WO2010130393A3 - Schmelztablette, enthaltend ein vardenafil-salz - Google Patents

Schmelztablette, enthaltend ein vardenafil-salz Download PDF

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Publication number
WO2010130393A3
WO2010130393A3 PCT/EP2010/002859 EP2010002859W WO2010130393A3 WO 2010130393 A3 WO2010130393 A3 WO 2010130393A3 EP 2010002859 W EP2010002859 W EP 2010002859W WO 2010130393 A3 WO2010130393 A3 WO 2010130393A3
Authority
WO
WIPO (PCT)
Prior art keywords
vardenafil
tablet containing
salt
orodispersible tablet
vardenafil salt
Prior art date
Application number
PCT/EP2010/002859
Other languages
English (en)
French (fr)
Other versions
WO2010130393A2 (de
Inventor
Ralph Stefan
Sandra Brueck
Original Assignee
Ratiopharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ratiopharm Gmbh filed Critical Ratiopharm Gmbh
Priority to EP10721683A priority Critical patent/EP2429528A2/de
Publication of WO2010130393A2 publication Critical patent/WO2010130393A2/de
Publication of WO2010130393A3 publication Critical patent/WO2010130393A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)

Abstract

Die Erfindung betrifft ein Verfahren zur Herstellung von Schmelztabletten enthaltend ein pharmazeutisch verträgliches Salz von Vardenafil, umfassend die Schritte (i) Herstellen einer Mischung enthaltend pharmazeutisch verträgliches Vardenafil-Salz, Schleimstoff, Süßungsmittel, Aromamittel, und (ii) Direktkompression der Mischung zu Schmelztabletten. Ebenfalls betrifft die Erfindung Tabletten, erhältlich gemäß dem erfindungsgemäßen Verfahren.
PCT/EP2010/002859 2009-05-12 2010-05-10 Schmelztablette, enthaltend ein vardenafil-salz WO2010130393A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10721683A EP2429528A2 (de) 2009-05-12 2010-05-10 Schmelztablette, enthaltend ein vardenafil-salz

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102009020888A DE102009020888A1 (de) 2009-05-12 2009-05-12 Schmelztablette, enthaltend ein Vardenafil-Salz
DE102009020888.7 2009-05-12

Publications (2)

Publication Number Publication Date
WO2010130393A2 WO2010130393A2 (de) 2010-11-18
WO2010130393A3 true WO2010130393A3 (de) 2011-10-20

Family

ID=42269437

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/002859 WO2010130393A2 (de) 2009-05-12 2010-05-10 Schmelztablette, enthaltend ein vardenafil-salz

Country Status (3)

Country Link
EP (1) EP2429528A2 (de)
DE (1) DE102009020888A1 (de)
WO (1) WO2010130393A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ303877B6 (cs) 2011-11-24 2013-06-05 Zentiva, K.S. Zpusob prípravy a izolace solí vardenafilu s kyselinami
US20160317542A1 (en) 2013-12-09 2016-11-03 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
JP2021506986A (ja) 2017-12-20 2021-02-22 クラリア・ファルマ・ホールディング・アクチボラグ バルデナフィルを含むフィルム配合物、その調製法、およびその使用
IT201900020350A1 (it) * 2019-11-05 2021-05-05 Alpex Pharma Sa Formulazione orodispersibile di vardenafil

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000040254A1 (en) * 1998-12-31 2000-07-13 Daewoong Pharmaceutical Co., Ltd. Pharmaceutical composition for oral administration having therapeutic activity on gastrointestinal disorders
WO2006058250A2 (en) * 2004-11-24 2006-06-01 Spi Pharma, Inc. Orally disintegrating compositions
WO2006092222A1 (de) * 2005-03-01 2006-09-08 Bayer Healthcare Ag Arzneiformen mit kontrollierter bioverfügbarkeit
WO2006092207A1 (de) * 2005-03-01 2006-09-08 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen eigenschaften

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA46166C2 (uk) 1997-11-12 2002-05-15 Баєр Акцієнгезельшафт 2-фенілзаміщені імідазотриазинони як інгібітори фосфодіестерази, спосіб їх одержання та лікарський засіб на їх основі
MX2008000087A (es) 2005-06-23 2008-03-18 Schering Corp Formulaciones orales rapidamente absorbentes de inhibidores de la fosfodiesterasa 5.
DE102007027067A1 (de) 2007-06-12 2008-12-18 Ratiopharm Gmbh Verfahren zur Herstellung eines Arzneimittels enthaltend Vardenafil Hydrochlorid Trihydrat

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000040254A1 (en) * 1998-12-31 2000-07-13 Daewoong Pharmaceutical Co., Ltd. Pharmaceutical composition for oral administration having therapeutic activity on gastrointestinal disorders
WO2006058250A2 (en) * 2004-11-24 2006-06-01 Spi Pharma, Inc. Orally disintegrating compositions
WO2006092222A1 (de) * 2005-03-01 2006-09-08 Bayer Healthcare Ag Arzneiformen mit kontrollierter bioverfügbarkeit
WO2006092207A1 (de) * 2005-03-01 2006-09-08 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen eigenschaften

Also Published As

Publication number Publication date
DE102009020888A1 (de) 2010-11-18
WO2010130393A2 (de) 2010-11-18
EP2429528A2 (de) 2012-03-21

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