WO2011031005A3 - Single drop microextraction method combined with capillary electrophoresis-mass spectrometry - Google Patents

Single drop microextraction method combined with capillary electrophoresis-mass spectrometry Download PDF

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Publication number
WO2011031005A3
WO2011031005A3 PCT/KR2010/004751 KR2010004751W WO2011031005A3 WO 2011031005 A3 WO2011031005 A3 WO 2011031005A3 KR 2010004751 W KR2010004751 W KR 2010004751W WO 2011031005 A3 WO2011031005 A3 WO 2011031005A3
Authority
WO
WIPO (PCT)
Prior art keywords
mass spectrometry
capillary electrophoresis
method combined
single drop
microextraction method
Prior art date
Application number
PCT/KR2010/004751
Other languages
French (fr)
Other versions
WO2011031005A2 (en
Inventor
Doosoo Chung
Kihwan Choi
Jihye Kim
Zeid A Alothman
Saud I Alresayes
Ahmed Yacine Badjah Hadj Ahmed
Original Assignee
Snu R & Db Foundation
The Intellectual Property And Technology Licensing Program
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Snu R & Db Foundation, The Intellectual Property And Technology Licensing Program filed Critical Snu R & Db Foundation
Publication of WO2011031005A2 publication Critical patent/WO2011031005A2/en
Publication of WO2011031005A3 publication Critical patent/WO2011031005A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/4473—Arrangements for investigating the separated zones, e.g. localising zones by electric means

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

The present invention relates to a single-drop microextraction (SDME) method combined with capillary electrophoresis (CE)-mass spectrometry (MS) in which the SDME method is combined with CE and MS such that the pretreatment, separation and analysis of a sample can be carried out continuously while the sample can be analyzed with high sensitivity.
PCT/KR2010/004751 2009-09-08 2010-07-20 Single drop microextraction method combined with capillary electrophoresis-mass spectrometry WO2011031005A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090084408A KR101160389B1 (en) 2009-09-08 2009-09-08 The coupling system of single drop microextraction with capillary electrophoresis-mass spectrometry
KR10-2009-0084408 2009-09-08

Publications (2)

Publication Number Publication Date
WO2011031005A2 WO2011031005A2 (en) 2011-03-17
WO2011031005A3 true WO2011031005A3 (en) 2011-06-23

Family

ID=43732899

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/004751 WO2011031005A2 (en) 2009-09-08 2010-07-20 Single drop microextraction method combined with capillary electrophoresis-mass spectrometry

Country Status (2)

Country Link
KR (1) KR101160389B1 (en)
WO (1) WO2011031005A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103235066B (en) * 2013-04-16 2014-06-04 云南省烟草公司大理州公司 Hanging drop liquid phase micro-extraction method for extracting aroma component in tobacco leaf
CN103487534B (en) * 2013-10-11 2014-12-31 云南烟草科学研究院 Automatic single drop micro-extraction apparatus for trapping thermogravimetric escaping gas
CN104792769B (en) * 2015-04-09 2017-09-19 宁波大学 The dynamic micro-extraction of compound, detection combined unit and method in aqueous sample
CN106492895B (en) * 2016-12-08 2019-01-29 北京工业大学 A kind of device and method preparing nanotip pipette
KR102201770B1 (en) * 2016-12-23 2021-01-12 한국표준과학연구원 Capillary electrophoresis-electrospray ionization-mass spectrometry using single droplet micro-extraction and large-volume stacking method
CN107782826B (en) * 2017-09-29 2020-07-10 武汉大学 High-density supermolecule single-droplet micro-extraction device and application

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580434A (en) * 1996-02-29 1996-12-03 Hewlett-Packard Company Interface apparatus for capillary electrophoresis to a matrix-assisted-laser-desorption-ionization mass spectrometer
JPH09243600A (en) * 1996-03-08 1997-09-19 Hitachi Ltd Mass analyser
US20050233085A1 (en) * 1999-09-13 2005-10-20 The Regents Of The University Of California Method for preparing a solid phase microextraction device using aerogel
KR20060042798A (en) * 2004-11-10 2006-05-15 한국과학기술연구원 Method for determination of pahs and pcbs in sample by gc/ms with spme

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008241244A (en) 2005-07-11 2008-10-09 Osaka Univ Quantitative analyzing method of anionic compound due to ce/ms
KR100858596B1 (en) * 2006-09-09 2008-09-17 재단법인서울대학교산학협력재단 Surface Treatment Method of Capillary for Droplet Formation and Surface treated Capillary, and Prouction Method of Droplet for Microextraction of Chemical Using Thereof
KR101144974B1 (en) * 2007-07-14 2012-05-11 삼성전자주식회사 Large-volume stacking method using the electroosmotic flow pump in capillary electrophoresis interlocked with mass spectrometry and the equipment for it
KR101023915B1 (en) * 2007-09-21 2011-03-22 삼성전자주식회사 Dual stacking method combining large volume single drop microextraction and sweeping and the capillary for large volume single drop microextraction

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580434A (en) * 1996-02-29 1996-12-03 Hewlett-Packard Company Interface apparatus for capillary electrophoresis to a matrix-assisted-laser-desorption-ionization mass spectrometer
JPH09243600A (en) * 1996-03-08 1997-09-19 Hitachi Ltd Mass analyser
US20050233085A1 (en) * 1999-09-13 2005-10-20 The Regents Of The University Of California Method for preparing a solid phase microextraction device using aerogel
KR20060042798A (en) * 2004-11-10 2006-05-15 한국과학기술연구원 Method for determination of pahs and pcbs in sample by gc/ms with spme

Also Published As

Publication number Publication date
KR101160389B1 (en) 2012-06-26
WO2011031005A2 (en) 2011-03-17
KR20110026658A (en) 2011-03-16

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