WO2011069540A1 - Dispositif de filtration - Google Patents

Dispositif de filtration Download PDF

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Publication number
WO2011069540A1
WO2011069540A1 PCT/EP2009/066701 EP2009066701W WO2011069540A1 WO 2011069540 A1 WO2011069540 A1 WO 2011069540A1 EP 2009066701 W EP2009066701 W EP 2009066701W WO 2011069540 A1 WO2011069540 A1 WO 2011069540A1
Authority
WO
WIPO (PCT)
Prior art keywords
filtering device
holder
sample
fastening element
fat
Prior art date
Application number
PCT/EP2009/066701
Other languages
English (en)
Inventor
Thomas Palm
Original Assignee
Foss Analytical Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Foss Analytical Ab filed Critical Foss Analytical Ab
Priority to EP09799585A priority Critical patent/EP2509698A1/fr
Priority to CN200980162771.8A priority patent/CN102648037B/zh
Priority to PCT/EP2009/066701 priority patent/WO2011069540A1/fr
Priority to US13/505,671 priority patent/US9664602B2/en
Publication of WO2011069540A1 publication Critical patent/WO2011069540A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
    • B01D35/14—Safety devices specially adapted for filtration; Devices for indicating clogging
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
    • B01D35/30—Filter housing constructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D55/00—Accessories for container closures not otherwise provided for
    • B65D55/02—Locking devices; Means for discouraging or indicating unauthorised opening or removal of closure
    • B65D55/022—Locking devices; Means for discouraging or indicating unauthorised opening or removal of closure with ratchet effect between relatively rotating parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D55/00—Accessories for container closures not otherwise provided for
    • B65D55/02—Locking devices; Means for discouraging or indicating unauthorised opening or removal of closure
    • B65D55/06—Deformable or tearable wires, strings, or strips; Use of seals, e.g. destructible locking pins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Definitions

  • the present invention relates to a filtering device, particularly a one for use in the wet chennistry analysis of a sample and most particularly to a filtering device for use in the analysis of a foodstuff sample by fat extraction.
  • sample involving the removal of one or more components of the sample by liquid chemical extraction and the subsequent analysis of one or both the residue and the extract by means of any of a number of known analysis techniques, including but not limited to, optical analysis techniques.
  • the fat may be extracted from the food by solvent extraction.
  • the food may be contained in a filtering device comprising a filter body for retaining a sample and which is formed, at least in part, by a filter medium.
  • the American patent with number US 6,479,295 discloses a method for wet chemical analysis of samples for fat content by which a sample is contained in and encapsulated by a filter body formed entirely of a filter media.
  • the patent application with number WO 02/33403 also discloses a filter container for use in the wet chemical analysis of the fat content of an item.
  • the filter container here comprises an impervious glass cylinder and a porous filter located at one end of the cylinder and being slidable therein.
  • the patent application with number WO 99/02959 discloses a filter body formed of a filter medium retained in a rigid skeleton and suitable for the filtration of a food sample during fibre analysis.
  • a single use filtering device comprising a filter body formed at least in part of a filter medium and configured to hold a sample during filtration and a fastening element adapted to retain the filter body, the fastening element being configured for releasably mounting the filter body to a holder, wherein the fastening element is adapted to undergo an irreversible structural alteration during the mounting or removal of the filtering device from the holder to inhibit the releasable remounting of the filtering device to the holder.
  • a single use filtering device is beneficial, as it eliminates the risk of
  • the single use filtering device may improve the accuracy, the repeatability and/or the reproducibility of wet chemical analysis, compared to multiple-use filtering devices.
  • the fastening element enables efficient mounting of the filtering device to a holder, which holder may be integral with or separate from an apparatus used in the wet chemical analysis process and which holder preferably has a complementary detent for engaging with the fastening element.
  • the fastening element further enables efficient positioning of the filter body. Releasably mounting of the filtering device to a holder may be an effective way of holding the filter body in a desired position in relation to an apparatus or instrument.
  • the fastening element being arranged such that it is irreversibly
  • the fastening element may be arranged for snap-fit mounting of said
  • Said snap-fit mounting may be an efficient way of mounting said filtering device to said holder.
  • Said snap-fit mounting may further be an efficient way of arranging the fastening element for irreversible structural altering during mounting or removal to prevent remounting of the filtering device to the holder.
  • the fastening element may comprise at least one recess and/or at least one hole and/or at least one protruding member arranged to engage with said holder for said snap-fit mounting.
  • At least one recess and/or at least one hole and/or at least one member being resilient may enable efficient snap-fit mounting of said filtering device to said holder.
  • a method for extraction of fat from a sample utilizing the filtering device comprising charging a filter body of a filtering device with the sample; mounting the filtering device to a holder by means of a fastening element of said filtering device; extracting fat from the sample contained in the filtering device; removing the filtering device from the holder, wherein the mounting or removing of said filtering device is performed such that the fastening element is irreversibly structurally altered to prevent remounting of the filtering device to the holder.
  • Mounting the filtering device to a holder by means of a fastening device may be efficient for mounting the filtering device to an apparatus.
  • Extracting fat from the sample in the filtering device may be efficient for separating the fat from other compounds of the sample, such as from the sample matrix.
  • the fat may be extracted from the sample and out of the filtering device while other compounds of the sample may be retained in the filtering device. Extraction of fat from the sample may be employed as a step in an analysis of the fat in the sample.
  • Said irreversible structural altering of the fastening element is an effective means for preventing the filtering device from being remounted to the holder and thus re-use of the filtering device may be prevented.
  • Said fat extraction may further comprise hydrolysing the sample in the filtering device. Hydrolysing the sample in the filtering device may enable hydrolysis of the fat in the sample. Hydrolysis of the sample may release fat from the sample and make fat from the sample available for further treatment or analysis, such as extracting fat. Hydrolysis of the fat in the sample may make available free fatty acids, and thus free fatty acids originating from the sample may efficiently be, for example, extracted.
  • Said extracting fat may be preceded by said hydrolysing of the sample.
  • Hydrolysis of the sample prior to extraction may free fat from the sample, for example in the form of free fatty acids, which may be extracted thereafter.
  • Said hydrolysis of the sample may take place in a first apparatus and said extracting fat may take place in a second apparatus.
  • Said hydrolysis of the sample and said extracting fat taking place in a first and in a second apparatus respectively may enable efficient handling of both said hydrolysis of sample and said extracting of fat.
  • Said holder may be a part of said first apparatus. Said holder being a part of said first apparatus effectively prevents the first apparatus to be used a second time with the same filtering device.
  • FIG. 1 illustrates a perspective view of a filtering device according to one embodiment of the invention and a holder, which filtering device has not been mounted to the holder;
  • FIG. 2 illustrates a perspective view of a filtering device according to one embodiment of the invention and a holder, which filtering device is mounted to the holder;
  • FIG. 3 illustrates a perspective view of a filtering device according to one embodiment of the invention and a holder, which filtering device has been removed from the holder;
  • FIG. 4 illustrates a perspective view of a filtering device according to a second embodiment of the invention, which filtering device has not yet been mounted to the illustrated holder.
  • the fat may refer to lipids.
  • the fat may, for example, comprise fatty acids, free fatty acids, or triesters of glycerol and/or fatty acids.
  • the sample may contain fat. Hydrolysis of the fat in the sample may make available free fatty acids and/or fat chemically released from the sample, thus extraction of fat and/or free fatty acids originating from the sample may efficiently be enabled.
  • the hydrolysis may comprise hydrolysis of esters of fatty acids and
  • the fatty acids or free fatty acids may be saturated or unsaturated.
  • the fat may be liquid or solid at room temperature, or a mixture of at room temperature liquid and solid fats.
  • the fat may be vegetable fat or animal fat, or mixtures thereof.
  • the fat may be fat present in the sample, naturally or as additives, or combinations thereof.
  • the fat may or may not be chemically bound to the sample, compounds of the sample, and/or the sample matrix.
  • One fraction of the fat may be chemically bound to the sample, compounds of the sample, and/or the sample matrix, while another part may not be chemically bound to the sample, compounds of the sample, and/or the sample matrix.
  • sample, and/or the sample matrix may be broken by said hydrolysing of the sample.
  • said hydrolysing the sample in the filtering device may enable hydrolysis of fat bound to the sample and extracting the fat.
  • the breaking of chemical bonds may release fat bound to the sample, compounds of the sample, and/or the sample matrix, thus enabling efficient extracting of such fat from the sample.
  • the hydrolysis may break bonds within the fat, and bonds may be broken such that the fat releases, for example, free fatty acids, thus enabling efficient extracting of, for example, free fatty acids originating from the fat.
  • the sample may be, for example, food, foodstuffs, fodder or feed, or
  • the filter medium of the filtering device may have pores adapted for
  • the release of the fat may be dependent of the polarity of the fluid which the filter medium is in contact with. If the filter medium is in contact with a solution in which the fat has poor solubility, such as an aqueous solution, the fat may remain in the filter body. If the filter medium is in contact with a solution in which the fat has high solubility, such as a solvent, for example an organic solvent, the fat may be released from the filter body through the filter medium.
  • a solution in which the fat has poor solubility such as an aqueous solution
  • the fat may remain in the filter body.
  • a solution in which the fat has high solubility such as a solvent, for example an organic solvent
  • the extraction may be realised by a flow of solvent passing the sample.
  • the extraction may be realised by reflux of solvent, by heating the solvent such that solvent evaporates followed by condensation of the evaporated solvent and allowing the condensed solvent to pass the sample resulting in extracting fat possibly remaining in the sample.
  • the solvent may be an organic solvent, such as alcohol, ether,
  • the extracting fat from a sample may comprise hydrolysing the sample, extracting fat, or combinations thereof.
  • the filtering device may be removed from the holder after hydrolysing the sample; after extracting fat; after hydrolysing the sample and prior to extracting fat; after extracting fat and prior to hydrolysing the sample; or any suitable combination thereof.
  • the fastening element may be made of any suitable material, which
  • the fastening element may be from materials selected from the group consisting of polymers, such as plastics or rubbers; metals, such as iron, tin, steel, stainless steel, copper, or alloys; or combinations thereof, or any other suitable material or combinations of materials suitable for the purpose of the invention.
  • the filter body and/or the fastening element may be produced by
  • the holder may be a part of said first apparatus.
  • the holder may be a part of said first apparatus.
  • the holder may additionally or alternatively be an item separate from either apparatus.
  • the fastening element may be arranged for any type of mounting of said filtering device to said holder.
  • the fastening element may, for example, be arranged for snap-fit mounting, mounting by threading, or mounting as a result of friction between the fastening element and the holder, or combinations thereof.
  • the fastening element may comprise at least one recess and/or at least one hole and/or at least one protruding member arranged to engage with said holder for mounting of the filtering device to the holder.
  • the fastening element may comprise at least one recess and/or at least one hole and/or at least one protruding member arranged to engage with said holder for said snap-fit mounting.
  • Said at least one recess and/or at least one hole of the fastening element may engage with at least one protruding member of the holder, when the fastening element is mounted or being mounted to the holder.
  • Said at least one protruding member of the fastening element may engage with at least one recess and/or at least one hole of the holder, when the fastening element is mounted or being mounted to the holder.
  • the fastening element may engage with said holder by at least one recess and/or at least one hole receiving at least one protruding member of the holder and/or at least one protruding member being received by at least one recess and/or at least one hole of the holder.
  • protruding member may be resilient
  • the filtering device may comprise at least one guide arranged to contact at least one feed-track of the holder, and/or the filtering device may comprise at least one feed-track arranged to contact at least one guide of the holder.
  • Said at least one guide and/or at least one feed-track of the filtering device may be arranged in contact with the filter and/or the fastening element.
  • the filter and/or the fastening element may be an efficient means of positioning the filter and/or the fastening element in relation to the holder during mounting of said filtering device to said holder.
  • Said guide may be, for example, a pin.
  • Said at least one protruding member may be a lug, tap, tongue, tine or flange.
  • the holder may, for example, be a part of a hydrolysis apparatus or a part of an extraction apparatus. It is realised that the holder may be part of any other apparatus or device suitable for the invention. Thus, the holder may be a part of or mounted to an analytical apparatus, a hydrolysing
  • the holder may be a releasable part of any such apparatus.
  • the holder may be free and independent from an apparatus.
  • the holder may be moved, with the filtering device mounted to the holder, for example, between different apparatuses. Such movement may be realised by the holder being mounted to a robot or manually.
  • the filtering device may be moved between said first and said second apparatus mounted to the holder. Said hydrolysing of the sample and said extracting fat may take place in a single apparatus.
  • Said irreversibly structurally altering may be, for example, plastic
  • any type of irreversible structurally altering of the fastening element during mounting or removal, to prevent remounting of the filtering device to the holder or re-use of the filter, may be used.
  • the irreversible structural altering may be the result of force, or chemical reactions or alterations involving the material of which the fastening element is made.
  • the fastening element may comprise weakenings of the material, such as a notch or relative thickness change, for achieving said irreversible structural altering.
  • Said irreversible structural altering of the fastening element may be an efficient means for preventing the filtering device from being remounted to the holder and thus re-use of the filtering device may be prevented.
  • Said fastening element may be arranged such that it is irreversibly
  • Said fastening element may be arranged such that it is irreversibly
  • Said extracting fat from the sample in the filtering device may be efficient for separating the fat from other compounds of the sample.
  • the fat may be extracted from the sample and out of the filtering device while other compounds of the sample are retained in the filtering device. Extraction of fat from the sample may be efficient for analysis of the fat in the sample.
  • the filtering device 1 comprises the fastening element 3 and a filter body 4 which, in the present embodiment consists substantially entirely of a suitable filter medium.
  • Figure 1 illustrates an exemplary embodiment of a filtering device 1
  • the fastening element 3 comprises a pair of generally identical and opposing through holes 5, each being a hole through the material of the fastening element 3.
  • the filter body 4 is fastened to the fastening element 3 such that the holes 5 and the material 7 surrounding the holes 5 are positioned outside of the filter body 4 as seen in the illustration.
  • the holder 2 comprises a pair of generally identical and opposing detents in the form of protruding members 6, each of which protrudes from the inner surface of the holder 2 with an upper surface 9 at an angle indicated by a.
  • the illustration in Fig. 1 is schematic, and the angle indicated by a may be larger or smaller than what is illustrated in the figure.
  • the fastening element 3 is made of flexible plastic, and as a result the material 7 surrounding the holes 5 is resilient and can be elastically deformed if a force or pressure is applied to it, such as a force from the protruding members 6 when the filtering device is being mounted to the holder 2. It is realised that there may be more or less than two holes 5 and corresponding protruding members 6, such as 1 , 3, 4, 5, or more holes or protruding members.
  • protrusion 6 is intended to apply equally to the other hole and protrusion which are not illustrated.
  • Figure 2 illustrates the filtering device 1 mounted to the holder 2 by
  • the filtering device 1 inserting the filtering device 1 into the holder 2 in a direction from above.
  • the resilient material 7 surrounding the hole 5 is bent in a direction toward the centre of the filtering device 1 as a result of pressure from the corresponding protruding member 6 as the material 7 contacts with and slides over the inclined surface 9, until it slides past the surface 9 and the material 7, being resilient causes the hole 5 to snap over the corresponding protruding member 6.
  • the filtering device 1 is snap-fit mounted to the holder 2.
  • the material of the fastening element 3 may be relatively rigid plastic so that as a result the material 7 surrounding the hole 5 tends to resist deformation if a pressure is applied to it, such as from the protruding member 6.
  • the protruding member 6 is made elastically deformable such that it tends to move towards the inner surface of the holder 2 upon exertion of a suitable force, such as from the material 7 surrounding the hole 5 as the filtering device is inserted into the holder 2.
  • the fastening element 3 further comprises a biasing means, here in the form of wings or tabs 1 1 which are formed of the resiliently flexible material 7.
  • the biasing means 1 1 is intended for contact with a shoulder or protrusion, here illustrated as a ridge 13, located in the inner surface of the holder 2 before the holder 2 and filtering device 3 are snap-fit connected.
  • a shoulder or protrusion here illustrated as a ridge 13 located in the inner surface of the holder 2 before the holder 2 and filtering device 3 are snap-fit connected.
  • This bias force increases as the filtering device 1 is moved to achieve the snap-fit connection.
  • the wings 13 tend to resist this deformation and thus exert a bias force urging the base of the hole 5 into contact with the protrusion 6 and the filtering device 1 out of the holder 2.
  • the filtering device is advantageously held firmly in the holder 2 by a positive engagement of protrusion 6 with the material surrounding the hole 5.
  • the protruding member 6 acts as a barb if the filtering device 1 should be removed or attempted to be removed from the holder 2.
  • the filtering device effectively cannot be removed from the holder 2 without the fastening element 3 being irreversibly structurally altered.
  • the hole 5 may be positioned at any other position of the fastening
  • the filtering device 1 has been removed from the holder 2, and the fastening element has been irreversibly structurally altered by the material 7 surrounding the hole 5 having been broken by the corresponding protruding member 6.
  • this is realised by arranging for a section of the material 7, here towards the base of the hole 5, being made thinner than other parts of the fastening element 3 surrounding the hole 5.
  • the irreversible structural altering may be realised in several other ways, for example, by a tab comprising a hole, which tab has weakenings, for example as provided by perforations, such that the tab would be torn off from the fastening element 3.
  • the filtering device 1 can no longer be fastened to the holder 2 properly a second time.
  • the filtering devicel could be inserted a second time into the holder 2, the filtering device 1 would not be snap-fit mounted to the holder 2 and the filtering device 1 would not be secured to the holder 2.
  • the wings 1 1 now also help prevent the filtering device 1 being reliably held in the holder 2 a second time since the fastening element 3 can no longer engage with the detent 6 to resist the bias force that is exerted by the wings 1 1 as they are urged against the ridge 13 during mounting.
  • the filtering device 1 would not function properly during re-use, as it would not be held safely in position in relation to the holder 2, and it might, for example, float or sink out of position, if positioned in a liquid, such as during hydrolysis of the sample or during extraction of fat from the sample.
  • the fastening element 3 of the filtering devicel is an effective means for ensuring the single use of a filter medium of the filter body 4, as a second use of the filtering device 1 is prevented.
  • FIG. 4 a filtering device 8 according to a further embodiment of the
  • the present invention is shown comprising a fastening element 10 and filter body 12.
  • the filtering device 8 is illustrated as not yet being mounted in holder 14.
  • the fastening element 10 is, in the present example, provided with support legs 16, 18, 20 (although greater or fewer may be provided) by which is supported the filter body 12.
  • a tongue 24 is here provided on a support leg 20 which is intended to engage with and slide in a corresponding groove 26 in the holder 14 to limit the relative orientation of the filtering device 8 and holder 14 as it is inserted into the holder 14 from above.
  • the length of the tongue 24 is selected so that it engages with the groove 26 as the filtering device 8 is entered into the holder 14 to initially prevent rotation of the filtering device 8 in the holder 14 but slides free of the groove 26 as the filtering device 8 is fully inserted into the holder 14. In this manner the filtering device 8 may be rotated in the holder 14 when fully mounted.
  • the fastening element 10 is provided with a snap-hook 28 in which is formed a hole 30 closed by a flexible tine 32 connected at one end so as to be able to move in to the hole 30 when urged in that direction by an external force.
  • the tine 32 Upon removal of the external force the tine 32 is self- biased to move back towards its position closing the hole 30. Movement of the tine 32 in the opposite direction, away from the hole is prevented by its engagement with a lip 34 of the snap-hook 28.
  • the snap-hook 28 of the fastening element 10 is designed to undergo an irreversible structural alteration in response to the exertion of a force upon it.
  • the holder 14 is provided with a pin 36 which extends inwards from an inner surface of the holder 14 and which engages with the snap-hook 28 when the filtering device 8 and holder 10 are rotated relative to one another around a longitudinal axis of the filtering device 8 after the filtering device 8 is fully received in the holder 14. Relative rotation in one direction will bring the pin 36 into contact with a rear surface 40 of the snap-hook 28 and prevent engagement of the pin 36 with the snap-hook 28. Relative rotation in the other direction will bring the pin 36 into contact with the flexible tine 32 of the snap-hook 28.
  • the snap-hook 28 is provided with a structural weakness (here a thinning of the material of the fastening element 10) at a location 38 where the snap-hook 28 connects to the main body of the fastening element 10 and generally opposite the flexible tine 32.
  • the tine 32 may be provided with a structural weakness. If the filtering device 8 is rotated to urge the pin 36 back into contact with the tine 32 after the pin 36 has been located in the hole 30, typically when removing the filtering device, the fastening element 10 will be irreversibly structurally altered by structural failure of the tine 32.
  • the invention has been exemplified above by a fastening element in which the irreversible structural alteration requires a physical interaction between elements of the filtering device and those of a holder it will be appreciated that the irreversible structural alteration of the fastening element may be achieved in other ways without departing from the invention as claimed.
  • a portion of the fastening element may be formed of a different material selected to react, for example dissolve, after contact with chemicals employed in a filtration process in which the filtering device is intended for use so as to achieve the necessary irreversible structural alteration.
  • the filtering device with sample is mounted to a holder of a hydrolysis apparatus, by means of the fastening element of the filtering device.
  • the hydrolysis apparatus comprises a container with a warm aqueous solution of hydrochloric acid (HCI), and the filtering device mounted to the holder is positioned such that the filter with the sample is submerged in the solution wherein hydrolysis occurs, allowing HCI to pass through the filter and react with the sample, while the holder remains above the HCI surface.
  • HCI hydrochloric acid
  • the hydrolysis results in breaking of chemical bonds, resulting in freeing of fat bound to the sample matrix. Due to the solution being aqueous and the fat being poorly or not at all soluble in aqueous solution, the fat remains in the filtering device in proximity to or in contact with the sample.
  • the solution is removed and the filter with the sample and free fat is rinsed in water followed by drying.
  • the filtering device is removed from the holder resulting in the fastening element being irreversibly structurally altered, such that the filtering device cannot be mounted a second time to the holder.
  • the filtering device with the sample and free fat, is positioned in an extraction apparatus for extracting fat from the sample.
  • the sample and fat in the filter is submerged in solvent with such properties that the fat has high solubility in the solvent, which solvent passes through the filter, and as one result the fat is extracted from the sample to the solvent and allowed to pass through the filter to the solvent outside of the filter.
  • the solvent containing fat may thereafter be treated, for example by heating or/and reducing the pressure, such that solvent is evaporated and dried fat remaining.
  • the remaining fat may be weighed and thus the fat content of the sample may be estimated.
  • the extraction of fat may be conducted by heating the solvent in which the filter is submerged such that solvent will evaporate.
  • the evaporated solvent may then be condensed and allowed to drip back into the filter in which fat may be extracted to the solvent and allowed to pass through the filter by the solvent after which the solvent may evaporate, be condensed and enter the filter again for extraction of fat.
  • the solvent may be organic solvent, and the solvent may be selected such that the fat has high or good solubility in the solvent.
  • the single use filtering device may improve the accuracy, the repeatability and/or the reproducibility of the extraction as compared to multiple-use filtering devices.

Abstract

Dispositif de filtration à usage unique (1), comprenant un corps de filtre (4) qui est constitué au moins en partie d'un milieu filtrant configuré pour contenir un échantillon pendant la filtration, et un élément de fixation (3) configuré pour monter de façon détachable le dispositif de filtration (1) sur un support (2). L'élément de fixation (3) est conçu pour subir une déformation structurelle irréversible pendant le montage du dispositif de filtration (1) sur le support (2) ou son enlèvement de celui-ci de manière à interdire tout nouveau montage du dispositif de filtration (1) dans le support (2).
PCT/EP2009/066701 2009-12-09 2009-12-09 Dispositif de filtration WO2011069540A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP09799585A EP2509698A1 (fr) 2009-12-09 2009-12-09 Dispositif de filtration
CN200980162771.8A CN102648037B (zh) 2009-12-09 2009-12-09 过滤设备
PCT/EP2009/066701 WO2011069540A1 (fr) 2009-12-09 2009-12-09 Dispositif de filtration
US13/505,671 US9664602B2 (en) 2009-12-09 2009-12-09 Filtering device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2009/066701 WO2011069540A1 (fr) 2009-12-09 2009-12-09 Dispositif de filtration

Publications (1)

Publication Number Publication Date
WO2011069540A1 true WO2011069540A1 (fr) 2011-06-16

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/066701 WO2011069540A1 (fr) 2009-12-09 2009-12-09 Dispositif de filtration

Country Status (4)

Country Link
US (1) US9664602B2 (fr)
EP (1) EP2509698A1 (fr)
CN (1) CN102648037B (fr)
WO (1) WO2011069540A1 (fr)

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US20120225490A1 (en) 2012-09-06
CN102648037A (zh) 2012-08-22
CN102648037B (zh) 2015-02-04
EP2509698A1 (fr) 2012-10-17

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