WO2010121341A2 - Composite bioactif pour réparation osseuse - Google Patents

Composite bioactif pour réparation osseuse Download PDF

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Publication number
WO2010121341A2
WO2010121341A2 PCT/BR2010/000144 BR2010000144W WO2010121341A2 WO 2010121341 A2 WO2010121341 A2 WO 2010121341A2 BR 2010000144 W BR2010000144 W BR 2010000144W WO 2010121341 A2 WO2010121341 A2 WO 2010121341A2
Authority
WO
WIPO (PCT)
Prior art keywords
bioactive
composite
bone repair
bone
matrix
Prior art date
Application number
PCT/BR2010/000144
Other languages
English (en)
Portuguese (pt)
Other versions
WO2010121341A3 (fr
Inventor
Catarine Bezerra Cavalcanti
Nereide Stela Santos MAGALHÃES
José Lamartine de Andrade AGUIAR
Original Assignee
Universidade Federal De Pernambuco - Ufpe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade Federal De Pernambuco - Ufpe filed Critical Universidade Federal De Pernambuco - Ufpe
Priority to PCT/BR2010/000144 priority Critical patent/WO2010121341A2/fr
Publication of WO2010121341A2 publication Critical patent/WO2010121341A2/fr
Publication of WO2010121341A3 publication Critical patent/WO2010121341A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Definitions

  • the present invention applies to the fields of health sciences, pharmacotechnics and biological tissue engineering.
  • the invention relates to bone tissue fixation, filling of critical bone tissue defects, osteoconduction and osteoinduction.
  • the invention applies to the controlled release of drugs and nanodevices.
  • the area of engineering of biological tissues it can be highlighted the use as bone substitutes with function of conduction and tissue induction.
  • the composite was also developed with the purpose of being used as fixation pins of bone tissue lesions or machined in the screw model with the same function and application. Another application is in the form of laminates to correct critical flat bone defects and also as fixation plates.
  • Composites are among the most commonly used materials for bioactive function bone repair in order to accelerate the process of osteoconduction and osteoinduction in the treatment of critical bone tissue defects. They may be derived from organic or inorganic matrices and reinforcements.
  • inorganic composites For matrix and reinforcement composites of inorganic origin, there are no systematic studies of cytotoxicity and biococompatibility. Its usual industrial application is used as packaging materials and components for machines and engines.
  • inorganic composites are bioactive and biocompatible products, specifically bioceramics and glass and titanium derivatives used particularly in dentistry, traumatology and orthopedics.
  • bioactivity and biocompatibility are inorganic derivatives that do not allow remodeling of organic tissues.
  • the organic matrix composites used for biological applications are mostly protein derivatives such as collagen from different animal sources. These products are biologically active and may lead to immune rejection responses.
  • the composites are also the alloys that present resistance and biointegration and are used as fixators and implants. Metal alloys remain in the tissues, are stable but do not allow remodeling.
  • materials for biological application should preferably be non-toxic, biocompatible, with adequate physical and chemical characteristics (good strength, flexibility, elastic deformation and purity) to different tissues and biointegrable inducing remodeling of the implant area.
  • materials for biological application should preferably be non-toxic, biocompatible, with adequate physical and chemical characteristics (good strength, flexibility, elastic deformation and purity) to different tissues and biointegrable inducing remodeling of the implant area.
  • Previous innovations for the same purpose utilizing microbial polysaccharides such as bacterial cellulose, carry out chemical processes by chemical modifications of the cellulose chain by adding functional groups (WO / 2009/039238).
  • the bioactive composite for bone repair presented here differs from what is currently known to be characterized as a product consisting entirely of organic, matrix and inorganic components, reinforcement, which together is bioactive, nontoxic, biocompatible, moldable, resistant, flexible and its obtaining process do not use chemical reactions or baths in solutions. It combines in one product properties of biocompatibility, biointegration and fixation of bone tissue.
  • the invention is a composite whose matrix is a polysaccharide and the reinforcement is a compound of inorganic origin (calcium hydroxide, hydroxyapatite and calcium phosphate).
  • the reinforcement was used to associate a bioactive induction in the composite, specific to bone tissue.
  • the reinforcement was used in different concentrations in relation to the matrix, to obtain composites with rupture resistance and different elastic deformation indices suitable to the specific applications of osteofixation, critical defects filling, osteoinduction, osteoconduction and osteorepation.
  • the reinforcement may be calcium hydroxide, hydroxyapatite or calcium phosphate, or a two to two combination of these in different proportions, or the three reinforcements combined in different proportions may be used.
  • the biopolymer must be emulsified to form the basic matrix at different concentrations for the addition of one of the reinforcements. Dispersion of components should be by agitation. Excess water should be removed which will result in a paste that can be shaped and dehydrated. The resulting mass is a resilient, resilient and elastically deformable composite.
  • the matrix relating to these experiments was of biological origin, composed entirely of sugars and glucuronic acid, organic components found as metabolic actives in living beings, including man.
  • Organic matrix is a polysaccharide consisting of sugars from natural sources that does not elicit an immune response of rejection like protein derivatives.
  • Bacterial expolysaccharide was obtained based on the production process described in PI9603700-8; PI0301912-8 and PI0504376-0.
  • the biopolymer was emulsified from a 1g volume weight suspensions of the biopolymer to 50 to 150mL of water, forming the base matrix at different concentrations for the specific addition of one or combination of reinforcement at concentrations of 0.01 to 3%. relative to the matrix.
  • experiments were performed with calcium hydroxide and calcium phosphate. Dispersion of the components was by continuous stirring for 30 minutes. Excess water was removed by filtration. The resulting paste was modeled by cold extrusion and compression between plates. Then the dough was dehydrated in a particle free environment.
  • the resulting mass is a non-toxic, bioactive, biocompatible, moldable, tear-resistant and elastically deformable composite.
  • the product to which the present invention relates exhibited calcium phosphate deposition on its surface, which is a precursor of hydroxyapatite, an organic material present in 90% of bone tissue.
  • a biodegradable natural product obtained from raw material from renewable sources as apatite-organic polymer composites is an attraction of various methods of manufacturing biomaterials as bone remodeling.
  • the invention relates to the development of a bioactive composite whose polymeric matrix is composed of polysaccharide.
  • As reinforcement calcium derivatives such as calcium hydroxide, apatite hydroxide, calcium phosphate are used to obtain bioactive composites with specificity for bone tissue.
  • the reinforcement was used at different concentrations in relation to the matrix to obtain modelable composites, with resistance to rupture and with different elastic deformation indices suitable to the specific applications of osteofixation, osteorepation, osteoinduction and osteoconduction for the treatment of bone tissue injuries. loss of substance including critical defects.
  • the invention is a composite whose matrix is a polysaccharide and the reinforcement is a compound of inorganic origin (calcium hydroxide, hydroxyapatite and calcium phosphate).
  • the reinforcement was used to associate a bioactive induction in the composite, specific to for bone tissue.
  • the reinforcement was used in different concentrations in relation to the matrix, to obtain composites with rupture resistance and different elastic deformation indices suitable to the specific applications of osteofixation, critical defects filling, osteoinduction, osteoconduction and osteorepation.
  • the biopolymer must be emulsified to form the basic matrix at different concentrations for the addition of one of the reinforcements. Dispersion of components should be by agitation. Excess water should be removed which will result in a paste that can be shaped and dehydrated. The resulting mass is a resilient, resilient and elastically deformable composite.
  • the matrix of these experiments is of biological origin, composed entirely of sugars and glucuronic acid, organic components found as metabolic actives in living beings, including man.
  • Organic matrix is a polysaccharide consisting of sugars from natural sources that does not elicit an immune response of rejection like protein derivatives.
  • Bacterial expolysaccharide was obtained based on the production process described in PI9603700-8; PI0301912-8 and PI0504376-0.
  • the biopolymer was emulsified from a 1g volume weight suspensions of the biopolymer to 50 to 150mL of water, forming the base matrix at different concentrations and the addition of one or the reinforcements or their association at a concentration of 0.01 to 3. , 0% of the matrix.
  • experiments were performed with calcium hydroxide and calcium phosphate. Dispersion of the components was by continuous stirring for 30 minutes. Excess water was removed by filtration. The resulting paste was modeled by cold extrusion and compression between plates. Then the dough was dehydrated in a safe environment with low level of particulate matter. The resulting mass is a non-toxic, bioactive, biocompatible, moldable, tear-resistant and elastically deformable composite.
  • the product to which the present invention relates exhibited calcium phosphate deposition on its surface, which is a precursor of hydroxyapatite, an organic material present in 90% of bone tissue.
  • a natural, biodegradable product obtained from raw materials from renewable sources such as apatite-organic polymer composites is an attraction of various methods of manufacturing biomaterials as bone remodeling.

Abstract

La présente invention trouve une application en médecine, en pharmacologie et en ingénierie des tissus biologiques. Elle concerne la mise au point d'un composite bioactif pour réparation osseuse, dont la matrice polymère est constituée de polysaccharide. Comme matière de renforcement, on utilise des dérivés de calcium tels que l'hydroxyde de calcium, l'hydroxyapatite et le phosphate de calcium, avec pour objectif d'obtenir des composés bioactifs à spécificité pour le tissu osseux. La matière de renforcement a été utilisée en concentrations différentes par rapport à la matrice en vue de l'obtention de composites modelables et usinés en modèles de vis, tiges et plaques résistant à la rupture et présentant différents indices de déformation élastique, qui conviennent à des applications spécifiques de fixation osseuse, de réparation osseuse, d'ostéoinduction et d'ostéoconduction pour le traitement de lésions du tissu osseux avec perte de substance, y compris les défauts critiques.
PCT/BR2010/000144 2009-04-22 2010-04-15 Composite bioactif pour réparation osseuse WO2010121341A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/BR2010/000144 WO2010121341A2 (fr) 2009-04-22 2010-04-15 Composite bioactif pour réparation osseuse

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BR000178/PE 2009-04-22
PCT/BR2010/000144 WO2010121341A2 (fr) 2009-04-22 2010-04-15 Composite bioactif pour réparation osseuse

Publications (2)

Publication Number Publication Date
WO2010121341A2 true WO2010121341A2 (fr) 2010-10-28
WO2010121341A3 WO2010121341A3 (fr) 2011-01-06

Family

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Family Applications (1)

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PCT/BR2010/000144 WO2010121341A2 (fr) 2009-04-22 2010-04-15 Composite bioactif pour réparation osseuse

Country Status (1)

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WO (1) WO2010121341A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9356548B2 (en) 2012-05-10 2016-05-31 Denso Corporation Vibration damping control apparatus for vehicle, vibration damping control system for vehicle, and vehicle motion control apparatus

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040030403A1 (en) * 2000-07-04 2004-02-12 Jean Guezennec Use of a polysaccharide excreted by the vibrio diabolicus species in bone repair
BRPI0504376A (pt) * 2005-10-06 2007-06-12 Univ Fed Pernambuco produção de exopolissacarideo celulósico sintetizado por sphingomonas paucimobilis a partir de melaço, xarope, rapadura, açúcar mascavo e caldo de cana de açúcar in natura para aplicação médica, farmacológica, fìsica e biológica
WO2009039238A2 (fr) * 2007-09-19 2009-03-26 Ut-Battelle, Llc Composite d'hydrogel d'hydroxyapatite déficient en calcium biorésorbable

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9603700A (pt) * 1996-08-27 1998-11-17 Melo Francisco De Assis Dutra Biopolímero produzido por materiais provenientes da cultura da cana-de-açúcar via microorganismo zooglea sp. para utilização nas áreas de química e bioquímica fio cirúrgico e membranas biodegradáveis
BR0301912A (pt) * 2003-05-14 2005-04-19 Univ Fed Pernambuco Gel obtido de polìmero produzido a partir da sìntese do melaço da cana-de-açúcar e de outros açúcares, via microorganismo zoogloea sp.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040030403A1 (en) * 2000-07-04 2004-02-12 Jean Guezennec Use of a polysaccharide excreted by the vibrio diabolicus species in bone repair
BRPI0504376A (pt) * 2005-10-06 2007-06-12 Univ Fed Pernambuco produção de exopolissacarideo celulósico sintetizado por sphingomonas paucimobilis a partir de melaço, xarope, rapadura, açúcar mascavo e caldo de cana de açúcar in natura para aplicação médica, farmacológica, fìsica e biológica
WO2009039238A2 (fr) * 2007-09-19 2009-03-26 Ut-Battelle, Llc Composite d'hydrogel d'hydroxyapatite déficient en calcium biorésorbable

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BARBOSA ET AL.: 'Polysaccharides as scaffolds for bone regeneration' ITBM-RBM vol. 26, 2005, ISSN 1297-9570 pages 212 - 217 *
DING, SHINN-JYH: 'Preparation and properties of chitosan/calcium phosphate composites for bone repair' DENTAL MATERIALS JOURNAL vol. 25, no. 4, 2006, ISSN 0109-5641 pages 706 - 712 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9356548B2 (en) 2012-05-10 2016-05-31 Denso Corporation Vibration damping control apparatus for vehicle, vibration damping control system for vehicle, and vehicle motion control apparatus

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Publication number Publication date
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