WO2011054995A3 - Vaccins prophylactiques contre la grippe obtenus à partir de capsides virales de birnavirus contenant l'antigène m2e du virus de la grippe - Google Patents

Vaccins prophylactiques contre la grippe obtenus à partir de capsides virales de birnavirus contenant l'antigène m2e du virus de la grippe Download PDF

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Publication number
WO2011054995A3
WO2011054995A3 PCT/ES2010/070716 ES2010070716W WO2011054995A3 WO 2011054995 A3 WO2011054995 A3 WO 2011054995A3 ES 2010070716 W ES2010070716 W ES 2010070716W WO 2011054995 A3 WO2011054995 A3 WO 2011054995A3
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WO
WIPO (PCT)
Prior art keywords
flu
birnavirus
antigen
prophylactic
vaccines
Prior art date
Application number
PCT/ES2010/070716
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English (en)
Spanish (es)
Other versions
WO2011054995A2 (fr
Inventor
Thomas Zurcher
Cayetano Von Kobbe
Juan José BERNAL
Ignacio JIMÉNEZ TORRES
María VELA CUENCA
Ana Diaz Blazquez
Miguel Angel Llamas Matias
Diana Martin Lorenzo
Arcadio GARCÍA DE CASTRO
Original Assignee
Chimera Pharma, S. L. U.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chimera Pharma, S. L. U. filed Critical Chimera Pharma, S. L. U.
Publication of WO2011054995A2 publication Critical patent/WO2011054995A2/fr
Publication of WO2011054995A3 publication Critical patent/WO2011054995A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/10011—Birnaviridae
    • C12N2720/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/10011—Birnaviridae
    • C12N2720/10023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des vaccins prophylactiques pour la prévention de la grippe chez les êtres humains. En particulier, les vaccins de la présente invention sont formés de capsides pseudo-virales chimériques de birnavirus contenant l'antigène M2e du virus de la grippe.
PCT/ES2010/070716 2009-11-06 2010-11-05 Vaccins prophylactiques contre la grippe obtenus à partir de capsides virales de birnavirus contenant l'antigène m2e du virus de la grippe WO2011054995A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP200930968 2009-11-06
ES200930968 2009-11-06

Publications (2)

Publication Number Publication Date
WO2011054995A2 WO2011054995A2 (fr) 2011-05-12
WO2011054995A3 true WO2011054995A3 (fr) 2011-06-30

Family

ID=43806896

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2010/070716 WO2011054995A2 (fr) 2009-11-06 2010-11-05 Vaccins prophylactiques contre la grippe obtenus à partir de capsides virales de birnavirus contenant l'antigène m2e du virus de la grippe

Country Status (1)

Country Link
WO (1) WO2011054995A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013059168A2 (fr) * 2011-10-21 2013-04-25 Research Development Foundation Virus espirito santo et procédés de détection et de prévention d'une infection par ledit virus
CN103083656A (zh) * 2011-10-27 2013-05-08 苏州科贝生物技术有限公司 甲型流感病毒保守肽M2e与病毒样颗粒的缀合物及应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0887412A1 (fr) * 1997-05-26 1998-12-30 Akzo Nobel N.V. Vaccin recombinant du birnavirus
WO2002088339A2 (fr) * 2001-05-02 2002-11-07 Institut National De La Recherche Agronomique (Inra) Particules pseudovirales de birnavirus
WO2007009673A1 (fr) * 2005-07-15 2007-01-25 Consejo Superior De Investigaciones Científicas Particules chimeriques vides d'apparence virale tirees du virus de la bursite infectieuse (ibdv), procede de production et applications
EP1752468A1 (fr) * 2004-04-30 2007-02-14 Consejo Superior de Investigaciones Cientificas Procede de production de capsules virales vides en levure composees de proteines derivees de pvp2 du virus entrainant la maladie de la bursite infectieuse (ibdv)
WO2007020017A1 (fr) * 2005-08-12 2007-02-22 Bionostra, S.L. Composition destinee a l'immunisation des oiseaux et administree par aerosol
WO2009026465A2 (fr) * 2007-08-21 2009-02-26 Dynavax Technologies Corporation Composition et procédés de fabrication et d'utilisation de protéines de la grippe
WO2009135518A1 (fr) * 2008-05-09 2009-11-12 Chimera Pharma S.L.U. Protéines de fusion chimères et particules de type viral de birnavirus vp2

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0996717T3 (da) 1997-08-05 2006-04-10 Vlaams Interuniv Inst Biotech Immunbeskyttende influenzaantigen og anvendelse deraf til vaccination

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0887412A1 (fr) * 1997-05-26 1998-12-30 Akzo Nobel N.V. Vaccin recombinant du birnavirus
WO2002088339A2 (fr) * 2001-05-02 2002-11-07 Institut National De La Recherche Agronomique (Inra) Particules pseudovirales de birnavirus
EP1752468A1 (fr) * 2004-04-30 2007-02-14 Consejo Superior de Investigaciones Cientificas Procede de production de capsules virales vides en levure composees de proteines derivees de pvp2 du virus entrainant la maladie de la bursite infectieuse (ibdv)
WO2007009673A1 (fr) * 2005-07-15 2007-01-25 Consejo Superior De Investigaciones Científicas Particules chimeriques vides d'apparence virale tirees du virus de la bursite infectieuse (ibdv), procede de production et applications
WO2007020017A1 (fr) * 2005-08-12 2007-02-22 Bionostra, S.L. Composition destinee a l'immunisation des oiseaux et administree par aerosol
WO2009026465A2 (fr) * 2007-08-21 2009-02-26 Dynavax Technologies Corporation Composition et procédés de fabrication et d'utilisation de protéines de la grippe
WO2009135518A1 (fr) * 2008-05-09 2009-11-12 Chimera Pharma S.L.U. Protéines de fusion chimères et particules de type viral de birnavirus vp2

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LETZEL TOBIAS ET AL: "Molecular and structural bases for the antigenicity of VP2 of infectious bursal disease virus", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 81, no. 23, 1 December 2007 (2007-12-01), pages 12827 - 12835, XP002514417, ISSN: 0022-538X, [retrieved on 20070919], DOI: DOI:10.1128/JVI.01501.07 *
REMOND M ET AL: "Infectious bursal disease subviral particles displaying the foot-and-mouth disease virus major antigenic site", VACCINE, ELSEVIER LTD, GB, vol. 27, no. 1, 1 January 2009 (2009-01-01), pages 93 - 98, XP025714114, ISSN: 0264-410X, [retrieved on 20081105], DOI: DOI:10.1016/J.VACCINE.2008.10.036 *
VAN LOON A A W M ET AL: "Alteration of amino acids in VP2 of very virulent infectious bursal disease virus results in tissue culture adaptation and attenuation in chickens", JOURNAL OF GENERAL VIROLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, SPENCERS WOOD, GB, vol. 83, no. 1, 1 January 2002 (2002-01-01), pages 121 - 129, XP002514415, ISSN: 0022-1317 *

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