WO2012001337A1 - Composition for dental health - Google Patents
Composition for dental health Download PDFInfo
- Publication number
- WO2012001337A1 WO2012001337A1 PCT/GB2011/000399 GB2011000399W WO2012001337A1 WO 2012001337 A1 WO2012001337 A1 WO 2012001337A1 GB 2011000399 W GB2011000399 W GB 2011000399W WO 2012001337 A1 WO2012001337 A1 WO 2012001337A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- vitamin
- fluoride
- sodium
- toothpaste
- mouthwash
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- This invention concerns a composition, combined with standard constituents of toothpastes and mouthwashes for use in dental and oral hygiene, infections and inflammations.
- Toothpaste is a paste or gel dentifrice used with a toothbrush as an accessory to clean and maintain the aesthetics and health of teeth. It aids in removing dental plaque and food from the teeth, helps to eliminate or mask halitosis, and delivers active ingredients such as fluoride or xylitol in order to prevent tooth and gum disease (gingivitis). Most of the cleaning is done by the mechanical use of the toothbrush.
- Fluoride in various forms is the most popular active ingredient in toothpaste. It is included in toothpastes in order to prevent cavities. It occurs naturally in small amounts in plants and animals.
- Sodium fluoride is the most common form of flouride used in toothpastes. Some brands of toothpaste use sodium monofluorophosphate. Other ingredients are less commonly used, including Hydroxyapatite nanocrystals and calcium phosphate for remineralisation of teeth, and potassium nitrate to reduce sensitivity.
- Triclosan which is an antibacterial agent, is an active ingredient in some toothpastes, that is used to prevent gingivitis.
- Abrasives in toothpaste reduce the time needed to remove plaque from the teeth by half.
- Abrasives like the dental polishing agents used in dental surgeries, also cause a small amount of enamel erosion which is termed "polishing" action.
- Some brands contain powdered white mica, which acts as a mild abrasive, and adds a cosmetically pleasing glittery shimmer to the paste. Removal of plaque and calculus prevents caries and periodontal disease. The polishing of teeth removes stains from tooth surfaces, but has not been shown to improve dental health beyond the effects of the removal of plaque and calculus.
- toothpastes contain sodium lauryl sulfate. It is largely a foaming agent although it also acts as a powerful antimicrobial. However, sodium lauryl sulfate may cause a greater frequency of mouth ulcers in some people as it can dry out the protective layer of oral tissues causing the underlying tissues to become damaged.
- Toothpaste comes in a variety of colours and flavours.
- the more usual flavorings are some variation on mint, spearmint, peppermint, and regular mint.
- More exotic flavours include : anise, apricot, cinnamon, fennel, lavender, neem, ginger, vanilla, lemon, orange, pine.
- Unflavoured toothpaste does exist, however, most are flavoured and sweetened. Because sugar promotes growth of bacteria that cause tooth decay, artificial sweeteners such as sorbitol or saccharin are generally used instead. Mouthwash
- Mouthwash (or mouth rinse) is a product used to enhance oral hygiene. Antiseptic and anti-plaque mouth rinse claims to kill the dental plaque causing dental caries, gingivitis, and bad breath. Anti-cavity mouth rinse uses fluoride to protect against tooth decay. However, the use of mouthwash does not eliminate the need for both brushing and flossing.
- Active ingredients in commercial brands of mouthwash can include thymol, eucalyptol, methylparaben, hydrogen peroxide, domiphen bromide, fluoride, enzymes and calcium. Ingredients also include water, sweeteners such as sorbitol, sucralose, sodium saccharine, and xylitol, which doubles as a bacterial inhibitor. Sometimes a significant amount of ethanol is added.
- Commercial mouthwashes usually contain a preservative such as sodium benzoate and methylparaben to preserve freshness once the container has been opened. Many newer brands are alcohol free and contain odour elimination agents such as oxidizers to keep future bad breath from developing.
- Sensodyne Multiaction with iso-active® technology generally cleansing
- Active ingredients Potassium Nitrate 5% (for antihypersensitivity), Sodium fluoride 0.15% w/v fluoride ion (for anticavity);
- Inactive ingredients Water, sorbitol, glycerin, hydrated silica, PEG-8, sodium methyl cocoyl taurate, isopentane, flavor, cocamidopropyl betaine, xanthan gum, carrageenan, sodium saccharin, sucralose, sodium hydroxide, FD&C blue #1.
- Sensodyne Multiaction with iso-active® technology generally cleansing & whitening
- Active ingredients Potassium Nitrate 5% (for anti -hypersensitivity), Sodium fluoride 0.15% w/v fluoride ion (for anticavity);
- Inactive ingredients Water, glycerin, sorbitol, hydrated silica, pentasodium triphosphate, PEG-8, isopentane, flavor, sodium methyl cocoyl taurate, cocamidopropyl betaine, xanthan gum carrageenan, sodium hydroxide, sodium saccharin, sucralose, FD & C Blue, #1.
- Sensodyne Pronamel - Active ingredients Potassium nitrate 5% w/w, Sodium Fluoride (1450 ppm fluoride); Inactive ingredients : Water, glycerin, sorbitol, hydrated silica, PEG-6, cocamidopropyl betaine, xanthan gum carrageenan, sodium hydroxide, sodium saccharin, aroma, titanium dioxide, limonene, anise alcohol.
- Sensodyne TOTAL CARE (gentle whitening) - Active ingredients : Potassium nitrate, Sodium Fluoride (1400 ppm fluoride); Inactive Ingredients : Water, glycerin, sorbitol, hydrated silica, pentasodium triphosphate, PEG-6, cocamidopropyl betaine, xanthan gum carrageenan, sodium hydroxide, sodium saccharin, aroma, titanium dioxide, sodium methyl cocoyl taurate.
- Pearl Drops-party sparkle - Ingredients Aqua, Sorbitol, Hydrated Silica, Glycerin, Sodium Hexametaphosphate, Sodium Lauryl Sulfate, PEG- 12, Aroma, Sodium Monofluorophosphate, Cellulose Gum, Sodium Saccharin, Mica, Cinnamal, Benzyl Alcohol, CI 42053, CI 77891. Contains Sodium Monofluorophosphate (1000 ppm F).
- Colgate- sensitive pro-relief - Ingredients arginine-8%, Hydrated silica, calcium carbonate, glycerin, water, bicarbonate, flavour, cellulose gum, sodium saccharin, FD&C blue no. 1 (CI 42090).
- Colgate -enamel protect - Ingredients : Aqua, Sorbitol, Glycerin, Hydrated Silica, Potassium Nitrate, PEG- 12, Sodium Lauryl Sulfate, Aroma, Cellulose Gum, Tetrasodium Pyrophosphate, Sodium Fluoride, Sodium Saccharin, Xanthan Gum, Eugenol, Limonene, CI 77891.
- Colgate-cavity protection Ingredients: Dicalcium Phosphate Dihydrate, Aqua, Glycerin, Sorbitol, PEG- 12, Sodium Lauryl Sulfate, Aroma, Cellulose Gum, Sodium Monofluorophosphate, Tetrasodium Pyrophosphate, Sodium Saccharin, Calcium Glycerophosphate, Sodium Fluoride, Limonene.
- Colgate total-plus whitening - Active Substances Sodium Fluoride 0.32% w/w (1450ppm F ) Triclosan 0.3% w/w; Other Ingredients: Copolymer, Dental Type Silica, Glycerol, Sorbitol, Sodium Laurilsulfate, 89303/89854 Flavour, Carmellose Sodium, Titanium Dioxide, Saccharin Sodium, Carrageenan, Sodium Hydroxide, Mica, Water, CI Food Blue 2 (El 33).
- Colgate-Sensitive whitening - Ingredients Sodium Fluoride (1450 ppmF-), Aqua, Glycerin, Sorbitol, Hydrated Silica, Potsium Nitrate, PEG- 12, Tetrasodium Pyrophosphate, PVM/MA Copolymer, Sodium Lauryl Sulfate, Aroma, Cellulose Gum, Sodium Hydroxide, Sodium Saccharin, Xanthan Gum, Eugenol, Limonene, CI 77891, CI 42051.
- Listerine Total Care Mouthwash Aqua, Alcohol, Sorbitol, Aroma, Poloxamer 407, Benzoic Acid, Eucalyptol, Methyl Salicylate, Thymol, Menthol, Sodium Fluoride, Zinc Chloride, Sucralose, Sodium Saccharin, Sodium Benzoate, Benzyl Alcohol, CI 16035, CI 42090, Contains Sodium Fluoride (0.022% w/v lOO ppm F)
- This invention concerns a novel composition, combined with standard constituents of toothpastes and mouthwashes, for use in dental and oral hygiene, infections and inflammations.
- the active ingredients are combined with standard constituents of toothpastes or mouthwashes. These additional ingredients can be altered and adapted to need, by either adding further ingredients, substituting ingredients, or by eliminating existing ingredients. In order to maximize the effect of the composition, after brushing, additional paste containing the active composition may be applied directly to the teeth and gums for 1 to 2 minutes before rinsing.
- sweetener such as sorbitol or sodium saccharin
- colouring such as Aqua
- flavouring such as spearmint or menthol
- aroma water
- mild abrasives such as mica or sodium bicarbonate
- sodium lauryl sulfate cellulose gum (texturant).
- alcohol carrier for the flavour and as an anti-bacterial
- sweetener such as sorbitol or sodium saccharin
- colouring such as Aqua
- flavouring such as spearmint or limonene
- aroma water
- sodium benzoate preservative
- Pelargonium sidoides extract - The genus Pelargonium comprises approximately 280 known species, of which 80% are grown in the interior of South Africa. Plant species are distinguished by the colour of the flowers, the shape of the leaves, and the pollen colour.
- Pelargonium sidoides is a small geranium-like plant that grows in a rosette from thick and very dark brown underground roots that grow up to 15cm in length. Sparsely branched stems grow from the base and display deep red to black flowers, and the species is distinguished by the cordate or heart shaped leaves. The pollen of the plant species is yellow. In contrast, Pelargonium reniforme has magenta red to black flowers, kidney shaped leaves, and white to green pollen.
- Extracts of Pelargonium sidoides are composed of 6 main components that account for 70% to 80% of the total weight : substituted and unsubstituted oligomeric prodelphinidins, monomelic and oligomeric carbohydrates, minerals, peptides, purine derivatives, and highly substituted benzopyranones. Nearly 230 components have been detected in each of the plant species essential oils, with sesquiterpenes the most abundant.
- Coumarin, 5,6-dimethoxy, 7-hydroxy-coumarin, and several related ethers, glycosides, and sulfates have been isolated from both species of Pelargonium. Many of these coumarins also are found in the roots of other South African Pelargonium species.
- Pelargonium sidoides contains similar flavonoids and phenolics. The high tannin content (about 9%) may justify the plant's use in GI complaints in cases of bacterial toxin-induced secretory diarrhea. The broad spectrum of activity against viruses and bacteria may be caused by the coumarins and phenolic acids. Pelargonium sidoides extract may be useful in oral infective disorders as it has antiviral (herpes simplex virus), antibacterial (Staphylococcus aureus, Streptococcus pneumoniae), and antifungal (Candida albicans) activity against the causative organisms of oral disorders like gingivitis, periodontitis, glossitis and oral candidiasis.
- Vitamin A can lead to an enrichment of vitamin A in buccal mucosal cells. In this way metaplastic alterations of the buccal mucosal epithelium might be prevented or reversed by the application of topical retinyl palmitate. Vitamin A can reduce gingival bleeding activity and can be effective in the treatment of mild periodontitis.
- Vitamin C - Vitamin C can reduce the total supragingival calculus score and reduce the number of bleeding sites.
- Vitamin E - Topical vitamin E may be an effective therapy in patients with chemotherapy-induced oral mucositis.
- Coenzyme Q10 Topical application may improve adult periodontitis.
- Folic acid - Folic acid appears to have an influence on gingival health via local influence. There is significant improvement in gingival inflammation. Topically applied folinic acid may be effective in facilitating resolution of oral lesions. Niacinamide - Niacinamide appears to have an influence on gingival health via local influence. There is significant improvement in gingival inflammation.
- Zinc - Zinc citrate can enable significant inhibition of dental plaque formation, hence suggesting a new antiplaque and possible multi-benefit dentifrice for oral hygiene. Zinc in certain forms can reduce oral malodor.
- Arginine - Arginine may help to provide significantly increased dentin hypersensitivity relief.
- Calcium carbonate - Calcium carbonate may help to provide significantly increased dentin hypersensitivity relief.
- Fluoride - Fluoride helps to prevent cavities, and has effects on the formation of dental enamel and bones.
- Strontium chloride - Strontium Chloride may be an effective means for reducing the discomfort and pain engendered by thermal and tactile stimuli in patients with dentinal hypersensitivity.
- Papain - Papain is a proteolytic enzyme with low specificity, suitable for cleaning the salivary protein plaque that has a whitening effect on the tooth surfaces.
- compositions for use in dental and oral hygiene, infections and inflammations.
- the composition consists, in the form of a toothpaste or mouthwash : Pelargonium sidoides extract, Vitamin A, Vitamin C, Vitamin E, Folic acid, Niacinamide, Zinc, Coenzyme Q10, Arginine, Calcium carbonate, Fluoride, Strontium chloride and Papain, combined with standard constituents of toothpastes or mouthwashes.
Abstract
Composition in the form of a toothpaste or mouthwash for dental and oral hygiene, infections and inflammations, in which the active ingredients are Pelargonium sidoides extract, Vitamin A, Vitamin C, Vitamin E, Folic acid, Niacinamide, Zinc, Coenzyme Q1O, Arginine, Calcium carbonate, Fluoride, Strontium chloride, and Papain combined with standard constituents of toothpastes or mouthwashes.
Description
Composition for dental health
DESCRIPTION OF INVENTION
TECHNICAL FIELD
This invention concerns a composition, combined with standard constituents of toothpastes and mouthwashes for use in dental and oral hygiene, infections and inflammations.
BACKGROUND ART
Toothpaste
Toothpaste is a paste or gel dentifrice used with a toothbrush as an accessory to clean and maintain the aesthetics and health of teeth. It aids in removing dental plaque and food from the teeth, helps to eliminate or mask halitosis, and delivers active ingredients such as fluoride or xylitol in order to prevent tooth and gum disease (gingivitis). Most of the cleaning is done by the mechanical use of the toothbrush.
Fluoride in various forms is the most popular active ingredient in toothpaste. It is included in toothpastes in order to prevent cavities. It occurs naturally in small amounts in plants and animals. Sodium fluoride is the most common form of flouride used in toothpastes. Some brands of toothpaste use sodium monofluorophosphate. Other ingredients are less commonly used, including Hydroxyapatite nanocrystals and calcium phosphate for remineralisation of
teeth, and potassium nitrate to reduce sensitivity. Triclosan, which is an antibacterial agent, is an active ingredient in some toothpastes, that is used to prevent gingivitis.
In addition to fluoride, the other fundamental ingredient in most toothpastes is an abrasive. Abrasives in toothpaste reduce the time needed to remove plaque from the teeth by half. Abrasives, like the dental polishing agents used in dental surgeries, also cause a small amount of enamel erosion which is termed "polishing" action. Some brands contain powdered white mica, which acts as a mild abrasive, and adds a cosmetically pleasing glittery shimmer to the paste. Removal of plaque and calculus prevents caries and periodontal disease. The polishing of teeth removes stains from tooth surfaces, but has not been shown to improve dental health beyond the effects of the removal of plaque and calculus.
Many, though not all, toothpastes contain sodium lauryl sulfate. It is largely a foaming agent although it also acts as a powerful antimicrobial. However, sodium lauryl sulfate may cause a greater frequency of mouth ulcers in some people as it can dry out the protective layer of oral tissues causing the underlying tissues to become damaged.
Toothpaste comes in a variety of colours and flavours. The more usual flavorings are some variation on mint, spearmint, peppermint, and regular mint. More exotic flavours include : anise, apricot, cinnamon, fennel, lavender, neem, ginger, vanilla, lemon, orange, pine. Unflavoured toothpaste does exist, however, most are flavoured and sweetened. Because sugar promotes growth of bacteria that cause tooth decay, artificial sweeteners such as sorbitol or saccharin are generally used instead.
Mouthwash
Mouthwash (or mouth rinse) is a product used to enhance oral hygiene. Antiseptic and anti-plaque mouth rinse claims to kill the dental plaque causing dental caries, gingivitis, and bad breath. Anti-cavity mouth rinse uses fluoride to protect against tooth decay. However, the use of mouthwash does not eliminate the need for both brushing and flossing.
Active ingredients in commercial brands of mouthwash can include thymol, eucalyptol, methylparaben, hydrogen peroxide, domiphen bromide, fluoride, enzymes and calcium. Ingredients also include water, sweeteners such as sorbitol, sucralose, sodium saccharine, and xylitol, which doubles as a bacterial inhibitor. Sometimes a significant amount of ethanol is added. Commercial mouthwashes usually contain a preservative such as sodium benzoate and methylparaben to preserve freshness once the container has been opened. Many newer brands are alcohol free and contain odour elimination agents such as oxidizers to keep future bad breath from developing.
Oral hygiene products
The following are the formulations of commonly used oral and dental hygiene products :
Sensodyne Multiaction with iso-active® technology (general cleansing) - Active ingredients : Potassium Nitrate 5% (for antihypersensitivity), Sodium fluoride 0.15% w/v fluoride ion (for anticavity); Inactive ingredients : Water, sorbitol, glycerin, hydrated silica, PEG-8, sodium methyl cocoyl taurate, isopentane,
flavor, cocamidopropyl betaine, xanthan gum, carrageenan, sodium saccharin, sucralose, sodium hydroxide, FD&C blue #1.
Sensodyne Multiaction with iso-active® technology (general cleansing & whitening) - Active ingredients Potassium Nitrate 5% (for anti -hypersensitivity), Sodium fluoride 0.15% w/v fluoride ion (for anticavity); Inactive ingredients : Water, glycerin, sorbitol, hydrated silica, pentasodium triphosphate, PEG-8, isopentane, flavor, sodium methyl cocoyl taurate, cocamidopropyl betaine, xanthan gum carrageenan, sodium hydroxide, sodium saccharin, sucralose, FD & C Blue, #1.
Sensodyne Pronamel - Active ingredients : Potassium nitrate 5% w/w, Sodium Fluoride (1450 ppm fluoride); Inactive ingredients : Water, glycerin, sorbitol, hydrated silica, PEG-6, cocamidopropyl betaine, xanthan gum carrageenan, sodium hydroxide, sodium saccharin, aroma, titanium dioxide, limonene, anise alcohol.
Sensodyne TOTAL CARE (gentle whitening) - Active ingredients : Potassium nitrate, Sodium Fluoride (1400 ppm fluoride); Inactive Ingredients : Water, glycerin, sorbitol, hydrated silica, pentasodium triphosphate, PEG-6, cocamidopropyl betaine, xanthan gum carrageenan, sodium hydroxide, sodium saccharin, aroma, titanium dioxide, sodium methyl cocoyl taurate.
Pearl Drops-replenishing white - Ingredients : Sodium Bicarbonate (Baking Soda), Glycerin, PEG-8, Hydrated Silica, Silica, PEG PPG- 116/66 Copolymer, Calcium Sulphate, Sodium Lauryl Sulfate, Aroma, Dipotassium Phosphate,
Sodium Carbonate, Sodium Saccharin, Cellulose Gum, Sodium Fluoride, Limonene, CI 77891.
Pearl Drops-party sparkle - Ingredients : Aqua, Sorbitol, Hydrated Silica, Glycerin, Sodium Hexametaphosphate, Sodium Lauryl Sulfate, PEG- 12, Aroma, Sodium Monofluorophosphate, Cellulose Gum, Sodium Saccharin, Mica, Cinnamal, Benzyl Alcohol, CI 42053, CI 77891. Contains Sodium Monofluorophosphate (1000 ppm F).
Pearl Drops-Hollywood smile - Ingredients : Sorbitol, Aqua, Hydrated Silica, Glycerin, Alumina, Sodium Dodecylbenzenesulfonate, PEG- 12, Aroma, Pentasodium Triphosphate, Pentapotassium Triphosphate, Zinc Peroxide, Cellulose Gum, Sodium Fluoride, Sodium Saccharin, Pearl Powder, Limonene, CI 74160, CI 77891. Contains Sodium Fluoride (1300 ppm F).
Swiss Dent- Stainless extensive bleaching- RDA 40 - Ingredients : Nanoxyd, Calcium peroxide, papain, bromelain, Fluoride, Coenzyme Q10, vitamin E, baking soda.
Swiss Dent- Nanowhitening gentle bleaching- RDA 25 - Ingredients : Nanoxyd, Calcium peroxide, papain, bromelain, Fluoride, Coenzyme Q10, vitamin E, baking soda.
Swissdent Purefreshness Breath Control - Contains sodium fluoride. Ingredients : Nanoxyd, Calcium peroxide, papain, bromelain, Fluoride, Coenzyme Q10, vitamin E, baking soda.
Retardex® - Active Ingredients : CloSYS Π brand of Stabilised Chlorine Dioxide, Aqua, Hydrated Silica, Sorbitol, Glycerin, Cellulose Gum, Trisodium Phosphate, Sodium Saccharin, Mentha Piperita, Mentha Spicata, Menthol, Sodium Bicarbonate, Sodium Chlorite, Limonene, CI 77891/Titanium Dioxide. Arm and Hammer- enamel care (For natural whitening) - Ingredients : Sodium Bicarbonate (Baking Soda), Glycerin, PEG-8, Hydrated Silica, Silica, PEG/PPG- 116/66 Copolymer, Calcium Sulfate, Sodium Lauryl Sulfate, Aroma, Dipotassium Phosphate, Sodium Saccharin, Cellulose Gum, Sodium Fluoride, Limonene, CI 42053, CI 77891.
Arm and Hammer- advanced whitening - Ingredients : Sorbitol, Sodium Bicarbonate, Aqua, Hydrated Silica, Glycerin, Tetrasodium Pyrophosphate, Aroma, Sodium Lauroyl Sarcosinate, Sodium Saccharin, Cellulose Gum, Sodium Lauryl Sulfate, Limonene, CI 77891.
Colgate- sensitive pro-relief - Ingredients : arginine-8%, Hydrated silica, calcium carbonate, glycerin, water, bicarbonate, flavour, cellulose gum, sodium saccharin, FD&C blue no. 1 (CI 42090).
Colgate -enamel protect - Ingredients : Aqua, Sorbitol, Glycerin, Hydrated Silica, Potassium Nitrate, PEG- 12, Sodium Lauryl Sulfate, Aroma, Cellulose Gum, Tetrasodium Pyrophosphate, Sodium Fluoride, Sodium Saccharin, Xanthan Gum, Eugenol, Limonene, CI 77891.
Colgate-cavity protection - Ingredients : Dicalcium Phosphate Dihydrate, Aqua, Glycerin, Sorbitol, PEG- 12, Sodium Lauryl Sulfate, Aroma, Cellulose Gum,
Sodium Monofluorophosphate, Tetrasodium Pyrophosphate, Sodium Saccharin, Calcium Glycerophosphate, Sodium Fluoride, Limonene.
Colgate total-plus whitening - Active Substances : Sodium Fluoride 0.32% w/w (1450ppm F ) Triclosan 0.3% w/w; Other Ingredients: Copolymer, Dental Type Silica, Glycerol, Sorbitol, Sodium Laurilsulfate, 89303/89854 Flavour, Carmellose Sodium, Titanium Dioxide, Saccharin Sodium, Carrageenan, Sodium Hydroxide, Mica, Water, CI Food Blue 2 (El 33).
Colgate-Sensitive whitening - Ingredients : Sodium Fluoride (1450 ppmF-), Aqua, Glycerin, Sorbitol, Hydrated Silica, Potsium Nitrate, PEG- 12, Tetrasodium Pyrophosphate, PVM/MA Copolymer, Sodium Lauryl Sulfate, Aroma, Cellulose Gum, Sodium Hydroxide, Sodium Saccharin, Xanthan Gum, Eugenol, Limonene, CI 77891, CI 42051.
Listerine Total Care Mouthwash : Aqua, Alcohol, Sorbitol, Aroma, Poloxamer 407, Benzoic Acid, Eucalyptol, Methyl Salicylate, Thymol, Menthol, Sodium Fluoride, Zinc Chloride, Sucralose, Sodium Saccharin, Sodium Benzoate, Benzyl Alcohol, CI 16035, CI 42090, Contains Sodium Fluoride (0.022% w/v lOO ppm F)
Aquafresh Mild and Minty Mouthwash Aqua, Alcohol, Aroma, Cocamidopropyl Betaine, Sodium Saccharin, Cetylpyridinium Chloride, Sodium Fluoride, PEG-60 Hydrogenated Castor Oil, Sodium Bicarbonate, CI 42051, CI 75810, CI 15985
DISCLOSURE OF INVENTION
This invention concerns a novel composition, combined with standard constituents of toothpastes and mouthwashes, for use in dental and oral hygiene, infections and inflammations.
The following are the active ingredients of the toothpaste and mouthwash :
Pelargonium sidoides extract
Vitamin A
Vitamin C
Vitamin E
Niacinamide
Folic acid
Zinc
Coenzyme Q10
Arginine
Calcium carbonate
Fluoride
Strontium chloride
Papain
The active ingredients are combined with standard constituents of toothpastes or mouthwashes. These additional ingredients can be altered and adapted to need, by either adding further ingredients, substituting ingredients, or by eliminating existing ingredients.
In order to maximize the effect of the composition, after brushing, additional paste containing the active composition may be applied directly to the teeth and gums for 1 to 2 minutes before rinsing.
The following is an example of the additional ingredients of the formulation when used in a toothpaste : sweetener (such as sorbitol or sodium saccharin), colouring (such as Aqua), flavouring (such as spearmint or menthol), aroma, water, mild abrasives (such as mica or sodium bicarbonate), sodium lauryl sulfate (foaming agent), cellulose gum (texturant).
The following is an example of the additional ingredients of the formulation when used in a mouthwash : alcohol (carrier for the flavour and as an anti-bacterial), sweetener (such as sorbitol or sodium saccharin), colouring (such as Aqua), flavouring (such as spearmint or limonene), aroma, water, sodium benzoate (preservative).
The following are the reasons for the inclusion of the active ingredients in the toothpaste and mouthwash :
Pelargonium sidoides extract - The genus Pelargonium comprises approximately 280 known species, of which 80% are grown in the interior of South Africa. Plant species are distinguished by the colour of the flowers, the shape of the leaves, and the pollen colour. Pelargonium sidoides is a small geranium-like plant that grows in a rosette from thick and very dark brown underground roots that grow up to 15cm in length. Sparsely branched stems grow from the base and display deep red to black flowers, and the species is distinguished by the cordate or heart shaped leaves. The pollen of the plant species is yellow. In contrast,
Pelargonium reniforme has magenta red to black flowers, kidney shaped leaves, and white to green pollen. Both plant species may be found along the sea coast and interior portions of South Africa. Because of poor seed viability, a clonal method of propagation has been developed to reduce pressure on natural populations. The plant species indigenous to areas of South Africa are widely used by traditional healers of the Zulu, Basuto, Xhosa, and Mfengi tribes to treat dysentery, diarrhea, hepatic complaints, wounds, colds, fatigue, fevers, generalized weakness, and infections of the respiratory tract including tuberculosis. Western use of the Pelargonium sidoides and Pelargonium reniforme species to treat tuberculosis is traced back to the Englishman Major Charles Stevens in 1897 when he was treated by a tribal healer with an extract from the roots of Pelargonium species. Originally, the plant source of the drug was identified as Pelargonium reniform. However, further botanical investigations discovered the closely related species Pelargonium sidoides, which is now predominately used for therapeutic purposes. Chemical analyses have led to characterization of about 65 metabolites including phenolic and cinnamic acids, tannins, flavonoids, and coumarins in both plant species. Extracts of Pelargonium sidoides are composed of 6 main components that account for 70% to 80% of the total weight : substituted and unsubstituted oligomeric prodelphinidins, monomelic and oligomeric carbohydrates, minerals, peptides, purine derivatives, and highly substituted benzopyranones. Nearly 230 components have been detected in each of the plant species essential oils, with sesquiterpenes the most abundant. Coumarin, 5,6-dimethoxy, 7-hydroxy-coumarin, and several related ethers, glycosides, and sulfates have been isolated from both species of Pelargonium. Many of these coumarins also are found in the roots of other South African Pelargonium species. Pelargonium sidoides contains similar flavonoids and phenolics. The high tannin content
(about 9%) may justify the plant's use in GI complaints in cases of bacterial toxin-induced secretory diarrhea. The broad spectrum of activity against viruses and bacteria may be caused by the coumarins and phenolic acids. Pelargonium sidoides extract may be useful in oral infective disorders as it has antiviral (herpes simplex virus), antibacterial (Staphylococcus aureus, Streptococcus pneumoniae), and antifungal (Candida albicans) activity against the causative organisms of oral disorders like gingivitis, periodontitis, glossitis and oral candidiasis.
Vitamin A - Vitamin A as retinyl palmitate and its fomation of retinol can lead to an enrichment of vitamin A in buccal mucosal cells. In this way metaplastic alterations of the buccal mucosal epithelium might be prevented or reversed by the application of topical retinyl palmitate. Vitamin A can reduce gingival bleeding activity and can be effective in the treatment of mild periodontitis.
Vitamin C - Vitamin C can reduce the total supragingival calculus score and reduce the number of bleeding sites.
Vitamin E - Topical vitamin E may be an effective therapy in patients with chemotherapy-induced oral mucositis.
Coenzyme Q10 : Topical application may improve adult periodontitis.
Folic acid - Folic acid appears to have an influence on gingival health via local influence. There is significant improvement in gingival inflammation. Topically applied folinic acid may be effective in facilitating resolution of oral lesions.
Niacinamide - Niacinamide appears to have an influence on gingival health via local influence. There is significant improvement in gingival inflammation.
Zinc - Zinc citrate can enable significant inhibition of dental plaque formation, hence suggesting a new antiplaque and possible multi-benefit dentifrice for oral hygiene. Zinc in certain forms can reduce oral malodor.
Arginine - Arginine may help to provide significantly increased dentin hypersensitivity relief.
Calcium carbonate - Calcium carbonate may help to provide significantly increased dentin hypersensitivity relief.
Fluoride - Fluoride helps to prevent cavities, and has effects on the formation of dental enamel and bones.
Strontium chloride - Strontium Chloride may be an effective means for reducing the discomfort and pain engendered by thermal and tactile stimuli in patients with dentinal hypersensitivity.
Papain - Papain is a proteolytic enzyme with low specificity, suitable for cleaning the salivary protein plaque that has a whitening effect on the tooth surfaces.
INDUSTRIAL APPLICABILITY
According to this invention, there is a composition, combined with standard constituents of toothpastes and mouthwashes, for use in dental and oral hygiene, infections and inflammations. In its optimal embodiment the composition consists, in the form of a toothpaste or mouthwash : Pelargonium sidoides extract, Vitamin A, Vitamin C, Vitamin E, Folic acid, Niacinamide, Zinc, Coenzyme Q10, Arginine, Calcium carbonate, Fluoride, Strontium chloride and Papain, combined with standard constituents of toothpastes or mouthwashes.
Claims
1. A composition in the form of a toothpaste or mouthwash for dental and oral infections and inflammations, in which the active ingredients are Pelargonium sidoides extract, vitamin A, vitamin C, vitamin E, folic acid, niacinamide, zinc, coenzyme QIO, arginine, calcium carbonate, fluoride, strontium chloride and papain, combined with the following in toothpastes : sweetener, colouring, flavouring, aroma, water, sodium bicarbonate, sodium lauryl sulfate, cellulose gum, and the following in mouthwashes : alcohol, sweetener, colouring, flavouring, aroma, water, sodium benzoate.
2. A composition in the form of a toothpaste or mouthwash for dental and oral infections and inflammations, in which the active ingredients are Pelargonium sidoides extract, vitamin A, vitamin C, vitamin E, folic acid, niacinamide, zinc, coenzyme QIO, arginine, calcium carbonate, fluoride, strontium chloride, and papain, combined with standard constituents of toothpastes or mouthwashes.
3. A composition in the form of a toothpaste or mouthwash for dental and oral infections and inflammations, in which the active ingredients are Pelargonium sidoides extract, vitamin A, vitamin C, vitamin E, folic acid, niacinamide, zinc, coenzyme QIO, arginine, calcium carbonate, fluoride, strontium chloride and papain, combined with other constituents of toothpastes or mouthwashes.
4. A composition in the form of a toothpaste or mouthwash for dental and oral infections and inflammations, in which the active ingredients are Pelargonium extract, vitamin A, vitamin C, vitamin E, folic acid, niacinamide, zinc, coenzyme QIO, arginine, calcium carbonate, fluoride, strontium chloride, and papain, combined with other constituents of toothpastes or mouthwashes.
5. A composition in the form of a toothpaste or mouthwash for dental and oral infections and inflammations, in which the active ingredients are Pelargonium extract, vitamin A, vitamin C, vitamin E, folic acid, niacinamide, zinc, coenzyme QIO, arginine, calcium carbonate, fluoride, strontium chloride, and papain.
6. A composition in the form of a toothpaste or mouthwash for dental and oral infections and inflammations, in which the active ingredients are Pelargonium, vitamins, zinc, coenzyme QIO, arginine, calcium carbonate, fluoride, strontium chloride and papain.
7. A composition in the form of a toothpaste or mouthwash, in which the active ingredients are Pelargonium, vitamins, zinc, coenzyme QIO, arginine, calcium carbonate, fluoride, strontium chloride, and papain.
8. A composition in the form of a toothpaste or mouthwash, in which the active ingredients are comprising Pelargonium, vitamins, zinc, coenzyme QIO, arginine, calcium carbonate, fluoride, strontium chloride, and papain.
9. A claim according to any one of claims 1 to 8 that is only in the form of a toothpaste.
10. A claim according to any one of claims 1 to 8 that is only in the form of a mouthwash.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LTEP11711963.6T LT2588067T (en) | 2010-07-01 | 2011-03-22 | Composition for dental health |
RS20170050A RS55604B1 (en) | 2010-07-01 | 2011-03-22 | Composition for dental health |
SI201131076A SI2588067T1 (en) | 2010-07-01 | 2011-03-22 | Composition for dental health |
ES11711963.6T ES2611854T3 (en) | 2010-07-01 | 2011-03-22 | Composition for dental health |
EP11711963.6A EP2588067B1 (en) | 2010-07-01 | 2011-03-22 | Composition for dental health |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1011074.0 | 2010-07-01 | ||
GB1011074.0A GB2481630A (en) | 2010-07-01 | 2010-07-01 | Composition for dental health |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2012001337A1 true WO2012001337A1 (en) | 2012-01-05 |
Family
ID=42669026
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2011/000399 WO2012001337A1 (en) | 2010-07-01 | 2011-03-22 | Composition for dental health |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP2588067B1 (en) |
ES (1) | ES2611854T3 (en) |
GB (1) | GB2481630A (en) |
HU (1) | HUE030778T2 (en) |
LT (1) | LT2588067T (en) |
PL (1) | PL2588067T3 (en) |
PT (1) | PT2588067T (en) |
RS (1) | RS55604B1 (en) |
SI (1) | SI2588067T1 (en) |
WO (1) | WO2012001337A1 (en) |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014088535A1 (en) * | 2012-12-03 | 2014-06-12 | Colgate-Palmolive Company | Compositions and methods for treating dental caries |
WO2015094849A1 (en) * | 2013-12-19 | 2015-06-25 | Colgate-Palmolive Company | Oral care composition |
WO2018091300A1 (en) | 2016-11-18 | 2018-05-24 | Unilever N.V. | Oral care composition for oral biofilm removal |
US10123956B2 (en) | 2014-12-23 | 2018-11-13 | Colgate-Palmolive Company | Oral care compositions |
US10952943B2 (en) | 2018-12-21 | 2021-03-23 | Colgate-Palmolive Company | Zinc-arginine-chloride complex |
IT202100002672A1 (en) * | 2021-02-08 | 2022-08-08 | Neilos S R L | "COMPOSITION WITH IMMUNOSTIMULATING ACTION USEFUL FOR THE PREVENTION AND/OR TREATMENT OF RESPIRATORY DISEASES" |
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Publication number | Priority date | Publication date | Assignee | Title |
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US20150313813A1 (en) * | 2012-12-05 | 2015-11-05 | Colgate-Palmolive Company | Fluoride-Stable Zinc Containing Oral Care Compositions |
EP3065833B1 (en) * | 2013-11-07 | 2019-01-30 | Unilever Plc. | Compositions and methods for treating tooth hypersensitivity |
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US20190076335A1 (en) * | 2017-09-12 | 2019-03-14 | IntraMont Technologies, Inc. | Oral-surface administered preparation for the prevention of illnesses acquired via the oral cavity and the pharynx |
US11517523B2 (en) | 2017-09-12 | 2022-12-06 | IntraMont Technologies, Inc. | Oral-surface administered preparation for the prevention of illnesses acquired via the oral cavity and the pharynx |
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Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010028609A (en) * | 1999-09-22 | 2001-04-06 | 오세군 | Composition of toothpaste containing antiseptic herbal extracts |
WO2002002128A2 (en) * | 2000-06-30 | 2002-01-10 | The Procter & Gamble Company | Oral compositions comprising antimicrobial agents |
US6372198B1 (en) * | 2000-09-14 | 2002-04-16 | Joseph M. Abbate | Dentifrice for the mineralization and remineralization of teeth |
US20050079140A1 (en) * | 2003-10-08 | 2005-04-14 | Nussen Kenneth H. | Toothpaste formulation with green tea extract and fluoride |
WO2006109344A2 (en) * | 2005-04-13 | 2006-10-19 | Gasparini, Gianluigi | Composition to be used for the treatment of parodontal pathologies |
US20070053849A1 (en) * | 2000-06-30 | 2007-03-08 | The Procter & Gamble Company | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
US20070122362A1 (en) * | 2005-11-26 | 2007-05-31 | Giniger Martin S | Hydrogel sheets and shapes for oral care |
US20070231277A1 (en) * | 2006-03-31 | 2007-10-04 | Deepak Sharma | Multicomponent whitening compositions and containers |
WO2009043588A2 (en) * | 2007-10-02 | 2009-04-09 | LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH | Ph regulating antibacterial films for the oral or vaginal cavity |
CN101502482A (en) * | 2009-03-27 | 2009-08-12 | 玉溪健坤生物药业有限公司 | Toothpaste containing coenzyme Q10 and preparation method thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA65321A (en) * | 2003-07-09 | 2004-03-15 | Rytta Yukhymivna Khoruzha | Composition for treating viral lesions of oral mucosa |
US20060140881A1 (en) * | 2004-12-22 | 2006-06-29 | Guofeng Xu | Oral care compositions containing flavonoids and flavans |
DE502006002773D1 (en) * | 2006-03-01 | 2009-03-19 | Divapharma Chur Ag | Use of Pelargonium extracts in combination with Plantago for the manufacture of a medicament for the treatment of pharyngitis |
US9682256B2 (en) * | 2006-07-14 | 2017-06-20 | Colgate-Palmolive Company | Methods of making compositions comprising films |
CN1994270A (en) * | 2006-12-28 | 2007-07-11 | 上海交通大学 | Method for preparing water from fragrant plant stem and leaf |
DE202008008532U1 (en) * | 2008-06-30 | 2009-08-13 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Lollipop composition for the treatment of inflammatory diseases of the oropharynx |
-
2010
- 2010-07-01 GB GB1011074.0A patent/GB2481630A/en not_active Withdrawn
-
2011
- 2011-03-22 LT LTEP11711963.6T patent/LT2588067T/en unknown
- 2011-03-22 WO PCT/GB2011/000399 patent/WO2012001337A1/en active Application Filing
- 2011-03-22 HU HUE11711963A patent/HUE030778T2/en unknown
- 2011-03-22 RS RS20170050A patent/RS55604B1/en unknown
- 2011-03-22 SI SI201131076A patent/SI2588067T1/en unknown
- 2011-03-22 PT PT117119636T patent/PT2588067T/en unknown
- 2011-03-22 PL PL11711963T patent/PL2588067T3/en unknown
- 2011-03-22 ES ES11711963.6T patent/ES2611854T3/en active Active
- 2011-03-22 EP EP11711963.6A patent/EP2588067B1/en active Active
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010028609A (en) * | 1999-09-22 | 2001-04-06 | 오세군 | Composition of toothpaste containing antiseptic herbal extracts |
WO2002002128A2 (en) * | 2000-06-30 | 2002-01-10 | The Procter & Gamble Company | Oral compositions comprising antimicrobial agents |
US20070053849A1 (en) * | 2000-06-30 | 2007-03-08 | The Procter & Gamble Company | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
US6372198B1 (en) * | 2000-09-14 | 2002-04-16 | Joseph M. Abbate | Dentifrice for the mineralization and remineralization of teeth |
US20050079140A1 (en) * | 2003-10-08 | 2005-04-14 | Nussen Kenneth H. | Toothpaste formulation with green tea extract and fluoride |
WO2006109344A2 (en) * | 2005-04-13 | 2006-10-19 | Gasparini, Gianluigi | Composition to be used for the treatment of parodontal pathologies |
US20070122362A1 (en) * | 2005-11-26 | 2007-05-31 | Giniger Martin S | Hydrogel sheets and shapes for oral care |
US20070231277A1 (en) * | 2006-03-31 | 2007-10-04 | Deepak Sharma | Multicomponent whitening compositions and containers |
WO2009043588A2 (en) * | 2007-10-02 | 2009-04-09 | LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH | Ph regulating antibacterial films for the oral or vaginal cavity |
CN101502482A (en) * | 2009-03-27 | 2009-08-12 | 玉溪健坤生物药业有限公司 | Toothpaste containing coenzyme Q10 and preparation method thereof |
Non-Patent Citations (2)
Title |
---|
DATABASE WPI Week 200164, Derwent World Patents Index; AN 2001-569531, XP002661799 * |
DATABASE WPI Week 200961, Derwent World Patents Index; AN 2009-M94126, XP002661800 * |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104822422A (en) * | 2012-12-03 | 2015-08-05 | 高露洁-棕榄公司 | Compositions and methods for treating dental caries |
US9526681B2 (en) | 2012-12-03 | 2016-12-27 | Colgate-Palmolive Company | Compositions and methods for treating dental caries |
WO2014088535A1 (en) * | 2012-12-03 | 2014-06-12 | Colgate-Palmolive Company | Compositions and methods for treating dental caries |
US10441517B2 (en) | 2013-12-19 | 2019-10-15 | Colgate-Palmolive Company | Oral care composition |
WO2015094849A1 (en) * | 2013-12-19 | 2015-06-25 | Colgate-Palmolive Company | Oral care composition |
AU2014366398B2 (en) * | 2013-12-19 | 2017-03-23 | Colgate-Palmolive Company | Oral care composition |
US11260002B2 (en) | 2013-12-19 | 2022-03-01 | Colgate-Palmolive Company | Oral care composition |
US10123956B2 (en) | 2014-12-23 | 2018-11-13 | Colgate-Palmolive Company | Oral care compositions |
US10420716B2 (en) | 2014-12-23 | 2019-09-24 | Colgate-Palmolive Company | Oral care compositions |
US10639258B2 (en) | 2014-12-23 | 2020-05-05 | Colgate-Palmolive Company | Oral care compositions |
WO2018091300A1 (en) | 2016-11-18 | 2018-05-24 | Unilever N.V. | Oral care composition for oral biofilm removal |
US10952943B2 (en) | 2018-12-21 | 2021-03-23 | Colgate-Palmolive Company | Zinc-arginine-chloride complex |
US11826448B2 (en) | 2018-12-21 | 2023-11-28 | Colgate-Palmolive Company | Zinc-arginine-chloride complex |
IT202100002672A1 (en) * | 2021-02-08 | 2022-08-08 | Neilos S R L | "COMPOSITION WITH IMMUNOSTIMULATING ACTION USEFUL FOR THE PREVENTION AND/OR TREATMENT OF RESPIRATORY DISEASES" |
WO2022168019A1 (en) * | 2021-02-08 | 2022-08-11 | Neilos S.r.l. | Composition with immunostimulant action useful for the prevention and treatment of respiratory diseases |
Also Published As
Publication number | Publication date |
---|---|
ES2611854T3 (en) | 2017-05-10 |
RS55604B1 (en) | 2017-06-30 |
GB201011074D0 (en) | 2010-08-18 |
SI2588067T1 (en) | 2017-04-26 |
LT2588067T (en) | 2017-02-27 |
GB2481630A (en) | 2012-01-04 |
HUE030778T2 (en) | 2017-06-28 |
EP2588067A1 (en) | 2013-05-08 |
PL2588067T3 (en) | 2017-08-31 |
EP2588067B1 (en) | 2016-10-26 |
PT2588067T (en) | 2017-01-31 |
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