WO2011067236A3 - Raltegravir-polymorphe - Google Patents

Raltegravir-polymorphe Download PDF

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Publication number
WO2011067236A3
WO2011067236A3 PCT/EP2010/068485 EP2010068485W WO2011067236A3 WO 2011067236 A3 WO2011067236 A3 WO 2011067236A3 EP 2010068485 W EP2010068485 W EP 2010068485W WO 2011067236 A3 WO2011067236 A3 WO 2011067236A3
Authority
WO
WIPO (PCT)
Prior art keywords
raltegravir
polymorphs
novel polymorphs
production
relates
Prior art date
Application number
PCT/EP2010/068485
Other languages
English (en)
French (fr)
Other versions
WO2011067236A2 (de
Inventor
Dirk Fischer
Original Assignee
Ratiopharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ratiopharm Gmbh filed Critical Ratiopharm Gmbh
Publication of WO2011067236A2 publication Critical patent/WO2011067236A2/de
Publication of WO2011067236A3 publication Critical patent/WO2011067236A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Die Erfindung betrifft neue Polymorphe von Raltegravir, Verfahren zu ihrer Herstellung und die neuen Polymorphe enthaltende pharmazeutische Formulierungen.
PCT/EP2010/068485 2009-12-02 2010-11-30 Raltegravir-polymorphe WO2011067236A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102009056636.8 2009-12-02
DE102009056636A DE102009056636A1 (de) 2009-12-02 2009-12-02 Raltegravir-Polymorphe

Publications (2)

Publication Number Publication Date
WO2011067236A2 WO2011067236A2 (de) 2011-06-09
WO2011067236A3 true WO2011067236A3 (de) 2011-10-13

Family

ID=43606408

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/068485 WO2011067236A2 (de) 2009-12-02 2010-11-30 Raltegravir-polymorphe

Country Status (2)

Country Link
DE (1) DE102009056636A1 (de)
WO (1) WO2011067236A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2762339B1 (de) 2013-02-04 2016-04-06 C.R.F. Società Consortile per Azioni Hybridantriebsstrang für Kraftfahrzeug
EP2957445B1 (de) 2014-06-17 2016-09-14 C.R.F. Società Consortile per Azioni Hybridantriebsstrang für Kraftfahrzeuge mit Eingriffsvorrichtungen auf gegenüberliegenden Seiten des Elektromotors
EP2957447B1 (de) 2014-06-17 2016-09-14 C.R.F. Società Consortile per Azioni Hybridantrieb für Kraftfahrzeuge mit Hilfsvorrichtungen
EP2957444B1 (de) 2014-06-17 2016-09-14 C.R.F. Società Consortile per Azioni Hybridantrieb für Kraftfahrzeuge mit einer Riemengetriebevorrichtung zwischen Elektromotor und Differenzial
EP2957446B1 (de) 2014-06-17 2016-09-14 C.R.F. Società Consortile per Azioni Hybridantriebseinheit für Kraftfahrzeuge mit einer Vorrichtung zur Übertragung an eine weitere Achse des Kraftfahrzeuges
EP2979911B1 (de) 2014-07-29 2016-09-21 C.R.F. Società Consortile per Azioni Hybridantrieb für Kraftfahrzeuge mit variabler Getriebevorrichtung zwischen elektrischer Maschine und Differenzial

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA007060B1 (ru) 2001-10-26 2006-06-30 Иституто Ди Ричерке Ди Биолоджиа Молеколаре П. Анджелетти Спа N-замещённые гидроксипиримидинон-карбоксамидные ингибиторы вич интегразы
UA87884C2 (uk) 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Crystalline Form of N-(2-(4-(4-fluorobenzylcarbamoyl) 5-hydroxy-1-methyl-6- oxo-1, 6-dihydropyrimidin-2-yl)propan-2-yl) 5-methyl-1,3,4-oxadiazole-2- carboxamide", IP.COM JOURNAL, IP.COM INC., WEST HENRIETTA, NY, US, 14 January 2010 (2010-01-14), XP013136412, ISSN: 1533-0001 *
SUMMA VINCENZO ET AL: "Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 51, no. 18, 25 September 2008 (2008-09-25), pages 5843 - 5855, XP002615638, ISSN: 0022-2623, [retrieved on 20080903], DOI: DOI:10.1021/JM800245Z *

Also Published As

Publication number Publication date
WO2011067236A2 (de) 2011-06-09
DE102009056636A1 (de) 2011-06-09

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