WO2011117685A3 - Peptidos anticonceptivos derivados del veneno de la araña - Google Patents

Peptidos anticonceptivos derivados del veneno de la araña Download PDF

Info

Publication number
WO2011117685A3
WO2011117685A3 PCT/IB2010/054298 IB2010054298W WO2011117685A3 WO 2011117685 A3 WO2011117685 A3 WO 2011117685A3 IB 2010054298 W IB2010054298 W IB 2010054298W WO 2011117685 A3 WO2011117685 A3 WO 2011117685A3
Authority
WO
WIPO (PCT)
Prior art keywords
contraceptive
peptide
active agent
agent
relates
Prior art date
Application number
PCT/IB2010/054298
Other languages
English (en)
French (fr)
Other versions
WO2011117685A2 (es
Inventor
Fernando Romero Mejia
Raúl SANCHEZ GUTIERREZ
Eduardo Bustos Obregon
Antonio De Miranda
Andrés RUDOLPHY FONTAINE
Original Assignee
Universidad De La Frontera
Universidad De Chile
Universidad Federal De Sao Paulo
Laboratorios Andromaco S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad De La Frontera, Universidad De Chile, Universidad Federal De Sao Paulo, Laboratorios Andromaco S.A. filed Critical Universidad De La Frontera
Priority to ES10848300.9T priority Critical patent/ES2529713T3/es
Priority to BR112012024138A priority patent/BR112012024138B8/pt
Priority to EP10848300.9A priority patent/EP2551280B1/en
Priority to CN201080066642.1A priority patent/CN103097402B/zh
Publication of WO2011117685A2 publication Critical patent/WO2011117685A2/es
Publication of WO2011117685A3 publication Critical patent/WO2011117685A3/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Insects & Arthropods (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención está dirigida a un agente activo con propiedades anticonceptivas. Dicho agente activo corresponde a una fracción molecular del veneno de Ia araña Latrodectus mirabilis. El agente activo corresponde a un péptido con una secuencia de acuerdo a SEQ ID NO 1, o secuencias similares en al menos un 85%, obtenido mediante síntesis química o bien mediante tecnología de ADN recombinante. En una realización preferida, el agente activo con propiedad anticonceptiva corresponde a un péptido de entre 10 y 30 aminoácidos, preferentemente 20 aminoácidos. Dicha realización preferida está ejemplificada en Ia secuencia SEQ ID NO 2, o secuencias similares en al menos un 85%, obtenida mediante síntesis química o bien mediante tecnología de ADN recombinante. Además se divulga el método para obtener el péptido anticonceptivo que comprende clonar Ia secuencia nucleotídica en un microorganismo. Composición farmacéutica anticonceptiva que comprende al menos un péptido de acuerdo a Io citado previamente y uno ó más vehículos farmacéuticamente aceptables. Y por ultimo se divulga el uso del péptido porque sirve para preparar un fármaco útil como agente anticonceptivo, como agente espermicida.
PCT/IB2010/054298 2010-03-23 2010-09-23 Peptidos anticonceptivos derivados del veneno de la araña WO2011117685A2 (es)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES10848300.9T ES2529713T3 (es) 2010-03-23 2010-09-23 Péptidos anticonceptivos derivados de veneno de araña
BR112012024138A BR112012024138B8 (pt) 2010-03-23 2010-09-23 peptídeo anticoncepcional derivado do veneno da aranha latrodectus mirabilis, sequência nucleotídica, métodos para a obtenção do peptídeo, composição farmacêutica e usos do peptídeo e da composição farmacêutica
EP10848300.9A EP2551280B1 (en) 2010-03-23 2010-09-23 Contraceptive peptides derived from spider venom
CN201080066642.1A CN103097402B (zh) 2010-03-23 2010-09-23 源自蜘蛛毒素的避孕肽

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CL2010000261A CL2010000261A1 (es) 2010-03-23 2010-03-23 Peptidos derivados del veneno de latrodectus mirabilis, secuencias que lo codifican, procedimiento de produccion de dichos peptidos, composiciones farmaceuticas que los comprenden, y uso anticonceptivos de las mismas.
CL261-2010 2010-03-23

Publications (2)

Publication Number Publication Date
WO2011117685A2 WO2011117685A2 (es) 2011-09-29
WO2011117685A3 true WO2011117685A3 (es) 2012-01-05

Family

ID=44657132

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2010/054298 WO2011117685A2 (es) 2010-03-23 2010-09-23 Peptidos anticonceptivos derivados del veneno de la araña

Country Status (7)

Country Link
US (1) US8980842B2 (es)
EP (1) EP2551280B1 (es)
CN (1) CN103097402B (es)
BR (1) BR112012024138B8 (es)
CL (1) CL2010000261A1 (es)
ES (1) ES2529713T3 (es)
WO (1) WO2011117685A2 (es)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060257868A1 (en) * 2002-08-07 2006-11-16 Children's Medical Center Corporation Tissue specific genes and gene clusters
WO2009083808A2 (en) * 2007-12-31 2009-07-09 Universidad De La Frontera Compositions and methods for treating erectile dysfunction

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2660069B1 (fr) 1990-03-20 1994-03-04 Recherche Developpement Activ Co Procede pour la mise en evidence de la capacite d'un spermatozouide a subir la reaction acrosomale.
US6815539B1 (en) 1997-10-22 2004-11-09 Icagen, Incorporated PH sensitive potassium channel in spermatocytes
WO2000044395A1 (en) 1999-02-01 2000-08-03 University Of Virginia Patent Foundation Methods and compositions for modulating fertility
MXPA03010069A (es) 2001-05-03 2004-04-02 Childrens Medical Center Canal de cation especeifico de espermatozoide, y aplicaciones relacionadas con los usos para el mismo.
US8729248B2 (en) 2001-10-22 2014-05-20 Children's Medical Center Corporation Sperm-specific cation channel, CATSPER2, and uses therefor
WO2004015066A2 (en) 2002-08-07 2004-02-19 Children's Medical Center Corporation Sperm-specific cation channel, catsper-4, and uses therefor
WO2005009222A2 (en) 2003-07-23 2005-02-03 Cornell Research Foundation, Inc. Method of determining sperm capacitation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060257868A1 (en) * 2002-08-07 2006-11-16 Children's Medical Center Corporation Tissue specific genes and gene clusters
WO2009083808A2 (en) * 2007-12-31 2009-07-09 Universidad De La Frontera Compositions and methods for treating erectile dysfunction

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LOPEZ-GONZALEZ, I. ET AL.: "Scorpion toxins that block T-type Ca+2 channels in spermatogenic cells inhibit the sperm acrosome reaction", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS., vol. 300, no. 2, 10 January 2003 (2003-01-10), pages 408 - 414, XP055073977 *
PARODI, J. ET AL.: "Synaptic effects of low molecular weight components from Chilean Black Widow spider venom", NEUROTOXICOLOGY., vol. 29, no. 6, 1 November 2008 (2008-11-01), pages 1121 - 1126, XP025680416 *
ROMERO, F. ET AL.: "Effects of arachnotoxin on intracelular pH and calcium in human spermatozoa", FERTILITY & STERILITY., vol. 87, no. 6, 1 June 2007 (2007-06-01), pages 1345 - 1349, XP022247766 *
See also references of EP2551280A4 *

Also Published As

Publication number Publication date
US8980842B2 (en) 2015-03-17
CL2010000261A1 (es) 2010-06-11
EP2551280A4 (en) 2013-09-18
EP2551280B1 (en) 2014-11-05
CN103097402A (zh) 2013-05-08
BR112012024138B8 (pt) 2020-01-28
ES2529713T3 (es) 2015-02-24
BR112012024138A2 (pt) 2017-10-31
EP2551280A2 (en) 2013-01-30
US20110237523A1 (en) 2011-09-29
WO2011117685A2 (es) 2011-09-29
CN103097402B (zh) 2014-07-23
BR112012024138B1 (pt) 2020-01-14

Similar Documents

Publication Publication Date Title
NZ621868A (en) Growth hormone polypeptides and methods of making and using same
EP2594582A3 (en) Peptide vaccines with Seq Id No: 110, 111, 387, 112, 394 114, 116, 117 or 121 for cancers expressing tumor-associated antigens
JP2014508510A5 (es)
MX2012008999A (es) Composicion farmaceutica para el tratamiento y/o prevencion del cancer.
MX340015B (es) Composicion farmaceutica para el tratamiento y/o prevencion del cancer.
MX2012009000A (es) Composicion farmaceutica para el tratamiento y/o prevencion del cancer.
MX340016B (es) Composicion farmaceutica para el tratamiento y/o prevencion del cancer.
NZ601818A (en) Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of gastric cancer and other cancers
NZ587105A (en) Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage
NZ602845A (en) Inhibiting peptides derived from trem-like transcript 1 (tlt-1) and uses thereof
WO2013004716A9 (en) Peptide beads
UA100127C2 (ru) Пептид cdh3 и лекарственное средство, содержащее его
NZ602693A (en) Immunogenic proteins and compositions for the treatment and prevention of streptococcus agalactiae
JP2012102105A5 (es)
WO2011053065A3 (ko) 카테콜 폴리에틸렌글리콜 유도체와 단백질 또는 펩타이드의 접합체 및 이의 제조방법
MX2009007261A (es) Vacuna de peptido foxp3.
JP2008531463A5 (es)
WO2008047370A3 (en) Compositions and methods for inducing angiogenesis
JP2013542196A5 (es)
WO2010103515A3 (en) Compositions and methods for prevention and treatment of neurodegenerative diseases
MX2010005816A (es) Epítopos de péptido de stat3.
WO2010057275A8 (en) Cyclic peptides and uses thereof
WO2011117685A3 (es) Peptidos anticonceptivos derivados del veneno de la araña
GB201018125D0 (en) Peptide
WO2011061720A3 (en) Viral citrullinated peptides and uses thereof

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 201080066642.1

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: 2010848300

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112012024138

Country of ref document: BR

REG Reference to national code

Ref country code: BR

Ref legal event code: B01E

Ref document number: 112012024138

Country of ref document: BR

REG Reference to national code

Ref country code: BR

Ref legal event code: ERR

Ref document number: 112012024138

Country of ref document: BR

REG Reference to national code

Ref country code: BR

Ref legal event code: B01E

Ref document number: 112012024138

Country of ref document: BR

ENP Entry into the national phase

Ref document number: 112012024138

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20120924