WO2011005978A9 - Procédés de manipulation de la signalisation cellulaire - Google Patents

Procédés de manipulation de la signalisation cellulaire Download PDF

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Publication number
WO2011005978A9
WO2011005978A9 PCT/US2010/041392 US2010041392W WO2011005978A9 WO 2011005978 A9 WO2011005978 A9 WO 2011005978A9 US 2010041392 W US2010041392 W US 2010041392W WO 2011005978 A9 WO2011005978 A9 WO 2011005978A9
Authority
WO
WIPO (PCT)
Prior art keywords
light
cell
protein
transducing
generating
Prior art date
Application number
PCT/US2010/041392
Other languages
English (en)
Other versions
WO2011005978A2 (fr
WO2011005978A3 (fr
Inventor
Ute Hochgeschwender
Original Assignee
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duke University filed Critical Duke University
Publication of WO2011005978A2 publication Critical patent/WO2011005978A2/fr
Publication of WO2011005978A9 publication Critical patent/WO2011005978A9/fr
Publication of WO2011005978A3 publication Critical patent/WO2011005978A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]

Abstract

L'invention concerne des procédés de suivi et/ou de modulation de la signalisation cellulaire, et spécifiquement, des polynucléotides, des polypeptides, des cellules, des tests, des animaux non humains génétiquement modifiés, et des procédés qui impliquent une protéine produisant de la lumière et une protéine transduisant la lumière, qui peuvent être utilisés pour manipuler, suivre et étudier la signalisation cellulaire dans divers types de cellules.
PCT/US2010/041392 2009-07-08 2010-07-08 Procédés de manipulation de la signalisation cellulaire WO2011005978A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22396509P 2009-07-08 2009-07-08
US61/223,965 2009-07-08

Publications (3)

Publication Number Publication Date
WO2011005978A2 WO2011005978A2 (fr) 2011-01-13
WO2011005978A9 true WO2011005978A9 (fr) 2011-03-03
WO2011005978A3 WO2011005978A3 (fr) 2011-04-21

Family

ID=43429837

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/041392 WO2011005978A2 (fr) 2009-07-08 2010-07-08 Procédés de manipulation de la signalisation cellulaire

Country Status (1)

Country Link
WO (1) WO2011005978A2 (fr)

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US9992981B2 (en) * 2010-11-05 2018-06-12 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of reward-related behaviors

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US9238150B2 (en) 2005-07-22 2016-01-19 The Board Of Trustees Of The Leland Stanford Junior University Optical tissue interface method and apparatus for stimulating cells
US8926959B2 (en) 2005-07-22 2015-01-06 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US8906360B2 (en) 2005-07-22 2014-12-09 The Board Of Trustees Of The Leland Stanford Junior University Light-activated cation channel and uses thereof
US20090093403A1 (en) 2007-03-01 2009-04-09 Feng Zhang Systems, methods and compositions for optical stimulation of target cells
US10052497B2 (en) 2005-07-22 2018-08-21 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US9274099B2 (en) 2005-07-22 2016-03-01 The Board Of Trustees Of The Leland Stanford Junior University Screening test drugs to identify their effects on cell membrane voltage-gated ion channel
WO2008086470A1 (fr) 2007-01-10 2008-07-17 The Board Of Trustees Of The Leland Stanford Junior University Système pour stimulation optique de cellules cibles
US8401609B2 (en) 2007-02-14 2013-03-19 The Board Of Trustees Of The Leland Stanford Junior University System, method and applications involving identification of biological circuits such as neurological characteristics
US10434327B2 (en) 2007-10-31 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Implantable optical stimulators
US10035027B2 (en) 2007-10-31 2018-07-31 The Board Of Trustees Of The Leland Stanford Junior University Device and method for ultrasonic neuromodulation via stereotactic frame based technique
ES2608498T3 (es) 2008-04-23 2017-04-11 The Board Of Trustees Of The Leland Stanford Junior University Sistemas, métodos y composiciones para la estimulación óptica de células diana
EP2294208B1 (fr) 2008-05-29 2013-05-08 The Board of Trustees of The Leland Stanford Junior University Lignée cellulaire, système et procédé pour un contrôle optique de messagers secondaires
SG191604A1 (en) 2008-06-17 2013-07-31 Univ Leland Stanford Junior Apparatus and methods for controlling cellular development
WO2010006049A1 (fr) 2008-07-08 2010-01-14 The Board Of Trustees Of The Leland Stanford Junior University Matériaux et approches pour stimulation optique du système nerveux périphérique
NZ602416A (en) 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto
EP2465931B1 (fr) * 2009-08-10 2014-12-24 Tohoku University Rhodopsine canal photoréceptrice d'une efficacité d'expression améliorée
EP2547762B1 (fr) 2010-03-17 2018-04-25 The Board of Trustees of the Leland Stanford Junior University Molécules laissant passer les ions sensibles à la lumière
WO2012061741A2 (fr) * 2010-11-05 2012-05-10 The Board Of Trustees Of The Leland Stanford Junior University. Contrôle et caractérisation d'états psychotiques
EP2635108B1 (fr) 2010-11-05 2019-01-23 The Board of Trustees of the Leland Stanford Junior University Opsines chimériques activées par la lumière et leurs procédés d'utilisation
CN103313752B (zh) 2010-11-05 2016-10-19 斯坦福大学托管董事会 用于光遗传学方法的光的上转换
EP2635111B1 (fr) 2010-11-05 2018-05-23 The Board of Trustees of the Leland Stanford Junior University Protéines stabilisées de type opsine a fonction discontinue (ssfo) et leurs procédés d'utilisation
US8932562B2 (en) 2010-11-05 2015-01-13 The Board Of Trustees Of The Leland Stanford Junior University Optically controlled CNS dysfunction
JP6328424B6 (ja) 2010-11-05 2018-07-11 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 記憶機能の制御および特性化
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
US8868351B2 (en) 2011-10-13 2014-10-21 The Cleveland Clinic Foundation Estimation of neural response for optical stimulation
CN104093833B (zh) 2011-12-16 2017-11-07 斯坦福大学托管董事会 视蛋白多肽及其使用方法
EP2817068B1 (fr) 2012-02-21 2017-04-12 The Board of Trustees of the Leland Stanford Junior University Compositions destinées à traiter les troubles neurogènes du plancher pelvien
US9687672B2 (en) 2012-08-13 2017-06-27 Brown University Optogenetic control of endothelial cells
JP6132350B2 (ja) * 2012-10-26 2017-05-24 国立研究開発法人産業技術総合研究所 人工生物発光酵素
US10533231B2 (en) 2012-10-26 2020-01-14 National Institute Of Advanced Industrial Science And Technology Artificial bioluminescent enzyme
US9636380B2 (en) 2013-03-15 2017-05-02 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of inputs to the ventral tegmental area
ES2742492T3 (es) 2013-03-15 2020-02-14 Univ Leland Stanford Junior Control optogenético del estado conductual
US10220092B2 (en) 2013-04-29 2019-03-05 The Board Of Trustees Of The Leland Stanford Junior University Devices, systems and methods for optogenetic modulation of action potentials in target cells
WO2015023782A1 (fr) 2013-08-14 2015-02-19 The Board Of Trustees Of The Leland Stanford Junior University Compositions et procédés pour réguler une douleur
US9926359B2 (en) 2013-11-26 2018-03-27 Emory University Optogenetic inhibition of overactive neuronal activity
EP2881747A1 (fr) 2013-12-05 2015-06-10 S.I.S.S.A. Scuola Internazionale Superiore di Studi Avanzati Dispositif, appareil et système destinés à être utilisés dans la photonique, la nanotechnologie, la biologie et la microscopie
US11242374B2 (en) 2015-01-22 2022-02-08 Brown University Minimally-invasive and activity-dependent control of excitable cells
WO2016209654A1 (fr) 2015-06-22 2016-12-29 The Board Of Trustees Of The Leland Stanford Junior University Procédés et dispositifs pour l'imagerie et/ou la commande optogénétique de neurones réagissant à la lumière
US11294165B2 (en) 2017-03-30 2022-04-05 The Board Of Trustees Of The Leland Stanford Junior University Modular, electro-optical device for increasing the imaging field of view using time-sequential capture
US20210246185A1 (en) * 2018-06-04 2021-08-12 Howard Hughes Medical Institute Inverted transporter polypeptides and methods of using

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US20080244760A1 (en) * 2004-10-04 2008-10-02 The John Hopkins University Transgenic Frog Lines and Assays Employing Them

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9992981B2 (en) * 2010-11-05 2018-06-12 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of reward-related behaviors

Also Published As

Publication number Publication date
WO2011005978A2 (fr) 2011-01-13
WO2011005978A3 (fr) 2011-04-21

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