WO2010110602A3 - 인간 성체 줄기세포 또는 전구세포를 이용한 흑질 치밀부에서의 도파민 신경세포의 재생방법 - Google Patents

인간 성체 줄기세포 또는 전구세포를 이용한 흑질 치밀부에서의 도파민 신경세포의 재생방법 Download PDF

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Publication number
WO2010110602A3
WO2010110602A3 PCT/KR2010/001820 KR2010001820W WO2010110602A3 WO 2010110602 A3 WO2010110602 A3 WO 2010110602A3 KR 2010001820 W KR2010001820 W KR 2010001820W WO 2010110602 A3 WO2010110602 A3 WO 2010110602A3
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WO
WIPO (PCT)
Prior art keywords
adult stem
human adult
stem cells
dopaminergic neurons
substantia nigra
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PCT/KR2010/001820
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English (en)
French (fr)
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WO2010110602A2 (ko
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임진호
이영재
맹성호
고성은
Original Assignee
(주)마리아 바이오텍
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Publication of WO2010110602A2 publication Critical patent/WO2010110602A2/ko
Publication of WO2010110602A3 publication Critical patent/WO2010110602A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본원발명은 인간 성체 줄기세포 또는 이를 체외에서 배양한 신경 전구세포로부터 도파민 신경세포를 재생 또는 복원시키는 방법에 관한 것이며, 특히, 인간 성체 줄기세포 및 이를 분화시킨 신경 전구세포를 이용하여 흑질 치밀부에서 도파민 신경세포를 재생하거나 복원하는 방법에 관한 것으로, 파킨슨 질환과 같은 신경계 질환에서 세포 대체 요법을 위한 효율적인 공급원으로서 기능할 수 있다.
PCT/KR2010/001820 2009-03-24 2010-03-24 인간 성체 줄기세포 또는 전구세포를 이용한 흑질 치밀부에서의 도파민 신경세포의 재생방법 WO2010110602A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2009-0024759 2009-03-24
KR1020090024759A KR101229536B1 (ko) 2009-03-24 2009-03-24 인간 성체 줄기세포 또는 전구세포를 이용한 흑질 치밀부에서의 도파민 신경세포의 재생방법

Publications (2)

Publication Number Publication Date
WO2010110602A2 WO2010110602A2 (ko) 2010-09-30
WO2010110602A3 true WO2010110602A3 (ko) 2011-02-24

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PCT/KR2010/001820 WO2010110602A2 (ko) 2009-03-24 2010-03-24 인간 성체 줄기세포 또는 전구세포를 이용한 흑질 치밀부에서의 도파민 신경세포의 재생방법

Country Status (2)

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KR (1) KR101229536B1 (ko)
WO (1) WO2010110602A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116179489A (zh) * 2021-03-26 2023-05-30 广西大学 一种体外高效诱导人体细胞重编程为神经元细胞的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060233766A1 (en) * 2004-12-23 2006-10-19 Messina Darin J Treatment of Parkinson's disease and related disorders using postpartum derived cells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060233766A1 (en) * 2004-12-23 2006-10-19 Messina Darin J Treatment of Parkinson's disease and related disorders using postpartum derived cells

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BURNSTEIN, R.M. ET AL.: "Differentiation and migration of long term expanded human neural progenitors in a partial lesion model of parkinson's disease", THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, vol. 36, 2004, pages 702 - 713 *
PARISH, C.L. ET AL.: "Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 118, no. 1, January 2008 (2008-01-01), pages 149 - 160 *
SVENDSEN, C.N. ET AL.: "Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease", EXPERIMENTAL NEUROLOGY, vol. 148, 1997, pages 135 - 146, XP001180971, DOI: doi:10.1006/exnr.1997.6634 *

Also Published As

Publication number Publication date
WO2010110602A2 (ko) 2010-09-30
KR20100106681A (ko) 2010-10-04
KR101229536B1 (ko) 2013-02-04

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