WO2011074881A3 - Substances destinées à inhiber l'expression de gènes pour la sensibilité à des troubles allergiques - Google Patents

Substances destinées à inhiber l'expression de gènes pour la sensibilité à des troubles allergiques Download PDF

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Publication number
WO2011074881A3
WO2011074881A3 PCT/KR2010/008995 KR2010008995W WO2011074881A3 WO 2011074881 A3 WO2011074881 A3 WO 2011074881A3 KR 2010008995 W KR2010008995 W KR 2010008995W WO 2011074881 A3 WO2011074881 A3 WO 2011074881A3
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WO
WIPO (PCT)
Prior art keywords
group
genes
sensitivity
allergic disorders
formula
Prior art date
Application number
PCT/KR2010/008995
Other languages
English (en)
Korean (ko)
Other versions
WO2011074881A2 (fr
Inventor
후쿠이히로유키
미즈구치히로유키
타카이시요시히사
카시와다요시키
네모토히사오
Original Assignee
국립대학법인 토쿠시마대학
이기덕
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 국립대학법인 토쿠시마대학, 이기덕 filed Critical 국립대학법인 토쿠시마대학
Publication of WO2011074881A2 publication Critical patent/WO2011074881A2/fr
Publication of WO2011074881A3 publication Critical patent/WO2011074881A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La présente invention concerne une substance destinée à inhiber l'expression de gènes pour la sensibilité aux troubles allergiques, qui cible le mécanisme d'expression de gènes pour la sensibilité aux troubles allergiques. La substance est représentée par la formule générale (1) ci-dessous. Formule : (voir formule (1) dans le corps de la description) (Dans la formule, R représente un hydrogène ou un groupe hydrocarboné aliphatique saturé ou insaturé contenant une structure linéaire ou ramifiée, ou un groupe cycloalkyle, aryle, aralkyle, alkyloxy, alcényloxy, alcynyloxy, aryloxy ou aralkyloxy éventuellement substitué, ou leurs dérivés).
PCT/KR2010/008995 2009-12-15 2010-12-15 Substances destinées à inhiber l'expression de gènes pour la sensibilité à des troubles allergiques WO2011074881A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009284069A JP2011126791A (ja) 2009-12-15 2009-12-15 アレルギー疾患感受性遺伝子発現抑制物質
JP2009-284069 2009-12-15

Publications (2)

Publication Number Publication Date
WO2011074881A2 WO2011074881A2 (fr) 2011-06-23
WO2011074881A3 true WO2011074881A3 (fr) 2011-11-17

Family

ID=44167871

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/008995 WO2011074881A2 (fr) 2009-12-15 2010-12-15 Substances destinées à inhiber l'expression de gènes pour la sensibilité à des troubles allergiques

Country Status (2)

Country Link
JP (1) JP2011126791A (fr)
WO (1) WO2011074881A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240158856A1 (en) * 2021-08-04 2024-05-16 Hangzhou Zheda Dixun Biological Gene Engineering Co., Ltd Primer probe set for human histamine receptor hrh1 mrna detection, kit and detection method
CN113604557A (zh) * 2021-08-04 2021-11-05 杭州浙大迪迅生物基因工程有限公司 一种人组胺受体HRH1 mRNA检测引物探针组、试剂盒和应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A. L. TOKES ET AL.: "Absolute configuration and total synthesis of (-)-cabenegrin A-I", TETRAHEDRON, vol. 55, no. 30, 1999, pages 9283 - 9296 *
H. ZHOU ET AL.: "Anti-Inflammatory and antiproliferative activities of trifolirhizin, a flavonoid from Sophora flavescens roots", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 57, no. 11, 10 June 2009 (2009-06-10), pages 4580 - 4585 *
M. IINUMA ET AL.: "Flavonoid compounds in roots of Sophora tetraptera.", PHYTOCHEMISTRY, vol. 39, no. 3, 1995, pages 667 - 672 *

Also Published As

Publication number Publication date
WO2011074881A2 (fr) 2011-06-23
JP2011126791A (ja) 2011-06-30

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