WO2011074782A3 - 리포좀 조성물, 그 제조방법, 및 폐렴 백신으로서의 그 용도 - Google Patents

리포좀 조성물, 그 제조방법, 및 폐렴 백신으로서의 그 용도 Download PDF

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Publication number
WO2011074782A3
WO2011074782A3 PCT/KR2010/007762 KR2010007762W WO2011074782A3 WO 2011074782 A3 WO2011074782 A3 WO 2011074782A3 KR 2010007762 W KR2010007762 W KR 2010007762W WO 2011074782 A3 WO2011074782 A3 WO 2011074782A3
Authority
WO
WIPO (PCT)
Prior art keywords
composition
liposome
usage
preparation
pneumonia vaccine
Prior art date
Application number
PCT/KR2010/007762
Other languages
English (en)
French (fr)
Other versions
WO2011074782A2 (ko
Inventor
박신정
한상인
서국헌
김양진
김진남
최명준
Original Assignee
(재)전라남도생물산업진흥재단
(주)정필
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by (재)전라남도생물산업진흥재단, (주)정필 filed Critical (재)전라남도생물산업진흥재단
Priority to EP10837779.7A priority Critical patent/EP2514410B1/en
Publication of WO2011074782A2 publication Critical patent/WO2011074782A2/ko
Publication of WO2011074782A3 publication Critical patent/WO2011074782A3/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

본 발명은 폐렴 구균 협막 다당류(Pneumococcal capsular polysaccharide) 항원이 봉입된 리포좀을 포함하는 리포좀 조성물로서, 상기 리포좀을 형성하는 화합물은 포스파티딜콜린 및 포스파티딜에탄올아민에서 선택된 인지질; 및 콜레스테롤 및 콜레스테롤 헤미숙시네이트에서 선택된 콜레스테롤 또는 그 유도체를 포함하고, 상기 리포좀은 운반체 단백질(carrier protein)을 포함하지 않는 것을 특징으로 하는 리포좀 조성물, 그 조성물을 제조하는 방법, 그 조성물의 폐렴 예방 백신 용도에 관한 것이다.
PCT/KR2010/007762 2009-12-16 2010-11-04 리포좀 조성물, 그 제조방법, 및 폐렴 백신으로서의 그 용도 WO2011074782A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10837779.7A EP2514410B1 (en) 2009-12-16 2010-11-04 Liposome composition, preparation method thereof, and usage of the composition as pneumonia vaccine

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2009-0125698 2009-12-16
KR20090125698 2009-12-16
KR1020100106035A KR20110068831A (ko) 2009-12-16 2010-10-28 리포좀 조성물, 그 제조방법, 및 폐렴 백신으로서의 그 용도
KR10-2010-0106035 2010-10-28

Publications (2)

Publication Number Publication Date
WO2011074782A2 WO2011074782A2 (ko) 2011-06-23
WO2011074782A3 true WO2011074782A3 (ko) 2011-11-03

Family

ID=44167804

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/007762 WO2011074782A2 (ko) 2009-12-16 2010-11-04 리포좀 조성물, 그 제조방법, 및 폐렴 백신으로서의 그 용도

Country Status (3)

Country Link
EP (1) EP2514410B1 (ko)
KR (1) KR20110068831A (ko)
WO (1) WO2011074782A2 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9107906B1 (en) 2014-10-28 2015-08-18 Adma Biologics, Inc. Compositions and methods for the treatment of immunodeficiency
US10259865B2 (en) 2017-03-15 2019-04-16 Adma Biologics, Inc. Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection
WO2019075372A1 (en) 2017-10-13 2019-04-18 The Research Foundation For The State University Of New York COMPREHENSIVE VACCINE DESIGN AGAINST THE PROGRESSION OF COMMENSITY DISEASES

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040043954A1 (en) * 1999-05-14 2004-03-04 Gregory Gregoriadis Liposomes
WO2007039584A1 (en) * 2005-09-30 2007-04-12 Lipoxen Technologies Limited Multivalent liposomal vaccine compositions comprising polysaccharide antigens and a protein adjuvant
US20080171053A1 (en) * 2003-12-31 2008-07-17 Francis Gigliotti Polypeptides And Immunogenic Conjugates Capable of Inducing Antibodies Against Pathogens, and Uses Thereof
KR20080081063A (ko) * 2005-12-22 2008-09-05 글락소스미스클라인 바이오로지칼즈 에스.에이. 백신

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9813100D0 (en) 1998-06-18 1998-08-19 Secr Defence Method of forming liposomes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040043954A1 (en) * 1999-05-14 2004-03-04 Gregory Gregoriadis Liposomes
US20080171053A1 (en) * 2003-12-31 2008-07-17 Francis Gigliotti Polypeptides And Immunogenic Conjugates Capable of Inducing Antibodies Against Pathogens, and Uses Thereof
WO2007039584A1 (en) * 2005-09-30 2007-04-12 Lipoxen Technologies Limited Multivalent liposomal vaccine compositions comprising polysaccharide antigens and a protein adjuvant
KR20080081063A (ko) * 2005-12-22 2008-09-05 글락소스미스클라인 바이오로지칼즈 에스.에이. 백신

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ALVING, C. R ET AL.: "Lipid A and liposomes containing lipid A as antigens and adjuvants.", VACCINE., vol. 26, no. 24, 26 December 2007 (2007-12-26), pages 3036 - 3045, XP022703341 *
CHANG, J. S ET AL.: "Development of Thl-mediated CD8+ effector T cells by vaccination with epitope peptides encapsulated in pH-sensitive liposomes.", VACCINE., vol. 19, no. 27, 14 June 2001 (2001-06-14), pages 3608 - 3614, XP004241777 *
See also references of EP2514410A4 *

Also Published As

Publication number Publication date
EP2514410A4 (en) 2013-08-28
EP2514410A2 (en) 2012-10-24
EP2514410B1 (en) 2016-05-04
WO2011074782A2 (ko) 2011-06-23
KR20110068831A (ko) 2011-06-22

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