ES2529713T3 - Péptidos anticonceptivos derivados de veneno de araña - Google Patents
Péptidos anticonceptivos derivados de veneno de araña Download PDFInfo
- Publication number
- ES2529713T3 ES2529713T3 ES10848300.9T ES10848300T ES2529713T3 ES 2529713 T3 ES2529713 T3 ES 2529713T3 ES 10848300 T ES10848300 T ES 10848300T ES 2529713 T3 ES2529713 T3 ES 2529713T3
- Authority
- ES
- Spain
- Prior art keywords
- contraceptive
- peptide
- active agent
- corresponds
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 230000002254 contraceptive effect Effects 0.000 title abstract 5
- 239000003433 contraceptive agent Substances 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 239000002708 spider venom Substances 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 4
- 108020004511 Recombinant DNA Proteins 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 241001387432 Latrodectus mirabilis Species 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 229940124558 contraceptive agent Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000934 spermatocidal agent Substances 0.000 abstract 1
- 239000002435 venom Substances 0.000 abstract 1
- 210000001048 venom Anatomy 0.000 abstract 1
- 231100000611 venom Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Insects & Arthropods (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gynecology & Obstetrics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención está dirigida a un agente activo con propiedades anticonceptivas. Dicho agente activo corresponde a una fracción molecular del veneno de Ia araña Latrodectus mirabilis. El agente activo corresponde a un péptido con una secuencia de acuerdo a SEQ ID NO 1, o secuencias similares en al menos un 85%, obtenido mediante síntesis química o bien mediante tecnología de ADN recombinante. En una realización preferida, el agente activo con propiedad anticonceptiva corresponde a un péptido de entre 10 y 30 aminoácidos, preferentemente 20 aminoácidos. Dicha realización preferida está ejemplificada en Ia secuencia SEQ ID NO 2, o secuencias similares en al menos un 85%, obtenida mediante síntesis química o bien mediante tecnología de ADN recombinante. Además se divulga el método para obtener el péptido anticonceptivo que comprende clonar Ia secuencia nucleotídica en un microorganismo. Composición farmacéutica anticonceptiva que comprende al menos un péptido de acuerdo a Io citado previamente y uno ó más vehículos farmacéuticamente aceptables. Y por ultimo se divulga el uso del péptido porque sirve para preparar un fármaco útil como agente anticonceptivo, como agente espermicida.
Description
Claims (1)
-
imagen1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CL2612010 | 2010-03-23 | ||
| CL2010000261A CL2010000261A1 (es) | 2010-03-23 | 2010-03-23 | Peptidos derivados del veneno de latrodectus mirabilis, secuencias que lo codifican, procedimiento de produccion de dichos peptidos, composiciones farmaceuticas que los comprenden, y uso anticonceptivos de las mismas. |
| PCT/IB2010/054298 WO2011117685A2 (es) | 2010-03-23 | 2010-09-23 | Peptidos anticonceptivos derivados del veneno de la araña |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2529713T3 true ES2529713T3 (es) | 2015-02-24 |
Family
ID=44657132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10848300.9T Active ES2529713T3 (es) | 2010-03-23 | 2010-09-23 | Péptidos anticonceptivos derivados de veneno de araña |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8980842B2 (es) |
| EP (1) | EP2551280B1 (es) |
| CN (1) | CN103097402B (es) |
| BR (1) | BR112012024138B8 (es) |
| CL (1) | CL2010000261A1 (es) |
| ES (1) | ES2529713T3 (es) |
| WO (1) | WO2011117685A2 (es) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2660069B1 (fr) | 1990-03-20 | 1994-03-04 | Recherche Developpement Activ Co | Procede pour la mise en evidence de la capacite d'un spermatozouide a subir la reaction acrosomale. |
| US6815539B1 (en) | 1997-10-22 | 2004-11-09 | Icagen, Incorporated | PH sensitive potassium channel in spermatocytes |
| EP1156819A4 (en) | 1999-02-01 | 2003-01-02 | Univ Virginia | METHODS AND COMPOSITIONS FOR REGULATING FERTILITY |
| MXPA03010069A (es) | 2001-05-03 | 2004-04-02 | Childrens Medical Center | Canal de cation especeifico de espermatozoide, y aplicaciones relacionadas con los usos para el mismo. |
| US8729248B2 (en) | 2001-10-22 | 2014-05-20 | Children's Medical Center Corporation | Sperm-specific cation channel, CATSPER2, and uses therefor |
| US8110668B2 (en) * | 2002-08-07 | 2012-02-07 | Children's Medical Center Corporation | Sperm-specific cation channel, catsper-3 and uses therefor |
| WO2004015066A2 (en) | 2002-08-07 | 2004-02-19 | Children's Medical Center Corporation | Sperm-specific cation channel, catsper-4, and uses therefor |
| US7160676B2 (en) | 2003-07-23 | 2007-01-09 | Cornell Research Foundation, Inc. | Method of determining sperm capacitation |
| CL2007003884A1 (es) * | 2007-12-31 | 2009-09-25 | Laboratorios Andromaco S A | Péptido derivado del veneno de la araña viuda negra, procedimiento para preparar dicho péptido, composición farmacéutica que lo comprende, y uso de dicha composición para la preparación de un medicamente útil para el tratamiento de la disfunción sexual. |
-
2010
- 2010-03-23 CL CL2010000261A patent/CL2010000261A1/es unknown
- 2010-09-23 CN CN201080066642.1A patent/CN103097402B/zh not_active Expired - Fee Related
- 2010-09-23 BR BR112012024138A patent/BR112012024138B8/pt not_active IP Right Cessation
- 2010-09-23 WO PCT/IB2010/054298 patent/WO2011117685A2/es active Application Filing
- 2010-09-23 EP EP10848300.9A patent/EP2551280B1/en not_active Not-in-force
- 2010-09-23 ES ES10848300.9T patent/ES2529713T3/es active Active
-
2011
- 2011-03-22 US US13/053,751 patent/US8980842B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012024138A2 (pt) | 2017-10-31 |
| US20110237523A1 (en) | 2011-09-29 |
| US8980842B2 (en) | 2015-03-17 |
| CL2010000261A1 (es) | 2010-06-11 |
| BR112012024138B1 (pt) | 2020-01-14 |
| BR112012024138B8 (pt) | 2020-01-28 |
| CN103097402A (zh) | 2013-05-08 |
| WO2011117685A2 (es) | 2011-09-29 |
| CN103097402B (zh) | 2014-07-23 |
| EP2551280A4 (en) | 2013-09-18 |
| WO2011117685A3 (es) | 2012-01-05 |
| EP2551280A2 (en) | 2013-01-30 |
| EP2551280B1 (en) | 2014-11-05 |
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