WO2011129649A3 - 미세유체장치 및 이것을 이용한 타깃의 분리방법 - Google Patents

미세유체장치 및 이것을 이용한 타깃의 분리방법 Download PDF

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Publication number
WO2011129649A3
WO2011129649A3 PCT/KR2011/002703 KR2011002703W WO2011129649A3 WO 2011129649 A3 WO2011129649 A3 WO 2011129649A3 KR 2011002703 W KR2011002703 W KR 2011002703W WO 2011129649 A3 WO2011129649 A3 WO 2011129649A3
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WO
WIPO (PCT)
Prior art keywords
targets
filtering unit
filtering
different types
microfluidic device
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PCT/KR2011/002703
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English (en)
French (fr)
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WO2011129649A2 (ko
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전병희
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주식회사 싸이토젠
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Publication of WO2011129649A2 publication Critical patent/WO2011129649A2/ko
Publication of WO2011129649A3 publication Critical patent/WO2011129649A3/ko

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G01N2035/1053—General features of the devices using the transfer device for another function for separating part of the liquid, e.g. filters, extraction phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Ecology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

본 발명은 샘플로부터 타깃을 분리하기 위한 미세유체장치 및 이것을 이용한 타깃의 분리방법을 개시한다. 본 발명에 따른 미세유체장치는 제1 필터링장치, 운반유체 공급장치와 제2 필터링장치로 구성되어 있다. 제1 필터링장치는 복수 유형의 타깃들이 여과되어 있는 여과면이 그 여과 방향과 반대 방향을 향하도록 배치되어 있다. 운반유체 공급장치는 제1 필터링장치의 상류에 장착되어 있고, 복수 유형의 타깃들을 하류로 수송하는 운반유체를 제1 필터링장치에 공급한다. 제2 필터링장치는 제1 필터링장치의 하류에 장착되어 있으며, 제1 필터링장치로부터 복수 유형의 타깃들을 받아들여 여과한다. 본 발명에 따른 타깃의 분리방법은 샘플에 포함되어 있는 복수의 논타깃들과 복수 유형의 타깃들 중 전처리에 의하여 논타깃들을 제거한 후, 전처리에서 획득한 타깃들을 후처리에 의하여 분리한다.
PCT/KR2011/002703 2010-04-15 2011-04-15 미세유체장치 및 이것을 이용한 타깃의 분리방법 WO2011129649A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020100035006A KR20110115478A (ko) 2010-04-15 2010-04-15 미세유체장치 및 이것을 이용한 타깃의 분리방법
KR10-2010-0035006 2010-04-15

Publications (2)

Publication Number Publication Date
WO2011129649A2 WO2011129649A2 (ko) 2011-10-20
WO2011129649A3 true WO2011129649A3 (ko) 2012-04-05

Family

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Application Number Title Priority Date Filing Date
PCT/KR2011/002703 WO2011129649A2 (ko) 2010-04-15 2011-04-15 미세유체장치 및 이것을 이용한 타깃의 분리방법

Country Status (2)

Country Link
KR (1) KR20110115478A (ko)
WO (1) WO2011129649A2 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2831219A4 (en) * 2012-03-30 2016-02-24 Univ Mcgill METHOD AND DEVICES FOR MULTI-DIMENSIONAL SEPARATION, ISOLATION AND CHARACTERIZATION OF CIRCULATING TUMOR CELLS
KR101404507B1 (ko) * 2012-04-12 2014-06-10 한국과학기술원 다수의 박막 구조물의 조합을 이용한 미소입자 처리 장치
KR101660376B1 (ko) * 2013-07-15 2016-11-09 주식회사 싸이토젠 시료의 예비평가 및 세포 포획용 칩
KR101770991B1 (ko) 2013-07-15 2017-08-24 주식회사 싸이토젠 슬라이드 조립체
KR101962975B1 (ko) * 2013-07-15 2019-03-27 주식회사 싸이토젠 슬라이드 조립체
JP6247391B2 (ja) * 2013-07-15 2017-12-13 サイトゲン カンパニー リミテッド スライド組立体
KR101987065B1 (ko) * 2017-08-07 2019-06-10 주식회사 싸이토젠 Eml4-alk유전자 변이 분석방법

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003304865A (ja) * 2002-04-11 2003-10-28 Asahi Kasei Corp 細胞分離方法
KR20060004958A (ko) * 2003-04-25 2006-01-16 제이에스알 가부시끼가이샤 바이오칩 및 바이오칩 키트 및 그의 제조 방법 및 사용방법
JP2007003478A (ja) * 2005-06-27 2007-01-11 Sekisui Chem Co Ltd 血液分離材、血液分離装置および真空検体採取容器
US20070269893A1 (en) * 2004-06-04 2007-11-22 Boehringer Ingelheim Microparts Gmbh Device for Collecting Blood and Separating Blood Constituents, Method for Separating Blood Constituents and Use of Said Device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003304865A (ja) * 2002-04-11 2003-10-28 Asahi Kasei Corp 細胞分離方法
KR20060004958A (ko) * 2003-04-25 2006-01-16 제이에스알 가부시끼가이샤 바이오칩 및 바이오칩 키트 및 그의 제조 방법 및 사용방법
US20070269893A1 (en) * 2004-06-04 2007-11-22 Boehringer Ingelheim Microparts Gmbh Device for Collecting Blood and Separating Blood Constituents, Method for Separating Blood Constituents and Use of Said Device
JP2007003478A (ja) * 2005-06-27 2007-01-11 Sekisui Chem Co Ltd 血液分離材、血液分離装置および真空検体採取容器

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KANG, SUK HO: "Particle Technology", 1995, SCITECH, SEOUL, ISBN: 89-386-3023-4, article KANG, SUK HO: "Particle Technology", pages: 34 *

Also Published As

Publication number Publication date
WO2011129649A2 (ko) 2011-10-20
KR20110115478A (ko) 2011-10-21

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