WO2011031042A3 - 페길레이션된 삼요오드화 아릴 화합물 및 그를 포함하는 ｘ-선 조영제 - Google Patents

페길레이션된 삼요오드화 아릴 화합물 및 그를 포함하는 ｘ-선 조영제 Download PDF

Info

Publication number
WO2011031042A3
WO2011031042A3 PCT/KR2010/005977 KR2010005977W WO2011031042A3 WO 2011031042 A3 WO2011031042 A3 WO 2011031042A3 KR 2010005977 W KR2010005977 W KR 2010005977W WO 2011031042 A3 WO2011031042 A3 WO 2011031042A3
Authority
WO
WIPO (PCT)
Prior art keywords
pegylated
contrast agent
ray contrast
aryl compound
same
Prior art date
Application number
PCT/KR2010/005977
Other languages
English (en)
French (fr)
Other versions
WO2011031042A2 (ko
Inventor
정봉열
정인화
우익제
방성식
고효석
Original Assignee
주식회사 페라온
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 페라온 filed Critical 주식회사 페라온
Publication of WO2011031042A2 publication Critical patent/WO2011031042A2/ko
Publication of WO2011031042A3 publication Critical patent/WO2011031042A3/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/69—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

본 발명은 페길레이션된 삼요오드화 아릴 화합물 및 그를 포함하는 X-선 조영제에 관한 것이다. 본 발명의 페길레이션된 삼요오드화 아릴 화합물은 낮은 점도 및 오스몰농도를 나타낼 뿐만 아니라 신장독성의 문제를 유발하지 않아 X-선 조영제에 효과적으로 사용될 수 있다.
PCT/KR2010/005977 2009-09-09 2010-09-02 페길레이션된 삼요오드화 아릴 화합물 및 그를 포함하는 ｘ-선 조영제 WO2011031042A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090084915A KR101209633B1 (ko) 2009-09-09 2009-09-09 페길레이션된 삼요오드화 아릴 화합물 및 그를 포함하는 ｘ-선 조영제
KR10-2009-0084915 2009-09-09

Publications (2)

Publication Number Publication Date
WO2011031042A2 WO2011031042A2 (ko) 2011-03-17
WO2011031042A3 true WO2011031042A3 (ko) 2011-08-25

Family

ID=43732925

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/005977 WO2011031042A2 (ko) 2009-09-09 2010-09-02 페길레이션된 삼요오드화 아릴 화합물 및 그를 포함하는 ｘ-선 조영제

Country Status (2)

Country Link
KR (1) KR101209633B1 (ko)
WO (1) WO2011031042A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101418431B1 (ko) * 2012-09-28 2014-07-11 경북대학교 산학협력단 인산염을 포함하는 삼요오드화 화합물 및 이를 포함하는 ｘ-선 조영제
KR101638851B1 (ko) * 2014-06-13 2016-07-12 경북대학교 산학협력단 신규한 삼요오드화 화합물, 이의 제조방법 및 이를 포함하는 x-선 조영제

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005108379A1 (de) * 2004-05-05 2005-11-17 Schering Aktiengesellschaft Trimere makrocyclisch substituierte halogen-benzolderivate
WO2009047317A1 (en) * 2007-10-12 2009-04-16 Ge Healthcare As Contrast agents
WO2009047315A1 (en) * 2007-10-12 2009-04-16 Ge Healthcare As Contrast agents
WO2009047316A1 (en) * 2007-10-12 2009-04-16 Ge Healthcare As Contrast agents
WO2009060021A1 (en) * 2007-11-07 2009-05-14 Ge Healthcare As Contrast agents
WO2009106551A2 (en) * 2008-02-27 2009-09-03 Ge Healthcare As Contrast agents

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005108379A1 (de) * 2004-05-05 2005-11-17 Schering Aktiengesellschaft Trimere makrocyclisch substituierte halogen-benzolderivate
WO2009047317A1 (en) * 2007-10-12 2009-04-16 Ge Healthcare As Contrast agents
WO2009047315A1 (en) * 2007-10-12 2009-04-16 Ge Healthcare As Contrast agents
WO2009047316A1 (en) * 2007-10-12 2009-04-16 Ge Healthcare As Contrast agents
WO2009060021A1 (en) * 2007-11-07 2009-05-14 Ge Healthcare As Contrast agents
WO2009106551A2 (en) * 2008-02-27 2009-09-03 Ge Healthcare As Contrast agents

Also Published As

Publication number Publication date
WO2011031042A2 (ko) 2011-03-17
KR101209633B1 (ko) 2012-12-06
KR20110027016A (ko) 2011-03-16

Similar Documents

Publication Publication Date Title
IL220283A0 (en) 4-oxo-ih-quinoline-3- carboxamides, compositions comprising the same and uses thereof
IL216014A0 (en) Antibodies immunorective with heregulin-her3 complexes, compositions comprising the same and uses thereof
IL220563A0 (en) Pteridinone compounds, compositions comprising the same and uses thereof
IL205880A0 (en) Aminoglycoside analogs, compositions comprising the same and uses thereof
IL225926A (en) Boronate compounds, preparations containing them and their uses
AP2012006314A0 (en) Antiparistic dihydroazole compounds and compositions comprising same.
IL216094A0 (en) Self-complementary adeno-associated viral vectors, compositions comprising the same and uses thereof
IL216254A (en) Compounds, pharmaceutical compositions and their uses
EP2153838A4 (en) ANTI-NOROVIRUS AGENT AND COMPOSITION COMPRISING SAME
IL204621A0 (en) Bicyclic - ?? - amino acid derivatives, compositions comprising the same and uses thereof
IL211762A0 (en) Pegylated opiods, compositions comprising the same and uses thereof
IL217541A0 (en) Triazolopyridine compounds, compositions comprising the same and uses thereof
EP2499195A4 (en) Oxygen scavengers, compositions comprising the scavengers, and artcles made from the compositions
IL213365A (en) Imidazopyrazine and their pharmaceutical preparations
HK1195728A1 (zh) 超快作用胰島素組合物
EP2223969A4 (en) RESIN COMPOSITION, TRANSPARENT ELEMENT DERIVED FROM THE RESIN COMPOSITION AND USE
IL212836A0 (en) Azaquinolinone derivatives, compositions comprising the same and uses thereof
BR112013007229A2 (pt) ''composição,mistura e processo''.
IL226270A0 (en) History of hydroxamic acid, preparations containing them and their uses
IL212278A0 (en) Morpholinopurine derivatives, compositions comprising the same and uses thereof
EP2258775A4 (en) POLY (LACTIC ACID) COMPOSITION AND FILM COMPRISING SAME
IL220284A0 (en) Insulin analogues with chlorinated amino acids, compositions comprising the same and uses thereof
IL215592A (en) Compounds, preparations containing them and their uses in the treatment or prevention of conditions in the eyes
SI2739615T1 (sl) Fenil-3-aza-biciklo(3.1.0)heks-3-il-metanoni in njihova uporaba kot zdravilo
IL207066A0 (en) Iap inhibitor compounds, compositions comprising the same and uses thereof

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10815587

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 10815587

Country of ref document: EP

Kind code of ref document: A2