WO2010112503A1 - Verwendung der herzratenvariabilitätsänderung zur korrelation von magnetfeldänderungen mit der physiologischen befindlichkeit und verfahren dafür - Google Patents
Verwendung der herzratenvariabilitätsänderung zur korrelation von magnetfeldänderungen mit der physiologischen befindlichkeit und verfahren dafür Download PDFInfo
- Publication number
- WO2010112503A1 WO2010112503A1 PCT/EP2010/054191 EP2010054191W WO2010112503A1 WO 2010112503 A1 WO2010112503 A1 WO 2010112503A1 EP 2010054191 W EP2010054191 W EP 2010054191W WO 2010112503 A1 WO2010112503 A1 WO 2010112503A1
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- WO
- WIPO (PCT)
- Prior art keywords
- magnetic field
- change
- heart rate
- test subject
- rate variability
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
- A61B5/0245—Detecting, measuring or recording pulse rate or heart rate by using sensing means generating electric signals, i.e. ECG signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
- A61B5/02405—Determining heart rate variability
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
Definitions
- Non-thermal effects can occur when the power is low to very low. These effects are not based on warming of tissue, but lead through different other mechanisms to changes in the body.
- Athermal effects can have a negative impact on the body in terms of stress, functional changes in cells, organs or cellular processes and cell rhythms, as well as organic diseases or DNA damage.
- the electromagnetic field in the ultra-low frequency range up to 15 Hz exerts a central and decisive control function on biological processes in cells, plants, animals and humans.
- IMF field Low homogeneity of the IMF field interferes with the biological processes of organisms in different ways. It represents, especially with prolonged exposure, a stressful situation for living beings and can manifest to a variety of symptoms up to manifest. Cause illness.
- Extremely long-acting stimuli can also trigger overload reactions in the area of electromagnetic radiation in the sense of hypersensitivity or "allergy" to the corresponding causative agent. This effect known from allergology can also occur in connection with roslectrosmog. If a person comes in contact with the appropriate frequency, sometimes even very high-risk states can be triggered (localized or generalized convulsions, pain, numbness, tinnitus, dizziness, headache, sleep attacks, etc.)
- the object of the present invention was thus to provide an objectified approach for studying the influence of magnetic fields and, in particular, due to the omnipresence of magnetic fields in the environment of the influence of specific changes of magnetic fields on organisms, in particular humans.
- Heart rate variability determination is a recognized method of objectified evaluation of the physiological
- heart rate variability analysis was based originally based on the observation that in heart failure patients or in patients with cardiac insufficiency and thus a high cardiac risk, the heart rate variability is compromised and the heart almost one kind of emergency program monotonous and less variable than in healthy persons.
- the invention is directed to the use of an apparatus for analyzing heart rate variability for determining changes in the physiological state of a test subject due to a change in a magnetic field applied to the test subject, comprising analyzing the heart rate variability of the test subject before and after each change of the test subject acting magnetic field.
- the invention is directed to a method for determining changes in the physiological state of a test subject based on its heart rate variability due to a change in a magnetic field applied to the test subject, comprising the steps of:
- the test subject is a mammal, and more preferably a human.
- other types are also testable if they have a corresponding regulatory system that varies the heart rate.
- the renewed analysis of the heart rate viability can also be carried out only after 1 to 30 days after changing the magnetic field, so that even longer-term influences due to the magnetic field change that do not occur immediately after the change can be detected.
- both measurements can be combined, so an immediate measurement and a subsequent control measurement can be performed.
- analyzing the heart rate viability involves several steps:
- the analyzing may further include generating a
- R-value which numerically reflects the quality of the physiological state of the test subject over the measurement period.
- the R value which will be described in more detail below, is an accepted measure for easy evaluation of heart rate variability in a single number.
- the invention comprises m another preferred
- Embodiment further, the use of a device for measuring the magnetic field acting on the test subject, for correlation of the magnetic field change with the change of the physiological state of the test subject.
- a measurement of the magnetic field can be carried out in a frequency range of 0 to 15 Hz of oscillating or fluctuating magnetic fields. Frequencies in the ultra-low frequency spectrum are currently suspected to have a strong impact on living organisms, including To have people and are therefore in the focus of interest.
- the frequency range of 0-15 Hz is particularly preferred for measurements to avoid interferences with influences of technical frequencies (beginning with 16 2/3 Hz at
- the measurement is on a plane at a spatial location where the test subject is at least partially present during analysis of heart rate variability, the measurement comprising the following steps.
- the area should be dimensioned so that it can capture the significant influences of the magnetic field on the test subject.
- the orientation of the measuring plane for example horizontal or vertical
- the orientation of the measuring plane also plays a role and is adapted to the question.
- the change of the magnetic field can be easily and predictably performed where only a single magnetic field source dominates (the geomagnetic field can be considered as given). Especially in the
- the change of the magnetic field can be carried out taking into account the measured magnetic field homogeneity by either making changes which increase the homogeneity of the magnetic field or by making a change due to previously performed passes of metrologically tracked magnetic field changes and to them
- Changes in heart rate variability of a test subject may be expected to result in a desired change in heart rate variability. It has been found that the majority of subjects respond favorably to a homogeneous magnetic field. However, there may also be instances where a beneficial effect, as seen by changes in heart rate variability, is achieved in non-homogeneous magnetic fields. In such a case, as well as experimentally evoked magnetic field changes, one may resort to analyzes of previous changes and measurements to influence the magnetic field applied to the test subject in any direction, for example by installing equipment to generate corresponding magnetic fields in the test subject, for example his workplace.
- the analysis of the heart rate variability can be carried out over different periods of time, for example before and after the magnetic field change individually for in each case between 2 min and 48 h, or preferably before and / or after the magnetic field change for 3 and / or 5 min
- the analysis of heart rate variability may be performed before and / or after the magnetic field change over a period of 10 to 30 hours ⁇ long term measurement).
- Default values for performing the HRV measurement are 5 min and 24 h.
- a second analysis of heart rate variability after the magnetic field change is made after 1 to 6 weeks, for example also to be able to record longer-term effects of the magnetic field change for the test subject.
- the change of the magnetic field is carried out by switching on or off of devices emitting electromagnetic waves, the spatial displacement of electric or radio radiation emitting devices in / from the vicinity of the measuring field, the placement or removal of permanent magnets in / from the magnetic field, and / or attaching or removing shielding devices around the test subject or electromagnetic radiation sources.
- Shielding devices include e.g. Metallic or metallized films, plates, nonwovens or fabrics, which already prevent the irradiation of the electromagnetic waves. Although permanent magnets do not affect the oscillation of the magnetic field as such (when examining an oscillating magnetic field), they may cause a shift in the amplitudes.
- the use of heart rate variability analysis according to the invention has numerous advantages.
- the measuring method takes into account the linearity and complexity of the human organism. Insights into the self-organization of organisms are included as well as chaotic or fractal phenomena. Improvements or deteriorations in a dynamic system, such as the animal organism, are easily quantifiable. This complex requirement is currently only met by the HRV measurement.
- the body reactions to changes in the homogeneity of the UlSfF field start immediately, usually within seconds to minutes.
- the HRV measurement method fulfills the requirement to be able to detect changes in the human regulatory system immediately and immediately (that is, in real time).
- the HRV measurement method is able to detect the finest changes in the regulatory system of the animal body.
- the measurement is purely technical and is not influenced by the operator. The operator is not part of the measuring system.
- energy and information-medical measuring methods are capable of recording subtle changes in the body, they are usually dependent on the operator's involvement in the measurement itself, eg by operating a measuring stylus, and mostly on its fate and experience dependent.
- the HRV measurement is a recognized and well-understood procedure in other areas of the study of factors influencing the physiological condition.
- the HRV measuring method represents a standardized medical-technical procedure.
- the HRV measurement is stored with globally valid task force parameters. (Task Force 1996).
- the invention can be used in various fields.
- a use in the field of building health where a possible influence of magnetic fields on the inhabitants should be minimized, just as possible as in the scientific field, to investigate the influence of spatially / temporally targeted changed magnetic fields on laboratory animals.
- HRV heart rate variability
- HRV like the measurement of erythrocyte sedimentation rate, is an unspecific, but highly sensitive, method that already reacts to minimal changes in the biological system.
- the heartbeat of a mammal is, roughly and simply said, regulated on the one hand by the sympathetic, on the other hand by the parasympathetic nervous system.
- the stronger expression, the increased dominance of one or the other parts of this antagonistic system can now be read in the HRV, which can be used for the interpretation of the data on familiar to the expert guidelines.
- the HRV can thus also be considered as a measurement system for the stress level of a biological system.
- HRV is firstly a non-invasive procedure and secondly a real-time measurement, which brings great benefits.
- the short-term HRV allows the following assessments:
- the long-term HRV also allows the following assessments, especially in humans. Generally:
- SDNN standard deviation of all NN intervals
- SDNN-i mean of the standard deviations of all NN intervals for all five-minute sections at 24-hour recording
- SDANN Standard deviation of the mean value of the NN intervals in all five minutes of the total recording.
- SDANN-i Standard deviation of the mean normal MN interval for all five-minute intervals at one
- r-MSSD square root of the square mean of the sum of all differences between adjacent NN intervals
- pNN50 percentage of intervals with at least 50 ms deviation from the previous interval (higher values indicate increased parasympathetic activity)
- SDSD standard deviation of the differences between adjacent NN intervals
- NN50 Number of pairs of adjacent NN intervals that deviate more than 50 ms from each other in the entire recording.
- RI Relaxation Index
- the RI 1 / SI
- the RI is a measure of the recovery ability of the organism.
- Age-corrected norm 50 '% VI (variability index):
- HRV triangular index integral of the density distribution (number of all NN intervals divided by the maximum (height) of the density distribution)
- TIMN Length of the base of the minimum quadratic difference of the triangular interpolation for the highest value of the histogram of all NN-intervals
- a system suitable for practicing the invention provides, for example, the ProQuant Medical Equipment Trade GmbH, Graz, AT, under the
- Type designation "Cardio test”.
- 3 ECG electrodes are applied (below the left and right axilla and left iliac crest).
- the electrodes are connected to the HRV device by means of one electrode cable each.
- test object is lying or sitting quietly, should not move or speak as much as possible.
- the heart rate is recorded. This recording of the heartbeat rhythm can be followed by a graphic window showing the frequency response.
- the first measurement started is referred to as a "reference measurement.” It represents the initial state of a person and is stored in a log with a date and time, and then manipulation of any kind that affects biological processes, such as the magnetic field change carried out according to the invention on a test subject can then be followed by a further measurement, which is referred to as "control measurement” or final measurement.
- the results of the control measurement are automatically compared by a software with the reference measurement. Qualitative or quantitative differences to the reference measurement are shown graphically and in numbers.
- the software used by way of example generates
- Score charts with multiple graph windows that can be evaluated by the user.
- the "R Value” graph shows the sum of the individual results, with 50% of the healthy average population.
- the graph window "Change” shows the difference between the two measurements: Negative values for deterioration are shown in red in the diagram, improvements are displayed as positive values and in green.
- the diagram window "Balance” shows the degree of activation of the sympathetic ("activation") or parasympathetic ("relaxation") A clear change is present when a percentage difference between two measurements, for example, between the two according to the invention before and after the change of the Magnetic field measurements of at least 20% in one direction
- the initial state of a test subject is determined by reference measurement. Subsequently, a change of the magnetic field, for example, the UNF field is performed.
- the measurement by means of a long-term HRV device enables the detection of longer exposure periods.
- Such a measurement may be useful, for example, if small changes in the physiological condition of a test subject are to be recorded or if it is to be expected that the influence of the magnetic field is lower, so that its changes correspondingly result in a smaller change in the HRV analysis becomes.
- fluctuations which are due to influences other than the magnetic field change are more easily compensated on the basis of their character usually over the measuring period (for example stress level, hunger / thirst, sleep deficits, etc.). It must be ensured that the test subject has a sufficiently long Period during Gesatnt measuring time at the desired exposure to parts of a magnetic field stops. It can be assumed, for example, that when measured at a workstation with a typical working time of 8 hours, a 24-hour long HRV measurement still yields results in which the influence of the magnetic field change clearly impacts the overall result when comparing two performed HRV measurements.
- An exemplary HRV recorder from the company ProQuant is about the size of a matchbox ⁇ 5 x 2 x 1 cm), and a weight of only 25 grams. He is attached to the chest with the help of a patch. Two electrodes for receiving the heartbeat signal are connected to the HRV recorder and also glued to the chest and worn for 24 hours to record heart rate data.
- test subject human
- HRV recorder for. he sends the device including both electrodes according to the enclosed description. Then the memory is pushed into the intended opening, by latching the memory, the measurement is started automatically.
- the recorder remains on the body of the subject for 24 hours, whereby neither everyday activities nor sleep are restricted or hindered by the device.
- the laptop reads out the data stored in the memory.
- Example 3
- the R value (regulation value) is displayed as an average of several HRV parameters (RMSSD, SDNN, VI, RI) and thus reflects the overall regulatory status of the patient.
- RMSSD HRV parameter
- SDNN HRV parameter
- VI VI
- RI HRV parameter
- the main parameter which represents the sum of variables, is again the R-value ("short-term measurement"), numerically it represents the quality of the total regulation over 24h.
- LF low frequency 0.04 - 0.15 Hz
- vasomotor center HF high frequency 0.15-0.4 Hz parasympathetic High Frequency (HF) blue
- LFl Low Frequency 1
- LF2 Low Frequency 2
- VLF very low Frequency
- the so-called power spectrum which is also represented in a graph by the software, corresponds to the quantitative distribution of the individual spectral frequencies.
- the frequencies are plotted in Hertz (Hz) from 0.0 to 0.40 Herta (Hz) for orientation.
- Hz Hertz
- Hz Herta
- a color representation allows the interpretation of the respective frequency components, wherein the blue to green color spectrum means no to small proportions and the yellow to red color spectrum medium to high proportions of the corresponding frequency.
- a precision parameter 05/40 from the manufacturer IIREC, Linz, AT with a deviation of max. 0.5% with a vertical magnetic induction of 40 microtesla and a frequency range of 0-18 Hz is assumed below.
- the device detects the vertical magnetic flux density over a regular square grid with distances of 10cm on a surface of 1x1 m, in sleeping places of
- Ix2m for laboratory measurements also 0.5 x 0.5m with 5cm distance.
- the values in microtesla measured at the grid points are interpolated by means of a data analysis program and displayed as a 2D diagram.
- the two-dimensional evaluation graph illustrates the immediate measurement result, the distribution of the vertical magnetic flux density (in microtesla). Lines connect points of equal vertical flux density (similar to contour lines). The intervening surfaces are colored.
- the graph shows for each measurement point the biologically effective stimulus intensity, which results from inhomogeneities of the magnetic field. Calculated for this size is a unit Millitesla / m 2 . In the illustration, a small disc appears at each measuring point whose diameter is proportional to the stimulus intensity of the measuring point. The corresponding assessment value is entered above.
- the graphic results represent an individual biophysical assessment of the field conditions.
- the spatial distribution of the stimulus points or stimulus zones the strength of the stimulus points or stimulus zones
- the assessment includes: - a case-related assessment based on the
- Type P point
- Type L line
- Type A area
- Type WP working place
- Workplace Type LP living place
- Other stay eg living room If the method is to be used to improve the physiological state of test subjects, there is a need for magnetic field changes from the type of place of residence and the maximum strength of the stimulus points or stimulus zones. It is graded according to a well-known scale as follows:
- the measuring grid is adjusted at chest height of the person normally located in this place.
- Measuring grid defined measuring area in a grid of 10cm. The measured value of each measured point is entered into the measuring software on the laptop.
- the measurement data are sent via the Internet to the evaluation portal, as a result, again via the Internet, a complete measurement protocol (see above) including short classification of the measured site with regard to its biological quality.
- a complete measurement protocol see above
- R-value regulation value
- An HRV recorder (s.o.) is sent by post to the person whose work or sleeping space is to be measured.
- the test person places the measuring device together with the electrodes according to the enclosed description, starts the measurement by inserting the memory module, and takes the device off again after 24 hours. The measurement is ended automatically by removing the memory. The subject then sends the device and memory back.
- a measuring technician goes on-site and performs the magnetic field measurement. The measurement is also evaluated.
- the measurement technician receives an overall evaluation of both measurements and the further recommended / necessary 1 steps not required are automatically specified in writing.
- Example 5 For demonstration purposes, the HRV measurement is combined with a magnetic field measurement according to Example 4, and a rating as described in Example 5 is used.
- test subject a German businessman, had sleep disturbances, reported stress symptoms and burn-out conditions; suffered from impaired concentration and recurrent urinary tract infections. He put this stress subjectively on his professional burdens. It was in the example due to the described sleep disorders first measured the sleeping space and not the workplace.
- FIG. Fig. 1 illustrates the immediate measurement result as a distribution of the vertical flux density m mT.
- the lines connect points of the same vertical flux density.
- the intervening surfaces are highlighted in different colors, which is rendered as grayscale.
- the coordinates are long in m
- the normal value in Central Europe is approximately 42 mT.
- the measured values lie between 10 and 80 mT, which already shows a strong inhomogeneity of the magnetic field at the sleeping place.
- 2 shows the result of a mathematical evaluation by means of the evaluation software supplied with the device. For each measuring point, it shows the biologically effective stimulus intensity which results from the inhomogeneities of the measuring field. This great one has the unit [mT / m 2 ].
- the exemplary measured sleeping place is the following
- the case-related assessment yields many points of irritation distributed over the entire measurement field.
- the first long-term HRV measurement performed on the test subject according to the invention yields the result shown in FIG. 3 that represents the "balance" of the measurement.
- FIG. 3 represents the "balance" of the measurement.
- the second HRV analysis according to the invention gave the result shown in FIG. 6 at the R value.
- the curve has shifted significantly, the physiological state is significantly better, recognizable by the fact that the R-value compared to the first measurement has risen from 32% to 66%.
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Abstract
Description
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Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SG2011071792A SG175028A1 (en) | 2009-04-02 | 2010-03-30 | Use of the heart rate variability change to correlate magnetic field changes with physiological sensitivity and method therefor |
AU2010230281A AU2010230281A1 (en) | 2009-04-02 | 2010-03-30 | Use of the heart rate variability change to correlate magnetic field changes with physiological sensitivity and method therefor |
EP10719279A EP2413789A1 (de) | 2009-04-02 | 2010-03-30 | Verwendung der herzratenvariabilitätsänderung zur korrelation von magnetfeldänderungen mit der physiologischen befindlichkeit und verfahren dafür |
US13/262,114 US20120078079A1 (en) | 2009-04-02 | 2010-03-30 | Use of the heart rate variability change to correlate magnetic field changes with physiological sensitivity and method therefor |
CA2757401A CA2757401A1 (en) | 2009-04-02 | 2010-03-30 | Use of the heart rate variability change to correlate magnetic field changes with physiological sensitivity and method therefor |
IL215477A IL215477A0 (en) | 2009-04-02 | 2011-10-02 | Use of the heart rate variability change to correlate magnetic field changes with physiological sensitivity and method therefor |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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DE102009002134.5 | 2009-04-02 | ||
DE102009002134.5A DE102009002134B4 (de) | 2009-04-02 | 2009-04-02 | Verfahren zur Erfassung einer Änderung des Regulationssystems eines menschlichen Testsubjekts anhand seiner Herzratenvariabilität aufgrund von Änderungen der Inhomogenität eines auf das Testsubjekt einwirkenden Magnetfelds |
Publications (1)
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WO2010112503A1 true WO2010112503A1 (de) | 2010-10-07 |
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Family Applications (1)
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PCT/EP2010/054191 WO2010112503A1 (de) | 2009-04-02 | 2010-03-30 | Verwendung der herzratenvariabilitätsänderung zur korrelation von magnetfeldänderungen mit der physiologischen befindlichkeit und verfahren dafür |
Country Status (8)
Country | Link |
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US (1) | US20120078079A1 (de) |
EP (1) | EP2413789A1 (de) |
AU (1) | AU2010230281A1 (de) |
CA (1) | CA2757401A1 (de) |
DE (1) | DE102009002134B4 (de) |
IL (1) | IL215477A0 (de) |
SG (1) | SG175028A1 (de) |
WO (1) | WO2010112503A1 (de) |
Cited By (1)
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AT516204A1 (de) * | 2014-08-29 | 2016-03-15 | Peter R Mmag Hauschild | Verfahren und Anordnung zur Analyse der Interaktion von elektromagnetischen Hochfrequenz-Immissionen mit vegetativen Regulationsmechanismen eines Testsubjekts |
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DE102013007448A1 (de) * | 2013-05-02 | 2014-11-20 | Rayonex Biomedical Gmbh | Verfahren zum Betrieb eines Bioresonanzgeräts |
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2009
- 2009-04-02 DE DE102009002134.5A patent/DE102009002134B4/de not_active Expired - Fee Related
-
2010
- 2010-03-30 CA CA2757401A patent/CA2757401A1/en not_active Abandoned
- 2010-03-30 AU AU2010230281A patent/AU2010230281A1/en not_active Abandoned
- 2010-03-30 US US13/262,114 patent/US20120078079A1/en not_active Abandoned
- 2010-03-30 EP EP10719279A patent/EP2413789A1/de not_active Withdrawn
- 2010-03-30 SG SG2011071792A patent/SG175028A1/en unknown
- 2010-03-30 WO PCT/EP2010/054191 patent/WO2010112503A1/de active Application Filing
-
2011
- 2011-10-02 IL IL215477A patent/IL215477A0/en unknown
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AT516204A1 (de) * | 2014-08-29 | 2016-03-15 | Peter R Mmag Hauschild | Verfahren und Anordnung zur Analyse der Interaktion von elektromagnetischen Hochfrequenz-Immissionen mit vegetativen Regulationsmechanismen eines Testsubjekts |
AT516204B1 (de) * | 2014-08-29 | 2016-07-15 | Peter R Mmag Msc Hauschild | Verfahren und Anordnung zur Analyse der Interaktion von elektromagnetischen Hochfrequenz-Immissionen mit vegetativen Regulationsmechanismen eines Testsubjekts |
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DE102009002134B4 (de) | 2014-10-23 |
EP2413789A1 (de) | 2012-02-08 |
IL215477A0 (en) | 2011-12-29 |
DE102009002134A1 (de) | 2010-10-28 |
SG175028A1 (en) | 2011-11-28 |
CA2757401A1 (en) | 2010-10-07 |
AU2010230281A1 (en) | 2011-12-22 |
US20120078079A1 (en) | 2012-03-29 |
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