WO2010140795A2 - Composition de type placenta humain contenant un facteur de croissance dérivé du placenta humain et des cytokines, et utilisation cosmétique associée - Google Patents

Composition de type placenta humain contenant un facteur de croissance dérivé du placenta humain et des cytokines, et utilisation cosmétique associée Download PDF

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Publication number
WO2010140795A2
WO2010140795A2 PCT/KR2010/003435 KR2010003435W WO2010140795A2 WO 2010140795 A2 WO2010140795 A2 WO 2010140795A2 KR 2010003435 W KR2010003435 W KR 2010003435W WO 2010140795 A2 WO2010140795 A2 WO 2010140795A2
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WO
WIPO (PCT)
Prior art keywords
growth factor
cosmetic composition
placenta
derived growth
platelet
Prior art date
Application number
PCT/KR2010/003435
Other languages
English (en)
Korean (ko)
Other versions
WO2010140795A3 (fr
Inventor
정형민
김주미
Original Assignee
(주)차바이오앤디오스텍
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Application filed by (주)차바이오앤디오스텍 filed Critical (주)차바이오앤디오스텍
Publication of WO2010140795A2 publication Critical patent/WO2010140795A2/fr
Publication of WO2010140795A3 publication Critical patent/WO2010140795A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A61K8/982—Reproductive organs; Embryos, Eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions

Definitions

  • the present invention relates to a cosmetic composition for the manufacture of cosmetics containing growth factors and cytokines, and more specifically to the cosmetic composition by analyzing the growth factors and cytokines derived from placenta and reconstituting the components having excellent effects on skin regeneration and whitening It relates to a cosmetic composition artificially recombined.
  • Skin is an indispensable organ in our lives and one of the most vulnerable organs in the human body. Skin aging can be divided into two categories, internal aging and external aging, depending on the cause. Intrinsic aging is an aging process that occurs naturally as the body ages and the physiological function of the body decreases. Extrinsic aging refers to aging caused by external factors such as ultraviolet (UV), dry air, reactive oxygen species and stress. As the skin ages due to these internal and external factors, the most common symptom is wrinkle formation on the skin surface.
  • UV ultraviolet
  • Placenta is an organ that develops in the womb of a pregnant mammal. Placenta has the effect of inhibiting the activity of the enzyme tyrosinase, which catalyzes the production of melanin granules from tyrosine, thereby inhibiting the production of melanin pigment and promoting the release of cells containing melanin pigment, thus preventing and improving blemishes. It is effective in preventing and causing pigmentation as well as whitening (Mallick S et al., Pigment Cell Res. Feb 18 (1), 25-33, 2005).
  • Placenta contains essential amino acids, melatonin, RNA, DNA and other nucleic acid components, antioxidant enzymes, hyaluronic acid, antioxidants, immune cofactors (cytokine), placental peptides, insulin-like-growth factor ), Growth factors such as epidermal growth factors (EGFS) and unique senescent cell activating factors (SCAFS) and cytokines are known to be useful for fatigue and immune augmentation.
  • EGFS epidermal growth factors
  • SCAFS unique senescent cell activating factors
  • cytokines are known to be useful for fatigue and immune augmentation.
  • Japanese Patent Application Laid-Open No. 35-15399 discloses a color white cosmetic compound comprising placenta extract and koji acid or koji acid derivative in a cosmetic base.
  • Korean Patent Laid-Open Publication No. 2004-0082144 discloses a skin coating composition comprising the addition of organic germanium and ubiquinone to a placental extract.
  • Republic of Korea Patent Publication No. 2008-0096219 discloses a cosmetic raw material to increase the amino acid content by treating proteolytic enzymes in pig placenta.
  • these inventions can be extracted directly from the mammalian placenta including humans and used as a cosmetic raw material, according to the extraction method may contain a large amount of impurities not involved in skin care, immune rejection in case of skin in particular skin wounds There is a risk of causing a reaction, and since it is extracted from nature, there is a restriction on supply and demand of raw materials, especially in the case of placenta, the sale of cosmetics containing the placenta extract is banned for reasons of ethical issues.
  • the present invention is to solve the above-mentioned problems, instead of using the placenta extract as a direct cosmetic raw material, extracting and analyzing various growth factors and cytokines derived from the placenta, and then effective in improving wrinkles and skin whitening from these
  • the present inventors obtain extracts of various components from the placenta, analyze various growth factors and cytokines from these extracts, derive various combinations from these growth factors and cytokines, and reconstruct each of the components.
  • the present invention was found to have an excellent effect on wrinkle improvement and skin whitening in combination of certain components.
  • FGF-2 Basic Fibroblast Growth Factor-2
  • PDGF-AA Platelet-derived growth factor-AA
  • VEGF vascular endothelial growth factor
  • the present invention provides a cosmetic composition further comprises 40-40,000 pg / ml Flt-3 ligand (Flt-3 Ligand) in the active ingredients.
  • the present invention provides a cosmetic composition further comprises 300-300,000 pg / ml of Lantis (RANTES, CCL5) to the active ingredients.
  • RANTES Lantis
  • the present invention is an interleukin-10 (Interleukin-10, IL-10) 80-80,000 pg / ml or Interferon- ⁇ -inducing factor-10 (Interferon gamma inducible protein-10, IP-10) 80- It provides a cosmetic composition further comprises one or more selected from the group consisting of 80,0000 pg / ml, Platelet-derived growth factor-BB (PDGF-BB) 30-30,000 pg / ml.
  • PDGF-BB Platelet-derived growth factor-BB
  • the cosmetic composition of the present invention unlike the conventional cosmetic composition using the placenta extract as a direct cosmetic raw material, by analyzing the placenta extract to find growth factors and cytokines effective for wrinkle improvement and skin whitening, and then improve the skin wrinkles from a combination of these components
  • By providing it as the most effective cosmetic raw material for skin whitening there is no fear of occurrence of ethical problems, and unlike the conventional placenta extract cosmetic composition which contained unnecessary ingredients, a cosmetic composition having an excellent effect on wrinkle improvement and skin whitening even with a small amount Has the effect of providing.
  • 1 is a table showing the ingredient names and effective substance content of growth factors and cytokines analyzed by using the placenta extract of the present invention using multiplex cytokine array.
  • the human placenta is washed, throttled, broken and lyophilized in vacuo to lower the water content to less than 10%.
  • 100 g of powdered placenta and supercritical solvent in the supercritical extractor reactor were dissolved in carbon dioxide into the extraction reactor, and the temperature in the reactor was adjusted to 35 ° C., and extracted for about 45 minutes while maintaining the pressure at 3000 psi.
  • Insoluble material was collected in a separation tank, and soluble material was returned to its original state to gasification of carbon dioxide to obtain a placental extract.
  • Table 1 shows the ingredient names and effective substance contents of growth factors and cytokines effective for wrinkle improvement and skin whitening by analyzing the active ingredients of the placenta extract obtained by the method (A) using a multiplex cytokine array.
  • FGF-2, PDGF-AA, VEGF, Flt-3 Ligand, RANTES, IL-10, IP-10, PDGF-BB, etc. are found to act as active ingredients of the placenta extract. lost.
  • FGF-2 Basic fibroblast growth factor
  • PDGF-AA Platelet-derived growth factor-AA
  • VEGF Vascular endothelial 4,000 pg / ml of growth factor
  • Example 3 The cosmetic composition of Example 3 was further mixed with 3,000 pg / ml of Lantis (RANTES, CCL5) to the cosmetic composition of Example 3.
  • RANTES Lantis
  • Example 4 (1) In the cosmetic composition of Example 4, 800 pg / ml of Interleukin-10 (IL-10), Interferon- ⁇ -inducing factor-10 (800-10 pg) / ml, platelet-derived growth factor-BB (Platelet-derived growth factor-BB, PDGF-BB) 30-0 pg / ml was further mixed to prepare a cosmetic composition of the present invention.
  • IL-10 Interleukin-10
  • BB Platelet-derived growth factor-BB
  • PDGF-BB PDGF-BB
  • a cosmetic cream was prepared by sufficiently stirring the weight%, an appropriate amount of preservative, a perfume, a pigment, and purified water.
  • the makeup cream according to the embodiment of the present invention showed an excellent effect on wrinkle improvement
  • the case of Example 5 showed the most excellent wrinkle improvement effect.
  • the present invention relates to a cosmetic composition for producing cosmetics containing growth factors and cytokines. It relates to a cosmetic composition artificially recombining the cosmetic composition by reconstituting the components having excellent effects on skin regeneration and whitening by analyzing growth factors and cytokines derived from the placenta.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne une composition cosmétique restructurée à partir d'un facteur de croissance dérivé du placenta humain et de cytokines. La présente invention concerne une composition cosmétique comprenant, comme ingrédients actifs, 300 à 300 000 pg/ml de facteur de croissance fibroblastique basique-2 (FGF-2), 100 à 100 000 pg/ml de facteur de croissance dérivé des plaquettes-AA (PDGF-AA), et 400 à 400 000 pg/ml de facteur de croissance de l'endothélium vasculaire (VEGF), et comprenant en outre 40 à 40 000 pg/ml de ligand à Flt-3, 300 à 300 000 pg/ml de RANTES (CCL5), 80 à 80 000 pg/ml d'interleukine-10 (IL-10), 80 à 80 000 pg/ml de protéine-10 inductible par l'interféron gamma (IP-10), et 30 à 30 000 pg/ml de facteur de croissance dérivé des plaquettes-BB (PDGF-BB), si besoin. La présente invention concerne une composition cosmétique qui présente d'excellents effets en termes d'élimination des rides et de blanchiment de la peau, même lorsqu'elle est appliquée en petites quantités, contrairement aux compositions cosmétiques classiques contenant des extraits de placenta dans lesquelles des composants non nécessaires sont inclus.
PCT/KR2010/003435 2009-06-01 2010-05-28 Composition de type placenta humain contenant un facteur de croissance dérivé du placenta humain et des cytokines, et utilisation cosmétique associée WO2010140795A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090048070A KR101289062B1 (ko) 2009-06-01 2009-06-01 인태반 유래 성장인자 및 사이토카인들을 함유한 유사 인태반 조성물 및 이의 화장품 용도
KR10-2009-0048070 2009-06-01

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WO2010140795A2 true WO2010140795A2 (fr) 2010-12-09
WO2010140795A3 WO2010140795A3 (fr) 2011-04-21

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WO (1) WO2010140795A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013157891A1 (fr) * 2012-04-19 2013-10-24 부산대학교 산학협력단 Composition pharmaceutique à usage topique destinée à prévenir ou à traiter les effets secondaires cutanés provoqués par un inhibiteur d'egfr
WO2022255809A1 (fr) 2021-06-02 2022-12-08 주식회사 엘지생활건강 Composition cosmétique imitant le placenta

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000074634A2 (fr) * 1999-06-03 2000-12-14 Au Jessie L S Methodes et compositions permettant de moduler la proliferation et la mort cellulaire
KR20020018566A (ko) * 2000-09-01 2002-03-08 액티브 올가닉스 인코포레이티드 모노-아실-(리소)-글리세롤인지질로 국소 활성의 효능을강화하는 방법 및 이의 용도
US20050261230A1 (en) * 1999-06-21 2005-11-24 Wraight Christopher J Method for the prophylaxis and/or treatment of medical disorders
KR100796817B1 (ko) * 2005-03-23 2008-01-22 정용지 모발과 피부의 치료를 위한 성장인자

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000074634A2 (fr) * 1999-06-03 2000-12-14 Au Jessie L S Methodes et compositions permettant de moduler la proliferation et la mort cellulaire
US20050261230A1 (en) * 1999-06-21 2005-11-24 Wraight Christopher J Method for the prophylaxis and/or treatment of medical disorders
KR20020018566A (ko) * 2000-09-01 2002-03-08 액티브 올가닉스 인코포레이티드 모노-아실-(리소)-글리세롤인지질로 국소 활성의 효능을강화하는 방법 및 이의 용도
KR100796817B1 (ko) * 2005-03-23 2008-01-22 정용지 모발과 피부의 치료를 위한 성장인자

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Publication number Publication date
KR101289062B1 (ko) 2013-07-22
KR20100129484A (ko) 2010-12-09
WO2010140795A3 (fr) 2011-04-21

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