WO2011032181A3 - Libraries of genetic packages comprising novel hc cdr3 designs - Google Patents

Libraries of genetic packages comprising novel hc cdr3 designs Download PDF

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Publication number
WO2011032181A3
WO2011032181A3 PCT/US2010/048830 US2010048830W WO2011032181A3 WO 2011032181 A3 WO2011032181 A3 WO 2011032181A3 US 2010048830 W US2010048830 W US 2010048830W WO 2011032181 A3 WO2011032181 A3 WO 2011032181A3
Authority
WO
WIPO (PCT)
Prior art keywords
libraries
novel
genetic packages
cdr3
designs
Prior art date
Application number
PCT/US2010/048830
Other languages
French (fr)
Other versions
WO2011032181A2 (en
Inventor
Robert C. Ladner
Original Assignee
Dyax Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dyax Corp. filed Critical Dyax Corp.
Priority to AU2010291902A priority Critical patent/AU2010291902A1/en
Priority to CA2773564A priority patent/CA2773564A1/en
Priority to EP10816294.2A priority patent/EP2478136A4/en
Priority to JP2012529006A priority patent/JP2013504602A/en
Publication of WO2011032181A2 publication Critical patent/WO2011032181A2/en
Publication of WO2011032181A3 publication Critical patent/WO2011032181A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Provided are compositions and methods for preparing and identifying antibodies having CDR3s that vary in sequence and in length from very short to very long. Libraries encoding antibodies with the CDR3s are also provided. The libraries can be provided by modifying a pre-existing nucleic acid library.
PCT/US2010/048830 2009-09-14 2010-09-14 Libraries of genetic packages comprising novel hc cdr3 designs WO2011032181A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2010291902A AU2010291902A1 (en) 2009-09-14 2010-09-14 Libraries of genetic packages comprising novel HC CDR3 designs
CA2773564A CA2773564A1 (en) 2009-09-14 2010-09-14 Libraries of genetic packages comprising novel hc cdr3 designs
EP10816294.2A EP2478136A4 (en) 2009-09-14 2010-09-14 Libraries of genetic packages comprising novel hc cdr3 designs
JP2012529006A JP2013504602A (en) 2009-09-14 2010-09-14 Newly designed gene package library containing HCCR3

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24217209P 2009-09-14 2009-09-14
US61/242,172 2009-09-14

Publications (2)

Publication Number Publication Date
WO2011032181A2 WO2011032181A2 (en) 2011-03-17
WO2011032181A3 true WO2011032181A3 (en) 2011-06-03

Family

ID=43733147

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/048830 WO2011032181A2 (en) 2009-09-14 2010-09-14 Libraries of genetic packages comprising novel hc cdr3 designs

Country Status (6)

Country Link
US (1) US20110082054A1 (en)
EP (1) EP2478136A4 (en)
JP (1) JP2013504602A (en)
AU (1) AU2010291902A1 (en)
CA (1) CA2773564A1 (en)
WO (1) WO2011032181A2 (en)

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EP3124497B1 (en) * 2007-09-14 2020-04-15 Adimab, LLC Rationally designed, synthetic antibody libraries and uses therefor
JP5833096B2 (en) 2010-03-31 2015-12-16 エイジェンシー フォー サイエンス， テクノロジー アンド リサーチＡｇｅｎｃｙ Ｆｏｒ Ｓｃｉｅｎｃｅ，Ｔｅｃｈｎｏｌｏｇｙ Ａｎｄ Ｒｅｓｅａｒｃｈ Amphiphilic linear peptide / peptoid and hydrogel containing the same
US8999916B2 (en) 2010-03-31 2015-04-07 Agency For Science, Technology And Research Crosslinked peptide hydrogels
US9687591B2 (en) 2010-03-31 2017-06-27 Agency For Science, Technology And Research Building stratified biomimetic tissues and organs using crosslinked ultrashort peptide hydrogel membranes
AU2011279073B2 (en) 2010-07-16 2016-06-09 Adimab, Llc Antibody libraries
US9120841B2 (en) * 2012-09-28 2015-09-01 Agency For Science, Technology And Research Amphiphilic linear peptidepeptoid and hydrogel comprising the same
US10829540B2 (en) 2015-05-01 2020-11-10 Medimmune Limited Phage display library, members thereof and uses of the same
EP3293293A1 (en) * 2016-09-08 2018-03-14 Italfarmaco SpA Hc-cdr3-only libraries with reduced combinatorial redundancy and optimized loop length distribution
EP3793603A4 (en) * 2018-05-16 2022-01-26 Chang Gung Memorial Hospital, Linkou Novel leucine-rich repeat neuronal protein 1 (lrrn1) antibodies and uses thereof
IL312003A (en) * 2021-10-15 2024-06-01 Astrazeneca Ab Anti-steap2 chimeric antigen receptors and uses thereof

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Also Published As

Publication number Publication date
EP2478136A2 (en) 2012-07-25
JP2013504602A (en) 2013-02-07
AU2010291902A1 (en) 2012-04-05
CA2773564A1 (en) 2011-03-17
EP2478136A4 (en) 2013-09-25
WO2011032181A2 (en) 2011-03-17
US20110082054A1 (en) 2011-04-07

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