WO2011057593A3 - Salts of prasugrel and a method of their production - Google Patents

Salts of prasugrel and a method of their production Download PDF

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Publication number
WO2011057593A3
WO2011057593A3 PCT/CZ2010/000116 CZ2010000116W WO2011057593A3 WO 2011057593 A3 WO2011057593 A3 WO 2011057593A3 CZ 2010000116 W CZ2010000116 W CZ 2010000116W WO 2011057593 A3 WO2011057593 A3 WO 2011057593A3
Authority
WO
WIPO (PCT)
Prior art keywords
prasugrel
acid
salts
production
formula
Prior art date
Application number
PCT/CZ2010/000116
Other languages
French (fr)
Other versions
WO2011057593A2 (en
Inventor
Hana Stepankova
Katerina Kaminska
Josef Hajicek
Hana Brusova
Original Assignee
Zentiva, K.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva, K.S. filed Critical Zentiva, K.S.
Publication of WO2011057593A2 publication Critical patent/WO2011057593A2/en
Publication of WO2011057593A3 publication Critical patent/WO2011057593A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to new pharmaceutically acceptable salts of the well-known substance reducing coagulation of blood, prasugrel of formula (I), which are characterized by high chemical stability, and a method of their production. The prasugrel salts are prepared from prasugrel of formula (I) in the base form by reaction with an inorganic or organic acid in a suitable solvent or in mixtures of solvents. The inorganic acid means hydrobromic acid, hydrogen bromide, hydroiodic and sulphuric acid and the organic acid means cyclamic, ethane sulfonic, benzene sulfonic and 2-naphthalene sulfonic acid.
PCT/CZ2010/000116 2009-11-16 2010-11-12 New salts of prasugrel and a method of their production WO2011057593A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20090762A CZ2009762A3 (en) 2009-11-16 2009-11-16 Novel salts of 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate known under unprotected name prasugrel and process of their preparation
CZPV2009-762 2009-11-16

Publications (2)

Publication Number Publication Date
WO2011057593A2 WO2011057593A2 (en) 2011-05-19
WO2011057593A3 true WO2011057593A3 (en) 2011-07-07

Family

ID=43618268

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CZ2010/000116 WO2011057593A2 (en) 2009-11-16 2010-11-12 New salts of prasugrel and a method of their production

Country Status (2)

Country Link
CZ (1) CZ2009762A3 (en)
WO (1) WO2011057593A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1728794E (en) 2000-07-06 2008-07-15 Ube Industries Maleate addition salt of hydropyridine derivatives
EP2451816A4 (en) * 2009-07-06 2013-02-27 Glenmark Generics Ltd Crystalline form of prasugrel hydrobromide, preparation and application thereof
PL2448945T3 (en) 2010-04-08 2015-06-30 Teva Pharma Crystalline forms of prasugrel salts
CZ305314B6 (en) * 2010-12-30 2015-07-29 Zentiva, K.S. Novel hydrobromide of the C 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate form known under unprotected name prasugrel and process for preparing thereof
CN102898437A (en) * 2011-07-21 2013-01-30 四川海思科制药有限公司 Acid-addition salt of Prasugrel, preparation method and application
CN103102356B (en) * 2011-11-11 2016-01-27 山东新时代药业有限公司 A kind of preparation method of prasugrel hydrobromide
CN102532161B (en) * 2012-02-27 2015-01-07 扬州市星斗药业有限公司 Prasugrel phenyl sulfonate and preparation method thereof
US8603537B2 (en) 2012-04-02 2013-12-10 Egis Pharmaceuticals Plc Prasugrel containing quickly released stable oral pharmaceutical compositions
CN103772408A (en) * 2012-10-26 2014-05-07 江苏先声药物研究有限公司 Crystal of prasugrel-1,5-napadisylate
CN103848844A (en) * 2012-12-07 2014-06-11 天津市汉康医药生物技术有限公司 Prasugrel salt-forming compound and preparation method thereof
CN106632391A (en) * 2016-12-23 2017-05-10 山东鲁抗医药股份有限公司 Prasugrel hydrochloride compound, preparation method of prasugrel hydrochloride compound and pharmaceutical composition containing prasugrel hydrochloride
ES2866401T3 (en) 2017-03-27 2021-10-19 Fruithy Holdings Ltd Poorly soluble complex or solvate thereof, pharmaceutical composition and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101255169A (en) * 2008-03-26 2008-09-03 山东大学 Prasugrel salt and preparation method thereof
EP2003136A1 (en) * 2006-04-06 2008-12-17 Daiichi Sankyo Company, Limited Process for producing high-purity prasugrel and acid addition salt thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI101150B (en) 1991-09-09 1998-04-30 Sankyo Co Process for the preparation of tetrahydrothione nopyridine derivatives useful as a drug
DE69526443T2 (en) 1994-10-07 2002-12-12 Ube Industries, Ltd. 2-SILYLOXY-TETRAHYDROTHIENOPYRIDINE, ITS SALT AND METHOD FOR THE PRODUCTION THEREOF
PT1728794E (en) 2000-07-06 2008-07-15 Ube Industries Maleate addition salt of hydropyridine derivatives
WO2009062044A2 (en) 2007-11-09 2009-05-14 Dr. Reddy's Laboratories Ltd. Processes for the preparation of prasugrel, and its salts and polymorphs
WO2009066326A2 (en) 2007-11-19 2009-05-28 Msn Laboratories Limited Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts
EP2257556A1 (en) 2008-02-06 2010-12-08 Helm AG Prasugrel salts with improved properties

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2003136A1 (en) * 2006-04-06 2008-12-17 Daiichi Sankyo Company, Limited Process for producing high-purity prasugrel and acid addition salt thereof
CN101255169A (en) * 2008-03-26 2008-09-03 山东大学 Prasugrel salt and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2008, XP002626090, retrieved from STN Database accession no. 2008:1079924 *

Also Published As

Publication number Publication date
CZ2009762A3 (en) 2011-05-25
WO2011057593A2 (en) 2011-05-19

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