WO2011128699A3 - Procédés inédits - Google Patents

Procédés inédits Download PDF

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Publication number
WO2011128699A3
WO2011128699A3 PCT/GB2011/050752 GB2011050752W WO2011128699A3 WO 2011128699 A3 WO2011128699 A3 WO 2011128699A3 GB 2011050752 W GB2011050752 W GB 2011050752W WO 2011128699 A3 WO2011128699 A3 WO 2011128699A3
Authority
WO
WIPO (PCT)
Prior art keywords
sunitinib
preparation
novel process
salts
relates
Prior art date
Application number
PCT/GB2011/050752
Other languages
English (en)
Other versions
WO2011128699A2 (fr
Inventor
Vinayak Govind Gore
Laxmikant Narahari Patkar
Bharati Pandit Choudhari
Mahesh Gorakhnath Hublikar
Kiran Shivaji Pokharkar
Prakash Vishnu Bansode
Original Assignee
Generics [Uk] Limited
Mylan India Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Generics [Uk] Limited, Mylan India Private Limited filed Critical Generics [Uk] Limited
Publication of WO2011128699A2 publication Critical patent/WO2011128699A2/fr
Publication of WO2011128699A3 publication Critical patent/WO2011128699A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des procédés inédits de préparation de sunitinib et de ses sels et, en particulier, du (2S)-2-hydroxybutanedioate de sunitinib. L'invention concerne, en outre, des intermédiaires inédits, leur utilisation dans le cadre de la préparation du sunitinib ou de ses sels et des procédés de préparation desdits intermédiaires. L'invention concerne également des compositions contenant du sunitinib ou ses sels pharmaceutiquement acceptables.
PCT/GB2011/050752 2010-04-16 2011-04-15 Procédés inédits WO2011128699A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1260/MUM/2010 2010-04-16
IN1260MU2010 2010-04-16

Publications (2)

Publication Number Publication Date
WO2011128699A2 WO2011128699A2 (fr) 2011-10-20
WO2011128699A3 true WO2011128699A3 (fr) 2012-03-08

Family

ID=44022027

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2011/050752 WO2011128699A2 (fr) 2010-04-16 2011-04-15 Procédés inédits

Country Status (1)

Country Link
WO (1) WO2011128699A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103319392B (zh) * 2013-07-10 2015-10-28 张家港市华昌药业有限公司 一种舒尼替尼中间体的制备方法
JP6612232B2 (ja) 2013-08-28 2019-11-27 クラウン バイオサイエンス インコーポレイテッド（タイカン） 対象のマルチキナーゼ阻害剤に対する応答性を予測する遺伝子発現シグネチャ、及びその使用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020156292A1 (en) * 2000-02-15 2002-10-24 Tang Peng Cho Pyrrole substituted 2-indolinone protein kinase inhibitors
WO2003070725A2 (fr) * 2002-02-15 2003-08-28 Pharmacia & Upjohn Company Procede de preparation de derives de l'indolinone
WO2009150523A1 (fr) * 2008-06-13 2009-12-17 Medichem, S.A. Procédé de préparation d’un sel 2-indolinone malate à substitution 3‑pyrrole

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100364991C (zh) 2001-08-15 2008-01-30 法玛西雅厄普约翰美国公司 2,4-二甲基-1h-吡咯-3-甲酰胺衍生物的苹果酸盐的晶体、其制备方法和其组合物
US20060009510A1 (en) 2004-07-09 2006-01-12 Pharmacia & Upjohn Company Llc Method of synthesizing indolinone compounds
JP2011526615A (ja) 2008-07-02 2011-10-13 ジェネリクス・（ユーケー）・リミテッド ３−ピロール置換２−インドリノン誘導体の調製
WO2010023473A2 (fr) 2008-08-25 2010-03-04 Generics [Uk] Limited Nouvelle forme cristalline et ses procédés de préparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020156292A1 (en) * 2000-02-15 2002-10-24 Tang Peng Cho Pyrrole substituted 2-indolinone protein kinase inhibitors
WO2003070725A2 (fr) * 2002-02-15 2003-08-28 Pharmacia & Upjohn Company Procede de preparation de derives de l'indolinone
WO2009150523A1 (fr) * 2008-06-13 2009-12-17 Medichem, S.A. Procédé de préparation d’un sel 2-indolinone malate à substitution 3‑pyrrole

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JERAD M MANLEY ET AL: "Early Amidation Approach to 3-[(4-Amido)pyrrol-2-yl]-2-indolinones", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON.; US, vol. 68, no. 16, 7 November 2003 (2003-11-07), pages 6447 - 6450, XP007905198, ISSN: 0022-3263, DOI: DOI:10.1021/JO034304Q *

Also Published As

Publication number Publication date
WO2011128699A2 (fr) 2011-10-20

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