WO2010126276A3 - Water-soluble sterol derivatives for lowering a cholesterol level, and method for preparing same - Google Patents

Water-soluble sterol derivatives for lowering a cholesterol level, and method for preparing same Download PDF

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Publication number
WO2010126276A3
WO2010126276A3 PCT/KR2010/002636 KR2010002636W WO2010126276A3 WO 2010126276 A3 WO2010126276 A3 WO 2010126276A3 KR 2010002636 W KR2010002636 W KR 2010002636W WO 2010126276 A3 WO2010126276 A3 WO 2010126276A3
Authority
WO
WIPO (PCT)
Prior art keywords
water
soluble
lowering
sterol derivatives
cholesterol level
Prior art date
Application number
PCT/KR2010/002636
Other languages
French (fr)
Korean (ko)
Other versions
WO2010126276A2 (en
Inventor
정대원
노승권
Original Assignee
Chung Dae-Won
Noh Seung-Kwon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chung Dae-Won, Noh Seung-Kwon filed Critical Chung Dae-Won
Publication of WO2010126276A2 publication Critical patent/WO2010126276A2/en
Publication of WO2010126276A3 publication Critical patent/WO2010126276A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The present invention relates to water-soluble sterol derivatives for lowering a cholesterol level and a method for preparing same. The method for preparing water-soluble sterol derivatives according to the present invention enables phytosterol intermediates and ethylene oxide to react in the presence of alkali metal or an alcoholate thereof under a solvent-free condition. The method of the present invention involves preparing water-soluble sterol derivatives for lowering a cholesterol level, which are soluble in water to a maximum of 3.5 wt % based on a sterol at a temperature of 4°C, and which are safer for the human body and thus can be valuably used as materials for water-soluble foods or medicine.
PCT/KR2010/002636 2009-04-28 2010-04-27 Water-soluble sterol derivatives for lowering a cholesterol level, and method for preparing same WO2010126276A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2009-0037255 2009-04-28
KR1020090037255A KR20100118418A (en) 2009-04-28 2009-04-28 Water-soluble sterol derivatives for reducing cholesterol and preparation thereof

Publications (2)

Publication Number Publication Date
WO2010126276A2 WO2010126276A2 (en) 2010-11-04
WO2010126276A3 true WO2010126276A3 (en) 2011-03-10

Family

ID=43032675

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/KR2010/002636 WO2010126276A2 (en) 2009-04-28 2010-04-27 Water-soluble sterol derivatives for lowering a cholesterol level, and method for preparing same
PCT/KR2010/002694 WO2010126308A2 (en) 2009-04-28 2010-04-28 Water-soluble sterol derivatives for lowering a cholesterol level and method for preparing same

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/002694 WO2010126308A2 (en) 2009-04-28 2010-04-28 Water-soluble sterol derivatives for lowering a cholesterol level and method for preparing same

Country Status (2)

Country Link
KR (1) KR20100118418A (en)
WO (2) WO2010126276A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100118418A (en) * 2009-04-28 2010-11-05 (주)유진사이언스 Water-soluble sterol derivatives for reducing cholesterol and preparation thereof
CN104370872B (en) * 2014-11-13 2016-05-04 张子剑 A kind of oxirane modification sheath stamen oil antiseptic and preparation method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000012167A (en) * 1999-03-04 2000-03-06 노승권 Water-soluble Sterol Derivatives for Lowering Cholesterol Level and Process for Preparing the Same
KR20000012170A (en) * 1999-03-10 2000-03-06 노승권 Intermediate Compounds for the Preparation of Water-soluble Sterol Derivatives for Lowering Cholesterol Level
KR20020012167A (en) * 1999-04-02 2002-02-15 내셔날 리서치 카운실 오브 캐나다 Water-soluble compositions of bioactive lipophilic compounds
KR20020029718A (en) * 2000-10-13 2002-04-19 노승권 Water Soluble Plant Sterol Derivatives for Lowering Cholesterol Level and Process for Preparing the Same
US20060183723A1 (en) * 2003-03-19 2006-08-17 Alfred Westfechtel Ethercarboxylic acid ester of sterol or stanol

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100118418A (en) * 2009-04-28 2010-11-05 (주)유진사이언스 Water-soluble sterol derivatives for reducing cholesterol and preparation thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000012167A (en) * 1999-03-04 2000-03-06 노승권 Water-soluble Sterol Derivatives for Lowering Cholesterol Level and Process for Preparing the Same
KR20000012170A (en) * 1999-03-10 2000-03-06 노승권 Intermediate Compounds for the Preparation of Water-soluble Sterol Derivatives for Lowering Cholesterol Level
KR20020012167A (en) * 1999-04-02 2002-02-15 내셔날 리서치 카운실 오브 캐나다 Water-soluble compositions of bioactive lipophilic compounds
KR20020029718A (en) * 2000-10-13 2002-04-19 노승권 Water Soluble Plant Sterol Derivatives for Lowering Cholesterol Level and Process for Preparing the Same
US20060183723A1 (en) * 2003-03-19 2006-08-17 Alfred Westfechtel Ethercarboxylic acid ester of sterol or stanol

Also Published As

Publication number Publication date
WO2010126308A2 (en) 2010-11-04
WO2010126308A3 (en) 2011-03-10
KR20100118418A (en) 2010-11-05
WO2010126276A2 (en) 2010-11-04

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