WO2011014648A3 - Procédés et système destinés à détecter l'amyloïde-β soluble - Google Patents

Procédés et système destinés à détecter l'amyloïde-β soluble Download PDF

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Publication number
WO2011014648A3
WO2011014648A3 PCT/US2010/043700 US2010043700W WO2011014648A3 WO 2011014648 A3 WO2011014648 A3 WO 2011014648A3 US 2010043700 W US2010043700 W US 2010043700W WO 2011014648 A3 WO2011014648 A3 WO 2011014648A3
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WO
WIPO (PCT)
Prior art keywords
soluble amyloid
probes
imaging
detecting soluble
methods
Prior art date
Application number
PCT/US2010/043700
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English (en)
Other versions
WO2011014648A2 (fr
Inventor
Chongzhao Ran
Anna Moore
Original Assignee
The General Hospital Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The General Hospital Corporation filed Critical The General Hospital Corporation
Priority to US13/387,963 priority Critical patent/US8986657B2/en
Publication of WO2011014648A2 publication Critical patent/WO2011014648A2/fr
Publication of WO2011014648A3 publication Critical patent/WO2011014648A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention concerne des procédés de détection de l'amyloïde-β soluble en utilisant des sondes d'imagerie dans le proche infrarouge (NIR) dérivées de la curcumine. A la suite de leur interaction avec l'amyloïde-β soluble, ces sondes subissent un certain nombre de changements, leur permettant d'être qualifiées de sondes "intelligentes". De plus, l'invention concerne des procédés de détection de l'amyloïde-β soluble par tomographie par émission de positons (PET), par imagerie par résonnance magnétique (MRI) et par imagerie multimodale en se basant sur les sondes d'imagerie dans le NIR dérivées de la curcumine et des dérivés de celles-ci.
PCT/US2010/043700 2009-07-31 2010-07-29 Procédés et système destinés à détecter l'amyloïde-β soluble WO2011014648A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/387,963 US8986657B2 (en) 2009-07-31 2010-07-29 Methods and system for detecting soluble amyloid-β

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23018209P 2009-07-31 2009-07-31
US61/230,182 2009-07-31

Publications (2)

Publication Number Publication Date
WO2011014648A2 WO2011014648A2 (fr) 2011-02-03
WO2011014648A3 true WO2011014648A3 (fr) 2011-06-16

Family

ID=43529937

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/043700 WO2011014648A2 (fr) 2009-07-31 2010-07-29 Procédés et système destinés à détecter l'amyloïde-β soluble

Country Status (2)

Country Link
US (1) US8986657B2 (fr)
WO (1) WO2011014648A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010017094A2 (fr) 2008-07-31 2010-02-11 The General Hospital Corporation DÉRIVÉS DE CURCUMINE POUR IMAGER DES PLAQUES DE β-AMYLOÏDE
WO2014025808A1 (fr) * 2012-08-06 2014-02-13 The General Hospital Corporation Analogues de curcumine
US9757477B2 (en) 2013-09-06 2017-09-12 The General Hospital Corporation Imaging brown adipose tissue with curcumin derivatives
CN106349261B (zh) * 2015-07-16 2019-03-26 中国科学院上海药物研究所 荧光开关型bodipy类化合物及其制备方法和应用
CN105622657B (zh) * 2016-03-09 2018-08-21 中国药科大学 姜黄素衍生物、其制备方法和应用
JP6846052B2 (ja) * 2016-03-22 2021-03-24 国立研究開発法人科学技術振興機構 クルクミンホウ素錯体及びこれを含有する医薬
WO2018005732A1 (fr) * 2016-06-29 2018-01-04 The General Hospital Corporation Demi-curcuminoïdes utilisés en tant qu'agents d'imagerie de l'amyloïde-bêta pet
JP6765518B2 (ja) * 2016-09-29 2020-10-07 コリア アトミック エナジー リサーチ インスティテュートＫｏｒｅａ Ａｔｏｍｉｃ Ｅｎｅｒｇｙ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ クルクミン誘導体、その製造方法、及びそれを含むベータ−アミロイドプラーク検出用光音響イメージング剤
US10434193B2 (en) * 2017-02-20 2019-10-08 Jacobson Research Laboratory Limited Composition for use in medical imaging and a method for preparing thereof
KR102317673B1 (ko) * 2019-03-08 2021-10-26 기초과학연구원 아밀로이드 베타 올리고머 및 플라크에 특이적인 이광자 프로브 및 pet용 추적자
CN113318116B (zh) * 2021-06-17 2023-08-25 成都奥睿药业有限公司 姜黄素二氟硼及其衍生物的用途
CN113861104B (zh) * 2021-11-08 2023-09-29 西安热工研究院有限公司 一种基于姜黄素的Schiff碱Fe3+荧光分子探针及其制备方法
CN114853787B (zh) * 2022-04-13 2023-06-06 河南大学 一种近红外二区aie分子探针及其制备方法和应用
CN115718086B (zh) * 2022-10-26 2024-04-26 齐鲁工业大学 一种Aβ荧光探针动态荧光光谱的表征系统及方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010569A1 (fr) * 1992-10-26 1994-05-11 Schenk Dale B PROCEDES ET COMPOSITIONS VISANT A DETECTER UN PEPTIDE β-AMYLOIDE SOLUBLE
WO2005092443A1 (fr) * 2004-03-26 2005-10-06 Cellzome Ag Traitement de maladies neurodegeneratives au moyen de la laptm4b
US20080118938A1 (en) * 2006-09-06 2008-05-22 Lisbell Estrada Methods and Compositions for the Detection of Protein Folding Disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8841326B2 (en) * 2004-02-12 2014-09-23 Stc.Unm Therapeutic curcumin derivatives
US7737183B2 (en) * 2006-10-17 2010-06-15 The Regents Of The University Of California β-amyloid and neurofibrillary tangle imaging agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010569A1 (fr) * 1992-10-26 1994-05-11 Schenk Dale B PROCEDES ET COMPOSITIONS VISANT A DETECTER UN PEPTIDE β-AMYLOIDE SOLUBLE
WO2005092443A1 (fr) * 2004-03-26 2005-10-06 Cellzome Ag Traitement de maladies neurodegeneratives au moyen de la laptm4b
US20080118938A1 (en) * 2006-09-06 2008-05-22 Lisbell Estrada Methods and Compositions for the Detection of Protein Folding Disorders

Also Published As

Publication number Publication date
US20120183474A1 (en) 2012-07-19
WO2011014648A2 (fr) 2011-02-03
US8986657B2 (en) 2015-03-24

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