WO2011099834A3 - Procedimiento para la purificación de diacereina cruda vía sal de potasio/dimetil formamida - Google Patents

Procedimiento para la purificación de diacereina cruda vía sal de potasio/dimetil formamida Download PDF

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Publication number
WO2011099834A3
WO2011099834A3 PCT/MX2010/000013 MX2010000013W WO2011099834A3 WO 2011099834 A3 WO2011099834 A3 WO 2011099834A3 MX 2010000013 W MX2010000013 W MX 2010000013W WO 2011099834 A3 WO2011099834 A3 WO 2011099834A3
Authority
WO
WIPO (PCT)
Prior art keywords
dimethylformamide
purification
procedure
potassium salt
diacerein
Prior art date
Application number
PCT/MX2010/000013
Other languages
English (en)
French (fr)
Other versions
WO2011099834A2 (es
Inventor
Umberto Casazza Bruno
Original Assignee
Interquim, S.A. De C.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Interquim, S.A. De C.V. filed Critical Interquim, S.A. De C.V.
Priority to PCT/MX2010/000013 priority Critical patent/WO2011099834A2/es
Publication of WO2011099834A2 publication Critical patent/WO2011099834A2/es
Priority to MX2012009147A priority patent/MX2012009147A/es
Publication of WO2011099834A3 publication Critical patent/WO2011099834A3/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/60—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un procedimiento para la purificación de Diacereina cruda con alto contenido de Aloe-emodina, mediante la obtención de la sal de potasio de diacereina, la cual es purificada con dimetilformamida y su posterior conversión a diacereina ácida, eliminando así prácticamente la totalidad de las impurezas, entre las cuales se encuentran Aloe-emodina, monoacetilrehinas I, Monoacetilrehinas II, Rheina y cromo.
PCT/MX2010/000013 2010-02-15 2010-02-15 Procedimiento para la purificación de diacereina cruda vía sal de potasio/dimetil formamida WO2011099834A2 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/MX2010/000013 WO2011099834A2 (es) 2010-02-15 2010-02-15 Procedimiento para la purificación de diacereina cruda vía sal de potasio/dimetil formamida
MX2012009147A MX2012009147A (es) 2010-02-15 2012-08-08 Procedimiento para la purificacion de diacerina cruda via sal de potasio/dimetil formamida.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/MX2010/000013 WO2011099834A2 (es) 2010-02-15 2010-02-15 Procedimiento para la purificación de diacereina cruda vía sal de potasio/dimetil formamida

Publications (2)

Publication Number Publication Date
WO2011099834A2 WO2011099834A2 (es) 2011-08-18
WO2011099834A3 true WO2011099834A3 (es) 2013-01-03

Family

ID=44368347

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MX2010/000013 WO2011099834A2 (es) 2010-02-15 2010-02-15 Procedimiento para la purificación de diacereina cruda vía sal de potasio/dimetil formamida

Country Status (1)

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WO (1) WO2011099834A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104262147A (zh) * 2014-08-25 2015-01-07 台州海辰药业有限公司 4,5-二乙酰氧-9,10-二氧-9,10-二氢-2-蒽羧酸的晶型及其制备方法
CN110105202B (zh) * 2019-05-16 2021-09-03 北京中医药大学 一种高效、快速分离制备大黄酸衍生物的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756782A (en) * 1995-02-07 1998-05-26 Steba Beheer B.V. Method for purifying diacetylrhein
WO1998056750A1 (en) * 1997-06-11 1998-12-17 Synteco S.R.L. A process for the preparation of diacerein
US6624192B1 (en) * 1991-06-25 2003-09-23 Madaus Ag Process for production of diacetylrhein
WO2010000879A2 (en) * 2008-12-09 2010-01-07 Evultis Sa Process for the preparation of non-genotoxic diacetylrhein (diacerein) and formulations comprising non-genotoxic diacetylrhein

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6624192B1 (en) * 1991-06-25 2003-09-23 Madaus Ag Process for production of diacetylrhein
US5756782A (en) * 1995-02-07 1998-05-26 Steba Beheer B.V. Method for purifying diacetylrhein
WO1998056750A1 (en) * 1997-06-11 1998-12-17 Synteco S.R.L. A process for the preparation of diacerein
WO2010000879A2 (en) * 2008-12-09 2010-01-07 Evultis Sa Process for the preparation of non-genotoxic diacetylrhein (diacerein) and formulations comprising non-genotoxic diacetylrhein

Also Published As

Publication number Publication date
WO2011099834A2 (es) 2011-08-18

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