WO2010134388A1 - Système de surveillance d'informations biologiques - Google Patents

Système de surveillance d'informations biologiques Download PDF

Info

Publication number
WO2010134388A1
WO2010134388A1 PCT/JP2010/056153 JP2010056153W WO2010134388A1 WO 2010134388 A1 WO2010134388 A1 WO 2010134388A1 JP 2010056153 W JP2010056153 W JP 2010056153W WO 2010134388 A1 WO2010134388 A1 WO 2010134388A1
Authority
WO
WIPO (PCT)
Prior art keywords
biological signal
biological
signal
value
threshold
Prior art date
Application number
PCT/JP2010/056153
Other languages
English (en)
Japanese (ja)
Inventor
誠 三原
修平 野口
毅史 中川
陽平 林
Original Assignee
Mihara Makoto
Noguchi Shuhei
Nakagawa Takashi
Hayashi Yohei
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mihara Makoto, Noguchi Shuhei, Nakagawa Takashi, Hayashi Yohei filed Critical Mihara Makoto
Publication of WO2010134388A1 publication Critical patent/WO2010134388A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons

Definitions

  • the present invention relates to a system and method for monitoring whether an abnormality has occurred in a living body.
  • a standard threshold value corresponding to the biological information can be used.
  • the standard threshold value can be changed according to age and sex.
  • a false positive alarm is an alarm that is transmitted because the threshold value is not appropriate although it is not abnormal. If a false positive alarm is transmitted, it will be a heavy burden on medical personnel such as doctors and nurses or accompanying nurses.
  • the present invention has been made in view of the above situation.
  • One of the objects of the present invention is to provide a biological information monitoring system or method that suppresses the occurrence of false positive alarms and does not require the accumulation of past data in principle.
  • the present invention is configured as described in any of the following items.
  • An input unit and a determination unit The input unit is configured to receive a first biological signal and a second biological signal, The second biological signal is a signal representing biological information of a different type from the first biological signal,
  • the determination unit (1) A process of automatically calculating a threshold for one of the first biological signal and the second biological signal based on the other value using a predetermined calculation formula; (2) A biological information monitoring system, wherein when one value of the first biological signal and the second biological signal exceeds the threshold, a process for generating an alarm command is performed. .
  • the living body includes not only human beings but also animals and plants, and further includes the concept of including cells and organs.
  • the determination unit is configured to recalculate a threshold value for the one biological signal and update the threshold value corresponding to the value of the other biological signal acquired at a predetermined time interval.
  • Biological information monitoring system The determination unit is configured to recalculate a threshold value for the one biological signal and update the threshold value corresponding to the value of the other biological signal acquired at a predetermined time interval.
  • each of the first biological signal and the second biological signal is a signal representing information about the body.
  • each of the first biological signal and the second biological signal is a signal representing information about a cell or an organ.
  • (Item 6) has an output unit, The living body according to any one of items 1 to 5, wherein the output unit is configured to transmit notification information to a user when receiving the alarm command generated by the determination unit.
  • Information monitoring system The living body according to any one of items 1 to 5, wherein the output unit is configured to transmit notification information to a user when receiving the alarm command generated by the determination unit.
  • the determination unit It is configured to generate or acquire a threshold corresponding to the other biological signal, Furthermore, when the value of the other biological signal does not exceed the threshold value corresponding to the other biological signal, the alarm command is not generated.
  • a biological information monitoring method comprising the following steps: (1) receiving a first biological signal and a second biological signal, wherein the second biological signal is a signal representing biological information of a different type from the first biological signal; (2) a step of automatically calculating a threshold value for one of the first biological signal and the second biological signal based on the other value by a predetermined calculation formula; (3) A step of generating an alarm command when one value of the first biological signal and the second biological signal exceeds the threshold value.
  • This computer program is stored in an appropriate recording medium (for example, an optical recording medium such as a CD-ROM or a DVD disk, a magnetic recording medium such as a hard disk or a flexible disk, or a magneto-optical recording medium such as an MO disk). Can be stored.
  • This computer program can be transmitted via a communication line such as the Internet.
  • the system according to the present embodiment includes various sensors 1, an input unit 2, a storage unit 3, a determination unit 4, an output unit 5, and an alarm device 6 as main components.
  • the sensor 1 various types of sensors for acquiring biological information can be used.
  • a plurality of sensors are indicated by reference numeral 1 as a whole.
  • the sensor 1 in this embodiment needs to acquire at least two types of biological information.
  • the following monitor can be used as a sensor in the present embodiment.
  • the above sensor is an example of a sensor, and other sensors can be used. Also, a plurality of sensors can be integrated to form one device. Even in such a case, in this specification, when a plurality of pieces of biological information can be acquired, it will be described as a plurality of sensors. Further, as the various cameras described above, an infrared camera can be used. When using a camera, it is possible to detect light such as chemiluminescence, bioluminescence, fluorescence, and visible light, which makes it possible to detect various biological information such as cell size, growth rate, and gene expression status. Become.
  • the input unit 2 is configured to receive a biological signal acquired from each sensor 1 described above.
  • a certain type of biological signal is referred to as a first biological signal
  • another type of biological signal is referred to as a second biological signal.
  • the second biological signal is a signal representing biological information of a different type from the first biological signal.
  • the input unit 2 may be configured to receive three or more types of biological signals.
  • the storage unit 3 is a part that stores various biological signals received by the input unit 2.
  • various storage media can be used.
  • the determination unit 4 is configured to perform the following processes (1) and (2).
  • (1) A process of automatically calculating a threshold value for one of the first biological signal and the second biological signal based on the other value using a predetermined calculation formula; (2) A process of generating an alarm command when one value of the first biological signal and the second biological signal exceeds a threshold value set therefor.
  • the output unit 5 receives an alarm command from the determination unit 4 and sends out an alarm command to the alarm device 6.
  • the alarm device 6 is for informing the user (patient, nurse, etc.) of the alarm based on the alarm command from the output unit 5.
  • the alarm device 6 typically, an alarm sound generator or a warning lamp lighting device can be used.
  • the alarm device 6 may be a transmission device for sending electronic mail to the user. In this case, the e-mail has a function as an alarm.
  • a device for making a call to a user's mobile phone or fixed phone may be used. In this case, a call to the telephone functions as an alarm.
  • Step SA-1 in FIG. 2 First, information from a living body is acquired using various sensors 1.
  • biological information acquired by an arbitrary sensor is referred to as a first biological signal
  • biological information acquired by another sensor is referred to as a second biological signal.
  • third and subsequent biological information exists.
  • the input unit 2 receives biological signals including the first biological signal and the second biological signal from the various sensors 1.
  • Each sensor 1 in the present embodiment periodically acquires a biological signal, and the input unit 2 grasps various biological information in real time.
  • Step SA-2 in FIG. 2 Next, the input unit 2 stores the biological signals acquired by the sensor 1 in the storage unit 3, respectively. Further, the input unit 2 sends each biological signal to the determination unit 4.
  • Step SA-3 in FIG. 2 the determination unit 4 automatically calculates a threshold value for at least one of the first biological signal and the second biological signal based on the other value using a predetermined calculation formula.
  • the threshold for the first biological signal is calculated based on the value of the second biological signal.
  • the threshold for the second biological signal may be calculated based on the value of the first biological signal or other biological signals.
  • the default calculation formula is set in advance by the setter. Specific examples of the calculation formula will be described in the examples described later.
  • each sensor 1 periodically or continuously acquires a biological signal, and the value of each biological signal is periodically updated.
  • the threshold value is recalculated and updated every time the value of the biological signal that is the basis of calculation is updated.
  • the value of the biological signal at the time of recalculation can be acquired and recalculated, and the threshold value can be updated.
  • Step SA-4 in FIG. 2 the determination unit 4 determines whether or not the value of the biological signal for which the threshold is set (the first biological signal in the above example) exceeds the set threshold. If it is determined that it exceeds, an alarm command is generated if conditions described later are satisfied.
  • Step SA-5 in FIG. 2 If the value of the biological signal does not exceed the threshold value, an alarm command is not generated. In this case, the determination by the determination unit 4 is performed again after waiting for the input of the next biological signal.
  • Steps SA-6 and SA-7 in FIG. 2 When the value of a certain biological signal (for example, the first biological signal) exceeds the set threshold value in the determination in step SA-4, the determination unit 4 continues with another biological signal (for example, the second biological signal). Check the status of the value. Specifically, it is determined whether the value of the second biological signal exceeds a threshold value corresponding to the second biological signal.
  • the threshold value for the second biological signal can be automatically calculated in the same manner as the threshold value for the first biological signal. Alternatively, the threshold for the second biological signal can be an appropriate predetermined value. Even if the first biological signal exceeds the threshold, if the second biological signal does not exceed the threshold, an alarm command is not generated (see step SA-5).
  • Step SA-8 in FIG. 2 On the other hand, if the result of determination in step SA-7 is that the second biological signal also exceeds the threshold value, the process proceeds to a process for issuing an alarm. That is, the determination unit 4 issues an alarm by the alarm device 6 via the output unit 5.
  • the threshold value for the acquired biological information can be automatically generated from the values of other biological information.
  • a mistake that the value is incorrectly set may occur.
  • since the threshold value is automatically set, such a mistake can be prevented.
  • a threshold for one piece of biological information is generated from the value of the other piece of biological information.
  • the other biological information serving as the basis of the threshold also represents a real-time situation of a specific biological body (for example, an individual). For this reason, in this embodiment, even if it does not use the historical information in a specific living body, there exists an advantage that it becomes possible to set a threshold appropriately according to individual difference of a living body.
  • a warning is not generated immediately, and the state of the other biological information is confirmed. Then, when the other biological information exceeds the threshold value, the process proceeds to a process for generating a warning.
  • specific biological information may show an abnormal value due to an attachment error or dropout during use. In such a case, it is possible to issue an alarm one by one, but in this case, false positive alarms are frequently generated, which imposes a heavy burden on medical personnel and nurses.
  • there is an advantage that the frequency of occurrence of false positive alarms can be reduced by not issuing an alarm unless the status of the other biological information is abnormal.
  • Example 1 A determination algorithm in the determination unit 4 when a cultured cell is assumed as a living body will be described.
  • logN A + Cexp ⁇ -exp [-B (tM)] ⁇ (For reference, for example, Kyushu University Agricultural Journal (Sei. Bull. Fac. AgL, KyushuUniv.) Vol. 61, No. 1, pp1-6 (2006 )).
  • This formula is derived from a modification of the Gompertz model.
  • N number of bacteria
  • A Logarithm of initial number of bacteria
  • C Increase in the number of bacteria in the stationary phase (logarithmic value)
  • B Value used to represent the maximum growth rate at time M
  • t temperature, B, C, and M are given as a function of NaCl concentration, temperature, and pH.
  • M is the time when the growth rate of the bacterium becomes maximum, and it can be predicted using values of NaCl concentration, temperature, and pH, although it can be accurately obtained through experiments.
  • the number of bacteria increases at 15 degrees and 20 degrees, so that the number of bacteria exceeds the threshold even in normal growth.
  • the threshold value for the number of bacteria is dynamically generated using the value, an alarm does not occur if the cell grows normally. Therefore, according to the first embodiment, it is possible to suppress the occurrence of a false positive alarm. Similarly, it is possible to suppress the occurrence of false positive alarms by setting conditions such as NaCl concentration and pH as one piece of biological information and generating a threshold value for the number of bacteria (the other biological information) based on this biological information. it can.
  • Estimated Mets The value of Mets estimated from the acceleration sensor is defined as estimated Mets.
  • HR (h) is obtained from the heart rate during exercise and the heart rate during rest, and the right side of the relational expression is calculated.
  • the estimated Mets is calculated by the acceleration sensor, and the left side of the relational expression is calculated using the estimated Mets. If the value on the right side exceeds the estimated Mets ⁇ 1.39 range, an alarm is activated. That is, the value of the left side, “estimated Mets ⁇ 1.39”, is the threshold value in this example.
  • the conventional monitoring system has a problem that an alarm is generated only when the heart rate increases due to exercise, despite being healthy. Such an alarm is a false positive alarm and is harmful.
  • the second embodiment by correcting the heart rate with Mets, the case where the heart rate is increased due to a disease at rest and the case where the heart rate is increased during exercise can be automatically distinguished and handled.
  • each embodiment described above can be implemented by incorporating appropriate computer software into the computer.
  • the computer software can be recorded on various computer-readable media.
  • the present invention can be applied to the use of preserving organs for transplantation.
  • the organ for transplantation is transported to a transplant destination patient in a state of being cooled and stored in physiological saline, a cryoprotectant, or an organ preservation solution.
  • physiological saline, a cryoprotectant, or an organ preservation solution hereinafter abbreviated as “organ etc.”.
  • a supercooled organ or the like becomes solid (ie, freezes) by changing external conditions.
  • a signal indicating an external condition applied to the organ for transplantation can be used as the first biological signal of the present invention.
  • the external conditions applied to the organ for transplantation are, for example, vibration, magnetic field strength, temperature, and a potential state in cells in the organ. And it is set as the temperature of an organ as a 2nd biological signal.
  • the threshold value in the second biological signal can be changed according to the fluctuation of the first biological signal. For example, if the vibration applied to the organ increases, the threshold for the lower limit of the organ temperature is increased. As a result, the possibility of freezing of the supercooled organ or the like can be reduced.
  • the iPS cell is an example of a pluripotent cell and a stem cell having self-proliferation ability, and this is a technology that is promising in the field of regenerative medicine.
  • the present invention can be used for preservation of iPS cells.
  • iPS cells other pluripotent cells and stem cells having self-proliferation ability can also be used.
  • the first biological signal includes, for example, the weight of the cultured cell colony in the iPS cell, the pH change of the drug solution, the extracellular potential, and the ion channel waveform (for example, Na peak or K peak).
  • the second biological signal is, for example, the cooling speed or storage temperature for iPS cells.
  • the viability of iPS cells can be maintained by setting the threshold value of the second biological signal using the first biological signal. Therefore, the present invention can also be applied to uses related to viability during freezing, storage and thawing of iPS cells.
  • the present invention can also be applied to sensing of a subject by a nursing robot or a life support robot.
  • a sensor in a nursing robot can be used as a sensor for acquiring the first biological signal or the second biological signal in the present invention. Accordingly, the robot can appropriately respond to the subject in accordance with the state of the subject.
  • iPS cells or cultured cells can be normally cultured can be determined by monitoring the culture conditions and other indicators of iPS cells or cultured cells using the present invention.
  • cell culture conditions such as temperature, carbon dioxide concentration, pH, etc. are defined as the first biological signal.
  • the number of cells is set as the second biological signal, and a threshold value of the second biological signal is generated from the first biological signal. If the apparatus for monitoring the second biological signal (parameter) and the apparatus for controlling the culture condition are attached to the incubator and the first biological signal (culture condition) is controlled while monitoring the second biological signal, The number of cells can be cultured.
  • the present invention can be used for monitoring for early detection of cancerous cells in cell culture.
  • iPS cells become cancerous.
  • the growth rate of cells differs (usually increases).
  • tumor marker value rises by canceration. If the test result (first biological signal) obtained by chromosome analysis or karyotype analysis is positive, the cell growth rate (this can be determined by the weight of the cell colony) and the tumor marker value Is the second biological signal, and the threshold value for this is changed. In this case, the upper limit value is lowered. As a result, the second biological signal is slightly increased from the normal value, so that it can be determined that the cancer is cancerous and an alarm can be generated.
  • test result (first biological signal) by chromosome analysis or karyotype analysis is negative, the upper limit value for the second biological signal is kept high.
  • the cell growth rate (second biological signal) or the tumor marker value (second biological signal) is slightly increased from the normal value, it is determined that the cancer is not cancerous, and the generation of a false alarm can be suppressed. it can.
  • the present invention can be used for monitoring for early detection of an infectious state in cell culture. This can be performed independently of the normal cell number monitoring.
  • iPS cells When culturing iPS cells, if iPS cells themselves or feeder cells for culturing iPS cells are infected with bacteria (for example, mycoplasma), cell culture is inhibited. First, it is determined by a DNA staining method or a PCR method whether or not the determination result of the infection in the cells (first biological signal) is positive. If it is positive, the proliferation speed of the number of cells (this can be judged by, for example, the weight of the cell colony) is set as the second biological signal, and the lower limit is increased. Thereby, even when the growth speed is slightly reduced, it can be determined that the patient is in an infectious state.
  • bacteria for example, mycoplasma
  • the infection determination result (first biological signal) by the DNA staining method or the PCR method is negative, the lower limit of the cell number proliferation speed (second biological signal) is kept low. As a result, even when the growth speed is slightly reduced, it is determined that there is no infection, and generation of false alarms can be suppressed.
  • each of the above-described components only needs to exist as a functional block, and does not have to exist as independent hardware.
  • a mounting method hardware or computer software may be used.
  • one functional element in the present invention may be realized by a set of a plurality of functional elements, and a plurality of functional elements in the present invention may be realized by one functional element.
  • the functional elements may be arranged at physically separated positions.
  • the functional elements may be connected by a network. It is also possible to realize functions or configure functional elements by grid computing.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

La présente invention concerne un système de surveillance d'informations biologiques ou un procédé afférent, l'occurrence d'une fausse alarme positive étant maintenue faible et l'accumulation de données préalables étant inutile en principe. Ledit système reçoit un premier signal biologique et un second signal biologique. Ledit second signal biologique est un signal représentant une sorte d'informations biologiques différente de celle représentée par le premier signal biologique. Le système calcule alors automatiquement le seuil du premier signal biologique ou du second signal biologique sur la base de la valeur de l'autre par une formule de calcul prédéfini. Le système produit une commande d'alarme lorsque la valeur du premier signal biologique ou du second signal dépasse le seuil.
PCT/JP2010/056153 2009-05-20 2010-04-05 Système de surveillance d'informations biologiques WO2010134388A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009122245 2009-05-20
JP2009-122245 2009-05-20

Publications (1)

Publication Number Publication Date
WO2010134388A1 true WO2010134388A1 (fr) 2010-11-25

Family

ID=43126076

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2010/056153 WO2010134388A1 (fr) 2009-05-20 2010-04-05 Système de surveillance d'informations biologiques

Country Status (1)

Country Link
WO (1) WO2010134388A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012115270A1 (fr) * 2011-02-25 2012-08-30 学校法人慶應義塾 Procédé de sélection d'un clone de cellule ips, et procédé de sélection d'un gène utilisé dans le procédé de sélection dudit clone
WO2013103053A1 (fr) * 2012-01-06 2013-07-11 京都府公立大学法人 Développement de procédé de discrimination simple des cellules souches embryonnaires et des cellules souches pluripotentes induites de faible qualité donnant des indications sur l'horloge biologique et développement d'un procédé d'évaluation de cellules donnant des indications sur de l'horloge biologique
JP2016178455A (ja) * 2015-03-19 2016-10-06 株式会社Ｎｔｔドコモ 情報処理装置、通知方法及びプログラム
CN117106577A (zh) * 2023-10-13 2023-11-24 北京万通益生物科技有限公司 一种基于物联网的乳酸菌热干法制备用环境监测系统

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006512168A (ja) * 2002-12-30 2006-04-13 カーディアック・ペースメーカーズ・インコーポレーテッド 拡張期血行動態を監視するための方法と装置
JP2007527776A (ja) * 2004-03-08 2007-10-04 マシモ・コーポレイション 生理的パラメータシステム
JP2008167933A (ja) * 2007-01-11 2008-07-24 Terumo Corp 状態監視装置および情報処理方法
JP2009028312A (ja) * 2007-07-27 2009-02-12 Omron Healthcare Co Ltd 活動量計

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006512168A (ja) * 2002-12-30 2006-04-13 カーディアック・ペースメーカーズ・インコーポレーテッド 拡張期血行動態を監視するための方法と装置
JP2007527776A (ja) * 2004-03-08 2007-10-04 マシモ・コーポレイション 生理的パラメータシステム
JP2008167933A (ja) * 2007-01-11 2008-07-24 Terumo Corp 状態監視装置および情報処理方法
JP2009028312A (ja) * 2007-07-27 2009-02-12 Omron Healthcare Co Ltd 活動量計

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012115270A1 (fr) * 2011-02-25 2012-08-30 学校法人慶應義塾 Procédé de sélection d'un clone de cellule ips, et procédé de sélection d'un gène utilisé dans le procédé de sélection dudit clone
JPWO2012115270A1 (ja) * 2011-02-25 2014-07-07 学校法人慶應義塾 ｉＰＳ細胞クローンの選択方法、及びその選択方法に用いる遺伝子の選択方法
WO2013103053A1 (fr) * 2012-01-06 2013-07-11 京都府公立大学法人 Développement de procédé de discrimination simple des cellules souches embryonnaires et des cellules souches pluripotentes induites de faible qualité donnant des indications sur l'horloge biologique et développement d'un procédé d'évaluation de cellules donnant des indications sur de l'horloge biologique
JPWO2013103053A1 (ja) * 2012-01-06 2015-05-11 京都府公立大学法人 体内時計を指標にした低品質ＥＳ細胞およびｉＰＳ細胞の簡易判別法の開発、体内時計を指標にした細胞評価法の開発
JP2016178455A (ja) * 2015-03-19 2016-10-06 株式会社Ｎｔｔドコモ 情報処理装置、通知方法及びプログラム
CN117106577A (zh) * 2023-10-13 2023-11-24 北京万通益生物科技有限公司 一种基于物联网的乳酸菌热干法制备用环境监测系统

Similar Documents

Publication Publication Date Title
JP6896915B2 (ja) 医療施設の複数のソースからのデータに基づく患者リスク評価
JP2008541235A5 (fr)
US11647967B2 (en) Generating automated alarms for clinical monitoring
CN104838382B (zh) 用于优化数据收集频率的方法、系统、介质及监测站
US9138144B2 (en) Adhesive bandage and a method for controlling patient information
WO2010134388A1 (fr) Système de surveillance d'informations biologiques
JP7108267B2 (ja) 生体情報処理システム、生体情報処理方法、及びコンピュータプログラム
US11908576B2 (en) Wearable sensor and healthcare management system using a wearable sensor
RU2012105300A (ru) Способ автоматической настройки предупреждения о меняющемся во времени параметре
JP2015513724A (ja) 急性肺損傷（ａｌｉ）／急性呼吸窮迫症候群（ａｒｄｓ）アセスメント及びモニタリング
JP2009136666A (ja) 生体信号測定システム及びこれを用いた健康管理サービス方法
CN112654286A (zh) 筛选结构性心脏病的设备、方法及系统
KR100647905B1 (ko) 수면 환경 제어 시스템 및 그 방법
KR102239557B1 (ko) 생체 신호 분석 알고리즘과 시스템 및 방법
CN110366385A (zh) 具有位置特定的情境警报的患者监测系统和方法
US10535244B2 (en) Patient monitoring system and method for activity tracking
CN104684472B (zh) 用于基于从氧饱和度下降的恢复响应对患者健康状况进行评估的系统和方法
KR20080114142A (ko) 코쿤형 육아 장치 및 이를 이용한 코쿤형 육아 관리 시스템
KR20230023624A (ko) 디지털 청진기에 의해 생성된 오디오 데이터의 분석을 통한 건강에 대한 통찰의 도출
Smith Vital signs: Vital for surviving in-hospital cardiac arrest?
US11694811B2 (en) Vital sign monitors for inpatient medicine wards
KR20180065039A (ko) 바이탈통합 의료장비를 이용한 스마트폰 유비쿼터스 헬스퀘어 진단시스템
Cuccaro et al. Carbapenem-resistant enterobacteriaceae: Don’t trust your neighbour
CN105792750A (zh) 创伤性脑损伤指南系统和方法
Gupta et al. Advanced telemedicine system for remote healthcare monitoring

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10777623

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 10777623

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: JP