WO2011116748A3 - Vorrichtung zur ableitung elektrophysiologischer signale von zellen - Google Patents

Vorrichtung zur ableitung elektrophysiologischer signale von zellen Download PDF

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Publication number
WO2011116748A3
WO2011116748A3 PCT/DE2011/000275 DE2011000275W WO2011116748A3 WO 2011116748 A3 WO2011116748 A3 WO 2011116748A3 DE 2011000275 W DE2011000275 W DE 2011000275W WO 2011116748 A3 WO2011116748 A3 WO 2011116748A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
electrode
deriving
passivation layer
electrophysiological signals
Prior art date
Application number
PCT/DE2011/000275
Other languages
English (en)
French (fr)
Other versions
WO2011116748A2 (de
Inventor
Bernhard Wolfrum
Andreas OFFENHÄUSER
Boris Hofmann
Friedrich Enno KÄTELHÖN
Marko Banzet
Original Assignee
Forschungszentrum Jülich GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungszentrum Jülich GmbH filed Critical Forschungszentrum Jülich GmbH
Priority to EP11719155A priority Critical patent/EP2550526A2/de
Publication of WO2011116748A2 publication Critical patent/WO2011116748A2/de
Publication of WO2011116748A3 publication Critical patent/WO2011116748A3/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Vorrichtung zur Ableitung elektrophysiologischer Signale von Zellen, umfassend eine Schichtstruktur aus Substrat und einer auf dem Substrat angeordneten Elektrode zur Ableitung der Signale über eine mit der Elektrode verbundene Leiterbahn (L), wobei die Schichtstruktur durch eine Passivierungsschicht passiviert ist, dadurch gekennzeichnet, dass die Passivierungsschicht über der Elektrode eine durch die Passivierungsschicht verlaufende Apertur (21) aufweist und zwischen der Elektrode und der Passivierungsschicht ein Spalt (22) als seitlicher Unterätz angeordnet ist. Ein Verfahren zur Herstellung der Vorrichtung wird angegeben, sowie eine Verwendung der auf diese Weise hergestellten Vorrichtung.
PCT/DE2011/000275 2010-03-25 2011-03-18 Vorrichtung zur ableitung elektrophysiologischer signale von zellen WO2011116748A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP11719155A EP2550526A2 (de) 2010-03-25 2011-03-18 Vorrichtung zur ableitung elektrophysiologischer signale von zellen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE201010012840 DE102010012840A1 (de) 2010-03-25 2010-03-25 Vorrichtung zur Ableitung elektrophysiologischer Signale von Zellen
DE102010012840.6 2010-03-25

Publications (2)

Publication Number Publication Date
WO2011116748A2 WO2011116748A2 (de) 2011-09-29
WO2011116748A3 true WO2011116748A3 (de) 2011-11-17

Family

ID=44279837

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2011/000275 WO2011116748A2 (de) 2010-03-25 2011-03-18 Vorrichtung zur ableitung elektrophysiologischer signale von zellen

Country Status (3)

Country Link
EP (1) EP2550526A2 (de)
DE (1) DE102010012840A1 (de)
WO (1) WO2011116748A2 (de)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030180965A1 (en) * 2002-03-25 2003-09-25 Levent Yobas Micro-fluidic device and method of manufacturing and using the same
US20060003145A1 (en) * 2004-02-04 2006-01-05 Hansen Carl L Ultra-smooth microfabricated pores on a planar substrate for integrated patch-clamping

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2741638C3 (de) * 1977-09-15 1980-03-27 Ernst Dipl.-Phys. Dr. 8000 Muenchen Remy Präparattrager mit Elektrodenanordnung fur die Zelluntersuchung, sowie seine Herstellung
US6610440B1 (en) * 1998-03-10 2003-08-26 Bipolar Technologies, Inc Microscopic batteries for MEMS systems
AU2001234996A1 (en) * 2000-02-11 2001-08-20 Yale University Planar patch clamp electrodes
US6932893B2 (en) * 2000-10-02 2005-08-23 Sophion Bioscience A/S System for electrophysiological measurements

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030180965A1 (en) * 2002-03-25 2003-09-25 Levent Yobas Micro-fluidic device and method of manufacturing and using the same
US20060003145A1 (en) * 2004-02-04 2006-01-05 Hansen Carl L Ultra-smooth microfabricated pores on a planar substrate for integrated patch-clamping

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BERNHARD WOLFRUM ET AL: "Nanofluidic Redox Cycling Amplification for the Selective Detection of Catechol", ANALYTICAL CHEMISTRY, vol. 80, no. 4, 1 February 2008 (2008-02-01), pages 972 - 977, XP055003581, ISSN: 0003-2700, DOI: 10.1021/ac7016647 *
BORIS HOFMANN ET AL: "Nanocavity electrode array for recording from electrogenic cells", LAB ON A CHIP, vol. 11, no. 6, 1 January 2011 (2011-01-01), pages 1054, XP055003584, ISSN: 1473-0197, DOI: 10.1039/c0lc00582g *
ENNO KA"TELHO"N ET AL: "Nanocavity Redox Cycling Sensors for the Detection of Dopamine Fluctuations in Microfluidic Gradients", ANALYTICAL CHEMISTRY, vol. 82, no. 20, 15 October 2010 (2010-10-15), pages 8502 - 8509, XP055003585, ISSN: 0003-2700, DOI: 10.1021/ac101387f *
MARCEL A. G. ZEVENBERGEN ET AL: "Electrochemical Correlation Spectroscopy in Nanofluidic Cavities", ANALYTICAL CHEMISTRY, vol. 81, no. 19, 1 October 2009 (2009-10-01), pages 8203 - 8212, XP055003583, ISSN: 0003-2700, DOI: 10.1021/ac9014885 *
See also references of EP2550526A2 *

Also Published As

Publication number Publication date
WO2011116748A2 (de) 2011-09-29
DE102010012840A1 (de) 2011-09-29
EP2550526A2 (de) 2013-01-30

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