WO2011033163A3 - Complejos metálicos miméticos de sod - Google Patents
Complejos metálicos miméticos de sod Download PDFInfo
- Publication number
- WO2011033163A3 WO2011033163A3 PCT/ES2010/070607 ES2010070607W WO2011033163A3 WO 2011033163 A3 WO2011033163 A3 WO 2011033163A3 ES 2010070607 W ES2010070607 W ES 2010070607W WO 2011033163 A3 WO2011033163 A3 WO 2011033163A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sod
- metal complexes
- macrocyclic
- present
- complexes
- Prior art date
Links
- 239000002184 metal Substances 0.000 title abstract 3
- 102000019197 Superoxide Dismutase Human genes 0.000 abstract 3
- 108010012715 Superoxide dismutase Proteins 0.000 abstract 3
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000001760 anti-analgesic effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002736 metal compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G47/00—Compounds of rhenium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención comprende un procedimiento para sintetizar complejos metálicos a partir de compuestos macrocíclicos poliazapiridinofanos,caracterizados por ser miméticos de la enzima superóxido dismutasa (SOD). Además la presente invención hace referencia a los propios compuestos metálicos macrocíclicos poliazapiridinofanos, a los complejos metálicos formados a partir de ellos y al uso de éstos en terapia para el tratamiento de enfermedades cuya etiología se basa en anomalías de la actividad de la SOD endógena, principalmente como antiinflamatorios, analgésicos y antioxidantes protectores del estrés oxidativo celular.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/497,135 US9145386B2 (en) | 2009-09-21 | 2010-09-20 | SOD-imitating metal complexes |
EP10816744.6A EP2492270B1 (en) | 2009-09-21 | 2010-09-20 | Sod-imitating metal complexes |
ES10816744.6T ES2569239T3 (es) | 2009-09-21 | 2010-09-20 | Complejos metálicos miméticos de SOD |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200930712A ES2355784B1 (es) | 2009-09-21 | 2009-09-21 | Complejos metalicos mimeticos de sod |
ESP200930712 | 2009-09-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011033163A2 WO2011033163A2 (es) | 2011-03-24 |
WO2011033163A3 true WO2011033163A3 (es) | 2011-07-07 |
Family
ID=43736319
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/ES2010/070607 WO2011033163A2 (es) | 2009-09-21 | 2010-09-20 | Complejos metálicos miméticos de sod |
Country Status (4)
Country | Link |
---|---|
US (1) | US9145386B2 (es) |
EP (1) | EP2492270B1 (es) |
ES (2) | ES2355784B1 (es) |
WO (1) | WO2011033163A2 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2414291B2 (es) * | 2011-12-16 | 2014-02-13 | Universitat De Valencia | Compuestos macrocíclicos de tipo escorpiando y su uso como antiparasitarios. |
ES2543850B1 (es) * | 2014-02-24 | 2016-06-16 | Universitat De Valencia | Uso de complejos metálicos miméticos de SOD como agentes alimentarios y como cosméticos |
WO2019007996A1 (en) | 2017-07-04 | 2019-01-10 | Bionos Biotech, S.L | USE OF METALLIC COMPLEXES OF MACROAZAPYRIDINOPHANES IN THE TREATMENT OF DISEASES |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6794371B1 (en) * | 1999-10-18 | 2004-09-21 | The Dow Chemical Company | Aminoalkylenephosphonates for treatment of bone disorders |
US20070298354A1 (en) * | 2006-06-27 | 2007-12-27 | Ni Ding | Carbon coating on an implantable device |
US20080085883A1 (en) * | 1999-01-25 | 2008-04-10 | Aeolus Sciences, Inc. | Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance |
EP1392328B1 (en) * | 2001-01-19 | 2009-08-12 | National Jewish Medical and Research Center | Medicament for protection in radiotherapy |
-
2009
- 2009-09-21 ES ES200930712A patent/ES2355784B1/es active Active
-
2010
- 2010-09-20 ES ES10816744.6T patent/ES2569239T3/es active Active
- 2010-09-20 WO PCT/ES2010/070607 patent/WO2011033163A2/es active Application Filing
- 2010-09-20 US US13/497,135 patent/US9145386B2/en active Active
- 2010-09-20 EP EP10816744.6A patent/EP2492270B1/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080085883A1 (en) * | 1999-01-25 | 2008-04-10 | Aeolus Sciences, Inc. | Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance |
US6794371B1 (en) * | 1999-10-18 | 2004-09-21 | The Dow Chemical Company | Aminoalkylenephosphonates for treatment of bone disorders |
EP1392328B1 (en) * | 2001-01-19 | 2009-08-12 | National Jewish Medical and Research Center | Medicament for protection in radiotherapy |
US20070298354A1 (en) * | 2006-06-27 | 2007-12-27 | Ni Ding | Carbon coating on an implantable device |
Also Published As
Publication number | Publication date |
---|---|
ES2355784B1 (es) | 2012-02-03 |
WO2011033163A2 (es) | 2011-03-24 |
EP2492270A4 (en) | 2013-01-16 |
US9145386B2 (en) | 2015-09-29 |
EP2492270B1 (en) | 2016-03-09 |
ES2569239T3 (es) | 2016-05-09 |
ES2355784A1 (es) | 2011-03-31 |
EP2492270A2 (en) | 2012-08-29 |
US20120178730A1 (en) | 2012-07-12 |
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