WO2011034397A3 - 필수 대사산물을 이용한 병원성 미생물의 약물 표적 예측 및 약물 탐색 방법 - Google Patents

필수 대사산물을 이용한 병원성 미생물의 약물 표적 예측 및 약물 탐색 방법 Download PDF

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WO2011034397A3
WO2011034397A3 PCT/KR2010/006469 KR2010006469W WO2011034397A3 WO 2011034397 A3 WO2011034397 A3 WO 2011034397A3 KR 2010006469 W KR2010006469 W KR 2010006469W WO 2011034397 A3 WO2011034397 A3 WO 2011034397A3
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screening
essential
pathogenic microorganisms
drugs
metabolite
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PCT/KR2010/006469
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English (en)
French (fr)
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WO2011034397A2 (ko
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이상엽
김현욱
김태용
이규양
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한국과학기술원
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Publication of WO2011034397A2 publication Critical patent/WO2011034397A2/ko
Publication of WO2011034397A3 publication Critical patent/WO2011034397A3/ko

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

본 발명은 필수 대사산물을 이용한 병원성 미생물의 약물 표적 예측 및 약물 탐색 방법에 관한 것으로, 보다 구체적으로는 대상 미생물을 선정하고, 선정된 미생물의 대사 네트워크 모델을 구축한 후, 필수 대사산물 분석 (metabolite essentiality) 방법을 적용하여 세포 성장에 필수적인 대사산물을 예측하고, 이들 중 유통 대사산물（currency metabolite) 및 소비하는 반응식의 개수가 기준 미달인 필수 대사산물들 제거한 후, 남은 필수 대사산물들과 이들을 소비하는 효소가 숙주의 대사에 없는 것들만을 추가 선별함으로써, 효율적인 병원성 미생물의 약물 표적 효소 또는 이를 코딩하는 약물 표적 유전자를 스크리닝하는 방법 및 이들 병원성 미생물의 성장을 억제할 수 있는 약물을 선별하는 스크리닝 방법에 관한 것이다.
PCT/KR2010/006469 2009-09-18 2010-09-20 필수 대사산물을 이용한 병원성 미생물의 약물 표적 예측 및 약물 탐색 방법 WO2011034397A2 (ko)

Applications Claiming Priority (2)

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KR20090088502 2009-09-18
KR10-2009-0088502 2009-09-18

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WO2011034397A2 WO2011034397A2 (ko) 2011-03-24
WO2011034397A3 true WO2011034397A3 (ko) 2011-10-06

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PCT/KR2010/000162 WO2011034263A1 (ko) 2009-09-18 2010-01-11 필수 대사산물을 이용한 병원성 미생물의 약물 표적 예측 방법
PCT/KR2010/006469 WO2011034397A2 (ko) 2009-09-18 2010-09-20 필수 대사산물을 이용한 병원성 미생물의 약물 표적 예측 및 약물 탐색 방법

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PCT/KR2010/000162 WO2011034263A1 (ko) 2009-09-18 2010-01-11 필수 대사산물을 이용한 병원성 미생물의 약물 표적 예측 방법

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KR (1) KR101243378B1 (ko)
WO (2) WO2011034263A1 (ko)

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FR2973227B1 (fr) * 2011-04-01 2014-08-08 Oreal Composition cosmetique comprenant du 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one
CN102663214B (zh) * 2012-05-09 2013-11-06 四川大学 一种集成药物靶标预测系统的构建和预测方法
CN117095741B (zh) * 2023-10-19 2024-01-30 华东交通大学 基于图自注意力的微生物-药物关联预测方法

Citations (3)

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Publication number Priority date Publication date Assignee Title
US20020168654A1 (en) * 2001-01-10 2002-11-14 Maranas Costas D. Method and system for modeling cellular metabolism
WO2008078911A1 (en) * 2006-12-22 2008-07-03 Korea Advanced Institute Of Science And Technology Method for screening essential metabolites in growth of microorganisms
US7440855B2 (en) * 2001-08-11 2008-10-21 The Regents Of The University Of California Identification of antibiotic targets and critical points in metabolic networks based on pathway analysis

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Publication number Priority date Publication date Assignee Title
US7869957B2 (en) * 2002-10-15 2011-01-11 The Regents Of The University Of California Methods and systems to identify operational reaction pathways
JP4665451B2 (ja) * 2003-07-29 2011-04-06 味の素株式会社 Ｌ−リジンまたはｌ−スレオニンの製造法
KR100655495B1 (ko) * 2005-07-11 2006-12-08 한국과학기술원 대사산물들의 플럭스 섬을 이용한 인-실리코 생물 개량방법
KR101132395B1 (ko) * 2008-03-24 2012-04-03 한국과학기술원 시스템 기법을 이용한 비브리오속 미생물의 약물 표적 예측

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020168654A1 (en) * 2001-01-10 2002-11-14 Maranas Costas D. Method and system for modeling cellular metabolism
US7440855B2 (en) * 2001-08-11 2008-10-21 The Regents Of The University Of California Identification of antibiotic targets and critical points in metabolic networks based on pathway analysis
WO2008078911A1 (en) * 2006-12-22 2008-07-03 Korea Advanced Institute Of Science And Technology Method for screening essential metabolites in growth of microorganisms

Non-Patent Citations (2)

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Title
DUROT M. ET AL.: "Genome-scale models of bacterial metabolism: reconstruction and applications.", FEMS MICROBIOL. REV., vol. 33, 2009, pages 164 - 190 *
LEE S Y ET AL.: "Systems biotechnology for strain improvement.", TRENDS BIOTECHNOL., vol. 23, no. 7, 2005, pages 349 - 358, XP025290683, DOI: doi:10.1016/j.tibtech.2005.05.003 *

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KR20110031143A (ko) 2011-03-24
WO2011034397A2 (ko) 2011-03-24
WO2011034263A1 (ko) 2011-03-24
KR101243378B1 (ko) 2013-03-25

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