WO2010127642A9 - Anticuerpos que reconocen sulfatidos y proteoglicanos sulfatados y su uso - Google Patents

Anticuerpos que reconocen sulfatidos y proteoglicanos sulfatados y su uso Download PDF

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Publication number
WO2010127642A9
WO2010127642A9 PCT/CU2010/000002 CU2010000002W WO2010127642A9 WO 2010127642 A9 WO2010127642 A9 WO 2010127642A9 CU 2010000002 W CU2010000002 W CU 2010000002W WO 2010127642 A9 WO2010127642 A9 WO 2010127642A9
Authority
WO
WIPO (PCT)
Prior art keywords
antibodies
sulphatides
recognize
present
sulphated
Prior art date
Application number
PCT/CU2010/000002
Other languages
English (en)
French (fr)
Other versions
WO2010127642A1 (es
Inventor
Cristina Mateo De Acosta Del Rio
Ana Maria Vazquez Lopez
Alejandro Lopez Requena
Yuniel Fernandez Marrero
Yosdel Soto Lopez
Victor Brito Navarro
Original Assignee
Centro De Inmunologia Molecular
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42355373&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2010127642(A9) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to AU2010244859A priority Critical patent/AU2010244859B2/en
Priority to US13/264,105 priority patent/US8470322B2/en
Priority to MX2011011665A priority patent/MX2011011665A/es
Priority to ES10721287.0T priority patent/ES2656849T3/es
Priority to SG2011080298A priority patent/SG175849A1/en
Priority to JP2012508894A priority patent/JP5354823B2/ja
Priority to BRPI1013991-5A priority patent/BRPI1013991B1/pt
Priority to CN201080019730.6A priority patent/CN102414222B/zh
Priority to RU2011149252/10A priority patent/RU2502744C2/ru
Priority to KR1020117024741A priority patent/KR101374263B1/ko
Application filed by Centro De Inmunologia Molecular filed Critical Centro De Inmunologia Molecular
Priority to CA2758994A priority patent/CA2758994C/en
Priority to EP10721287.0A priority patent/EP2428521B1/en
Publication of WO2010127642A1 publication Critical patent/WO2010127642A1/es
Publication of WO2010127642A9 publication Critical patent/WO2010127642A9/es
Priority to ZA2011/08832A priority patent/ZA201108832B/en
Priority to HK12108917.9A priority patent/HK1168362A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/323—Arteriosclerosis, Stenosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Cardiology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención está relacionada con el campo de la biotecnología Y particularmente con nuevos productos para ser usados en la salud humana. La presente invención proporciona nuevos anticuerpos monoclonales que reconocen de manera específica y con alta afinidad sulfátidos y proteoglicanos sulfatados. Los anticuerpos anti-sulfátidos y anti-proteoglicanos sulfatados descritos en la presente memoria descriptiva, proporcionan importantes agentes diagnósticos y terapéuticos para actuar sobre procesos patológicos asociados a la aparición de placas ateroscleróticas. Según esto, la invención proporciona composiciones farmacéuticas que comprenden los anticuerpos monoclonales de la invención o los fragmentos derivados de estos anticuerpos para su uso terapéutico y diagnostico asociado a enfermedades cardiovasculares. Adicionalmente la presente invención se relaciona con los fragmentos de los anticuerpos monoclonales que reconocen sulfátidos y proteoglicanos sulfatados, de modo que dichos fragmentos puedan ser usados en la terapia o el diagnostico de esta patología.
PCT/CU2010/000002 2009-05-04 2010-05-03 Anticuerpos que reconocen sulfatidos y proteoglicanos sulfatados y su uso WO2010127642A1 (es)

Priority Applications (14)

Application Number Priority Date Filing Date Title
EP10721287.0A EP2428521B1 (en) 2009-05-04 2010-05-03 Anti sulfatides and anti sulfated proteoglycans antibodies and their use
KR1020117024741A KR101374263B1 (ko) 2009-05-04 2010-05-03 항 황산염 및 항 항산화 프로테오글리칸 항체 및 이들의 용도
RU2011149252/10A RU2502744C2 (ru) 2009-05-04 2010-05-03 Антитела к сульфатидам и сульфатированным протеогликанам и их применение
ES10721287.0T ES2656849T3 (es) 2009-05-04 2010-05-03 Anticuerpos antisulfátidos y proteoglicanos antisulfatados y su uso
US13/264,105 US8470322B2 (en) 2009-05-04 2010-05-03 Anti sulfatides and anti sufated proteoglycans antibodies and their use
JP2012508894A JP5354823B2 (ja) 2009-05-04 2010-05-03 スルファチド及び硫酸化プロテオグリカンを認識する抗体並びにその使用
BRPI1013991-5A BRPI1013991B1 (pt) 2009-05-04 2010-05-03 Anticorpo monoclonal, composição farmacêutica, conjunto de reativos úteis no diagnóstico de lesões ateroscleróticas, e, uso de um anticorpo
AU2010244859A AU2010244859B2 (en) 2009-05-04 2010-05-03 Antibodies that recognize sulphatides and sulphated proteoglycans and the use thereof
MX2011011665A MX2011011665A (es) 2009-05-04 2010-05-03 Anticuerpos que reconocen sulfatidos y proteoglicanos sulfatados y su uso.
SG2011080298A SG175849A1 (en) 2009-05-04 2010-05-03 Antibodies that recognize sulphatides and sulphated proteoglycans and the use thereof
CN201080019730.6A CN102414222B (zh) 2009-05-04 2010-05-03 抗硫苷脂和抗硫酸化蛋白聚糖抗体及其用途
CA2758994A CA2758994C (en) 2009-05-04 2010-05-03 Antibodies that recognize sulphatides and sulphated proteoglycans and the use thereof
ZA2011/08832A ZA201108832B (en) 2009-05-04 2011-12-01 Antibodies that recognize sulphatides and sulphated proteoglycans and the use thereof
HK12108917.9A HK1168362A1 (en) 2009-05-04 2012-09-12 Antibodies that recognize sulphatides and sulphated proteoglycans and the use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CU2009-0071 2009-05-04
CU20090071A CU23736A1 (es) 2009-05-04 2009-05-04 Anticuerpos que reconocen sulfatidos y proteoglicanos sulfatados y su uso

Publications (2)

Publication Number Publication Date
WO2010127642A1 WO2010127642A1 (es) 2010-11-11
WO2010127642A9 true WO2010127642A9 (es) 2011-03-24

Family

ID=42355373

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CU2010/000002 WO2010127642A1 (es) 2009-05-04 2010-05-03 Anticuerpos que reconocen sulfatidos y proteoglicanos sulfatados y su uso

Country Status (21)

Country Link
US (1) US8470322B2 (es)
EP (1) EP2428521B1 (es)
JP (1) JP5354823B2 (es)
KR (1) KR101374263B1 (es)
CN (1) CN102414222B (es)
AR (1) AR076495A1 (es)
AU (1) AU2010244859B2 (es)
BR (1) BRPI1013991B1 (es)
CA (1) CA2758994C (es)
CL (1) CL2010000413A1 (es)
CU (1) CU23736A1 (es)
ES (1) ES2656849T3 (es)
HK (1) HK1168362A1 (es)
MX (1) MX2011011665A (es)
MY (1) MY158954A (es)
PE (1) PE20100808A1 (es)
RU (1) RU2502744C2 (es)
SG (1) SG175849A1 (es)
TW (1) TWI424852B (es)
WO (1) WO2010127642A1 (es)
ZA (1) ZA201108832B (es)

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770198A (en) 1988-05-18 1998-06-23 The Research Foundation Of The State Of New York Platelet-specific chimeric 7E3 immunoglobulin
US5196324A (en) 1989-12-15 1993-03-23 Eli Lilly And Company Monoclonal antibodies reactive with a human atheroma associated antigen
US20020018808A1 (en) 1990-12-10 2002-02-14 Alving Carl R. Vaccines against sterols
US5541296A (en) 1991-08-30 1996-07-30 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Monocyte adhesion protein and monoclonal antibody thereto
US6471965B1 (en) 1994-07-27 2002-10-29 Bio-Virus Research Incorporated Vaccine containing whole killed herpes viruses to prevent development of atherosclerotic plaque
JP4315257B2 (ja) * 1995-11-13 2009-08-19 生化学工業株式会社 新規コンドロイチン硫酸プロテオグリカン、そのコア蛋白質、それをコードするｄｎａおよびそれに対する抗体
AU721729B2 (en) 1996-05-01 2000-07-13 Avant Immunotherapeutics, Inc. Plasmid-based vaccine for treating atherosclerosis
CA2263316A1 (en) 1996-08-14 1998-02-19 Klara Berencsi Methods and compositions for preventing or retarding the development of atherosclerotic lesions
US6183752B1 (en) 1997-02-05 2001-02-06 Pasteur Merieux Serums Et Vaccins Restenosis/atherosclerosis diagnosis, prophylaxis and therapy
AU3817899A (en) 1998-04-15 1999-11-01 Inserm Therapy of atherosclerosis
US6808713B1 (en) 1998-12-28 2004-10-26 Aventis Pasteur Limited Chlamydia antigens and corresponding DNA fragments and uses thereof
US20030100508A1 (en) * 1999-02-24 2003-05-29 Maryline Simon Carbohydrate epitope mimic compounds and uses thereof
AR027591A1 (es) 2000-03-03 2003-04-02 Smithkline Beecham Biolog Inmunogeno para el tratamiento de la aterosclerosis; vacunas formuladas con dicho inmunogeno y procedimiento para el tratamiento o profilaxis de laaterosclerosis utilizando dicho inmunogeno.
SE0000855D0 (sv) 2000-03-15 2000-03-15 Karolinska Innovations Ab Antigenic composition useful as a vaccine against atherosclerosis
GB0121171D0 (en) 2001-08-31 2001-10-24 Glaxosmithkline Biolog Sa Vaccine
US20030105003A1 (en) 2001-04-05 2003-06-05 Jan Nilsson Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein
CU23007A1 (es) * 2001-04-06 2004-12-17 Ct De Inmunologia Molecular Ct De Inmunologia Mole Combinaciones inmunoterapéuticas para el tratamiencombinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos to de tumores que sobre-expresan gangliósidos
SE0302312D0 (sv) 2002-10-04 2003-08-27 Forskarpatent I Syd Ab Peptide-based passive immunization therapy for treatment of atherosclerosis
GB0305794D0 (en) 2003-03-13 2003-04-16 Glaxosmithkline Biolog Sa Vaccine
GB0305793D0 (en) 2003-03-13 2003-04-16 Glaxosmithkline Biolog Sa Vaccine
GB0305790D0 (en) 2003-03-13 2003-04-16 Glaxosmithkline Biolog Sa Novel Composition
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Also Published As

Publication number Publication date
HK1168362A1 (en) 2012-12-28
AR076495A1 (es) 2011-06-15
PE20100808A1 (es) 2011-01-07
CA2758994C (en) 2015-07-21
EP2428521A1 (en) 2012-03-14
RU2011149252A (ru) 2013-06-10
AU2010244859A1 (en) 2011-12-08
RU2502744C2 (ru) 2013-12-27
KR101374263B1 (ko) 2014-03-13
SG175849A1 (en) 2011-12-29
ES2656849T3 (es) 2018-02-28
BRPI1013991B1 (pt) 2021-08-31
JP5354823B2 (ja) 2013-11-27
US8470322B2 (en) 2013-06-25
MX2011011665A (es) 2012-06-01
AU2010244859B2 (en) 2014-05-29
CL2010000413A1 (es) 2011-02-25
MY158954A (en) 2016-11-30
KR20120016055A (ko) 2012-02-22
CN102414222B (zh) 2014-07-16
US20120121605A1 (en) 2012-05-17
WO2010127642A1 (es) 2010-11-11
CA2758994A1 (en) 2010-11-11
TW201103559A (en) 2011-02-01
CN102414222A (zh) 2012-04-11
BRPI1013991A2 (pt) 2016-04-05
TWI424852B (zh) 2014-02-01
EP2428521B1 (en) 2018-01-03
CU23736A1 (es) 2011-11-15
JP2012526056A (ja) 2012-10-25
ZA201108832B (en) 2012-08-29

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