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  • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
  • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
  • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
  • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P13/00—Drugs for disorders of the urinary system
  • A61P13/12—Drugs for disorders of the urinary system of the kidneys
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
  • A61P31/12—Antivirals
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P35/00—Antineoplastic agents
  • A61P35/02—Antineoplastic agents specific for leukemia
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P9/00—Drugs for disorders of the cardiovascular system
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07K—PEPTIDES
  • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
  • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
  • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
  • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
  • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
  • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
  • G01N33/57407—Specifically defined cancers
  • G01N33/57426—Specifically defined cancers leukemia
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
  • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
  • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
  • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
  • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
  • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
  • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • G01N33/6854—Immunoglobulins
  • G01N33/686—Anti-idiotype
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N2800/00—Detection or diagnosis of diseases
  • G01N2800/32—Cardiovascular disorders
  • G01N2800/328—Vasculitis, i.e. inflammation of blood vessels
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N2800/00—Detection or diagnosis of diseases
  • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Definitions

• cryoglobulinemic vasculitis or associated B cell malignancy is prognosed if SEQ ID NO: 1 or SEQ ID NO: 2 is present in the HCV-infected patient-derived nucleic acid that contains the IgH and VK sequences associated with WA Xid.
• the patient lacks a clinical symptom of cryoglobulinemic vasculitis or B cell malignancy.
• the invention also provides methods of early treatment of cryoglobulinemic vasculitis and B cell malignancy associated with HCV in a subject. First, a sample is obtained from a subject infected with hepatitis C virus (HCV). A suitable sample is a biological fluid comprising whole blood.
• HCV hepatitis C virus
• HCV is transmitted via blood-to-blood contact, e.g. , injection drug use (needle- sharing), tainted blood products, and sexual transmission, and manifests as hepatitis C in humans, an infectious disease affecting the liver. Most people have few, if any, symptoms after the initial infection, yet the virus persists in the liver in about 85% of those infected. Once established, chronic infection can progress to scarring of the liver (fibrosis), and advanced scarring (cirrhosis), which is generally apparent after many years. In some cases, patients with cirrhosis develop liver failure or other complications of cirrhosis, including liver cancer. Patients who develop cirrhosis or liver cancer may require a liver transplant;
• HCV-infected patients Asymptomatic HCV-infected patients, HCV-negative patients, and control patients with cryoglobulinemic vasculitis negative and positive for WA mRF were examined.
• Blood specimens for B cell clonal analysis were obtained from consecutive asymptomatic patients with and without HCV infection that consented to the study in the Gastroenterology clinic at the Lahey Clinic (Burlington, MA) over a six month period.
• HCV-infected patients had not received anti-viral treatment or chemotherapy.
• Patients with cryoglobulinemic vasculitis or Type III cryoglobulinemia were recruited from various departments at the Lahey Clinic. Blood samples on asymptomatic HCV-infected patients with RF, but without
• Type II group had WA BCE; this finding was consistent with the previously reported prevalence of WA mRF in HCV-infected patients with cryoglobulinemic vasculitis (Casato M, et al. 1997 Blood, 90: 3865-3873). None of the HCV-, Type II group had a WA BCE which confirmed the restriction of WA mRF to HCV-infected patients.

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• 2011
  • 2011-02-28 CA CA2791676A patent/CA2791676A1/en not_active Abandoned
  • 2011-02-28 WO PCT/US2011/026455 patent/WO2011109285A2/en not_active Ceased
  • 2011-02-28 JP JP2012556133A patent/JP6095984B2/ja not_active Expired - Fee Related
  • 2011-02-28 BR BR112012021795A patent/BR112012021795A2/pt not_active IP Right Cessation
  • 2011-02-28 US US13/581,759 patent/US9719141B2/en not_active Expired - Fee Related
  • 2011-02-28 AU AU2011223906A patent/AU2011223906B2/en not_active Ceased
  • 2011-02-28 EP EP11751140.2A patent/EP2542892A4/en not_active Withdrawn
• 2015
  • 2015-09-23 US US14/863,220 patent/US20160083801A1/en not_active Abandoned
• 2017
  • 2017-09-11 US US15/701,379 patent/US20180002763A1/en not_active Abandoned

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