer from the seeds of the tamarind tree for use in treating dry cough |
PL11745921T PL2593119T3 (en) | 2010-07-12 | 2011-07-01 | Polysaccharide polymer from the seeds of the tamarind tree for use in treating dry cough |
RS20160055A RS54637B1 (en) | 2010-07-12 | 2011-07-01 | Polysaccharide polymer from the seeds of the tamarind tree for use in treating dry cough |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10007151.3 | 2010-07-12 | ||
EP10007151 | 2010-07-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2012007113A1 true WO2012007113A1 (en) | 2012-01-19 |
Family
ID=43410370
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2011/003284 WO2012007113A1 (en) | 2010-07-12 | 2011-07-01 | Polysaccharide polymer from the seeds of the tamarind tree for use in treating dry cough |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP2593119B1 (en) |
CN (1) | CN102686232B (en) |
BR (1) | BR112012011818B1 (en) |
CO (1) | CO6561774A2 (en) |
EA (1) | EA023654B1 (en) |
ES (1) | ES2560954T3 (en) |
HU (1) | HUE028534T2 (en) |
MX (1) | MX2012005818A (en) |
MY (1) | MY162322A (en) |
PL (1) | PL2593119T3 (en) |
PT (1) | PT2593119E (en) |
RS (1) | RS54637B1 (en) |
SI (1) | SI2593119T1 (en) |
WO (1) | WO2012007113A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013023856A1 (en) * | 2011-08-12 | 2013-02-21 | Zambon S.P.A. | Use of a polysaccharide polymer from the seeds of the tamarind seed in protecting against tobacco-associated damages |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997028787A1 (en) | 1996-02-05 | 1997-08-14 | Farmigea S.P.A. | Ophthalmic solutions viscosified with tamarind seed polysaccharide |
WO2004113390A1 (en) * | 2003-06-20 | 2004-12-29 | Noveon Ip Holdings Corp. | Galactomannan hydrocolloids |
WO2006069213A1 (en) * | 2004-12-22 | 2006-06-29 | Schering Corporation | Pharmaceutical formulations |
WO2009040847A2 (en) * | 2007-08-13 | 2009-04-02 | N.B.S. S.R.L. | Dermocosmetic compositions based on tamarind seed polysaccharide and vegetable extracts |
-
2011
- 2011-07-01 PT PT117459214T patent/PT2593119E/en unknown
- 2011-07-01 SI SI201130726T patent/SI2593119T1/en unknown
- 2011-07-01 PL PL11745921T patent/PL2593119T3/en unknown
- 2011-07-01 ES ES11745921.4T patent/ES2560954T3/en active Active
- 2011-07-01 HU HUE11745921A patent/HUE028534T2/en unknown
- 2011-07-01 MY MYPI2012002079A patent/MY162322A/en unknown
- 2011-07-01 BR BR112012011818-8A patent/BR112012011818B1/en active IP Right Grant
- 2011-07-01 MX MX2012005818A patent/MX2012005818A/en active IP Right Grant
- 2011-07-01 CN CN201180004954.4A patent/CN102686232B/en active Active
- 2011-07-01 WO PCT/EP2011/003284 patent/WO2012007113A1/en active Application Filing
- 2011-07-01 RS RS20160055A patent/RS54637B1/en unknown
- 2011-07-01 EA EA201270563A patent/EA023654B1/en unknown
- 2011-07-01 EP EP11745921.4A patent/EP2593119B1/en active Active
-
2012
- 2012-06-25 CO CO12106368A patent/CO6561774A2/en not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997028787A1 (en) | 1996-02-05 | 1997-08-14 | Farmigea S.P.A. | Ophthalmic solutions viscosified with tamarind seed polysaccharide |
WO2004113390A1 (en) * | 2003-06-20 | 2004-12-29 | Noveon Ip Holdings Corp. | Galactomannan hydrocolloids |
WO2006069213A1 (en) * | 2004-12-22 | 2006-06-29 | Schering Corporation | Pharmaceutical formulations |
WO2009040847A2 (en) * | 2007-08-13 | 2009-04-02 | N.B.S. S.R.L. | Dermocosmetic compositions based on tamarind seed polysaccharide and vegetable extracts |
Non-Patent Citations (5)
Title |
---|
GUPTA V, PURI R, GUPTA S, JAIN S, RAO GK.: "Tamarind kernel gum: An upcoming natural polysaccharide", SYST REV PHARM, vol. 1, 2010, pages 50 - 4 |
LANG P. ET AL., MACROMOLECULES, vol. 26, 1993, pages 3992 - 3998 |
MURRAY R ET AL: "An outbreak of weaver's cough associated with tamarind seed powder", BRITISH JOURNAL OF INDUSTRIAL MEDICINE, BRITISH MEDICAL ASSOCIATION, LONDON, GB, vol. 14, no. 2, 1 April 1957 (1957-04-01), pages 105 - 110, XP009151988, ISSN: 0007-1072 * |
See also references of EP2593119A1 |
TUFFNELL P G ET AL: "An investigation into the acute respiratory reaction to the inhalation of tamarind seed preparations", BRITISH JOURNAL OF INDUSTRIAL MEDICINE, BRITISH MEDICAL ASSOCIATION, LONDON, GB, vol. 14, no. 4, 1 October 1957 (1957-10-01), pages 250 - 252, XP009151989, ISSN: 0007-1072 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013023856A1 (en) * | 2011-08-12 | 2013-02-21 | Zambon S.P.A. | Use of a polysaccharide polymer from the seeds of the tamarind seed in protecting against tobacco-associated damages |
EA024938B1 (en) * | 2011-08-12 | 2016-11-30 | Замбон С.П.А. | Use of a polysaccharide polymer from the seeds of the tamarind seed in protecting against tobacco-associated damages |
Also Published As
Publication number | Publication date |
---|---|
RS54637B1 (en) | 2016-08-31 |
CO6561774A2 (en) | 2012-11-15 |
PT2593119E (en) | 2016-03-01 |
MX2012005818A (en) | 2012-09-07 |
SI2593119T1 (en) | 2016-04-29 |
CN102686232A (en) | 2012-09-19 |
EA201270563A1 (en) | 2012-12-28 |
EA023654B1 (en) | 2016-06-30 |
BR112012011818A2 (en) | 2017-09-26 |
HUE028534T2 (en) | 2016-12-28 |
CN102686232B (en) | 2014-12-24 |
PL2593119T3 (en) | 2016-06-30 |
MY162322A (en) | 2017-05-31 |
ES2560954T3 (en) | 2016-02-23 |
EP2593119A1 (en) | 2013-05-22 |
EP2593119B1 (en) | 2015-11-04 |
BR112012011818B1 (en) | 2020-11-24 |
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