WO2011056630A3 - Inhibiteurs du virus de l'hépatite c se présentant sous la forme de petites molécules - Google Patents

Inhibiteurs du virus de l'hépatite c se présentant sous la forme de petites molécules Download PDF

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Publication number
WO2011056630A3
WO2011056630A3 PCT/US2010/054220 US2010054220W WO2011056630A3 WO 2011056630 A3 WO2011056630 A3 WO 2011056630A3 US 2010054220 W US2010054220 W US 2010054220W WO 2011056630 A3 WO2011056630 A3 WO 2011056630A3
Authority
WO
WIPO (PCT)
Prior art keywords
hepatitis
virus
small molecule
molecule inhibitors
pentaenes
Prior art date
Application number
PCT/US2010/054220
Other languages
English (en)
Other versions
WO2011056630A2 (fr
Inventor
John K. Snyder
Wan-Guo Wei
Feng Ni
Arthur Donny Strosberg
Smitha Kota
Virginia Takahashi
Original Assignee
Trustees Of Boston University
The Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trustees Of Boston University, The Scripps Research Institute filed Critical Trustees Of Boston University
Priority to US13/504,822 priority Critical patent/US9174988B2/en
Publication of WO2011056630A2 publication Critical patent/WO2011056630A2/fr
Publication of WO2011056630A3 publication Critical patent/WO2011056630A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des dérivés et des analogues des triazatétracyclo[7.7.0.01,13,.02,7]-hexadéca-2,4,6,10,12-pentaènes et des 5,7,1 l-triazatétracyclo[8.7.0.01,6.012,17]-heptadéca-6,8,12,14,16- pentaènes, des compositions pharmaceutiques contenant ces composés et des méthodes de traitement des infections par le virus de l'hépatite C faisant appel à ces composés.
PCT/US2010/054220 2009-10-27 2010-10-27 Inhibiteurs du virus de l'hépatite c se présentant sous la forme de petites molécules WO2011056630A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/504,822 US9174988B2 (en) 2009-10-27 2010-10-27 Small molecule inhibitors of hepatitis C virus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27985609P 2009-10-27 2009-10-27
US61/279,856 2009-10-27

Publications (2)

Publication Number Publication Date
WO2011056630A2 WO2011056630A2 (fr) 2011-05-12
WO2011056630A3 true WO2011056630A3 (fr) 2011-09-09

Family

ID=43970676

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/054220 WO2011056630A2 (fr) 2009-10-27 2010-10-27 Inhibiteurs du virus de l'hépatite c se présentant sous la forme de petites molécules

Country Status (2)

Country Link
US (1) US9174988B2 (fr)
WO (1) WO2011056630A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
GB2515941A (en) 2011-10-21 2015-01-07 Abbvie Inc Methods for treating HCV comprising at least two direct acting antiviral agent, ribavirin but not interferon
EA201490836A1 (ru) 2011-10-21 2014-11-28 Эббви Инк. Комбинационное лечение (например, с abt-072 или abt-333) с помощью daa для применения при лечении hcv
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
GB201322334D0 (en) 2013-12-17 2014-01-29 Agency Science Tech & Res Maleimide derivatives as modulators of WNT pathway
US11369623B2 (en) * 2015-06-16 2022-06-28 Prism Pharma Co., Ltd. Anticancer combination of a CBP/catenin inhibitor and an immune checkpoint inhibitor
CN109689063A (zh) 2016-04-28 2019-04-26 埃默里大学 含有炔烃的核苷酸和核苷治疗组合物及其相关用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080287449A1 (en) * 2007-04-26 2008-11-20 Deqiang Niu Aza-tripeptide hepatitis c serine protease inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080287449A1 (en) * 2007-04-26 2008-11-20 Deqiang Niu Aza-tripeptide hepatitis c serine protease inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WEI, W. ET AL.: "New small molecule inhibitors of hepatitis C virus", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 24, 21 October 2009 (2009-10-21), pages 6926 - 6930, XP029120881, DOI: doi:10.1016/j.bmcl.2009.10.070 *

Also Published As

Publication number Publication date
WO2011056630A2 (fr) 2011-05-12
US9174988B2 (en) 2015-11-03
US20130065875A1 (en) 2013-03-14

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