WO2011018545A3 - Modelo humanizado de psoriasis - Google Patents
Modelo humanizado de psoriasis Download PDFInfo
- Publication number
- WO2011018545A3 WO2011018545A3 PCT/ES2010/070551 ES2010070551W WO2011018545A3 WO 2011018545 A3 WO2011018545 A3 WO 2011018545A3 ES 2010070551 W ES2010070551 W ES 2010070551W WO 2011018545 A3 WO2011018545 A3 WO 2011018545A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- model
- humanised
- disease
- psoriasis model
- animal
- Prior art date
Links
- 201000004681 Psoriasis Diseases 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/02—Breeding vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Cell Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La presente invención se refiere a un nuevo modelo animal humanizado de psoriasis. Dicho modelo se genera mediante el injerto de equivalentes de piel humanizada en el animal, la inyección de linfocitos T y citoquinas implicadas en la generación de la enfermedad en humanos, y la realización de la técnica de tape-stripping para generar un daño en dichos equivalentes injertados. Dicho modelo puede ser utilizado para el estudio de la enfermedad así como para la identificación y evaluación de la eficacia de compuestos frente a dicha enfermedad.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/390,281 US20120208211A1 (en) | 2009-08-14 | 2010-08-12 | Humanised psoriasis model |
CA2780986A CA2780986A1 (en) | 2009-08-14 | 2010-08-12 | Humanised psoriasis model |
EP10808013.6A EP2465346A4 (en) | 2009-08-14 | 2010-08-12 | HUMANIZED MODEL OF PSORIASIS |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200930599A ES2352929B1 (es) | 2009-08-14 | 2009-08-14 | Modelo humanizado de psoriasis |
ESP200930599 | 2009-08-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011018545A2 WO2011018545A2 (es) | 2011-02-17 |
WO2011018545A3 true WO2011018545A3 (es) | 2011-07-07 |
Family
ID=43567847
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/ES2010/070551 WO2011018545A2 (es) | 2009-08-14 | 2010-08-12 | Modelo humanizado de psoriasis |
Country Status (5)
Country | Link |
---|---|
US (1) | US20120208211A1 (es) |
EP (1) | EP2465346A4 (es) |
CA (1) | CA2780986A1 (es) |
ES (1) | ES2352929B1 (es) |
WO (1) | WO2011018545A2 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2918166A1 (en) | 2014-03-10 | 2015-09-16 | Westfälische Wilhelms-Universität Münster | TTP/MRP14 double knock out mouse model of psoriasis |
WO2017201448A1 (en) * | 2016-05-20 | 2017-11-23 | U.S. Government As Represented By The Department Of Veterans Affairs | Animal models for psoriasis and screening methods |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996027019A1 (en) * | 1995-02-25 | 1996-09-06 | Imperial Cancer Research Technology Limited | Transgenic animals as model of psoriasis |
WO1998044095A1 (en) * | 1997-04-03 | 1998-10-08 | Vlaams Interuniversitair Instituut Voor Biotechnologie | Transgenic animal with controllable hyperproliferation and inflammation phenotype in the skin |
WO2000034459A1 (en) * | 1998-12-09 | 2000-06-15 | Protein Design Labs, Inc. | Animal model for psoriasis for the prevention and treatment of psoriasis in humans |
EP1557085A1 (en) * | 2004-01-21 | 2005-07-27 | Boehringer Ingelheim International GmbH | Mouse model for human psoriasis |
WO2009099590A2 (en) * | 2008-01-31 | 2009-08-13 | Brown University | Psoriatic phenotype mice, cell lines, treatments, and methods |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001085151A2 (en) * | 2000-05-08 | 2001-11-15 | Psoriasis Research Institute | Chimeric animal model and treatment of psoriasis |
US6593511B1 (en) * | 2000-05-12 | 2003-07-15 | Bioseek, Inc. | Models of chronic and acute inflammatory diseases |
-
2009
- 2009-08-14 ES ES200930599A patent/ES2352929B1/es not_active Expired - Fee Related
-
2010
- 2010-08-12 US US13/390,281 patent/US20120208211A1/en not_active Abandoned
- 2010-08-12 WO PCT/ES2010/070551 patent/WO2011018545A2/es active Application Filing
- 2010-08-12 CA CA2780986A patent/CA2780986A1/en not_active Abandoned
- 2010-08-12 EP EP10808013.6A patent/EP2465346A4/en not_active Withdrawn
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996027019A1 (en) * | 1995-02-25 | 1996-09-06 | Imperial Cancer Research Technology Limited | Transgenic animals as model of psoriasis |
WO1998044095A1 (en) * | 1997-04-03 | 1998-10-08 | Vlaams Interuniversitair Instituut Voor Biotechnologie | Transgenic animal with controllable hyperproliferation and inflammation phenotype in the skin |
WO2000034459A1 (en) * | 1998-12-09 | 2000-06-15 | Protein Design Labs, Inc. | Animal model for psoriasis for the prevention and treatment of psoriasis in humans |
EP1557085A1 (en) * | 2004-01-21 | 2005-07-27 | Boehringer Ingelheim International GmbH | Mouse model for human psoriasis |
WO2009099590A2 (en) * | 2008-01-31 | 2009-08-13 | Brown University | Psoriatic phenotype mice, cell lines, treatments, and methods |
Also Published As
Publication number | Publication date |
---|---|
WO2011018545A2 (es) | 2011-02-17 |
CA2780986A1 (en) | 2011-02-17 |
ES2352929A1 (es) | 2011-02-24 |
EP2465346A2 (en) | 2012-06-20 |
EP2465346A4 (en) | 2013-04-17 |
ES2352929B1 (es) | 2012-01-26 |
US20120208211A1 (en) | 2012-08-16 |
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