WO2011048612A3 - Procédé d'élaboration d'aminoindanes propargylés y compris un sel pharmaceutiquement acceptable correspondant - Google Patents

Procédé d'élaboration d'aminoindanes propargylés y compris un sel pharmaceutiquement acceptable correspondant Download PDF

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Publication number
WO2011048612A3
WO2011048612A3 PCT/IN2010/000671 IN2010000671W WO2011048612A3 WO 2011048612 A3 WO2011048612 A3 WO 2011048612A3 IN 2010000671 W IN2010000671 W IN 2010000671W WO 2011048612 A3 WO2011048612 A3 WO 2011048612A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
pharmaceutically acceptable
acceptable salts
aminoindans
propargylated
Prior art date
Application number
PCT/IN2010/000671
Other languages
English (en)
Other versions
WO2011048612A2 (fr
Inventor
Amit Anant Thanedar
Shekhar Ashok Deshmukh
Sunil Sudhakar Zope
Laxmikant Madhukar Kelkar
Joseph Prabahar Koilpillai
Jitendra Maganbhai Gajera
Original Assignee
Glenmark Generics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Generics Limited filed Critical Glenmark Generics Limited
Publication of WO2011048612A2 publication Critical patent/WO2011048612A2/fr
Publication of WO2011048612A3 publication Critical patent/WO2011048612A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
    • C07C209/28—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds by reduction with other reducing agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne l'élaboration d'un composé de formule (I), dans laquelle R1 = H ou correspond à la formule (b) et R2 est alkyle C1-C4, R3 = H ou alkyle C1-C4, et cette élaboration consiste à : a) faire réagir une dérivé indanone ou un sel correspondant de formule (II) avec propargyl amine ou un sel correspondant de formule (III) en présence d'un acide de Lewis; et b) soumettre le mélange de réaction résultant à une réduction
PCT/IN2010/000671 2009-10-14 2010-10-08 Procédé d'élaboration d'aminoindanes propargylés y compris un sel pharmaceutiquement acceptable correspondant WO2011048612A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2387MU2009 2009-10-14
IN2387/MUM/2009 2009-10-14

Publications (2)

Publication Number Publication Date
WO2011048612A2 WO2011048612A2 (fr) 2011-04-28
WO2011048612A3 true WO2011048612A3 (fr) 2011-08-11

Family

ID=43900759

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000671 WO2011048612A2 (fr) 2009-10-14 2010-10-08 Procédé d'élaboration d'aminoindanes propargylés y compris un sel pharmaceutiquement acceptable correspondant

Country Status (1)

Country Link
WO (1) WO2011048612A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120321896A1 (en) * 2010-02-01 2012-12-20 Kuppuswamy Nagarajan Rasagiline mesylate having large particle size and a process for preparation thereof
CN103864646B (zh) * 2014-02-21 2016-08-24 常州市第四制药厂有限公司 甲磺酸雷沙吉兰的杂质制备及分析方法
CN110776429B (zh) * 2018-07-30 2022-12-02 齐鲁制药有限公司 一种雷沙吉兰消旋中间体的改进制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786390A (en) * 1990-01-03 1998-07-28 Teva Pharmaceutical Industries Ltd. Pharmaceutical compositions of the R-enantiomer of N-propargyl -1-aminoindan
CN1990455A (zh) * 2005-12-29 2007-07-04 北京德众万全医药科技有限公司 一种简单、新颖的茚衍生物的制备方法
CN101062897A (zh) * 2006-04-25 2007-10-31 重庆医药工业研究院有限责任公司 一种制备2，3－二氢－1h－茚－1－胺及其衍生物的改进方法
CN101260048A (zh) * 2008-04-15 2008-09-10 苏州凯达生物医药技术有限公司 雷沙吉兰的制备方法
WO2010059913A2 (fr) * 2008-11-20 2010-05-27 Dr. Reddy's Laboratories Ltd. Préparation de rasagiline et de ses sels

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786390A (en) * 1990-01-03 1998-07-28 Teva Pharmaceutical Industries Ltd. Pharmaceutical compositions of the R-enantiomer of N-propargyl -1-aminoindan
CN1990455A (zh) * 2005-12-29 2007-07-04 北京德众万全医药科技有限公司 一种简单、新颖的茚衍生物的制备方法
CN101062897A (zh) * 2006-04-25 2007-10-31 重庆医药工业研究院有限责任公司 一种制备2，3－二氢－1h－茚－1－胺及其衍生物的改进方法
CN101260048A (zh) * 2008-04-15 2008-09-10 苏州凯达生物医药技术有限公司 雷沙吉兰的制备方法
WO2010059913A2 (fr) * 2008-11-20 2010-05-27 Dr. Reddy's Laboratories Ltd. Préparation de rasagiline et de ses sels

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Publication number Publication date
WO2011048612A2 (fr) 2011-04-28

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